ATE121790T1 - Verfahren und apparat zur messung der effekte von zellwirksamen mitteln auf lebende zellen. - Google Patents

Verfahren und apparat zur messung der effekte von zellwirksamen mitteln auf lebende zellen.

Info

Publication number
ATE121790T1
ATE121790T1 AT89911452T AT89911452T ATE121790T1 AT E121790 T1 ATE121790 T1 AT E121790T1 AT 89911452 T AT89911452 T AT 89911452T AT 89911452 T AT89911452 T AT 89911452T AT E121790 T1 ATE121790 T1 AT E121790T1
Authority
AT
Austria
Prior art keywords
living cells
effects
cell
measuring
active agents
Prior art date
Application number
AT89911452T
Other languages
English (en)
Inventor
John W Parce
Harden M Mcconnell
Gillian M Humphries
Karen M Kercso
John C Owicki
Josef Elek Kercso
Original Assignee
Molecular Devices Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Molecular Devices Corp filed Critical Molecular Devices Corp
Application granted granted Critical
Publication of ATE121790T1 publication Critical patent/ATE121790T1/de

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00Constructional details, e.g. recesses, hinges
    • C12M23/02Form or structure of the vessel
    • C12M23/12Well or multiwell plates
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M35/00Means for application of stress for stimulating the growth of microorganisms or the generation of fermentation or metabolic products; Means for electroporation or cell fusion
    • C12M35/08Chemical, biochemical or biological means, e.g. plasma jet, co-culture
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/46Means for regulation, monitoring, measurement or control, e.g. flow regulation of cellular or enzymatic activity or functionality, e.g. cell viability
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00Chemistry: molecular biology and microbiology
    • Y10S435/817Enzyme or microbe electrode

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Sustainable Development (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Analytical Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Toxicology (AREA)
  • Physiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Clinical Laboratory Science (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
AT89911452T 1988-10-21 1989-10-06 Verfahren und apparat zur messung der effekte von zellwirksamen mitteln auf lebende zellen. ATE121790T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US26052188A 1988-10-21 1988-10-21
US40889689A 1989-09-18 1989-09-18

Publications (1)

Publication Number Publication Date
ATE121790T1 true ATE121790T1 (de) 1995-05-15

Family

ID=26948047

Family Applications (1)

Application Number Title Priority Date Filing Date
AT89911452T ATE121790T1 (de) 1988-10-21 1989-10-06 Verfahren und apparat zur messung der effekte von zellwirksamen mitteln auf lebende zellen.

Country Status (7)

Country Link
US (1) US5496697A (de)
EP (1) EP0394406B1 (de)
JP (1) JP2993982B2 (de)
AT (1) ATE121790T1 (de)
CA (1) CA2001212A1 (de)
DE (1) DE68922390T2 (de)
WO (1) WO1990004645A1 (de)

Families Citing this family (120)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5935401A (en) * 1996-09-18 1999-08-10 Aclara Biosciences Surface modified electrophoretic chambers
CA2083496A1 (en) * 1990-06-13 1991-12-14 Richard B. Provonchee Fractionated agaroid compositions, their preparation, and use
FI913443A0 (fi) * 1991-07-17 1991-07-17 Rolf Kroneld Metod, apparat och indikator foer att indikera flyktiga kolvaeten eller miljoegifter i vatten och vaetskor.
DE4214112A1 (de) * 1991-08-02 1993-02-04 Europ Lab Molekularbiolog Neues verfahren zur sequenzierung von nukleinsaeuren
US5587128A (en) 1992-05-01 1996-12-24 The Trustees Of The University Of Pennsylvania Mesoscale polynucleotide amplification devices
US6953676B1 (en) 1992-05-01 2005-10-11 Trustees Of The University Of Pennsylvania Mesoscale polynucleotide amplification device and method
US5498392A (en) * 1992-05-01 1996-03-12 Trustees Of The University Of Pennsylvania Mesoscale polynucleotide amplification device and method
USRE43097E1 (en) 1994-10-13 2012-01-10 Illumina, Inc. Massively parallel signature sequencing by ligation of encoded adaptors
EP0743820A4 (de) * 1994-12-13 1997-06-11 Peter K Law Myoblast-therapie für säugetierkrankheiten
JP2930181B2 (ja) * 1995-06-20 1999-08-03 松下電器産業株式会社 神経細胞活動測定用2次元センサ及びこれを用いた測定装置
US6143247A (en) * 1996-12-20 2000-11-07 Gamera Bioscience Inc. Affinity binding-based system for detecting particulates in a fluid
US6168948B1 (en) 1995-06-29 2001-01-02 Affymetrix, Inc. Miniaturized genetic analysis systems and methods
US5856174A (en) 1995-06-29 1999-01-05 Affymetrix, Inc. Integrated nucleic acid diagnostic device
DE19526533C2 (de) * 1995-07-20 1997-06-05 Fraunhofer Ges Forschung Expositionsvorrichtung
WO1997017426A1 (en) * 1995-11-08 1997-05-15 Trustees Of Boston University Cellular physiology workstations for automated data acquisition and perfusion control
US5942443A (en) * 1996-06-28 1999-08-24 Caliper Technologies Corporation High throughput screening assay systems in microscale fluidic devices
CA2258489C (en) 1996-06-28 2004-01-27 Caliper Technologies Corporation High-throughput screening assay systems in microscale fluidic devices
US20060000722A1 (en) * 1996-06-28 2006-01-05 Caliper Life Sciences, Inc. High throughput screening assay systems in microscale fluidic devices
US6280967B1 (en) 1996-08-02 2001-08-28 Axiom Biotechnologies, Inc. Cell flow apparatus and method for real-time of cellular responses
US5804436A (en) * 1996-08-02 1998-09-08 Axiom Biotechnologies, Inc. Apparatus and method for real-time measurement of cellular response
US6558916B2 (en) 1996-08-02 2003-05-06 Axiom Biotechnologies, Inc. Cell flow apparatus and method for real-time measurements of patient cellular responses
US6632619B1 (en) * 1997-05-16 2003-10-14 The Governors Of The University Of Alberta Microfluidic system and methods of use
JP2002503336A (ja) * 1997-05-16 2002-01-29 アルバータ リサーチ カウンシル 微量流通システムおよびその使用方法
EP0985142A4 (de) * 1997-05-23 2006-09-13 Lynx Therapeutics Inc System und gerät zur sequentiellen behandlung von analyten
US6969488B2 (en) * 1998-05-22 2005-11-29 Solexa, Inc. System and apparatus for sequential processing of analytes
SE9702112D0 (sv) * 1997-06-04 1997-06-04 Holdingbolaget Vid Goeteborgs Method and apparatus for detection of a receptor antagonist
US6071748A (en) 1997-07-16 2000-06-06 Ljl Biosystems, Inc. Light detection device
US6141870A (en) 1997-08-04 2000-11-07 Peter K. Trzyna Method for making electrical device
US6982431B2 (en) * 1998-08-31 2006-01-03 Molecular Devices Corporation Sample analysis systems
US6576476B1 (en) 1998-09-02 2003-06-10 Ljl Biosystems, Inc. Chemiluminescence detection method and device
US6297018B1 (en) 1998-04-17 2001-10-02 Ljl Biosystems, Inc. Methods and apparatus for detecting nucleic acid polymorphisms
US6825921B1 (en) 1999-11-10 2004-11-30 Molecular Devices Corporation Multi-mode light detection system
WO1999041604A1 (en) * 1998-02-13 1999-08-19 Emory University Detection of neurodegenerative diseases, in vitro screening assays
FR2775522B1 (fr) * 1998-02-27 2000-04-28 Leces Bio-capteur environnemental de metrologie d'aerocontaminants
EP1064353B1 (de) * 1998-03-18 2002-11-06 Massachusetts Institute Of Technology Vaskularisierte perfundierte anordnungen für mikrogewebe und mikroorgane
US6132685A (en) * 1998-08-10 2000-10-17 Caliper Technologies Corporation High throughput microfluidic systems and methods
US6586235B1 (en) * 1998-12-04 2003-07-01 Flexcell International Corporation Apparatus for growing cells in culture under shear stress and/or strain
US20020019059A1 (en) * 1999-01-28 2002-02-14 Calvin Y.H. Chow Devices, systems and methods for time domain multiplexing of reagents
US6403317B1 (en) 1999-03-26 2002-06-11 Affymetrix, Inc. Electronic detection of hybridization on nucleic acid arrays
WO2000067037A2 (en) * 1999-04-29 2000-11-09 Dade Microscan Inc. A combined rapid anti-microbial susceptibility assay and microorganism identification system
DE19920811B4 (de) * 1999-05-06 2004-08-19 Micronas Gmbh Vorrichtung zur Durchführung von Untersuchungen an Zellkulturen
US7795012B2 (en) 1999-05-06 2010-09-14 Micronas Gmbh Device for performing analysis on cell cultures
WO2000073784A2 (en) * 1999-05-28 2000-12-07 Case Western Reserve University Devices and methods for assessing cellular transport for research, drug discovery and testing, clinical diagnoses, and therapy design
WO2001000783A2 (en) * 1999-06-25 2001-01-04 Advanced Tissue Sciences, Inc. Monitorable three-dimensional scaffolds and tissue culture systems
US6468763B1 (en) 1999-09-29 2002-10-22 Caliper Technologies Corp. Optical detection of transmembrane potential changes
GB9930719D0 (en) * 1999-12-24 2000-02-16 Central Research Lab Ltd Apparatus for and method of making electrical measurements on an object in a m edium
GB9930718D0 (en) * 1999-12-24 2000-02-16 Central Research Lab Ltd Apparatus for and method of making electrical measurements on objects
DE60038127T2 (de) * 2000-01-06 2009-03-05 Caliper Life Sciences, Inc., Mountain View Methoden und syteme zur überwachung intrazellulärer bindereaktionen
DE10006174A1 (de) * 2000-02-11 2001-09-27 Andre Schrattenholz Effektraum-/Effektorraum-Analyse
US7485454B1 (en) * 2000-03-10 2009-02-03 Bioprocessors Corp. Microreactor
US7011939B2 (en) * 2000-03-22 2006-03-14 Abbott Laboratories Apparatus and method for electrophysiological testing
US20040132174A1 (en) * 2000-03-28 2004-07-08 Smith Allan Joseph Hilling Perfusion incubator
AUPQ653000A0 (en) * 2000-03-28 2000-04-20 Cook Incorporated Perfusion incubator
US6541243B1 (en) * 2000-06-05 2003-04-01 Axon Instruments, Inc. Perfusion chamber for electrophysiological testing of oocytes
DE10028692C2 (de) * 2000-06-09 2002-06-06 Micronas Gmbh Verfahren zur Untersuchung von membranumschlossenen Biokompartimenten
US20020106715A1 (en) * 2001-02-02 2002-08-08 Medisel Ltd System and method for collecting data from individual cells
US20040058407A1 (en) * 2001-04-10 2004-03-25 Miller Scott E. Reactor systems having a light-interacting component
US20040058437A1 (en) * 2001-04-10 2004-03-25 Rodgers Seth T. Materials and reactor systems having humidity and gas control
US20050032204A1 (en) * 2001-04-10 2005-02-10 Bioprocessors Corp. Microreactor architecture and methods
AU2002303311B2 (en) * 2001-04-10 2007-01-25 Bioprocessors Corporation Microfermentor device and cell based screening method
US20040132166A1 (en) * 2001-04-10 2004-07-08 Bioprocessors Corp. Determination and/or control of reactor environmental conditions
US20070037277A1 (en) * 2001-04-25 2007-02-15 Michael Shuler Pharmacokinetic-based culture system with biological barriers
ATE364685T1 (de) * 2001-04-25 2007-07-15 Cornell Res Foundation Inc Anlagen und verfahren für zellkulturen auf pharmacokinetischer basis
US20070048727A1 (en) * 2001-04-25 2007-03-01 Michael Shuler Biliary barrier
DE10150971B8 (de) * 2001-10-05 2006-11-09 Technische Universität Dresden Verfahren und Vorrichtung zur Messung der Rezeptoraktivität an transfizierten Zellen
AU2002353741A1 (en) 2001-11-27 2003-06-10 Cellectricon Ab A method for combined sequential agent delivery and electroporation for cell structures and use thereof
ATE516879T1 (de) 2002-02-12 2011-08-15 Cellectricon Ab Systeme und verfahren zur schnellen änderung der lösungsumgebung von sensoren
EP1490520A4 (de) * 2002-03-12 2006-06-07 Surface Logix Inc Testvorrichtung, die die absorption, den stoffwechsel, die permeabiltät und/oder toxizität einer kandidatenverbindung analysiert
US20050026134A1 (en) * 2002-04-10 2005-02-03 Bioprocessors Corp. Systems and methods for control of pH and other reactor environment conditions
AU2003228950A1 (en) * 2002-05-08 2003-11-11 Scion Pharmaceuticals, Inc. Oocyte recording chamber
US20050106714A1 (en) * 2002-06-05 2005-05-19 Zarur Andrey J. Rotatable reactor systems and methods
JP4386835B2 (ja) 2002-08-21 2009-12-16 セレクトリコン アーベー パッチクランプ記録において高抵抗固着を獲得して維持するシステム及び方法
AU2003278461A1 (en) 2002-10-16 2004-05-04 Cellectricon Ab Nanoelectrodes and nanotips for recording transmembrane currents in a plurality of cells
US20040107986A1 (en) * 2002-12-06 2004-06-10 Neilson Andy C. High throughput microcalorimeter systems and methods
WO2004065618A2 (en) * 2003-01-16 2004-08-05 Thermogenic Imaging Methods and devices for monitoring cellular metabolism in microfluidic cell-retaining chambers
EP1628748A2 (de) * 2003-06-05 2006-03-01 Bioprocessors Corporation Reaktor mit speicherkomponente
DE10340473B4 (de) * 2003-09-03 2007-08-23 Eppendorf Ag Abdeckung einer Hybridisierungskammer
US7276351B2 (en) 2003-09-10 2007-10-02 Seahorse Bioscience Method and device for measuring multiple physiological properties of cells
US20070087401A1 (en) * 2003-10-17 2007-04-19 Andy Neilson Analysis of metabolic activity in cells using extracellular flux rate measurements
US8658349B2 (en) * 2006-07-13 2014-02-25 Seahorse Bioscience Cell analysis apparatus and method
DK1773978T3 (da) 2004-05-19 2014-05-26 Univ Pittsburgh Perfunderede, tredimensionelle celle/vævssygdomsmodeller
US20060019333A1 (en) * 2004-06-07 2006-01-26 Rodgers Seth T Control of reactor environmental conditions
US20050277187A1 (en) * 2004-06-07 2005-12-15 Bioprocessors Corp. Creation of shear in a reactor
WO2005121307A2 (en) * 2004-06-07 2005-12-22 Bioprocessor Corp. Gas control in a microreactor
US20050287673A1 (en) * 2004-06-07 2005-12-29 Bioprocessors Corp. Reactor mixing
WO2006133555A1 (en) * 2005-06-15 2006-12-21 Neurosilicon (1145990 Alberta Ltd.) Psychotropic drug screening device based on long-term photoconductive stimulation of neurons
US20080064088A1 (en) * 2006-09-08 2008-03-13 Michael Shuler Devices and methods for pharmacokinetic-based cell culture system
CN101187655B (zh) * 2006-11-15 2012-06-06 上海百傲科技有限公司 体外检测分析物对生物体的效应的方法和系统
DE102007016629A1 (de) * 2007-04-05 2008-10-09 Micronas Gmbh Sensor zur Erfassung eines toxischen oder gefährlichen Gasgemisches und Betriebsverfahren
DE102007038777A1 (de) * 2007-08-10 2009-02-19 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Zellkulturmesssystem und Verfahren für vergleichende Untersuchungen an Zellkulturen
DK3404093T3 (da) 2008-07-16 2020-03-16 Childrens Medical Center Anordning og fremgangsmåde til overvågning af celleadfærd
US8202702B2 (en) * 2008-10-14 2012-06-19 Seahorse Bioscience Method and device for measuring extracellular acidification and oxygen consumption rate with higher precision
CA2764678C (en) 2009-06-04 2017-12-12 Lockheed Martin Corporation Multiple-sample microfluidic chip for dna analysis
US20140152801A1 (en) 2009-10-28 2014-06-05 Alentic Microscience Inc. Detecting and Using Light Representative of a Sample
JP2013509618A (ja) * 2009-10-28 2013-03-14 アレンティック マイクロサイエンス インコーポレイテッド 顕微撮像法
US9075225B2 (en) 2009-10-28 2015-07-07 Alentic Microscience Inc. Microscopy imaging
AU2011315951B2 (en) 2010-10-15 2015-03-19 Lockheed Martin Corporation Micro fluidic optic design
ES2564855T3 (es) * 2010-11-12 2016-03-29 Abbvie Inc. Método y sistema óptico de alto rendimiento para determinar el efecto de una sustancia de ensayo sobre las células vivas
ES2641524T3 (es) * 2010-12-03 2017-11-10 Cellply S.R.L. Microanálisis de la función celular
US10571475B2 (en) 2010-12-03 2020-02-25 Cellply S.R.L. Rapid screening of monoclonal antibodies
EP2681306B1 (de) 2011-02-28 2019-01-09 President and Fellows of Harvard College Zellkultursystem
US10209241B2 (en) * 2011-08-12 2019-02-19 Rutgers, The State University Of New Jersey High throughput sensitization detection devices and methods
US9725687B2 (en) 2011-12-09 2017-08-08 President And Fellows Of Harvard College Integrated human organ-on-chip microphysiological systems
US9322054B2 (en) 2012-02-22 2016-04-26 Lockheed Martin Corporation Microfluidic cartridge
US20130337565A1 (en) 2012-06-19 2013-12-19 Medtrain Technologies, Llc Method and Apparatus for Patterning Cells
US9494577B2 (en) 2012-11-13 2016-11-15 Seahorse Biosciences Apparatus and methods for three-dimensional tissue measurements based on controlled media flow
DE102013200613A1 (de) * 2013-01-16 2014-07-17 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Vorrichtung und Verfahren zum Bestimmen einer Stärke einer Adhäsion eines biologischen Materials
WO2015013332A1 (en) 2013-07-22 2015-01-29 President And Fellows Of Harvard College Microfluidic cartridge assembly
US11119093B2 (en) 2013-12-20 2021-09-14 President And Fellows Of Harvard College Low shear microfluidic devices and methods of use and manufacturing thereof
GB2583047B (en) 2013-12-20 2021-03-24 Harvard College Organomimetic devices and methods of use and manufacturing thereof
US10118177B2 (en) 2014-06-02 2018-11-06 Seahorse Bioscience Single column microplate system and carrier for analysis of biological samples
GB2546424A (en) 2014-07-14 2017-07-19 Harvard College Systems and methods for improved performance of fluidic and microfluidic systems
CN104789468B (zh) * 2014-07-22 2017-10-20 奥克莱流体公司 颗粒筛选装置
WO2017019542A1 (en) 2015-07-24 2017-02-02 President And Fellows Of Harvard College Radial microfluidic devices and methods of use
US10591462B2 (en) 2016-03-03 2020-03-17 Mohammad Abdolahad Electrochemical method and device for detecting the effect of anticancer drugs
EP3258240B1 (de) 2016-06-14 2023-06-07 Cellply S.R.L. Screening-kit und -verfahren
US12104174B2 (en) 2016-09-13 2024-10-01 President And Fellows Of Harvard College Methods relating to intestinal organ-on-a-chip
WO2018183744A1 (en) 2017-03-29 2018-10-04 The Research Foundation For The State University Of New York Microfluidic device and methods
US11639925B2 (en) 2017-04-06 2023-05-02 Agilent Technologies, Inc. Method and apparatus for measuring physiological properties of biological samples
CN112268934B (zh) * 2020-09-16 2022-06-28 东南大学 一种针对循环肿瘤细胞的检测芯片及其检测方法

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL7302283A (de) * 1972-03-06 1973-09-10
CH595441A5 (en) * 1974-11-12 1978-02-15 Mueller Hans Maennedorf Control of nutrient substrate addn. in single cell protein prodn.
DE2502621C3 (de) * 1975-01-23 1978-09-14 Kernforschungsanlage Juelich Gmbh, 5170 Juelich Messung elastischer und dielektrischer Eigenschaften der Membran lebender Zellen
US4129483A (en) * 1977-03-03 1978-12-12 Bochner Barry R Device, composition and method for identifying microorganisms
US4350763A (en) * 1978-03-23 1982-09-21 Ajinomoto Company, Inc. Method for determining biochemical oxygen demand
GB2029025B (en) * 1978-03-28 1982-08-11 Ajinomoto Kk Method and apparatus for determining the concentration of a carbon source or of an l-amino acid
US4204037A (en) * 1978-04-04 1980-05-20 Nasa Method and automated apparatus for detecting coliform organisms
US4343782A (en) * 1978-04-20 1982-08-10 Shapiro Howard M Cytological assay procedure
DE2828232C2 (de) * 1978-06-28 1986-04-17 Kernforschungsanlage Jülich GmbH, 5170 Jülich Vorrichtung zur Bestimmung des dielektrischen Durchbruches und der Größe von als Umhüllung eine Membran aufweisenden Partikeln
US4235964A (en) * 1978-09-28 1980-11-25 Bochner Barry R Method for testing and identifying microorganisms
FR2484077B1 (fr) * 1980-06-06 1984-07-06 Inst Nat Sante Rech Med Procede et dispositif de mesure de la deformabilite de cellules vivantes, notamment des globules rouges du sang
SE448881B (sv) * 1981-03-12 1987-03-23 Erik Walum Apparat for genomforandet av perfusionsodling av en eller flera cellkulturer samt forfarande for perfusionsodling av en eller flera cellkulturer
SE430900B (sv) * 1981-06-04 1983-12-19 Bo Gustav Mattiasson Forfarande for bestemning av biokemiska data for mikroorganismer eller encelliga organismer
US4386157A (en) * 1981-10-26 1983-05-31 Beggs James M Administrator Of Method for detecting coliform organisms
IL65131A0 (en) * 1982-02-28 1982-04-30 Yeda Res & Dev Process for the production of agarose-polyaldehyde beads and their biological applications
US4512853A (en) * 1982-05-18 1985-04-23 Olin Corporation Method of monitoring pH
US4564598A (en) * 1982-07-12 1986-01-14 Syntex (U.S.A.) Inc. Limited volume method for particle counting
JPS59191655U (ja) * 1983-06-07 1984-12-19 株式会社 堀場製作所 流通型ガラス電極
SE8306050D0 (sv) * 1983-11-03 1983-11-03 Neil F Cleland Sensor for kemisk analys
US4591550A (en) * 1984-03-01 1986-05-27 Molecular Devices Corporation Device having photoresponsive electrode for determining analytes including ligands and antibodies
US4560881A (en) * 1984-03-13 1985-12-24 Syntex (U.S.A.) Inc. Method and apparatus for enhanced detection of electromagnetic signals
US4704353A (en) * 1984-04-27 1987-11-03 Molecular Devices Corporation Photoresponsive redox detection and discrimination
JPH06103300B2 (ja) * 1986-03-25 1994-12-14 ピービー ダイアグノスティック システムズ,インコーポレーテッド 生物学的診断装置
US4911794A (en) * 1986-06-20 1990-03-27 Molecular Devices Corporation Measuring with zero volume cell
IT1215491B (it) * 1987-05-15 1990-02-14 Enricerche Spa Biosensore con membrana enzimatica legata chimicamente a un dispositivo semiconduttore.

Also Published As

Publication number Publication date
JP2993982B2 (ja) 1999-12-27
CA2001212A1 (en) 1990-04-21
JPH03502642A (ja) 1991-06-20
EP0394406A1 (de) 1990-10-31
EP0394406B1 (de) 1995-04-26
WO1990004645A1 (en) 1990-05-03
US5496697A (en) 1996-03-05
DE68922390T2 (de) 1995-10-05
DE68922390D1 (de) 1995-06-01

Similar Documents

Publication Publication Date Title
DE68922390D1 (de) Verfahren und apparat zur messung der effekte von zellwirksamen mitteln auf lebende zellen.
DE3852108D1 (de) Vorrichtung und verfahren zur optischen messung der konzentration an material.
DE69418546D1 (de) Vorrichtung und Verfahren zur Messung der Konzentration von Glukose mittels Lichtstreuung
ATE143289T1 (de) Vorrichtung, mit verwendung in chemischen prüfverfahren
ATE229182T1 (de) Vorrichtung und verfahren zur echtzeitmessung der zellularen reaktion
NO880891D0 (no) Fremgangsmaate og apparat for maaling eller deteksjon av konsentrasjonen av en substans.
DE3152065A1 (de) Method and apparatus for determining glucose in biological fluids
FI885115A7 (fi) Laite kaasujen tunnistamiseksi ja pitoisuuden mittaamiseksi sekä menetelmä kaasujen tunnistamiseksi
DE69101315D1 (de) Verfahren und gerät zur messung der konzentration von absorbierenden stoffen.
DE3588209D1 (de) Verfahren zur elektrochemischen Bestimmung der Sauerstoffkonzentration
AT382971B (de) Verfahren und vorrichtung zur messung der blutgerinnungszeit
ATE38721T1 (de) Verfahren zum ueberwachen einer gaskonzentration in einer fluessigkeit.
DK222682A (da) Fremgangsmaade og apparat til kvantitativ bestemmelse af haemoglobinniveauet i en biologisk proeve
DE68925829D1 (de) Verfahren zur Messung der Viskositätsänderung im Blut oder Blutplasma und Detektor dazu
DE3485653D1 (de) Verfahren und vorrichtung zur messung des reaktionsgrades zwischen antigenen und zell-leukozytenantikoerpern.
DE58903504D1 (de) Verfahren zur messung der konzentration optisch aktiver substanzen und anordnung zur durchfuehrung des verfahrens.
DE3484383D1 (de) Vorrichtung zur messung der sauerstoffkonzentration und verfahren zu ihrer herstellung.
DE3582630D1 (de) Vorrichtung und verfahren zur messung der konzentration eines paramagnetischen gase.
DE3676651D1 (de) Verfahren und vorrichtung zum ermitteln der abmessungen eines laenglichen pruefobjektes.
ES8605098A1 (es) Metodo de medir ligandos del tipo de substancias medicinales y constituyentes trazos derivados de diversas enfermedades en fluidos corporales tales como suero sanguineo y orina.
AT361131B (de) Verfahren und vorrichtung zur messung der konzentration von niedrigmolekularen ver- bindungen in komplexen medien
DE69020984D1 (de) Apparat der Eintauchsart für automatische Ultraschalltests zur Detektion von Fehlern in Kugeln.
DE3172239D1 (en) Method and apparatus for the determination of substances in biological solutions by differential ph measurement
DE3863245D1 (de) Verfahren und vorrichtung zur optischen messung von teilchenabmessungen in weiten wertebereichen.
DE59010451D1 (de) Elektrochemische Messzelle zum Nachweis von Gaskomponenten in fluiden Medien

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties