ATE124268T1 - Verfahren zur herstellung von therapeutischen rhenium-phosphonat-mitteln. - Google Patents

Verfahren zur herstellung von therapeutischen rhenium-phosphonat-mitteln.

Info

Publication number: ATE124268T1
Authority: AT; Austria
Prior art keywords: solution; rhenium; range; producing therapeutic; concentration
Prior art date: 1989-05-02

Application number

AT90905853T

Other languages

English (en)

Inventor

David W Pipes

Original Assignee

Mallinckrodt Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-05-02

Filing date

1990-03-12

Publication date

1995-07-15

1990-03-12 Application filed by Mallinckrodt Inc filed Critical Mallinckrodt Inc

1995-07-15 Application granted granted Critical

1995-07-15 Publication of ATE124268T1 publication Critical patent/ATE124268T1/de

Links

XJXLJKHXOMIRMQ-UHFFFAOYSA-J [Re+4].[O-]P([O-])=O.[O-]P([O-])=O Chemical compound [Re+4].[O-]P([O-])=O.[O-]P([O-])=O XJXLJKHXOMIRMQ-UHFFFAOYSA-J 0.000 title 1
238000004519 manufacturing process Methods 0.000 title 1
230000001225 therapeutic effect Effects 0.000 title 1
239000000243 solution Substances 0.000 abstract 7
230000002285 radioactive effect Effects 0.000 abstract 3
239000003638 chemical reducing agent Substances 0.000 abstract 2
239000003446 ligand Substances 0.000 abstract 2
229910052702 rhenium Inorganic materials 0.000 abstract 2
WUAPFZMCVAUBPE-UHFFFAOYSA-N rhenium atom Chemical compound [Re] WUAPFZMCVAUBPE-UHFFFAOYSA-N 0.000 abstract 2
239000007787 solid Substances 0.000 abstract 2
239000007864 aqueous solution Substances 0.000 abstract 1
230000000536 complexating effect Effects 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
- A61K51/0478—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group complexes from non-cyclic ligands, e.g. EDTA, MAG3
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0489—Phosphates or phosphonates, e.g. bone-seeking phosphonates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2123/00—Preparations for testing in vivo

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Optics & Photonics (AREA)
Physics & Mathematics (AREA)
Epidemiology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Molecular Biology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Electrical Control Of Ignition Timing (AREA)
Medicinal Preparation (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

AT90905853T 1989-05-02 1990-03-12 Verfahren zur herstellung von therapeutischen rhenium-phosphonat-mitteln. ATE124268T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US07/346,411 US5021235A (en)	1989-05-02	1989-05-02	Preparation of rhenium phosphonate therapeutic agents for bone cancer without purification

Publications (1)

Publication Number	Publication Date
ATE124268T1 true ATE124268T1 (de)	1995-07-15

Family

ID=23359259

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT90905853T ATE124268T1 (de)	1989-05-02	1990-03-12	Verfahren zur herstellung von therapeutischen rhenium-phosphonat-mitteln.

Country Status (10)

Country	Link
US (1)	US5021235A (de)
EP (1)	EP0470965B1 (de)
JP (1)	JP3080984B2 (de)
AT (1)	ATE124268T1 (de)
AU (1)	AU646801B2 (de)
CA (1)	CA2064063A1 (de)
DE (1)	DE69020556T2 (de)
DK (1)	DK0470965T3 (de)
ES (1)	ES2076363T3 (de)
WO (1)	WO1990013530A1 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5393512A (en) *	1985-01-14	1995-02-28	Vanderheyden; Jean-Luc	Stable therapeutic radionuclide compositions and methods for preparation thereof
US5985240A (en) *	1989-08-09	1999-11-16	Rhomed Incorporated	Peptide radiopharmaceutical applications
US5320824A (en) *	1989-10-12	1994-06-14	Mallinckrodt Medical, Inc.	Radionuclide labelled particles useful for radiation synovectomy
EP0538402B1 (de) *	1990-07-06	2006-03-08	Mallinckrodt Inc.	Methode zur herstellung einer lösung aus radioaktiven rheniumkomplexen
US5186913A (en) *	1991-04-26	1993-02-16	Martin Marietta Energy Systems, Inc.	Tungsten-188/carrier-free rhenium-188 perrhenic acid generator system
US6106473A (en) *	1996-11-06	2000-08-22	Sts Biopolymers, Inc.	Echogenic coatings
RU2164420C2 (ru) *	1999-02-10	2001-03-27	Государственный научный центр Российской Федерации Физико-энергетический институт им. акад. А.И. Лейпунского	Способ получения радиотерапевтического препарата
KR20020023636A (ko) *	2000-09-23	2002-03-29	송영욱	신규한 방사성 레늄 주석 화합물
RU2432965C1 (ru) *	2010-05-12	2011-11-10	Учреждение Российской академии медицинских наук Медицинский радиологический научный центр РАМН (МРНЦ РАМН)	Способ получения радиофармпрепарата для радионуклидной терапии

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3192011A (en) *	1963-08-07	1965-06-29	Chase Brass & Copper Co	Process for producing high purity rhenium compounds
US3983227A (en) *	1973-05-23	1976-09-28	The Procter & Gamble Company	Dry mixture containing diphosphonates and a stannous salt useful in the preparation of Tc99M containing bone scanning agents
US4652440A (en) *	1984-05-03	1987-03-24	Paik Chang H	Method of stably radiolabeling antibodies with technetium and rhenium
US4778672A (en) *	1985-11-27	1988-10-18	University Of Cincinnati	Method of isolating radioactive perrhenate or pertechnetate from an aqueous solution
US4935222A (en) *	1986-06-13	1990-06-19	University Of Cincinnati	Procedure for isolating and purifying radioactive ligated rhenium pharmaceuticals and use thereof and kit
EP0300431A3 (de) *	1987-07-22	1990-06-27	Neorx Corporation	Methode zur Bindung von radionukliden Anschwefel enthaltende Chelate
US4925925A (en) *	1988-06-15	1990-05-15	University Of Cincinnati	Radioactive rhenium ligated to 2-hydroxy isobutyric acid and method of use

1989
- 1989-05-02 US US07/346,411 patent/US5021235A/en not_active Expired - Lifetime
1990
- 1990-03-12 WO PCT/US1990/001323 patent/WO1990013530A1/en not_active Ceased
- 1990-03-12 DK DK90905853.9T patent/DK0470965T3/da active
- 1990-03-12 ES ES90905853T patent/ES2076363T3/es not_active Expired - Lifetime
- 1990-03-12 DE DE69020556T patent/DE69020556T2/de not_active Expired - Fee Related
- 1990-03-12 AU AU53554/90A patent/AU646801B2/en not_active Ceased
- 1990-03-12 CA CA002064063A patent/CA2064063A1/en not_active Abandoned
- 1990-03-12 EP EP90905853A patent/EP0470965B1/de not_active Expired - Lifetime
- 1990-03-12 JP JP02505467A patent/JP3080984B2/ja not_active Expired - Fee Related
- 1990-03-12 AT AT90905853T patent/ATE124268T1/de not_active IP Right Cessation

Also Published As

Publication number	Publication date
US5021235A (en)	1991-06-04
AU646801B2 (en)	1994-03-10
EP0470965A1 (de)	1992-02-19
JP3080984B2 (ja)	2000-08-28
ES2076363T3 (es)	1995-11-01
EP0470965B1 (de)	1995-06-28
CA2064063A1 (en)	1990-11-03
DE69020556T2 (de)	1995-11-02
DE69020556D1 (de)	1995-08-03
JPH05500042A (ja)	1993-01-14
WO1990013530A1 (en)	1990-11-15
AU5355490A (en)	1990-11-29
DK0470965T3 (da)	1995-08-28

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Legal Events

Date	Code	Title	Description
1995-12-15	UEP	Publication of translation of european patent specification
1998-12-15	REN	Ceased due to non-payment of the annual fee