ATE122057T1 - Monoklonale antikörper gegen protein c. - Google Patents

Monoklonale antikörper gegen protein c.

Info

Publication number
ATE122057T1
ATE122057T1 AT90902092T AT90902092T ATE122057T1 AT E122057 T1 ATE122057 T1 AT E122057T1 AT 90902092 T AT90902092 T AT 90902092T AT 90902092 T AT90902092 T AT 90902092T AT E122057 T1 ATE122057 T1 AT E122057T1
Authority
AT
Austria
Prior art keywords
protein
antibody
activation
isolation
peptide
Prior art date
Application number
AT90902092T
Other languages
English (en)
Inventor
Charles T Esmon
Naomi L Esmon
Original Assignee
Oklahoma Med Res Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oklahoma Med Res Found filed Critical Oklahoma Med Res Found
Application granted granted Critical
Publication of ATE122057T1 publication Critical patent/ATE122057T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6464—Protein C (3.4.21.69)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21069—Protein C activated (3.4.21.69)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2405/00—Assays, e.g. immunoassays or enzyme assays, involving lipids
    • G01N2405/04—Phospholipids, i.e. phosphoglycerides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Analytical Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
AT90902092T 1988-12-30 1989-12-28 Monoklonale antikörper gegen protein c. ATE122057T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US29244788A 1988-12-30 1988-12-30

Publications (1)

Publication Number Publication Date
ATE122057T1 true ATE122057T1 (de) 1995-05-15

Family

ID=23124711

Family Applications (1)

Application Number Title Priority Date Filing Date
AT90902092T ATE122057T1 (de) 1988-12-30 1989-12-28 Monoklonale antikörper gegen protein c.

Country Status (11)

Country Link
EP (1) EP0407544B1 (de)
JP (1) JP2559537B2 (de)
KR (1) KR940002033B1 (de)
AT (1) ATE122057T1 (de)
AU (2) AU641634B2 (de)
CA (1) CA2006684C (de)
DE (1) DE68922491T2 (de)
DK (1) DK171826B1 (de)
ES (1) ES2074562T3 (de)
FI (1) FI101476B1 (de)
WO (1) WO1990007524A1 (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5298599A (en) * 1988-12-30 1994-03-29 Oklahoma Medical Research Foundation Expression and purification of recombinant soluble tissue factor
AT402262B (de) * 1991-06-20 1997-03-25 Immuno Ag Arzneimittel enthaltend aktiviertes protein c
EP0651655A4 (de) * 1992-07-24 1996-05-29 Oklahoma Med Res Found Blockierung der protein c aktivierung reduziert den blutverlust in mikrogefässen bei chirurgischen eingriffen.
CA2143125C (en) * 1992-08-27 2008-09-23 Koenraad Mertens Antibodies specific for a haemostatic protein, their use for isolating intact protein, haemostatic compositions devoid of proteolytic cleavage products of the protein
DE4320294A1 (de) * 1993-06-18 1994-12-22 Immuno Ag Verwendung von humanem Protein C zur Verhinderung und Behandlung von Thrombozytenablagerungen
US5532136A (en) * 1993-06-22 1996-07-02 Bionebraska, Inc. Monoclonal antibody assay and kit for detecting metal cations in body fluids
WO1995001797A1 (en) * 1993-07-09 1995-01-19 Smithkline Beecham Corporation Protein purification
HRP940645A2 (en) * 1993-10-06 1996-12-31 Immuno Ag Process for virus deactivation in the presence of polyalkylene glycol and the pharmaceutical preparation thus obtained
AU710106B2 (en) * 1994-06-10 1999-09-16 Oklahoma Medical Research Foundation Calcium binding recombinant antibody against protein c
TW200407335A (en) * 2002-07-22 2004-05-16 Chugai Pharmaceutical Co Ltd Non-neutralizing antibody to inhibit the inactivation of activated protein C
KR102057826B1 (ko) 2008-04-11 2019-12-20 추가이 세이야쿠 가부시키가이샤 복수 분자의 항원에 반복 결합하는 항원 결합 분자
EP2647706B1 (de) * 2010-11-30 2023-05-17 Chugai Seiyaku Kabushiki Kaisha Antigenbindende moleküle zur wiederholten bindung an mehrere antigenmoleküle
MX352889B (es) 2011-02-25 2017-12-13 Chugai Pharmaceutical Co Ltd Anticuerpo de fc especifico para fcyriib.
JP6322411B2 (ja) 2011-09-30 2018-05-09 中外製薬株式会社 複数の生理活性を有する抗原の消失を促進する抗原結合分子
TWI673063B (zh) * 2013-09-20 2019-10-01 日商中外製藥股份有限公司 抗蛋白ｃ抗體之出血性疾病的治療
KR101860280B1 (ko) 2014-12-19 2018-05-21 추가이 세이야쿠 가부시키가이샤 항-마이오스타틴 항체, 변이체 Fc 영역을 함유하는 폴리펩타이드, 및 사용 방법
BR112017011235A2 (pt) 2014-12-19 2018-02-06 Chugai Pharmaceutical Co Ltd anticorpos anti-c5 e métodos de uso
KR102605798B1 (ko) 2015-02-05 2023-11-23 추가이 세이야쿠 가부시키가이샤 이온 농도 의존적 항원 결합 도메인을 포함하는 항체, Fc 영역 개변체, IL-8에 결합하는 항체, 및 그들의 사용
WO2017110981A1 (en) 2015-12-25 2017-06-29 Chugai Seiyaku Kabushiki Kaisha Anti-myostatin antibodies and methods of use
EP3494991A4 (de) 2016-08-05 2020-07-29 Chugai Seiyaku Kabushiki Kaisha Zusammensetzung zur vorbeugung oder behandlung von erkrankungen im zusammenhang mit il-8
WO2018139623A1 (en) 2017-01-30 2018-08-02 Chugai Seiyaku Kabushiki Kaisha Anti-sclerostin antibodies and methods of use

Also Published As

Publication number Publication date
AU4422893A (en) 1994-01-27
EP0407544A1 (de) 1991-01-16
DK209090A (da) 1990-08-30
FI101476B (fi) 1998-06-30
JPH03504332A (ja) 1991-09-26
FI904262A0 (fi) 1990-08-29
DE68922491D1 (de) 1995-06-08
AU4968390A (en) 1990-08-01
EP0407544B1 (de) 1995-05-03
KR910700266A (ko) 1991-03-14
AU669540B2 (en) 1996-06-13
WO1990007524A1 (en) 1990-07-12
CA2006684C (en) 1996-12-17
DK171826B1 (da) 1997-06-23
FI101476B1 (fi) 1998-06-30
AU641634B2 (en) 1993-09-30
CA2006684A1 (en) 1990-06-30
JP2559537B2 (ja) 1996-12-04
KR940002033B1 (ko) 1994-03-14
ES2074562T3 (es) 1995-09-16
DK209090D0 (da) 1990-08-30
DE68922491T2 (de) 1995-11-09

Similar Documents

Publication Publication Date Title
DE68922491D1 (de) Monoklonale antikörper gegen protein c.
Thompson et al. Purification of eukaryotic RNA polymerase II by immunoaffinity chromatography. Elution of active enzyme with protein stabilizing agents from a polyol-responsive monoclonal antibody.
EP0930366A3 (de) Bindungsdomänen des Serrate-proteins
KITAHARA et al. Large-scale purification of porcine calpain I and calpain II and comparison of proteolytic fragments of their subunits
BG60256B1 (bg) Рекомбинантен метод за получаване на лимфотоксин
Xiao et al. Phosphorylation of HMG‐I by Protein Kinase C Attenuates Its Binding Affinity to the Promoter Regions of Protein Kinase C γ and Neurogranin/RC3 Genes
DE69435020D1 (en) Protein-tyrosin-phosphatase ptp-s31
Singh et al. Different forms of human liver glutathione S-transferases arise from dimeric combinations of at least four immunologically and functionally distinct subunits
DE69535855D1 (de) Calciumbindende rekombinante antikörper gegen protein c
Sørensen et al. Purification and characterization of osteopontin from human milk
Cesbron et al. Human coumarin prothrombin
Barnes et al. Glass-bead affinity chromatography of cell attachment and spreading-promoting factors of human serum
Williams et al. Dye-ligand affinity purification of human complement factor B and β2 glycoprotein I
Imamura et al. A novel nonmuscle alpha-actinin. Purification and characterization of chicken lung alpha-actinin.
Woodley et al. Specific identification of tissue kallikrein in exocrine tissues and in cell-free translation products with monoclonal antibodies
KR930002834B1 (ko) 항유로키나제 모노클론 항체 함유 면역흡착제 및 이를 사용하는 유로키나제 정제방법
NO903788L (no) Monoklonalt antistoff mot protein c.
Solomon et al. Affinity purification of antibodies using immobilized FB domain of protein A
Naguib et al. Purification of Chironex fleckeri venom components using Chironex immunoaffinity chromatography
Zibirre et al. Detection and localization of a cytoplasmic domain on the beta-subunit of Na+, K+-ATPase. A monoclonal antibody study.
ATE134218T1 (de) Methode zur reinigung rekombinanter t-pa von den ihren entsprechenden wirtszellproteinen
Werrbach-Perez et al. De novo synthesis of NGF subunits in S-180 mouse sarcoma cell line
WO2000017363A3 (en) Interleukin-1 like molecule: interleukin-1-zeta; nucleic acids, polypeptides, antibodies, their uses
Yasuda et al. Use of antibodies against synthetic peptides for analysis of molecular multiplicity: human deoxyribonuclease I polymorphism
Warr et al. β2 microglobulin-like polypeptide of the goldfish, Carassius auratus

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
EELA Cancelled due to lapse of time