ATE122683T1 - Epoxybernsteinsäurederivate, verwendbar als spezifische hemmer von cathepsin b. - Google Patents

Epoxybernsteinsäurederivate, verwendbar als spezifische hemmer von cathepsin b.

Info

Publication number
ATE122683T1
ATE122683T1 AT90305299T AT90305299T ATE122683T1 AT E122683 T1 ATE122683 T1 AT E122683T1 AT 90305299 T AT90305299 T AT 90305299T AT 90305299 T AT90305299 T AT 90305299T AT E122683 T1 ATE122683 T1 AT E122683T1
Authority
AT
Austria
Prior art keywords
acid derivatives
cathepsin
epoxysumptic
specific inhibitors
derivatives usable
Prior art date
Application number
AT90305299T
Other languages
English (en)
Inventor
Mitsuo Murata
Chihiro Yokoo
Kazunori Hanada
Original Assignee
Taisho Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Taisho Pharmaceutical Co Ltd filed Critical Taisho Pharmaceutical Co Ltd
Application granted granted Critical
Publication of ATE122683T1 publication Critical patent/ATE122683T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Epoxy Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
AT90305299T 1989-05-18 1990-05-16 Epoxybernsteinsäurederivate, verwendbar als spezifische hemmer von cathepsin b. ATE122683T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP12475389 1989-05-18

Publications (1)

Publication Number Publication Date
ATE122683T1 true ATE122683T1 (de) 1995-06-15

Family

ID=14893266

Family Applications (1)

Application Number Title Priority Date Filing Date
AT90305299T ATE122683T1 (de) 1989-05-18 1990-05-16 Epoxybernsteinsäurederivate, verwendbar als spezifische hemmer von cathepsin b.

Country Status (7)

Country Link
US (1) US5068354A (de)
EP (1) EP0407017B1 (de)
JP (1) JPH0372478A (de)
KR (1) KR900018083A (de)
AT (1) ATE122683T1 (de)
CA (1) CA2016261A1 (de)
DE (1) DE69019423T2 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2808877B2 (ja) * 1990-09-29 1998-10-08 大正製薬株式会社 エポキシスクシナム酸誘導体およびその中間体
US5444042A (en) * 1990-12-28 1995-08-22 Cortex Pharmaceuticals Method of treatment of neurodegeneration with calpain inhibitors
AU5825094A (en) * 1993-11-19 1995-06-06 Astra Aktiebolag Novel dipeptide derivatives
EP1022276B1 (de) * 1997-09-04 2003-05-28 Nippon Chemiphar Co., Ltd. Epoxybernsteinsäureamid-derivate
KR20030070677A (ko) * 2002-02-26 2003-09-02 신길수 화훼포장용기

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS55115878A (en) * 1979-02-27 1980-09-06 Taisho Pharmaceut Co Ltd Epoxysuccinic acid derivative

Also Published As

Publication number Publication date
EP0407017A1 (de) 1991-01-09
EP0407017B1 (de) 1995-05-17
US5068354A (en) 1991-11-26
DE69019423T2 (de) 1995-09-14
JPH0372478A (ja) 1991-03-27
KR900018083A (ko) 1990-12-20
CA2016261A1 (en) 1990-11-18
DE69019423D1 (de) 1995-06-22

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