ATE123275T1 - Substituierte pyrrolidinderivate als hiv-protease-hemmer. - Google Patents
Substituierte pyrrolidinderivate als hiv-protease-hemmer.Info
- Publication number
- ATE123275T1 ATE123275T1 AT93103713T AT93103713T ATE123275T1 AT E123275 T1 ATE123275 T1 AT E123275T1 AT 93103713 T AT93103713 T AT 93103713T AT 93103713 T AT93103713 T AT 93103713T AT E123275 T1 ATE123275 T1 AT E123275T1
- Authority
- AT
- Austria
- Prior art keywords
- hiv
- protease inhibitors
- hiv protease
- pyrrolidine derivatives
- compounds
- Prior art date
Links
- RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical class C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 title 1
- 239000004030 hiv protease inhibitor Substances 0.000 title 1
- 241000725303 Human immunodeficiency virus Species 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- -1 for example Chemical group 0.000 abstract 3
- 208000031886 HIV Infections Diseases 0.000 abstract 1
- 108091005804 Peptidases Proteins 0.000 abstract 1
- 239000004365 Protease Substances 0.000 abstract 1
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000000539 amino acid group Chemical group 0.000 abstract 1
- 125000005161 aryl oxy carbonyl group Chemical group 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 125000001589 carboacyl group Chemical group 0.000 abstract 1
- 230000000120 cytopathologic effect Effects 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 210000005260 human cell Anatomy 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Virology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Tropical Medicine & Parasitology (AREA)
- Molecular Biology (AREA)
- AIDS & HIV (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Peptides Or Proteins (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US85059692A | 1992-03-13 | 1992-03-13 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE123275T1 true ATE123275T1 (de) | 1995-06-15 |
Family
ID=25308596
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT93103713T ATE123275T1 (de) | 1992-03-13 | 1993-03-09 | Substituierte pyrrolidinderivate als hiv-protease-hemmer. |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US5552405A (de) |
| EP (1) | EP0560269B1 (de) |
| JP (1) | JP3198191B2 (de) |
| AT (1) | ATE123275T1 (de) |
| AU (1) | AU663164B2 (de) |
| CA (1) | CA2092653C (de) |
| DE (1) | DE69300169T2 (de) |
| HU (1) | HU215520B (de) |
| NZ (1) | NZ247124A (de) |
| PL (1) | PL173459B1 (de) |
| TW (1) | TW301651B (de) |
| ZA (1) | ZA931777B (de) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69333270T2 (de) | 1992-03-11 | 2004-08-05 | Narhex Ltd. | Aminderivate von oxo- und hydroxy- substituierten kohlenwasserstoffen |
| US6071895A (en) | 1992-03-11 | 2000-06-06 | Narhex Limited | Polar-substituted hydrocarbons |
| US5888992A (en) | 1992-03-11 | 1999-03-30 | Narhex Limited | Polar substituted hydrocarbons |
| BR9306058A (pt) | 1992-03-11 | 1997-11-18 | Narhex Ltd | Derivados de amina de hidrocarbonetos oxo- e hidroxi- substituidos |
| ATE116640T1 (de) * | 1992-03-13 | 1995-01-15 | Bio Mega Boehringer Ingelheim | Substituierte pipecoline-säurederivate als hiv- protease-hemmer. |
| US5559256A (en) * | 1992-07-20 | 1996-09-24 | E. R. Squibb & Sons, Inc. | Aminediol protease inhibitors |
| EP0610745A3 (en) * | 1993-02-09 | 1994-09-28 | Miles Inc | Novel aminomethylene derivatives as immunosuppressants. |
| IL110898A0 (en) * | 1993-09-10 | 1994-11-28 | Narhex Australia Pty Ltd | Polar-substituted hydrocarbons |
| US5883252A (en) * | 1996-01-26 | 1999-03-16 | Vertex Pharmaceuticals Incorporated | Aspartyl protease inhibitors |
| US6803466B1 (en) * | 1997-12-08 | 2004-10-12 | The Scripps Research Institute | HIV/FIV protease inhibitors having a small P3 residue |
| WO1999029311A1 (en) * | 1997-12-08 | 1999-06-17 | The Scripps Research Institute | Hiv/fiv protease inhibitors having a small p3 residue |
| US6251906B1 (en) | 1998-05-15 | 2001-06-26 | Abbott Laboratories | Retroviral protease inhibiting compounds |
| WO2003054155A2 (en) | 2001-12-19 | 2003-07-03 | Bristol-Myers Squibb Company | Pichia pastoris formate dehydrogenase and uses therefor |
| JP4482883B2 (ja) | 2003-05-22 | 2010-06-16 | リードケミカル株式会社 | 抗ウイルス作用を有する化合物およびその配合剤 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1340588C (en) * | 1988-06-13 | 1999-06-08 | Balraj Krishan Handa | Amino acid derivatives |
| EP0361341A3 (de) * | 1988-09-28 | 1991-07-03 | Miles Inc. | Therapeutika für AIDS auf der Basis von HIV-Protease-Inhibitoren |
| WO1991008221A1 (en) * | 1989-12-04 | 1991-06-13 | Wisconsin Alumni Research Foundation | Peptide inhibitors of hiv protease |
-
1993
- 1993-02-12 ZA ZA931777A patent/ZA931777B/xx unknown
- 1993-03-09 DE DE69300169T patent/DE69300169T2/de not_active Expired - Lifetime
- 1993-03-09 AT AT93103713T patent/ATE123275T1/de not_active IP Right Cessation
- 1993-03-09 EP EP93103713A patent/EP0560269B1/de not_active Expired - Lifetime
- 1993-03-11 NZ NZ247124A patent/NZ247124A/en unknown
- 1993-03-12 PL PL93298038A patent/PL173459B1/pl unknown
- 1993-03-12 AU AU35165/93A patent/AU663164B2/en not_active Ceased
- 1993-03-12 HU HU9300729A patent/HU215520B/hu not_active IP Right Cessation
- 1993-03-12 CA CA002092653A patent/CA2092653C/en not_active Expired - Lifetime
- 1993-03-15 JP JP05414193A patent/JP3198191B2/ja not_active Expired - Fee Related
- 1993-03-23 TW TW082102142A patent/TW301651B/zh active
-
1995
- 1995-07-31 US US08/509,268 patent/US5552405A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| EP0560269A1 (de) | 1993-09-15 |
| ZA931777B (en) | 1993-09-23 |
| PL173459B1 (pl) | 1998-03-31 |
| JPH0625158A (ja) | 1994-02-01 |
| DE69300169D1 (de) | 1995-07-06 |
| CA2092653A1 (en) | 1993-09-14 |
| JP3198191B2 (ja) | 2001-08-13 |
| AU663164B2 (en) | 1995-09-28 |
| US5552405A (en) | 1996-09-03 |
| PL298038A1 (en) | 1993-11-15 |
| NZ247124A (en) | 1995-09-26 |
| EP0560269B1 (de) | 1995-05-31 |
| AU3516593A (en) | 1993-09-16 |
| HUT70147A (en) | 1995-09-28 |
| DE69300169T2 (de) | 1995-10-26 |
| HU9300729D0 (en) | 1993-05-28 |
| TW301651B (de) | 1997-04-01 |
| HU215520B (hu) | 1999-01-28 |
| CA2092653C (en) | 1998-12-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |