ATE122048T1 - Alpha-kristalle von natriumcefanolin. - Google Patents

Alpha-kristalle von natriumcefanolin.

Info

Publication number: ATE122048T1
Authority: AT; Austria
Prior art keywords: sodium; cefanoline; alpha crystals; crystals; alpha
Prior art date: 1988-02-05

Application number

AT89101773T

Other languages

English (en)

Inventor

Toshinobu Uemura

Keiji Kai

Masateru Kodani

Fumiyo Yoshida

Matsuhiko Aratani

Original Assignee

Fujisawa Pharmaceutical Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-02-05

Filing date

1989-02-02

Publication date

1995-05-15

1989-02-02 Application filed by Fujisawa Pharmaceutical Co filed Critical Fujisawa Pharmaceutical Co

1995-05-15 Application granted granted Critical

1995-05-15 Publication of ATE122048T1 publication Critical patent/ATE122048T1/de

Links

239000013078 crystal Substances 0.000 title abstract 2
DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 title 1
229910052708 sodium Inorganic materials 0.000 title 1
239000011734 sodium Substances 0.000 title 1
229960003408 cefazolin sodium Drugs 0.000 abstract 1
FLKYBGKDCCEQQM-WYUVZMMLSA-M cefazolin sodium Chemical compound [Na+].S1C(C)=NN=C1SCC1=C(C([O-])=O)N2C(=O)[C@@H](NC(=O)CN3N=NN=C3)[C@H]2SC1 FLKYBGKDCCEQQM-WYUVZMMLSA-M 0.000 abstract 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
- C07D501/36—Methylene radicals, substituted by sulfur atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Cephalosporin Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

AT89101773T 1988-02-05 1989-02-02 Alpha-kristalle von natriumcefanolin. ATE122048T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP2633788		1988-02-05

Publications (1)

Publication Number	Publication Date
ATE122048T1 true ATE122048T1 (de)	1995-05-15

Family

ID=12190624

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT89101773T ATE122048T1 (de)	1988-02-05	1989-02-02	Alpha-kristalle von natriumcefanolin.

Country Status (7)

Country	Link
US (1)	US4898937A (de)
EP (1)	EP0327081B1 (de)
KR (1)	KR970004045B1 (de)
AT (1)	ATE122048T1 (de)
CA (1)	CA1339021C (de)
DE (1)	DE68922418T2 (de)
ES (1)	ES2071624T3 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3911321A1 (de) *	1989-04-07	1990-10-11	Hoechst Ag	Verfahren zur herstellung von cefazolin-natriumsalz
GB0216515D0 (en) *	2002-07-16	2002-08-28	Pfizer Ltd	Process
RU2244716C1 (ru) *	2003-06-27	2005-01-20	Савельев Евгений Александрович	Способ получения натриевой соли 7-(1-н-тетразол-1-ил)-ацетамидо-3-(2-метил-1,3,4-тиадиазол-5-ил)тиометил)- 3-цефем-4-карбоновой кислоты(цефазолина)
CN100391961C (zh)	2005-11-16	2008-06-04	天津大学	五水头孢唑林钠晶体结构及晶体分子组装制备方法
CN102924482B (zh) *	2012-11-05	2015-03-04	天津新丰制药有限公司	一种低含水量头孢西酮钠的制备方法
CN103965215B (zh) *	2014-04-30	2016-04-27	悦康药业集团有限公司	一种头孢唑林钠化合物及其无菌粉针
CN110041347A (zh) *	2018-01-16	2019-07-23	刘力	头孢唑啉钠新化合物及其组合物和用途

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4002748A (en) *	1976-01-19	1977-01-11	Eli Lilly And Company	Method of preparing sterile essentially amorphous cefazolin for reconstitution for parenteral administration
US4104470A (en) *	1977-06-03	1978-08-01	Eli Lilly And Company	Crystallization process for cefazolin sodium
JPS60120886A (ja) *	1983-12-02	1985-06-28	Takeda Chem Ind Ltd	セフェムカルボン酸のナトリウム塩の結晶

1989
- 1989-01-28 KR KR1019890000909A patent/KR970004045B1/ko not_active Expired - Fee Related
- 1989-02-02 EP EP89101773A patent/EP0327081B1/de not_active Expired - Lifetime
- 1989-02-02 DE DE68922418T patent/DE68922418T2/de not_active Expired - Fee Related
- 1989-02-02 US US07/305,167 patent/US4898937A/en not_active Expired - Lifetime
- 1989-02-02 ES ES89101773T patent/ES2071624T3/es not_active Expired - Lifetime
- 1989-02-02 AT AT89101773T patent/ATE122048T1/de not_active IP Right Cessation
- 1989-02-03 CA CA000590083A patent/CA1339021C/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
ES2071624T3 (es)	1995-07-01
DE68922418T2 (de)	1995-10-05
KR890013029A (ko)	1989-09-20
DE68922418D1 (de)	1995-06-08
EP0327081A2 (de)	1989-08-09
US4898937A (en)	1990-02-06
KR970004045B1 (ko)	1997-03-24
EP0327081A3 (de)	1991-04-03
CA1339021C (en)	1997-03-25
EP0327081B1 (de)	1995-05-03

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Legal Events

Date	Code	Title	Description
1995-12-15	UEP	Publication of translation of european patent specification
2004-11-15	REN	Ceased due to non-payment of the annual fee