ATE121620T1 - Verwendung von tenidap zur senkung des gesamtserumcholesterins, ldl-cholesterins und triglyceride. - Google Patents

Verwendung von tenidap zur senkung des gesamtserumcholesterins, ldl-cholesterins und triglyceride.

Info

Publication number: ATE121620T1
Authority: AT; Austria
Prior art keywords: cholesterol; tenidap; triglycerides; total serum; lower total
Prior art date: 1991-02-08

Application number

AT92300884T

Other languages

English (en)

Inventor

Leland David Loose

Naitee Ting

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-02-08

Filing date

1992-02-03

Publication date

1995-05-15

1992-02-03 Application filed by Pfizer filed Critical Pfizer

1995-05-15 Application granted granted Critical

1995-05-15 Publication of ATE121620T1 publication Critical patent/ATE121620T1/de

Links

108010028554 LDL Cholesterol Proteins 0.000 title abstract 2
238000008214 LDL Cholesterol Methods 0.000 title abstract 2
HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 title abstract 2
LXIKEPCNDFVJKC-QXMHVHEDSA-N tenidap Chemical compound C12=CC(Cl)=CC=C2N(C(=O)N)C(=O)\C1=C(/O)C1=CC=CS1 LXIKEPCNDFVJKC-QXMHVHEDSA-N 0.000 title abstract 2
229960003676 tenidap Drugs 0.000 title abstract 2
150000003626 triacylglycerols Chemical class 0.000 title abstract 2
IGPDWKCUDHIIRL-UHFFFAOYSA-N 5-chloro-2-oxo-3-[oxo(thiophen-2-yl)methyl]-3H-indole-1-carboxamide Chemical compound C12=CC(Cl)=CC=C2N(C(=O)N)C(=O)C1C(=O)C1=CC=CS1 IGPDWKCUDHIIRL-UHFFFAOYSA-N 0.000 abstract 1
241000124008 Mammalia Species 0.000 abstract 1
230000002917 arthritic effect Effects 0.000 abstract 1
230000002757 inflammatory effect Effects 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics

Landscapes

Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Epidemiology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Rheumatology (AREA)
Pain & Pain Management (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Obesity (AREA)
Hematology (AREA)
Diabetes (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicines Containing Plant Substances (AREA)
Coloring Foods And Improving Nutritive Qualities (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Plural Heterocyclic Compounds (AREA)

AT92300884T 1991-02-08 1992-02-03 Verwendung von tenidap zur senkung des gesamtserumcholesterins, ldl-cholesterins und triglyceride. ATE121620T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US65270991A	1991-02-08	1991-02-08
US07/727,786 US5122534A (en)	1991-02-08	1991-07-10	Use of tenidap to reduce total serum cholesterol, ldl cholesterol and triglycerides

Publications (1)

Publication Number	Publication Date
ATE121620T1 true ATE121620T1 (de)	1995-05-15

Family

ID=27096345

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT92300884T ATE121620T1 (de)	1991-02-08	1992-02-03	Verwendung von tenidap zur senkung des gesamtserumcholesterins, ldl-cholesterins und triglyceride.

Country Status (17)

Country	Link
US (1)	US5122534A (de)
EP (1)	EP0498588B1 (de)
JP (1)	JPH0558893A (de)
KR (1)	KR940011245B1 (de)
AT (1)	ATE121620T1 (de)
AU (1)	AU630580B2 (de)
CA (1)	CA2060789C (de)
DE (1)	DE69202162T2 (de)
DK (1)	DK0498588T3 (de)
HK (1)	HK219096A (de)
HU (1)	HUT62194A (de)
IE (1)	IE65596B1 (de)
MX (1)	MX9200544A (de)
MY (1)	MY106885A (de)
NZ (1)	NZ241555A (de)
PT (1)	PT100095A (de)
TW (1)	TW206153B (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE19513716A1 (de) *	1995-02-01	1996-08-08	Bayer Ag	Substituierte 2-Phenylindol-Derivate
US5545656A (en) *	1995-04-05	1996-08-13	Pfizer Inc.	2-Oxidole-1-carboxamide pharmaceutical agents for the treatment of alzheimer's disease
AU7503496A (en) *	1995-12-19	1997-07-14	Pfizer Inc.	Stable, long acting salts of indole derivatives for the treatment of joint diseases
EP0826685A1 (de) *	1996-08-21	1998-03-04	Pfizer Inc.	Stabile, lange aktive Salze von Carboxamiden für die Behandlung von Gelenkskrankheiten
DK1353666T3 (da)	2001-01-02	2013-10-14	Cleveland Clinic Foundation	Myeloperoxidase, en risikoindikator for cardiovasculær sygdom
US7780950B2 (en) *	2002-01-02	2010-08-24	The Cleveland Clinic Foundation	Systemic marker for monitoring anti-inflammatory and antioxidant actions of therapeutic agents
AU2003273096A1 (en) *	2002-10-22	2004-05-13	Korea Research Institute Of Chemical Technology	Furan derivatives for preventing and curing osteoporosis and pharmaceutical compositions containing the same
US20040198800A1 (en) *	2002-12-19	2004-10-07	Geoffrey Allan	Lipoxygenase inhibitors as hypolipidemic and anti-hypertensive agents
US7459286B1 (en) *	2003-10-22	2008-12-02	The Cleveland Clinic Foundation	Assessing the risk of a major adverse cardiac event in patients with chest pain
AU2004296829A1 (en)	2003-12-05	2005-06-23	The Cleveland Clinic Foundation	Risk markers for cardiovascular disease
US7378396B2 (en)	2004-08-11	2008-05-27	The Cleveland Clinic Foundation	Therapeutic agents and methods for cardiovascular disease

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4556672A (en) *	1984-03-19	1985-12-03	Pfizer Inc.	3-Substituted 2-oxindole-1-carboxamides as analgesic and anti-inflammatory agents
UA25898A1 (uk) *	1987-02-02	1999-02-26	Пфайзер Інк.	Спосіб одержаhhя кристалічhої hатрієвої солі 5-хлор-3-(2-теhоїл)-2-оксііhдол-1-карбоксаміду
US4853409A (en) *	1988-04-13	1989-08-01	Pfizer Inc.	3-substituted-2-oxindole-1-carboxamides for suppressing T-cell function
US4861794A (en) *	1988-04-13	1989-08-29	Pfizer Inc.	3-substituted-2-oxindole-1-carboxamides as inhibitors of interleukin-1 biosynthesis
US5008283A (en) *	1990-03-19	1991-04-16	Pfizer Inc.	Use of tenidap to inhibit activation of collagenase and to inhibit the activity of myeloperoxidase
US5006547A (en) *	1990-03-19	1991-04-09	Pfizer Inc.	Tenidap as an inhibitor of the release of elastase by neutrophils

1991
- 1991-07-10 US US07/727,786 patent/US5122534A/en not_active Expired - Lifetime
1992
- 1992-01-23 TW TW081100481A patent/TW206153B/zh active
- 1992-02-03 AT AT92300884T patent/ATE121620T1/de not_active IP Right Cessation
- 1992-02-03 DE DE69202162T patent/DE69202162T2/de not_active Expired - Fee Related
- 1992-02-03 EP EP92300884A patent/EP0498588B1/de not_active Expired - Lifetime
- 1992-02-03 DK DK92300884.1T patent/DK0498588T3/da active
- 1992-02-06 CA CA002060789A patent/CA2060789C/en not_active Expired - Fee Related
- 1992-02-06 PT PT100095A patent/PT100095A/pt not_active Application Discontinuation
- 1992-02-07 NZ NZ241555A patent/NZ241555A/en unknown
- 1992-02-07 HU HU9200395A patent/HUT62194A/hu unknown
- 1992-02-07 MX MX9200544A patent/MX9200544A/es not_active IP Right Cessation
- 1992-02-07 AU AU10831/92A patent/AU630580B2/en not_active Ceased
- 1992-02-07 JP JP4022610A patent/JPH0558893A/ja active Pending
- 1992-02-07 MY MYPI92000188A patent/MY106885A/en unknown
- 1992-02-07 KR KR1019920001790A patent/KR940011245B1/ko not_active Expired - Fee Related
- 1992-02-07 IE IE920405A patent/IE65596B1/en not_active IP Right Cessation
1996
- 1996-12-24 HK HK219096A patent/HK219096A/en not_active IP Right Cessation

Also Published As

Publication number	Publication date
US5122534A (en)	1992-06-16
IE65596B1 (en)	1995-11-01
DE69202162T2 (de)	1995-08-31
DE69202162D1 (de)	1995-06-01
AU1083192A (en)	1992-08-20
HUT62194A (en)	1993-04-28
KR920016094A (ko)	1992-09-24
EP0498588A1 (de)	1992-08-12
PT100095A (pt)	1993-04-30
HU9200395D0 (en)	1992-04-28
DK0498588T3 (da)	1995-07-10
TW206153B (de)	1993-05-21
MX9200544A (es)	1992-08-01
EP0498588B1 (de)	1995-04-26
HK219096A (en)	1997-01-03
JPH0558893A (ja)	1993-03-09
CA2060789C (en)	1995-10-17
IE920405A1 (en)	1992-08-12
NZ241555A (en)	1997-02-24
MY106885A (en)	1995-08-30
KR940011245B1 (ko)	1994-12-03
AU630580B2 (en)	1992-10-29
CA2060789A1 (en)	1992-08-09

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Legal Events

Date	Code	Title	Description
1995-11-15	UEP	Publication of translation of european patent specification
2005-11-15	REN	Ceased due to non-payment of the annual fee