ATE123059T1 - Menschliche, erythroid-spezifische transkriptionsenhancer. - Google Patents

Menschliche, erythroid-spezifische transkriptionsenhancer.

Info

Publication number: ATE123059T1
Authority: AT; Austria
Prior art keywords: specific transcription; human erythroid; transcription enhancers; enhancer element; erythroid
Prior art date: 1987-09-17

Application number

AT88909914T

Other languages

English (en)

Inventor

Dorothy Y H Tuan

Irving M London

William B Solomon

Original Assignee

Massachusetts Inst Technology

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-09-17

Filing date

1988-09-15

Publication date

1995-06-15

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26793935&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE123059(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1988-09-15 Application filed by Massachusetts Inst Technology filed Critical Massachusetts Inst Technology

1995-06-15 Application granted granted Critical

1995-06-15 Publication of ATE123059T1 publication Critical patent/ATE123059T1/de

Links

238000013518 transcription Methods 0.000 title abstract 2
230000035897 transcription Effects 0.000 title abstract 2
239000003623 enhancer Substances 0.000 title 1
108700028146 Genetic Enhancer Elements Proteins 0.000 abstract 3
210000000267 erythroid cell Anatomy 0.000 abstract 1
230000000925 erythroid effect Effects 0.000 abstract 1
238000001415 gene therapy Methods 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
108090000623 proteins and genes Proteins 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/008—Vector systems having a special element relevant for transcription cell type or tissue specific enhancer/promoter combination
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/30—Vector systems having a special element relevant for transcription being an enhancer not forming part of the promoter region
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/80—Vector systems having a special element relevant for transcription from vertebrates
- C12N2830/85—Vector systems having a special element relevant for transcription from vertebrates mammalian

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Genetics & Genomics (AREA)
Engineering & Computer Science (AREA)
Biotechnology (AREA)
Chemical & Material Sciences (AREA)
Zoology (AREA)
Biomedical Technology (AREA)
General Health & Medical Sciences (AREA)
Developmental Biology & Embryology (AREA)
Immunology (AREA)
Organic Chemistry (AREA)
Wood Science & Technology (AREA)
Bioinformatics & Cheminformatics (AREA)
General Engineering & Computer Science (AREA)
Cell Biology (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Virology (AREA)
Physics & Mathematics (AREA)
Biophysics (AREA)
Epidemiology (AREA)
Molecular Biology (AREA)
Plant Pathology (AREA)
Public Health (AREA)
Microbiology (AREA)
Medicinal Chemistry (AREA)
Biochemistry (AREA)
Hematology (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

AT88909914T 1987-09-17 1988-09-15 Menschliche, erythroid-spezifische transkriptionsenhancer. ATE123059T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US9802587A	1987-09-17	1987-09-17
US11367787A	1987-10-26	1987-10-26

Publications (1)

Publication Number	Publication Date
ATE123059T1 true ATE123059T1 (de)	1995-06-15

Family

ID=26793935

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT88909914T ATE123059T1 (de)	1987-09-17	1988-09-15	Menschliche, erythroid-spezifische transkriptionsenhancer.

Country Status (7)

Country	Link
US (1)	US5126260A (de)
EP (1)	EP0377676B1 (de)
JP (1)	JP2779192B2 (de)
AT (1)	ATE123059T1 (de)
CA (1)	CA1341119C (de)
DE (1)	DE3853886T2 (de)
WO (1)	WO1989002469A2 (de)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB8718779D0 (en) *	1987-08-07	1987-09-16	Grosveld F G	Dna sequence & expression vector
GB9027917D0 (en) *	1990-12-21	1991-02-13	Ici Plc	Expression systems
US5756353A (en) *	1991-12-17	1998-05-26	The Regents Of The University Of California	Expression of cloned genes in the lung by aerosol-and liposome-based delivery
US6627615B1 (en)	1991-12-17	2003-09-30	The Regents Of The University Of California	Methods and compositions for in vivo gene therapy
US5858784A (en)	1991-12-17	1999-01-12	The Regents Of The University Of California	Expression of cloned genes in the lung by aerosol- and liposome-based delivery
EP0646178A1 (de) *	1992-06-04	1995-04-05	The Regents Of The University Of California	Expression kassette mit im säugetier wirt funktionnellen regulator sequenzen
US6806084B1 (en)	1992-06-04	2004-10-19	The Regents Of The University Of California	Methods for compositions for in vivo gene delivery
US5631162A (en) *	1993-06-11	1997-05-20	Massachusetts Institute Of Technology	Retroviral vectors for transducing β-globin gene and β-locus control region derivatives
US6897016B1 (en) *	1993-11-12	2005-05-24	The Regents Of The University Of Colorado	Alteration of sequence of a target molecule
WO1996009385A1 (en) *	1994-09-19	1996-03-28	Massachusetts Institute Of Technology	Anti-sickling beta-globin protein, compositions and methods for treating sickle cell disease
US6153427A (en) *	1994-10-12	2000-11-28	Northeastern Ohio Universities College Of Medicine	Erythropoietin-inducible, erythroid-specific DNA construct
US6127345A (en) *	1997-01-21	2000-10-03	Smithkline Beecham Corporation	Polynucleotides encoding the glucose 6-phosphate dehydrogenase of Streptococcus pneumoniae
CN1159455C (zh) *	1998-06-08	2004-07-28	Acgt医药公司	Dna,rna和蛋白的检测
JP2004537539A (ja)	2001-06-29	2004-12-16	スローン − ケッタリングインスティチュートフォーキャンサーリサーチ	ヒトグロビン遺伝子をコードするベクターとその異常ヘモグロビン血症の治療におけるその使用
US20080216185A1 (en) *	2007-01-19	2008-09-04	Invitrogen Corporation	Compositions and Methods for Genetic Manipulation and Monitoring of Cell Lines
ES2325711B1 (es) *	2007-04-17	2010-06-17	Centro De Investigaciones Energeticas, Medioambientales Y Tecnologicas (Ciemat)	Vectores de expresion que comprenden el promotor del gen pklr humano y su uso para la elaboracion de composiciones farmaceuticas destinadas a terapia genica somatica con expresion especifica en celulas eritroides.
US20140037599A1 (en) *	2012-08-03	2014-02-06	The Trustees Of The University Of Pennsylvania	Compositions and Methods of Treating T Cell Deficiency
KR102673203B1 (ko)	2016-04-20	2024-06-10	센트로 데 인베스띠가씨오네스 에너제티까스 메디오암비엔딸레스 와이 테크놀로지까스, 오.에이., 엠.피.	Pklr의 유전자 발현 증강을 위한 조성물 및 방법
AU2018352583B2 (en)	2017-10-16	2025-04-17	Centro de Investigaciones Energeticas, Medioambientales Y Tecnologicas, O.A., M.P.	Lentiviral vectors for delivery of PKLR to treat Pyruvate Kinase Deficiency
US12539316B2 (en)	2018-04-11	2026-02-03	Spacecraft Seven, Llc	Compositions and methods for stem cell transplant
IL278213B2 (en)	2018-04-27	2026-04-01	Rocket Pharmaceuticals Ltd	A gene therapy vector encoding an e3 ubiquitin protein ligase (park2) and use thereof in treating or inhibiting the onset of parkinson’s disease (pd)
IL280465B2 (en)	2018-07-30	2025-03-01	Centro De Investig Energeticas Medioambientales Y Tecnologicas O A M P	Methods for gene modification of hematopoietic cells
US20220411822A1 (en) *	2020-01-22	2022-12-29	Altius Institute For Biomedical Sciences	Novel Erythroid Specific Enhancers and Uses Thereof
WO2022032226A1 (en)	2020-08-07	2022-02-10	Spacecraft Seven, Llc	Plakophilin-2 (pkp2) gene therapy using aav vector

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPH0789930B2 (ja) *	1984-03-08	1995-10-04	大正製薬株式会社	ウイルス性転写促進配列
US4663281A (en) *	1984-03-22	1987-05-05	Mass Institute Of Technology	Enhanced production of proteinaceous materials in eucaryotic cells

1988
- 1988-09-15 EP EP88909914A patent/EP0377676B1/de not_active Expired - Lifetime
- 1988-09-15 JP JP63509102A patent/JP2779192B2/ja not_active Expired - Lifetime
- 1988-09-15 WO PCT/US1988/003187 patent/WO1989002469A2/en not_active Ceased
- 1988-09-15 AT AT88909914T patent/ATE123059T1/de not_active IP Right Cessation
- 1988-09-15 DE DE3853886T patent/DE3853886T2/de not_active Expired - Lifetime
- 1988-09-16 CA CA000577652A patent/CA1341119C/en not_active Expired - Lifetime
1990
- 1990-12-04 US US07/622,356 patent/US5126260A/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
WO1989002469A2 (en)	1989-03-23
JP2779192B2 (ja)	1998-07-23
US5126260A (en)	1992-06-30
DE3853886D1 (de)	1995-06-29
JPH03500245A (ja)	1991-01-24
CA1341119C (en)	2000-10-17
DE3853886T2 (de)	1995-10-05
WO1989002469A3 (en)	1989-04-20
EP0377676A1 (de)	1990-07-18
EP0377676B1 (de)	1995-05-24

Legal Events

Date	Code	Title	Description
1996-01-15	UEP	Publication of translation of european patent specification
2008-12-15	EELA	Cancelled due to lapse of time

Publication	Publication Date	Title
DE3853886D1 (de)	1995-06-29	Menschliche, erythroid-spezifische transkriptionsenhancer.
IT8022740A0 (it)	1980-06-12	Procedimento per la produzione di etanolo in forte concentrazione impiegando microorganismi immobilizzati.
DE3875667D1 (de)	1992-12-10	Menschliche papillomavirusnukleinsaeureproben.
NO870440L (no)	1987-08-06	Fermenteringsapparat.
IT7820120A0 (it)	1978-02-09	Proteine filate e processo per ottenere dette proteine.
BG47033A3 (en)	1990-04-16	Method for preparing of derivatives of imidazolamine
DE3685397D1 (de)	1992-06-25	Sperrfreie serialisierung von zugriffen zu gemeinsamen mitteln.
IT7867133A0 (it)	1978-01-24	Procedimento per la purificazione di acque di rifiuto ricche in carboidrati e la produzione simultanea di mangimi ad alto contenuto in proteine
DE3780618D1 (de)	1992-08-27	Verwendung von buspiron zur verbesserung des kurzzeitgedaechtnisses.
DK184587A (da)	1987-10-18	Tiolaktam-n-eddikesyrederivater, produktion og anvendelse deraf
NO880763D0 (no)	1988-02-22	Bruk av gassholdig karbondioksyd for innstilling av ph i cellulosemasse.
FI885436A7 (fi)	1989-05-24	Fermenttori soluviljelmien viljelemiseksi
DE3778010D1 (de)	1992-05-07	Rechnersystem mit moduskonvertierung von rechnerbefehlen.
DK179785A (da)	1985-10-25	Fermenteringsproces
FI890450A7 (fi)	1989-01-30	Vasta-aineen sitoutumiskohdat, joilla on sterospesifistä syntaasiaktii visuutta, sekä niiden käyttömenetelmät
FI891625A0 (fi)	1989-04-05	Foerfarande foer framstaellning av aminocyanacetamid.
PT86552A (de)	1988-02-01	Gama-glutamyl-transpeptidase deren herstellung und deren verwendung
IT8720338A0 (it)	1987-04-30	Glucosio deidrogenasi e suaproduzione.
DE3877008D1 (de)	1993-02-11	Geraet zur sukzessiven umwandlung von zeitperioden in spannung.
DK451786A (da)	1987-03-24	Transglucosidase, fremstilling og anvendelse deraf
DE3650395D1 (de)	1995-10-19	Gärung zur Gewinnung von d-Milchsäure.
ATE103989T1 (de)	1994-04-15	Monoklonale antikoerper gegen e7-protein des humanen papillomvirus typ 16, verfahren zu ihrer herstellung sowie ihre verwendung.
IT7922634A0 (it)	1979-05-11	Enzima immobilizzato e metodo per la sua produzione.
DE3780855D1 (de)	1992-09-10	Zellkultur-methode.
DE68928061D1 (de)	1997-06-26	Expression von proteinsüssmitteln in hefe