ATE120202T1 - Antiherpes-peptidderivate mit einem 1,4-dioxo-c4- n-terminus. - Google Patents

Antiherpes-peptidderivate mit einem 1,4-dioxo-c4- n-terminus.

Info

Publication number
ATE120202T1
ATE120202T1 AT91109243T AT91109243T ATE120202T1 AT E120202 T1 ATE120202 T1 AT E120202T1 AT 91109243 T AT91109243 T AT 91109243T AT 91109243 T AT91109243 T AT 91109243T AT E120202 T1 ATE120202 T1 AT E120202T1
Authority
AT
Austria
Prior art keywords
alkyl
cycloalkyl
hydrogen
peptide derivatives
dioxo
Prior art date
Application number
AT91109243T
Other languages
English (en)
Inventor
Pierre Louis Beaulieu
Robert Deziel
Neil Moss
Original Assignee
Bio Mega Boehringer Ingelheim
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bio Mega Boehringer Ingelheim filed Critical Bio Mega Boehringer Ingelheim
Application granted granted Critical
Publication of ATE120202T1 publication Critical patent/ATE120202T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0819—Tripeptides with the first amino acid being acidic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06104—Dipeptides with the first amino acid being acidic
    • C07K5/06113—Asp- or Asn-amino acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
AT91109243T 1990-06-12 1991-06-06 Antiherpes-peptidderivate mit einem 1,4-dioxo-c4- n-terminus. ATE120202T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CA002018801A CA2018801C (en) 1990-06-12 1990-06-12 Antiherpes peptide derivatives having a 1,4-dioxo c n-terminus
US08/219,600 US5484771A (en) 1990-06-12 1994-03-29 Antiherpes peptide derivatives having a 1,4-dioxo-C, N-terminus

Publications (1)

Publication Number Publication Date
ATE120202T1 true ATE120202T1 (de) 1995-04-15

Family

ID=25674164

Family Applications (1)

Application Number Title Priority Date Filing Date
AT91109243T ATE120202T1 (de) 1990-06-12 1991-06-06 Antiherpes-peptidderivate mit einem 1,4-dioxo-c4- n-terminus.

Country Status (8)

Country Link
US (1) US5484771A (de)
EP (1) EP0461546B1 (de)
JP (1) JP3043833B2 (de)
AT (1) ATE120202T1 (de)
CA (1) CA2018801C (de)
DE (1) DE69108299T2 (de)
IL (1) IL98443A (de)
NZ (1) NZ238455A (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE169931T1 (de) 1992-03-12 1998-09-15 Boehringer Ingelheim Ca Ltd Isosterische peptidderivate gegen herpes
US5846941A (en) * 1992-03-12 1998-12-08 Boehringer Ingelheim (Canada) Ltd. Isosteric antiherpes peptide derivatives II
US5830864A (en) * 1992-03-12 1998-11-03 Boehringer Ingelheim (Canada), Ltd. Antiherpes peptide derivatives having a ureido n-terminus
WO2005026187A1 (ja) * 2003-09-10 2005-03-24 Riken 非天然型塩基を有するヌクレオシド又はヌクレオチド及びその利用
CA2927595C (en) * 2004-12-22 2023-01-31 Ambrx, Inc. Compositions containing, methods involving, and uses of non-natural amino acids and polypeptides
CA2625540C (en) 2005-11-08 2017-03-21 Ambrx, Inc. Accelerants for the modification of non-natural amino acids and non-natural amino acid polypeptides
US20080317670A1 (en) * 2005-12-14 2008-12-25 Ambrx, Inc. Compositions Containing, Methods Involving, and Uses of Non-Natural Amino Acids and Polypeptides
US9376438B2 (en) 2011-05-17 2016-06-28 Principia Biopharma, Inc. Pyrazolopyrimidine derivatives as tyrosine kinase inhibitors
US8962831B2 (en) 2011-05-17 2015-02-24 Principia Biopharma Inc. Tyrosine kinase inhibitors
JP6203848B2 (ja) 2012-09-10 2017-09-27 プリンシピア バイオファーマ インコーポレイテッド キナーゼ阻害剤としてのピラゾロピリミジン化合物
US8957080B2 (en) 2013-04-09 2015-02-17 Principia Biopharma Inc. Tyrosine kinase inhibitors
KR20160117614A (ko) 2014-02-21 2016-10-10 프린시피아 바이오파마, 인코퍼레이티드 Btk 억제제의 염 및 고체 형태
AU2015364335B2 (en) 2014-12-18 2020-11-26 Principia Biopharma Inc. Treatment of pemphigus
EP3313839A1 (de) 2015-06-24 2018-05-02 Principia Biopharma Inc. Tyrosin-kinase-inhibitoren
KR102391693B1 (ko) 2016-06-29 2022-04-29 프린시피아 바이오파마, 인코퍼레이티드 2-[3-[4-아미노-3-(2-플루오로-4-페녹시-페닐)피라졸로[3,4-d]피리미딘-1-일]피페리딘-1-카르보닐]-4-메틸-4-[4-(옥세탄-3-일)피페라진-1-일]펜트-2-엔니트릴의 변형 방출 제제
CN121426803A (zh) 2018-09-12 2026-01-30 诺华股份有限公司 抗病毒吡啶并吡嗪二酮化合物
US11667613B2 (en) 2019-09-26 2023-06-06 Novartis Ag Antiviral pyrazolopyridinone compounds
TWI877239B (zh) 2019-10-14 2025-03-21 美商普林斯匹亞生物製藥公司 藉由投予(R)-2-[3-[4-胺基-3-(2-氟-4-苯氧基-苯基)吡唑并[3,4-d]嘧啶-1-基]哌啶-1-羰基]-4-甲基-4-[4-(氧呾-3-基)哌-1-基]戊-2-烯腈來治療免疫血小板減少症之方法
MX2022009009A (es) 2020-01-22 2022-08-15 Principia Biopharma Inc Formas cristalinas de 2-[3-[4-amino-3-(2-fluoro-4-fenoxi-fenil)-1h -pirazolo[3,4-d]pirimidin-1-il]piperidin-1-carbonil]-4-metil-4-[4 -(oxetan-3-il)piperazin-1-il]pent-2-enonitrilo.

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1341029C (en) * 1985-02-04 2000-06-20 Michael Kolb Peptidase inhibitors
EP0292255A3 (de) * 1987-05-22 1990-08-22 Merck & Co. Inc. Hemmungsstoff für Ribonukleotid-Reduktase
JPH04500963A (ja) * 1988-09-26 1992-02-20 ジ・アップジョン・カンパニー マレアミド置換基を含有するレニン抑制ペプチド類
DE3839559A1 (de) * 1988-11-24 1990-05-31 Hoechst Ag Renin-hemmende aminodiol-derivate

Also Published As

Publication number Publication date
JP3043833B2 (ja) 2000-05-22
EP0461546B1 (de) 1995-03-22
EP0461546A3 (en) 1993-03-24
DE69108299D1 (de) 1995-04-27
CA2018801A1 (en) 1991-12-12
NZ238455A (en) 1993-12-23
US5484771A (en) 1996-01-16
EP0461546A2 (de) 1991-12-18
IL98443A (en) 1995-07-31
DE69108299T2 (de) 1995-08-10
CA2018801C (en) 2000-08-22
JPH04243892A (ja) 1992-08-31

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Legal Events

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RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties