ATE121087T1 - 4-alkylimidazolderivate. - Google Patents

4-alkylimidazolderivate.

Info

Publication number
ATE121087T1
ATE121087T1 AT91914167T AT91914167T ATE121087T1 AT E121087 T1 ATE121087 T1 AT E121087T1 AT 91914167 T AT91914167 T AT 91914167T AT 91914167 T AT91914167 T AT 91914167T AT E121087 T1 ATE121087 T1 AT E121087T1
Authority
AT
Austria
Prior art keywords
alkylimidazole derivatives
alkylimidazole
derivatives
angiotensin
potency
Prior art date
Application number
AT91914167T
Other languages
English (en)
Inventor
David John Carini
Original Assignee
Du Pont
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Du Pont filed Critical Du Pont
Application granted granted Critical
Publication of ATE121087T1 publication Critical patent/ATE121087T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Lubricants (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT91914167T 1990-07-13 1991-07-15 4-alkylimidazolderivate. ATE121087T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US55263790A 1990-07-13 1990-07-13
US07/650,258 US5137902A (en) 1990-07-13 1991-02-04 4-alkylimidazole derivatives and anti-hypertensive use thereof

Publications (1)

Publication Number Publication Date
ATE121087T1 true ATE121087T1 (de) 1995-04-15

Family

ID=27070086

Family Applications (1)

Application Number Title Priority Date Filing Date
AT91914167T ATE121087T1 (de) 1990-07-13 1991-07-15 4-alkylimidazolderivate.

Country Status (23)

Country Link
US (1) US5137902A (de)
EP (1) EP0539509B1 (de)
JP (1) JP2550455B2 (de)
KR (1) KR0162669B1 (de)
AT (1) ATE121087T1 (de)
AU (1) AU639400B2 (de)
BG (1) BG61341B1 (de)
CA (1) CA2087274C (de)
CZ (1) CZ280018B6 (de)
DE (1) DE69108913T2 (de)
DK (1) DK0539509T3 (de)
ES (1) ES2071325T3 (de)
FI (1) FI102752B1 (de)
HU (2) HUT63411A (de)
IE (1) IE69849B1 (de)
IL (1) IL98794A (de)
MY (1) MY140243A (de)
NO (1) NO303015B1 (de)
NZ (1) NZ238920A (de)
PL (1) PL168311B1 (de)
RO (1) RO111270B1 (de)
SK (1) SK279326B6 (de)
WO (1) WO1992000977A2 (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5616599A (en) * 1991-02-21 1997-04-01 Sankyo Company, Limited Angiotensin II antagosist 1-biphenylmethylimidazole compounds and their therapeutic use
DE4132633A1 (de) * 1991-10-01 1993-04-08 Bayer Ag Cyclisch substituierte imidazolyl-propensaeurederivate
US5250558A (en) * 1992-01-28 1993-10-05 Merck & Co., Inc. Substituted triazolinones, triazolinethiones, and triazolinimines as neurotensin antagonists used to treat psychosis
WO1993017681A1 (en) * 1992-03-02 1993-09-16 Abbott Laboratories Angiotensin ii receptor antagonists
GB9218449D0 (en) 1992-08-29 1992-10-14 Boots Co Plc Therapeutic agents
US5310929A (en) * 1992-08-06 1994-05-10 E. I. Du Pont De Nemours And Company Prodrugs of imidazole carboxylic acids as angiotensin II receptor antagonists
JP3501484B2 (ja) * 1992-12-17 2004-03-02 三共株式会社 ビフェニル誘導体
US5338740A (en) * 1993-07-13 1994-08-16 Pfizer Inc. Angiotensin II receptor antagonists
SE9903028D0 (sv) 1999-08-27 1999-08-27 Astra Ab New use
AU2001267404A1 (en) * 2000-05-04 2001-11-12 Ipf Pharmaceuticals Gmbh Novel compounds for the treatment of inflammatory and cardiovascular diseases
CA2568640C (en) 2004-06-04 2011-08-09 Teva Pharmaceutical Industries Ltd. Pharmaceutical composition containing irbesartan
WO2006029057A1 (en) * 2004-09-02 2006-03-16 Teva Pharmaceutical Industries, Ltd. Purification of olmesartan medoxomil
US20070054948A1 (en) * 2004-09-02 2007-03-08 Lilach Hedvati Purification of olmesartan medoxomil
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
MX2009013293A (es) 2007-06-04 2010-02-15 Synergy Pharmaceuticals Inc Agonistas de guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros trastornos.
EP2810951B1 (de) 2008-06-04 2017-03-15 Synergy Pharmaceuticals Inc. Für die Behandlung von gastrointestinalen Erkrankungen, Entzündungen, Krebs und anderen Erkrankungen geeignete Agonisten von Guanylatcyclase
CA2730603C (en) 2008-07-16 2019-09-24 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
JP2016514671A (ja) 2013-03-15 2016-05-23 シナジー ファーマシューティカルズ インコーポレイテッド グアニル酸シクラーゼのアゴニストおよびその使用
JP2016514670A (ja) 2013-03-15 2016-05-23 シナジー ファーマシューティカルズ インコーポレイテッド 他の薬物と組み合わせたグアニル酸シクラーゼ受容体アゴニスト
EA201592263A1 (ru) 2013-06-05 2016-05-31 Синерджи Фармасьютикалз, Инк. Ультрачистые агонисты гуанилатциклазы c, способ их получения и использования

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4820843A (en) * 1987-05-22 1989-04-11 E. I. Du Pont De Nemours And Company Tetrazole intermediates to antihypertensive compounds
US5015651A (en) * 1988-01-07 1991-05-14 E. I. Du Pont De Nemours And Company Treatment of hypertension with 1,2,4-angiotensin II antagonists
US4880804A (en) * 1988-01-07 1989-11-14 E. I. Du Pont De Nemours And Company Angiotensin II receptor blocking benzimidazoles
CA1338238C (en) * 1988-01-07 1996-04-09 David John Carini Angiotensin ii receptor blocking imidazoles and combinations thereof with diuretics and nsaids
US5064825A (en) * 1989-06-01 1991-11-12 Merck & Co., Inc. Angiotensin ii antagonists
HU217958B (hu) * 1989-06-30 2000-05-28 E. I. Du Pont De Nemours And Co. Helyettesített imidazolszármazékok, ezeket tartalmazó gyógyszerkészítmények és eljárás előállításukra
EP0479892A1 (de) * 1989-06-30 1992-04-15 E.I. Du Pont De Nemours And Company Arylgruppe substituierte imidazole mit zusammengeschmolzenen ringen
DE4132633A1 (de) * 1991-10-01 1993-04-08 Bayer Ag Cyclisch substituierte imidazolyl-propensaeurederivate

Also Published As

Publication number Publication date
DE69108913T2 (de) 1995-08-24
EP0539509B1 (de) 1995-04-12
NO303015B1 (no) 1998-05-18
JP2550455B2 (ja) 1996-11-06
SK279326B6 (sk) 1998-10-07
EP0539509A1 (de) 1993-05-05
AU8311691A (en) 1992-02-04
PL168311B1 (pl) 1996-02-29
CA2087274A1 (en) 1992-01-14
FI102752B (fi) 1999-02-15
FI930109L (fi) 1993-01-12
IL98794A (en) 1995-11-27
HU223530B1 (hu) 2004-08-30
PL297616A1 (de) 1992-07-13
ES2071325T3 (es) 1995-06-16
IE912438A1 (en) 1992-01-15
IL98794A0 (en) 1992-07-15
FI930109A0 (fi) 1993-01-12
CZ280018B6 (cs) 1995-09-13
BG61341B1 (en) 1997-06-30
RO111270B1 (ro) 1996-08-30
IE69849B1 (en) 1996-10-02
MY140243A (en) 2009-12-31
AU639400B2 (en) 1993-07-22
HUT63411A (en) 1993-08-30
KR0162669B1 (ko) 1998-12-01
WO1992000977A2 (en) 1992-01-23
NZ238920A (en) 1993-07-27
CZ391292A3 (en) 1993-12-15
JPH05508415A (ja) 1993-11-25
DE69108913D1 (de) 1995-05-18
SK391292A3 (en) 1993-07-07
DK0539509T3 (da) 1995-07-03
CA2087274C (en) 2002-02-19
HU9204058D0 (en) 1993-03-29
FI102752B1 (fi) 1999-02-15
NO930088D0 (no) 1993-01-11
BG97438A (bg) 1994-03-24
WO1992000977A3 (en) 1992-02-20
US5137902A (en) 1992-08-11
NO930088L (no) 1993-01-11

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
EELA Cancelled due to lapse of time