ATE121261T1 - Auf alpha-tocopherol basierte bläschen. - Google Patents
Auf alpha-tocopherol basierte bläschen.Info
- Publication number
- ATE121261T1 ATE121261T1 AT86906559T AT86906559T ATE121261T1 AT E121261 T1 ATE121261 T1 AT E121261T1 AT 86906559 T AT86906559 T AT 86906559T AT 86906559 T AT86906559 T AT 86906559T AT E121261 T1 ATE121261 T1 AT E121261T1
- Authority
- AT
- Austria
- Prior art keywords
- alpha
- based bubbles
- tocopherol based
- tocopherol
- optionally
- Prior art date
Links
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 title 2
- 229940087168 alpha tocopherol Drugs 0.000 title 1
- 229960000984 tocofersolan Drugs 0.000 title 1
- 239000002076 α-tocopherol Substances 0.000 title 1
- 235000004835 α-tocopherol Nutrition 0.000 title 1
- 239000002502 liposome Substances 0.000 abstract 4
- 239000000725 suspension Substances 0.000 abstract 2
- 239000002184 metal Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
- A61K9/1277—Preparation processes; Proliposomes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
- A61K31/355—Tocopherols, e.g. vitamin E
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
- A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers comprising non-phosphatidyl surfactants as bilayer-forming substances, e.g. cationic lipids or non-phosphatidyl liposomes coated or grafted with polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/10—Anthelmintics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/829—Liposomes, e.g. encapsulation
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
- Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
- Y10T428/2984—Microcapsule with fluid core [includes liposome]
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Dispersion Chemistry (AREA)
- Immunology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Neurosurgery (AREA)
- Biophysics (AREA)
- Neurology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Rheumatology (AREA)
- Transplantation (AREA)
- Ophthalmology & Optometry (AREA)
- Virology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Manufacturing Of Micro-Capsules (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US78674085A | 1985-10-15 | 1985-10-15 | |
| US06/911,138 US4861580A (en) | 1985-10-15 | 1986-09-24 | Composition using salt form of organic acid derivative of alpha-tocopheral |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE121261T1 true ATE121261T1 (de) | 1995-05-15 |
Family
ID=27120576
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT86906559T ATE121261T1 (de) | 1985-10-15 | 1986-10-06 | Auf alpha-tocopherol basierte bläschen. |
| AT91115181T ATE141156T1 (de) | 1985-10-15 | 1986-10-06 | Extrusionsverfahren für liposome |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT91115181T ATE141156T1 (de) | 1985-10-15 | 1986-10-06 | Extrusionsverfahren für liposome |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US4861580A (de) |
| EP (2) | EP0243446B1 (de) |
| JP (1) | JP2848583B2 (de) |
| AT (2) | ATE121261T1 (de) |
| AU (1) | AU6543786A (de) |
| CA (1) | CA1315678C (de) |
| DE (2) | DE3650556T2 (de) |
| IL (1) | IL80267A0 (de) |
| WO (1) | WO1987002219A1 (de) |
Families Citing this family (87)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX9203291A (es) * | 1985-06-26 | 1992-08-01 | Liposome Co Inc | Metodo para acoplamiento de liposomas. |
| US5059421A (en) * | 1985-07-26 | 1991-10-22 | The Liposome Company, Inc. | Preparation of targeted liposome systems of a defined size distribution |
| US5041278A (en) * | 1985-10-15 | 1991-08-20 | The Liposome Company, Inc. | Alpha tocopherol-based vesicles |
| US6759057B1 (en) | 1986-06-12 | 2004-07-06 | The Liposome Company, Inc. | Methods and compositions using liposome-encapsulated non-steroidal anti-inflammatory drugs |
| US5204112A (en) * | 1986-06-16 | 1993-04-20 | The Liposome Company, Inc. | Induction of asymmetry in vesicles |
| US5252263A (en) * | 1986-06-16 | 1993-10-12 | The Liposome Company, Inc. | Induction of asymmetry in vesicles |
| US6406713B1 (en) | 1987-03-05 | 2002-06-18 | The Liposome Company, Inc. | Methods of preparing low-toxicity drug-lipid complexes |
| US5616334A (en) * | 1987-03-05 | 1997-04-01 | The Liposome Company, Inc. | Low toxicity drug-lipid systems |
| MX9203808A (es) * | 1987-03-05 | 1992-07-01 | Liposome Co Inc | Formulaciones de alto contenido de medicamento: lipido, de agentes liposomicos-antineoplasticos. |
| US5154930A (en) * | 1987-03-05 | 1992-10-13 | The Liposome Company, Inc. | Pharmacological agent-lipid solution preparation |
| JPH02502978A (ja) * | 1987-04-16 | 1990-09-20 | ザ リポソーム カンパニー,インコーポレイテッド | リポソームの連続的サイズ減少方法及び装置 |
| KR920003601B1 (ko) * | 1987-09-03 | 1992-05-04 | 유니버시티 어브 죠지아 리서취 화운데이션 인코포레이티드 | 점안 싸이클로스포린(cyclosporin)의 조성물 |
| MX9203804A (es) * | 1987-10-19 | 1992-07-01 | Liposome Co Inc | Sistemas farmaceuticos a base de tocoferol. |
| WO1989003689A1 (en) * | 1987-10-19 | 1989-05-05 | The Liposome Company, Inc. | Tocopherol-based pharmaceutical systems |
| US5009819A (en) * | 1987-11-12 | 1991-04-23 | The Liposome Company, Inc. | Taste moderating composition |
| US5948441A (en) * | 1988-03-07 | 1999-09-07 | The Liposome Company, Inc. | Method for size separation of particles |
| US5049392A (en) * | 1989-01-18 | 1991-09-17 | The Liposome Company, Inc. | Osmotically dependent vesicles |
| ATE115862T1 (de) * | 1989-02-04 | 1995-01-15 | Akzo Nobel Nv | Tocole als impfstoffadjuvans. |
| JPH05500203A (ja) * | 1989-02-17 | 1993-01-21 | ザ リポソーム カンパニー,インコーポレイテッド | 鼻腔内搬送用及び局所適用脂質賦形剤 |
| EP0472639A4 (en) * | 1989-05-15 | 1992-07-01 | The Liposome Company, Inc. | Accumulation of drugs into liposomes by a proton gradient |
| FR2657526B1 (fr) * | 1990-01-31 | 1994-10-28 | Lvmh Rech | Utilisation d'un phosphate d'alpha-tocopherol, ou de l'un de ses derives, pour la preparation de compositions cosmetiques, dermatologiques, ou pharmaceutiques; compositions ainsi obtenues. |
| AU653325B2 (en) * | 1990-02-12 | 1994-09-29 | Lucky Limited | A composition durably releasing bioactive polypeptides |
| US5525232A (en) * | 1990-03-02 | 1996-06-11 | The Liposome Company, Inc. | Method for entrapment of cationic species in lemellar vesicles |
| IT1240354B (it) * | 1990-03-30 | 1993-12-07 | Poli Ind Chimica Spa | Formulazioni liposomiali di farmaci antimicotici,antibatterici e/o antantiflogistici per applicazione locale e vaginale |
| DK0555229T3 (da) * | 1990-07-31 | 1996-08-19 | Liposome Co Inc | Akkumulation af aminosyrer og peptider i liposomer |
| US5346703A (en) | 1990-08-07 | 1994-09-13 | Mediventures, Inc. | Body cavity drug delivery with thermo-irreversible polyoxyalkylene and ionic polysaccharide gels |
| CA2047969A1 (en) * | 1990-08-17 | 1992-02-18 | Thomas D. Madden | Benzoporphyrin vesicles |
| US5091111A (en) * | 1990-09-19 | 1992-02-25 | S. C. Johnson & Son, Inc. | Aqueous emulsion and aersol delivery system using same |
| US5145604A (en) * | 1990-09-19 | 1992-09-08 | S. C. Johnson & Son, Inc. | Aqueous emulsion and aerosol delivery system using same |
| GB9111611D0 (en) * | 1991-05-30 | 1991-07-24 | Sandoz Ltd | Liposomes |
| US5318780A (en) * | 1991-10-30 | 1994-06-07 | Mediventures Inc. | Medical uses of in situ formed gels |
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| US6139872A (en) * | 1996-08-14 | 2000-10-31 | Henkel Corporation | Method of producing a vitamin product |
| US6022560A (en) * | 1996-08-27 | 2000-02-08 | Clarion Pharmaceuticals Inc. | Pharmaceutical compositions, novel uses, and novel form of α-tocopherylphosphocholine |
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| US6203778B1 (en) * | 1998-12-08 | 2001-03-20 | The Regents Of The University Of California | Particulate radiopaque contrast agent for diagnostic imaging and microvascular characterization |
| ATE404172T1 (de) | 1998-12-30 | 2008-08-15 | Dexcel Ltd | Dispergierbares konzentrat zur verabreichung von cyclosporin |
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| DK2892524T3 (da) | 2012-09-04 | 2021-01-25 | Eleison Pharmaceuticals LLC | Forebyggelse af pulmonalt kræfttilbagefald med lipid-komplekseret cisplatin |
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| CN108136023B (zh) | 2015-08-12 | 2021-07-27 | 北卡罗莱纳州立大学 | 血小板膜包覆的药物递送系统 |
| WO2017204896A1 (en) * | 2016-05-26 | 2017-11-30 | Becton, Dickinson And Company | Methods and devices for liposome preparation by centrifugation |
| EP3773505B1 (de) | 2018-03-30 | 2026-04-29 | Insmed Incorporated | Verfahren zur kontinuierlichen herstellung von liposomalen arzneimittelprodukten |
| JP7449275B2 (ja) | 2018-05-02 | 2024-03-13 | インスメッド インコーポレイテッド | リポソーム薬物製剤の製造方法 |
| US10736847B2 (en) | 2018-07-03 | 2020-08-11 | Becton, Dickinson And Company | Inverting device for liposome preparation by centrifugation |
| EP4312536A1 (de) | 2021-04-01 | 2024-02-07 | Vestaron Corporation | Liposomformulierungen zur pestizidabgabe und verfahren zur herstellung und verwendung davon |
| JP2025521093A (ja) | 2022-05-10 | 2025-07-08 | ベクトン・ディキンソン・アンド・カンパニー | 真空媒介リポソーム調製のためのシステムおよびその使用方法 |
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| US3136695A (en) * | 1961-03-10 | 1964-06-09 | Strong Cobb Arner Inc | Anhydrous thixotropic gel sustained release therapeutic compositions and method of preparation |
| US3719690A (en) * | 1969-11-13 | 1973-03-06 | Eisai Co Ltd | Basic amino-acid salts of tocopherylsuccinate |
| US3993754A (en) * | 1974-10-09 | 1976-11-23 | The United States Of America As Represented By The United States Energy Research And Development Administration | Liposome-encapsulated actinomycin for cancer chemotherapy |
| US4086257A (en) * | 1976-10-12 | 1978-04-25 | Sears Barry D | Phosphatidyl quaternary ammonium compounds |
| US4088576A (en) * | 1976-12-13 | 1978-05-09 | Mott Lambert H | Method of manufacture of tubular inertial filter |
| CH624011A5 (de) * | 1977-08-05 | 1981-07-15 | Battelle Memorial Institute | |
| US4235871A (en) * | 1978-02-24 | 1980-11-25 | Papahadjopoulos Demetrios P | Method of encapsulating biologically active materials in lipid vesicles |
| US4263428A (en) * | 1978-03-24 | 1981-04-21 | The Regents Of The University Of California | Bis-anthracycline nucleic acid function inhibitors and improved method for administering the same |
| US4193983A (en) * | 1978-05-16 | 1980-03-18 | Syva Company | Labeled liposome particle compositions and immunoassays therewith |
| FR2438481A1 (fr) * | 1978-10-11 | 1980-05-09 | Bugard Pierre | Complexe lipoproteique normalisant l'efficacite de la vitamine e et des antioxydants de synthese |
| GR73668B (de) * | 1978-11-21 | 1984-03-28 | Hoffmann La Roche | |
| DE3000483A1 (de) * | 1979-01-09 | 1980-07-17 | Fuji Photo Film Co Ltd | Mikrokapseln fuer immunologische bestimmungen |
| CA1173360A (en) * | 1979-06-22 | 1984-08-28 | Jurg Schrank | Pharmaceutical preparations |
| DE3068743D1 (en) * | 1980-01-16 | 1984-08-30 | Weder Hans G | Process and dialysis-installation for the preparation of bilayer-vesicles and their use |
| US4376118A (en) * | 1980-10-06 | 1983-03-08 | Miles Laboratories, Inc. | Stable nonaqueous solution of tetracycline salt |
| GR77320B (de) * | 1980-12-22 | 1984-09-11 | Procter & Gamble | |
| US4522803A (en) * | 1983-02-04 | 1985-06-11 | The Liposome Company, Inc. | Stable plurilamellar vesicles, their preparation and use |
| EP0153955A1 (de) * | 1983-09-06 | 1985-09-11 | Health Research, Inc. | Verfahren zum verabreichen von liposomen zum herabsetzen der toxizität eines antitumor-arzneimittels |
| US4721612A (en) * | 1984-04-12 | 1988-01-26 | The Liposome Company, Inc. | Steroidal liposomes |
| US4891208A (en) * | 1985-04-10 | 1990-01-02 | The Liposome Company, Inc. | Steroidal liposomes |
| US4665204A (en) * | 1985-06-27 | 1987-05-12 | Henkel Corporation | Diester derivatives of tocopherol |
| JP2634047B2 (ja) * | 1985-10-15 | 1997-07-23 | ザ リポソ−ム カンパニ−,インコ−ポレイテツド | アルファトコフェロールをベースとした小胞体 |
| JP2894445B2 (ja) * | 1997-02-12 | 1999-05-24 | 日本たばこ産業株式会社 | Cetp活性阻害剤として有効な化合物 |
-
1986
- 1986-09-24 US US06/911,138 patent/US4861580A/en not_active Expired - Lifetime
- 1986-10-06 DE DE3650556T patent/DE3650556T2/de not_active Expired - Fee Related
- 1986-10-06 CA CA000519854A patent/CA1315678C/en not_active Expired - Fee Related
- 1986-10-06 AT AT86906559T patent/ATE121261T1/de not_active IP Right Cessation
- 1986-10-06 DE DE3650302T patent/DE3650302T2/de not_active Expired - Fee Related
- 1986-10-06 WO PCT/US1986/002101 patent/WO1987002219A1/en not_active Ceased
- 1986-10-06 EP EP86906559A patent/EP0243446B1/de not_active Expired - Lifetime
- 1986-10-06 AT AT91115181T patent/ATE141156T1/de not_active IP Right Cessation
- 1986-10-06 EP EP91115181A patent/EP0460720B1/de not_active Expired - Lifetime
- 1986-10-06 AU AU65437/86A patent/AU6543786A/en not_active Abandoned
- 1986-10-09 IL IL80267A patent/IL80267A0/xx not_active IP Right Cessation
-
1995
- 1995-04-18 JP JP7092141A patent/JP2848583B2/ja not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| EP0460720B1 (de) | 1996-08-14 |
| EP0243446B1 (de) | 1995-04-19 |
| IL80267A0 (en) | 1987-01-30 |
| JP2848583B2 (ja) | 1999-01-20 |
| AU6543786A (en) | 1987-05-05 |
| EP0460720A2 (de) | 1991-12-11 |
| DE3650556T2 (de) | 1997-02-13 |
| DE3650556D1 (de) | 1996-09-19 |
| EP0243446A1 (de) | 1987-11-04 |
| JPH0834745A (ja) | 1996-02-06 |
| ATE141156T1 (de) | 1996-08-15 |
| EP0460720A3 (en) | 1992-01-02 |
| US4861580A (en) | 1989-08-29 |
| CA1315678C (en) | 1993-04-06 |
| DE3650302D1 (de) | 1995-05-24 |
| DE3650302T2 (de) | 1995-09-07 |
| EP0243446A4 (de) | 1988-06-23 |
| WO1987002219A1 (en) | 1987-04-23 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |