ATE121401T1 - 2-substituierte 4,5-diphenylimidazole. - Google Patents

2-substituierte 4,5-diphenylimidazole.

Info

Publication number: ATE121401T1
Authority: AT; Austria
Prior art keywords: dpim; formula; substituted; diphenylimidazole; acyle
Prior art date: 1990-01-12

Application number

AT91901788T

Other languages

English (en)

Inventor

Andrew William Bridge

Neil Victor Harris

David John Lythgoe

Christopher Smith

Original Assignee

Rhone Poulenc Rorer Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-01-12

Filing date

1991-01-09

Publication date

1995-05-15

1990-01-12 Priority claimed from GB909000696A external-priority patent/GB9000696D0/en

1990-12-21 Priority claimed from GB909027892A external-priority patent/GB9027892D0/en

1991-01-09 Application filed by Rhone Poulenc Rorer Sa filed Critical Rhone Poulenc Rorer Sa

1995-05-15 Application granted granted Critical

1995-05-15 Publication of ATE121401T1 publication Critical patent/ATE121401T1/de

Links

-1 2-SUBSTITUTED 4,5-DIPHENYLIMIDAZOLE Chemical class 0.000 title abstract 2
102000004357 Transferases Human genes 0.000 abstract 1
108090000992 Transferases Proteins 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
125000002947 alkylene group Chemical group 0.000 abstract 1
RGJOEKWQDUBAIZ-UHFFFAOYSA-N coenzime A Natural products OC1C(OP(O)(O)=O)C(COP(O)(=O)OP(O)(=O)OCC(C)(C)C(O)C(=O)NCCC(=O)NCCS)OC1N1C2=NC=NC(N)=C2N=C1 RGJOEKWQDUBAIZ-UHFFFAOYSA-N 0.000 abstract 1
239000005516 coenzyme A Substances 0.000 abstract 1
229940093530 coenzyme a Drugs 0.000 abstract 1
KDTSHFARGAKYJN-UHFFFAOYSA-N dephosphocoenzyme A Natural products OC1C(O)C(COP(O)(=O)OP(O)(=O)OCC(C)(C)C(O)C(=O)NCCC(=O)NCCS)OC1N1C2=NC=NC(N)=C2N=C1 KDTSHFARGAKYJN-UHFFFAOYSA-N 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
150000002431 hydrogen Chemical class 0.000 abstract 1
150000002460 imidazoles Chemical class 0.000 abstract 1
239000003112 inhibitor Substances 0.000 abstract 1
229940079865 intestinal antiinfectives imidazole derivative Drugs 0.000 abstract 1
125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
238000002560 therapeutic procedure Methods 0.000 abstract 1
RZWIIPASKMUIAC-VQTJNVASSA-N thromboxane Chemical compound CCCCCCCC[C@H]1OCCC[C@@H]1CCCCCCC RZWIIPASKMUIAC-VQTJNVASSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/84—Sulfur atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/91—Nitro radicals
- C07D233/92—Nitro radicals attached in position 4 or 5
- C07D233/94—Nitro radicals attached in position 4 or 5 with hydrocarbon radicals, substituted by oxygen or sulfur atoms, attached to other ring members
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Hematology (AREA)
Diabetes (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Obesity (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Photoreceptors In Electrophotography (AREA)
Plural Heterocyclic Compounds (AREA)
Inks, Pencil-Leads, Or Crayons (AREA)
Polyurethanes Or Polyureas (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Luminescent Compositions (AREA)
Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
Macromonomer-Based Addition Polymer (AREA)
Adhesives Or Adhesive Processes (AREA)

AT91901788T 1990-01-12 1991-01-09 2-substituierte 4,5-diphenylimidazole. ATE121401T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB909000696A GB9000696D0 (en)	1990-01-12	1990-01-12	New compositions of matter
GB909027892A GB9027892D0 (en)	1990-12-21	1990-12-21	Imidazoles

Publications (1)

Publication Number	Publication Date
ATE121401T1 true ATE121401T1 (de)	1995-05-15

Family

ID=26296489

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT91901788T ATE121401T1 (de)	1990-01-12	1991-01-09	2-substituierte 4,5-diphenylimidazole.

Country Status (17)

Country	Link
EP (1)	EP0510036B1 (de)
JP (1)	JPH05503095A (de)
KR (1)	KR927003576A (de)
AT (1)	ATE121401T1 (de)
AU (1)	AU7066191A (de)
CA (1)	CA2073443A1 (de)
CS (1)	CS5291A3 (de)
DE (1)	DE69109090T2 (de)
FI (1)	FI923189A7 (de)
HU (1)	HUT61540A (de)
IE (1)	IE910098A1 (de)
IL (1)	IL96924A0 (de)
MX (1)	MX9203711A (de)
NO (1)	NO922729L (de)
NZ (1)	NZ236763A (de)
PT (1)	PT96467A (de)
WO (1)	WO1991010662A1 (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9019838D0 (en) *	1990-09-11	1990-10-24	Smith Kline French Lab	Compounds
US5212318A (en) *	1991-03-04	1993-05-18	Eastman Kodak Company	Preparation of omega-substituted alkanamide
GB9115005D0 (en) *	1991-07-11	1991-08-28	Rhone Poulenc Rorer Ltd	Novel compositions of matter
GB9115190D0 (en) *	1991-07-12	1991-08-28	Rhone Poulenc Rorer Ltd	New compositions of matter
US5364875A (en) *	1992-05-11	1994-11-15	The Du Pont Merck Pharmaceutical Company	Imidazoles linked to bicyclic heterocyclic groups for the treatment of atherosclerosis
US5310748A (en) *	1992-05-11	1994-05-10	The Du Pont Merck Pharmaceutical Company	Imidazoles for the treatment of atherosclerosis
IT1265209B1 (it) *	1993-11-22	1996-10-31	Pierrel Spa	Difenilimidazoli utili nel trattamento di dislipidemia, arteriosclerosi e malattie coronariche procedimento per la loro
US5491152A (en) *	1994-03-23	1996-02-13	The Du Pont Merck Pharmaceutical Company	Derivatives of cyclic ethers and sulfides for the treatment of atherosclerosis
DE19645313A1 (de)	1996-11-04	1998-05-07	Basf Ag	Substituierte 3-Benzylpyrazole
DE10107683A1 (de)	2001-02-19	2002-08-29	Merckle Gmbh Chem Pharm Fabrik	2-Thio-substituierte Imidazolderivate und ihre Verwendung in der Pharmazie
DE10114775A1 (de)	2001-03-26	2002-10-10	Gerhard Dannhardt	2-Mercapto-4,5-diarylimidazolderivate und ihre Verwendung in der Pharmazie
DE10238045A1 (de)	2002-08-20	2004-03-04	Merckle Gmbh Chem.-Pharm. Fabrik	2-Thio-substituierte Imidazolderivate und ihre Verwendung in der Pharmazie
MD4150C1 (ro) *	2011-10-11	2012-09-30	Институт Химии Академии Наук Молдовы	Procedeu de obţinere a compuşilor coordinativi ai Co(II), Ni(II) şi Zn(II) cu 2-nitro-4,5-difenilimidazol pornind de la 4,5-difenilimidazol şi nitraţii metalelor respective
MD4178C1 (ro) *	2012-02-27	2013-02-28	Институт Химии Академии Наук Молдовы	Procedeu de obţinere a 2-nitro-4,5-difenilimidazolului
CN106699738A (zh) *	2015-11-18	2017-05-24	南京大学	一类含甲硝唑吡唑类骨架的抗菌化合物的设计、合成及生物活性评价

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3323870A1 (de) *	1983-07-02	1985-01-03	A. Nattermann & Cie GmbH, 5000 Köln	Neue imidazol-2-ylthioalkansaeuren und ihre derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate
DK167187A (da) *	1986-04-02	1987-10-03	Otsuka Pharma Co Ltd	Carbostyrilderivater og salte deraf, fremgangsmaade til fremstilling af saadanne forbindelser og laegemiddel indeholdende disse
US4900744A (en) *	1988-09-14	1990-02-13	E. I. Du Pont De Nemours And Company	Antihypercholesterolemic 4,5-diaryl-2-substituted thioimidazoles

1991
- 1991-01-09 JP JP3502230A patent/JPH05503095A/ja active Pending
- 1991-01-09 EP EP91901788A patent/EP0510036B1/de not_active Expired - Lifetime
- 1991-01-09 KR KR1019920701647A patent/KR927003576A/ko not_active Withdrawn
- 1991-01-09 AU AU70661/91A patent/AU7066191A/en not_active Abandoned
- 1991-01-09 AT AT91901788T patent/ATE121401T1/de not_active IP Right Cessation
- 1991-01-09 FI FI923189A patent/FI923189A7/fi not_active Application Discontinuation
- 1991-01-09 CA CA002073443A patent/CA2073443A1/en not_active Abandoned
- 1991-01-09 HU HU9422A patent/HUT61540A/hu unknown
- 1991-01-09 MX MX9203711A patent/MX9203711A/es unknown
- 1991-01-09 DE DE69109090T patent/DE69109090T2/de not_active Expired - Fee Related
- 1991-01-09 WO PCT/EP1991/000023 patent/WO1991010662A1/en not_active Ceased
- 1991-01-10 IL IL96924A patent/IL96924A0/xx unknown
- 1991-01-11 IE IE009891A patent/IE910098A1/en unknown
- 1991-01-11 CS CS9152A patent/CS5291A3/cs unknown
- 1991-01-11 PT PT96467A patent/PT96467A/pt not_active Application Discontinuation
- 1991-01-14 NZ NZ236763A patent/NZ236763A/xx unknown
1992
- 1992-07-10 NO NO92922729A patent/NO922729L/no unknown

Also Published As

Publication number	Publication date
PT96467A (pt)	1991-10-15
FI923189L (fi)	1992-07-10
JPH05503095A (ja)	1993-05-27
HU9202294D0 (en)	1992-10-28
EP0510036B1 (de)	1995-04-19
IE910098A1 (en)	1991-07-17
NZ236763A (en)	1993-05-26
DE69109090D1 (de)	1995-05-24
WO1991010662A1 (en)	1991-07-25
MX9203711A (es)	1992-07-01
NO922729L (no)	1992-09-02
EP0510036A1 (de)	1992-10-28
IL96924A0 (en)	1992-03-29
KR927003576A (ko)	1992-12-18
FI923189A0 (fi)	1992-07-10
NO922729D0 (no)	1992-07-10
HUT61540A (en)	1993-01-28
FI923189A7 (fi)	1992-07-10
DE69109090T2 (de)	1995-09-14
CA2073443A1 (en)	1991-07-13
AU7066191A (en)	1991-08-05
CS5291A3 (en)	1992-02-19

Legal Events

Date	Code	Title	Description
1995-10-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
ATE121401T1 (de)	1995-05-15	2-substituierte 4,5-diphenylimidazole.
FI865147A0 (fi)	1986-12-17	Antimykotiskt verksamt nagellack.
NO165145C (no)	1991-01-02	Analogifremgangsmaate for fremstilling av terapeutisk aktive 1h-imidazo-(4,5-c)-kinolin-4-aminderivater.
EE200200148A (et)	2003-04-15	Kinasoliini derivaadid, nende valmistamise meetodning kasutamine
NO166126C (no)	1991-06-05	Analogifremgangsmaate ved fremstilling av terapeutisk aktive kinolonkarboksylsyrederivater.
NZ313696A (en)	2000-01-28	4-mercaptopyrrolidine derivatives as farnesyl transferase inhibitors
KR860005794A (ko)	1986-08-13	이미다졸 유도체의 제조방법
YU48089B (sh)	1997-01-08	Novi derivati tetrazola i postupak za njihovo pripremanje
DK0538192T3 (da)	1997-05-20	Hidtil ukendte 17beta-substituerede aza-androstan-derivater
ES513469A0 (es)	1983-05-01	Procedimiento para preparar derivados de pirimidona.
MD382C2 (ro)	1996-06-30	Procedeu de obţinere a piperazinilalchil-3(2H)-piridazinonelor sau a sărurilor lor farmaceutice admisibile
ES505329A0 (es)	1982-08-16	Procedimiento para la preparacion de derivados de imidazol del sistema de 1,4-benzodioxan-2-ilo
DE3061125D1 (en)	1982-12-30	1-(naphthyl-n-propyl)imidazole derivatives, compositions containing them, methods of making them and their use for pharmaceuticals
SE8602524L (sv)	1986-12-05	Kinolinderivat
NO861630L (no)	1986-10-28	Karbapenemderivater og fremgangsmaate til fremstilling derav.
DE60144246D1 (de)	2011-04-28	Imidazolderivate, verfahren zu deren herstellung und deren verwendung
FR2443460A1 (fr)	1980-07-04	Derives mercaptoacyles d'acides 4,5-dihydro-1h-pyrrole-2-carboxyliques et d'acides 1,4,5,6-tetrahydropyridine-2-carboxyliques, utiles comme agents hypotenseurs
NO883263D0 (no)	1988-07-22	Fremgangsmaate for fremstilling av terapeutisk aktive benzimidazol-derivater.
MY102275A (en)	1992-05-15	Antimykotische aminoazole ii
GB1433103A (en)	1976-04-22	Pharmacologically active pyrrolodiazepines
ATE18993T1 (de)	1986-04-15	Dibenzocycloheptenyliden-verbindungen zur verwendung bei der modulation der immunreaktion.
NO811185L (no)	1981-10-09	Fremgangsmaate for fremstilling av farmakologisk aktive tiazolderivater.
ATE30323T1 (de)	1987-11-15	5-phenylaethenylbenzimidazole.
FR2426685A2 (fr)	1979-12-21	Derives d'acides thiazolidinecarboxyliques et d'acides apparentes, utiles comme agents anti-hypertension
JPS53124267A (en)	1978-10-30	1-alkoxyacyl-3-(3,5-dihalogenophenyl)hydantoin derivatives, their preparation and bactericides for agricultural and horticultural uses containing the same as active agent