ATE121938T1 - Hemmung von muskelschwund und proteinabbau von muskeln bei säugetieren durch tetrazyklines. - Google Patents

Hemmung von muskelschwund und proteinabbau von muskeln bei säugetieren durch tetrazyklines.

Info

Publication number
ATE121938T1
ATE121938T1 AT91201657T AT91201657T ATE121938T1 AT E121938 T1 ATE121938 T1 AT E121938T1 AT 91201657 T AT91201657 T AT 91201657T AT 91201657 T AT91201657 T AT 91201657T AT E121938 T1 ATE121938 T1 AT E121938T1
Authority
AT
Austria
Prior art keywords
tetracyclines
protein degradation
mammals
muscle wasting
muscles
Prior art date
Application number
AT91201657T
Other languages
English (en)
Inventor
Bruce Schneider
Robert A Greenwald
Jonathan Maimon
Kenneth Gorray
Lorne M Golub
Thomas F Mcnamara
Nangavarum S Ramamurthy
Original Assignee
Univ New York State Res Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ New York State Res Found filed Critical Univ New York State Res Found
Application granted granted Critical
Publication of ATE121938T1 publication Critical patent/ATE121938T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/65—Tetracyclines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT91201657T 1990-06-28 1991-06-27 Hemmung von muskelschwund und proteinabbau von muskeln bei säugetieren durch tetrazyklines. ATE121938T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/545,395 US5045538A (en) 1990-06-28 1990-06-28 Inhibition of wasting and protein degradation of mammalian muscle by tetracyclines

Publications (1)

Publication Number Publication Date
ATE121938T1 true ATE121938T1 (de) 1995-05-15

Family

ID=24176048

Family Applications (1)

Application Number Title Priority Date Filing Date
AT91201657T ATE121938T1 (de) 1990-06-28 1991-06-27 Hemmung von muskelschwund und proteinabbau von muskeln bei säugetieren durch tetrazyklines.

Country Status (9)

Country Link
US (1) US5045538A (de)
EP (1) EP0464932B1 (de)
JP (1) JP3148284B2 (de)
AT (1) ATE121938T1 (de)
CA (1) CA2045885C (de)
DE (1) DE69109376T2 (de)
DK (1) DK0464932T3 (de)
ES (1) ES2075331T3 (de)
IE (1) IE67541B1 (de)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3016587B2 (ja) * 1989-12-04 2000-03-06 ザ・リサーチ・ファンデーション・オブ・ステート・ユニバーシティ・オブ・ニューヨーク 非ステロイド抗炎症剤及びテトラサイクリンの配合
US5308839A (en) * 1989-12-04 1994-05-03 The Research Foundation Of State University Of New York Composition comprising non-steroidal anti-inflammatory agent tenidap and effectively non-antibacterial tetracycline
US5770588A (en) * 1991-02-11 1998-06-23 The Research Foundation Of State University Of New York Non-antibacterial tetracycline compositions of the prevention and treatment of root caries
USRE40183E1 (en) 1991-10-04 2008-03-25 Wyeth Holdings Corporation 7-Substituted-9-substituted amino-6-demethyl-6-deoxytetracyclines
US5494903A (en) 1991-10-04 1996-02-27 American Cyanamid Company 7-substituted-9-substituted amino-6-demethyl-6-deoxytetracyclines
DK0599397T3 (da) * 1992-11-17 1996-09-16 Univ New York State Res Found Tetracycliner, herunder non-mikrobielle, kemisk-modificerede tetracycliner, inhiberer overdreven collagentværbinding ved diabetes
US5523297A (en) * 1993-03-02 1996-06-04 The Research Foundation Of State University Of New York Inhibition of excessive phospholipase A2 activity and/or production by non-antimicrobial tetracyclines
US6043231A (en) * 1993-03-02 2000-03-28 The Research Foundation Of State Univ. Of New York Inhibition of excessive phospholipase A2 activity and/or production by non-antimicrobial tetracyclines
US5668122A (en) * 1993-07-28 1997-09-16 Fife; Rose S. Method to treat cancer with tetracyclines
US6777217B1 (en) * 1996-03-26 2004-08-17 President And Fellows Of Harvard College Histone deacetylases, and uses related thereto
US5773430A (en) * 1997-03-13 1998-06-30 Research Foundation Of State University Of New York Serine proteinase inhibitory activity by hydrophobic tetracycline
US5929055A (en) * 1997-06-23 1999-07-27 The Research Foundation Of State University Of New York Therapeutic method for management of diabetes mellitus
AU2001599A (en) * 1997-12-19 1999-07-05 New York University Method for inhibiting cyclooxygenase-2 and tumor necrosis factor alpha
US6015804A (en) * 1998-09-11 2000-01-18 The Research Foundation Of State University Of New York Method of using tetracycline compounds to enhance interleukin-10 production
US5977091A (en) * 1998-09-21 1999-11-02 The Research Foundation Of State University Of New York Method of preventing acute lung injury
US6946453B2 (en) 1998-11-18 2005-09-20 Collagenex Pharmaceuticals, Inc. 4-dedimethylaminotracycline derivatives
WO2000028983A1 (en) * 1998-11-18 2000-05-25 Collagenex Pharmaceuticals, Inc. Novel 4-dedimethy laminotetra cycline derivatives
US6506740B1 (en) 1998-11-18 2003-01-14 Robert A. Ashley 4-dedimethylaminotetracycline derivatives
US20030129724A1 (en) 2000-03-03 2003-07-10 Grozinger Christina M. Class II human histone deacetylases, and uses related thereto
EP2311440A1 (de) 2001-04-05 2011-04-20 Collagenex Pharmaceuticals, Inc. Gesteuerte Freigabe von Tetracyclinverbindungen und Tetracyclinderivaten
US7211267B2 (en) 2001-04-05 2007-05-01 Collagenex Pharmaceuticals, Inc. Methods of treating acne
US7244853B2 (en) 2001-05-09 2007-07-17 President And Fellows Of Harvard College Dioxanes and uses thereof
EP1439843A4 (de) * 2001-10-05 2007-01-03 Tetragenex Pharmaceuticals Inc Tetracyclin-derivate und anwendungsverfahren
US20050277623A1 (en) * 2001-12-20 2005-12-15 Hanauske-Abel Hartmut M Treatment for averting or delaying premature delivery
AU2003226112B9 (en) 2002-03-29 2008-06-05 The Research Foundation Of State University Of New York Use of non-antibacterial tetracycline analogs and formulations thereof for the treatment of bacterial exotoxins
US6958161B2 (en) 2002-04-12 2005-10-25 F H Faulding & Co Limited Modified release coated drug preparation
CA2894736C (en) * 2003-04-07 2019-07-16 Supernus Pharmaceuticals, Inc. Once daily formulations of tetracyclines
CA2937005A1 (en) 2005-03-22 2006-09-28 President And Fellows Of Harvard College Treatment of protein degradation disorders
JP5409015B2 (ja) * 2006-02-14 2014-02-05 プレジデント アンド フェロウズ オブ ハーバード カレッジ ヒストンデアセチラーゼ阻害剤
AU2007345292B2 (en) * 2006-02-14 2013-10-31 Dana-Farber Cancer Institute, Inc. Bifunctional histone deacetylase inhibitors
US8304451B2 (en) * 2006-05-03 2012-11-06 President And Fellows Of Harvard College Histone deacetylase and tubulin deacetylase inhibitors
CA2731730C (en) 2008-07-23 2017-06-13 President And Fellows Of Harvard College Deacetylase inhibitors and uses thereof
WO2011019393A2 (en) 2009-08-11 2011-02-17 President And Fellows Of Harvard College Class- and isoform-specific hdac inhibitors and uses thereof
WO2017042196A2 (en) * 2015-09-08 2017-03-16 Ecole Polytechnique Federale De Lausanne (Epfl) Agents and methods using thereof for the prevention and treatment of stem cells senescence
US10905704B2 (en) 2015-09-08 2021-02-02 Ecole Polytechnique Federale De Lausanne (Epfl) Agents and methods using thereof for the prevention and treatment of stem cell muscle disorders

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4935412A (en) * 1983-12-29 1990-06-19 The Research Foundation Of State University Of New York Non-antibacterial tetracycline compositions possessing anti-collagenolytic properties and methods of preparing and using same
US4666897A (en) * 1983-12-29 1987-05-19 Research Foundation Of State University Inhibition of mammalian collagenolytic enzymes by tetracyclines
US4925833A (en) * 1983-12-29 1990-05-15 The Research Foundation Of State University Of New York Use of tetracycline to enhance bone protein synthesis and/or treatment of osteoporosis
US4704383A (en) * 1983-12-29 1987-11-03 The Research Foundation Of State University Of New York Non-antibacterial tetracycline compositions possessing anti-collagenolytic properties and methods of preparing and using same

Also Published As

Publication number Publication date
EP0464932B1 (de) 1995-05-03
DE69109376D1 (de) 1995-06-08
DK0464932T3 (da) 1995-07-17
JPH04230323A (ja) 1992-08-19
IE912242A1 (en) 1992-01-01
EP0464932A2 (de) 1992-01-08
ES2075331T3 (es) 1995-10-01
DE69109376T2 (de) 1995-09-07
JP3148284B2 (ja) 2001-03-19
CA2045885A1 (en) 1991-12-29
US5045538A (en) 1991-09-03
IE67541B1 (en) 1996-04-17
CA2045885C (en) 2003-05-13
EP0464932A3 (en) 1992-04-01

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