ATE124867T1 - Peptide, die eine reninhemmende aktivität besitzen, deren herstellung und verwendung. - Google Patents

Peptide, die eine reninhemmende aktivität besitzen, deren herstellung und verwendung.

Info

Publication number: ATE124867T1
Authority: AT; Austria
Prior art keywords: renin; alkyl; optionally substituted; production; inhibiting activity
Prior art date: 1989-02-16

Application number

AT90301735T

Other languages

English (en)

Inventor

Yasuhiro C O Sankyo C Morisawa

Mitsuru C O Sankyo Com Kataoka

Yuichiro C O Sankyo Compa Yabe

Hiroyuki C O Sankyo Comp Koike

Hidekuni C O Sankyo C Takahagi

Yasuteru C O Sankyo Com Iijima

Tatsuo Kokubu

Kunio Hiwada

Original Assignee

Sankyo Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-02-16

Filing date

1990-02-16

Publication date

1995-07-15

1990-02-16 Application filed by Sankyo Co filed Critical Sankyo Co

1995-07-15 Application granted granted Critical

1995-07-15 Publication of ATE124867T1 publication Critical patent/ATE124867T1/de

Links

102000004196 processed proteins & peptides Human genes 0.000 title 1
108090000765 processed proteins & peptides Proteins 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 3
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
206010020772 Hypertension Diseases 0.000 abstract 1
150000001412 amines Chemical class 0.000 abstract 1
150000001413 amino acids Chemical class 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000000753 cycloalkyl group Chemical group 0.000 abstract 1
125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 abstract 1
238000003745 diagnosis Methods 0.000 abstract 1
125000000623 heterocyclic group Chemical group 0.000 abstract 1
230000001077 hypotensive effect Effects 0.000 abstract 1
125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 abstract 1
125000001624 naphthyl group Chemical group 0.000 abstract 1
125000003884 phenylalkyl group Chemical group 0.000 abstract 1
230000036454 renin-angiotensin system Effects 0.000 abstract 1
125000006413 ring segment Chemical group 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
125000000335 thiazolyl group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D277/30—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Biochemistry (AREA)
Biophysics (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

AT90301735T 1989-02-16 1990-02-16 Peptide, die eine reninhemmende aktivität besitzen, deren herstellung und verwendung. ATE124867T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
JP3709789		1989-02-16
JP14957789		1989-06-14

Publications (1)

Publication Number	Publication Date
ATE124867T1 true ATE124867T1 (de)	1995-07-15

Family

ID=26376195

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT90301735T ATE124867T1 (de)	1989-02-16	1990-02-16	Peptide, die eine reninhemmende aktivität besitzen, deren herstellung und verwendung.

Country Status (10)

Country	Link
US (1)	US5378689A (de)
EP (1)	EP0383635B1 (de)
KR (1)	KR900012945A (de)
AT (1)	ATE124867T1 (de)
CA (1)	CA2010260A1 (de)
DE (1)	DE69020752T2 (de)
DK (1)	DK0383635T3 (de)
ES (1)	ES2077021T3 (de)
GR (1)	GR3017697T3 (de)
IE (1)	IE70080B1 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5587388A (en) *	1992-12-02	1996-12-24	Lucky Limited	Irreversible HIV protease inhibitors, intermediates, compositions and processes for the preparation thereof
US6573282B1 (en)	1995-09-12	2003-06-03	Adolor Corporation	Peripherally active anti-hyperalgesic opiates
US5849761A (en)	1995-09-12	1998-12-15	Regents Of The University Of California	Peripherally active anti-hyperalgesic opiates
CA2191924A1 (en)	1995-12-05	1997-06-06	Kevin Felsenstein	5-amino-6-cyclohexyl-4-hydroxy-hexanamide derivatives as inhibitors of .beta.-amyloid protein production
JP4727770B2 (ja) *	1997-09-26	2011-07-20	カルピス株式会社	尿中カテコールアミン低下、尿中ノルアドレナリン低下、尿中ドーパミン低下及びＦｉｓｃｈｅｒ比低下の少なくとも１つの軽減剤

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS5839149A (ja) *	1981-09-02	1983-03-07	Nec Corp	４線式割込接続方式
JPS59227851A (ja) *	1983-06-09	1984-12-21	Sankyo Co Ltd	レニン阻害作用を有するペプチド類
JPS60163899A (ja) *	1984-02-03	1985-08-26	Sankyo Co Ltd	レニン阻害ペプチド類
CA1269523A (en) *	1984-07-23	1990-05-29	Corning Glass Works	Photoelectrodes for solar energy conversion
US4727060A (en) *	1984-11-13	1988-02-23	Ciba-Geigy Corporation	Novel 5-amino-4-hydroxyvaleryl derivatives
JPS61275256A (ja) *	1984-11-27	1986-12-05	Sankyo Co Ltd	レニン阻害ペプチド
SU1676454A3 (ru) *	1984-11-30	1991-09-07	Санкио Компани Лимитед (Фирма)	Способ получени пептидов или их фармацевтически приемлемых солей
CA1286846C (en) *	1985-02-12	1991-07-23	Catherine Cazaubon	Peptide derivatives which inhibit renin and acid proteases
KR870005013A (ko) *	1985-11-29	1987-06-04	가와무라 요시부미	레닌-억제 올리고펩티드, 그의 제조방법 및 용도
EP0258289A4 (en) *	1986-01-16	1991-01-02	Joseph Dellaria	Peptide analogs
EP0278158A3 (de) *	1986-11-12	1990-05-23	Merck & Co. Inc.	Renin-Inhibitoren enthaltende Phenylalanin-Histidin-Stellvertreter
ES2062988T3 (es) *	1986-12-19	1995-01-01	Sankyo Co	Nuevos oligopeptidos inhibidores de la renina, su preparacion y su uso.
US4758584A (en) *	1987-02-05	1988-07-19	Ciba-Geigy Corporation	Antihypertensive 5-amino-4-hydroxyvaleryl derivatives substituted by sulphur-containing groups
ES2061652T3 (es) *	1987-07-01	1994-12-16	Pfizer	Polipeptidos que contienen homocicloestatina y cicloestatina como agentes antihipertensivos.
US4839357A (en) *	1987-10-02	1989-06-13	Merck & Co., Inc.	Renin inhibitors containing phenylalanyl-histidine replacements
EP0326364B1 (de) *	1988-01-26	1994-06-22	Sankyo Company Limited	Renin inhibierende Polypeptide, ihre Herstellung und Anwendung

1990
- 1990-02-16 IE IE58590A patent/IE70080B1/en not_active IP Right Cessation
- 1990-02-16 DE DE69020752T patent/DE69020752T2/de not_active Expired - Fee Related
- 1990-02-16 EP EP90301735A patent/EP0383635B1/de not_active Expired - Lifetime
- 1990-02-16 CA CA002010260A patent/CA2010260A1/en not_active Abandoned
- 1990-02-16 DK DK90301735.8T patent/DK0383635T3/da active
- 1990-02-16 KR KR1019900001918A patent/KR900012945A/ko not_active Ceased
- 1990-02-16 ES ES90301735T patent/ES2077021T3/es not_active Expired - Lifetime
- 1990-02-16 AT AT90301735T patent/ATE124867T1/de not_active IP Right Cessation
1993
- 1993-07-28 US US08/098,746 patent/US5378689A/en not_active Expired - Fee Related
1995
- 1995-10-11 GR GR950402806T patent/GR3017697T3/el unknown

Also Published As

Publication number	Publication date
EP0383635A3 (de)	1991-12-27
DK0383635T3 (da)	1995-11-20
DE69020752D1 (de)	1995-08-17
IE70080B1 (en)	1996-10-30
US5378689A (en)	1995-01-03
CA2010260A1 (en)	1990-08-16
EP0383635A2 (de)	1990-08-22
EP0383635B1 (de)	1995-07-12
GR3017697T3 (en)	1996-01-31
KR900012945A (ko)	1990-09-03
IE900585L (en)	1990-08-16
DE69020752T2 (de)	1996-03-28
ES2077021T3 (es)	1995-11-16

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Legal Events

Date	Code	Title	Description
1996-01-15	UEP	Publication of translation of european patent specification
1998-11-15	REN	Ceased due to non-payment of the annual fee