ATE125261T1 - 2-tetrahydrofuran-enantiomerderivate, zwischenprodukte davon und ihre herstellung. - Google Patents

2-tetrahydrofuran-enantiomerderivate, zwischenprodukte davon und ihre herstellung.

Info

Publication number: ATE125261T1
Authority: AT; Austria
Prior art keywords: compound; formula; tetrahydrofuran; enantiomer; production
Prior art date: 1990-06-19

Application number

AT91810477T

Other languages

English (en)

Inventor

Heinrich Estermann

William Joseph Houlihan

Prasad Koteswara Kapa

Russell Lee Underwood

Original Assignee

Sandoz Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-06-19

Filing date

1991-06-19

Publication date

1995-08-15

1991-06-19 Application filed by Sandoz Ag filed Critical Sandoz Ag

1995-08-15 Application granted granted Critical

1995-08-15 Publication of ATE125261T1 publication Critical patent/ATE125261T1/de

Links

239000013067 intermediate product Substances 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 3
LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 abstract 2
IXZHWGJCHBDVLV-UHFFFAOYSA-N C(CCC)(=O)O.C(CCC)(=O)O.OCC1(OCCC1)CO Chemical compound C(CCC)(=O)O.C(CCC)(=O)O.OCC1(OCCC1)CO IXZHWGJCHBDVLV-UHFFFAOYSA-N 0.000 abstract 1
206010028980 Neoplasm Diseases 0.000 abstract 1
WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical group C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 abstract 1
229910052799 carbon Inorganic materials 0.000 abstract 1
125000004432 carbon atom Chemical group C* 0.000 abstract 1
238000010511 deprotection reaction Methods 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
239000000543 intermediate Substances 0.000 abstract 1
201000006417 multiple sclerosis Diseases 0.000 abstract 1
125000004430 oxygen atom Chemical group O* 0.000 abstract 1
230000000144 pharmacologic effect Effects 0.000 abstract 1
238000006467 substitution reaction Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D307/10—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D307/12—Radicals substituted by oxygen atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
- C07F9/65515—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a five-membered ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
- C07F9/6571—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms
- C07F9/6574—Esters of oxyacids of phosphorus
- C07F9/65742—Esters of oxyacids of phosphorus non-condensed with carbocyclic rings or heterocyclic rings or ring systems

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
Immunology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Hematology (AREA)
Oncology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Furan Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Catalysts (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

AT91810477T 1990-06-19 1991-06-19 2-tetrahydrofuran-enantiomerderivate, zwischenprodukte davon und ihre herstellung. ATE125261T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US54043890A	1990-06-19	1990-06-19
US64739691A	1991-01-29	1991-01-29

Publications (1)

Publication Number	Publication Date
ATE125261T1 true ATE125261T1 (de)	1995-08-15

Family

ID=27066435

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT91810477T ATE125261T1 (de)	1990-06-19	1991-06-19	2-tetrahydrofuran-enantiomerderivate, zwischenprodukte davon und ihre herstellung.

Country Status (21)

Country	Link
EP (1)	EP0462935B1 (de)
JP (1)	JP2709330B2 (de)
KR (1)	KR920000772A (de)
AT (1)	ATE125261T1 (de)
AU (2)	AU649681B2 (de)
CA (1)	CA2044786A1 (de)
CS (1)	CS185191A3 (de)
DE (1)	DE69111311T2 (de)
DK (1)	DK0462935T3 (de)
ES (1)	ES2076502T3 (de)
FI (1)	FI912964L (de)
GR (1)	GR3017437T3 (de)
HK (1)	HK111996A (de)
HU (1)	HU210548B (de)
IE (1)	IE68417B1 (de)
IL (1)	IL98524A (de)
MY (1)	MY107022A (de)
NZ (1)	NZ238573A (de)
PL (1)	PL164981B1 (de)
PT (1)	PT97994B (de)
TW (1)	TW255897B (de)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5208352A (en) *	1992-04-02	1993-05-04	Sandoz Ltd.	Process for preparing the R- and S-isomers of 2-hydroxy-methyl-2-octadecyloxymethyl-tetrahydrofuran and their use in preparing stereoisomers of pharmacologically active compounds
ATE225982T1 (de) *	1998-07-17	2002-10-15	Fuji Photo Film Co Ltd	Photozelle und photoelektrochemische zelle

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0178261A3 (de) *	1984-10-10	1986-12-30	Sandoz Ag	Substituierte 2-Furanyl- oder -5-Oxo-2-furanyl-alkoxy-phosphorylalkylcyclimmoniumsalze
US4601987A (en) *	1985-02-27	1986-07-22	Massachusetts Institute Of Technology	Enzymatic production of optical isomers of 2-halopropionic acids
DE3666435D1 (en) *	1985-08-30	1989-11-23	Sandoz Ag	Substituted hydroxy-heterocyclyl-alkoxy phosphinyloxy trialkylaminium hydroxide inner salt oxides, processes for their preparation and their use as pharmaceuticals
US4673672A (en)	1985-10-28	1987-06-16	Sandoz Pharmaceuticals Corp.	Substituted-[hydroxy(tetrahydro)-5-oxo-(2- and 3-furanyl or 2-thienyl)alkoxyphosphinyloxy]-alkanaminium hydroxide, inner salt oxides
US4868319A (en) *	1987-12-22	1989-09-19	Sandoz Pharm. Corp.	Process for the preparation of monoalkylcarbamate group-containing compounds

1991
- 1991-06-06 HU HU911882A patent/HU210548B/hu not_active IP Right Cessation
- 1991-06-17 PT PT97994A patent/PT97994B/pt not_active IP Right Cessation
- 1991-06-17 CS CS911851A patent/CS185191A3/cs unknown
- 1991-06-17 CA CA002044786A patent/CA2044786A1/en not_active Abandoned
- 1991-06-17 IL IL9852491A patent/IL98524A/en not_active IP Right Cessation
- 1991-06-17 AU AU78439/91A patent/AU649681B2/en not_active Ceased
- 1991-06-17 NZ NZ238573A patent/NZ238573A/en unknown
- 1991-06-18 FI FI912964A patent/FI912964L/fi not_active Application Discontinuation
- 1991-06-18 KR KR1019910010079A patent/KR920000772A/ko not_active Ceased
- 1991-06-18 MY MYPI91001089A patent/MY107022A/en unknown
- 1991-06-18 JP JP3173245A patent/JP2709330B2/ja not_active Expired - Lifetime
- 1991-06-18 IE IE208191A patent/IE68417B1/en not_active IP Right Cessation
- 1991-06-18 PL PL91290719A patent/PL164981B1/pl unknown
- 1991-06-19 DK DK91810477.9T patent/DK0462935T3/da active
- 1991-06-19 DE DE69111311T patent/DE69111311T2/de not_active Expired - Fee Related
- 1991-06-19 EP EP91810477A patent/EP0462935B1/de not_active Expired - Lifetime
- 1991-06-19 AT AT91810477T patent/ATE125261T1/de not_active IP Right Cessation
- 1991-06-19 ES ES91810477T patent/ES2076502T3/es not_active Expired - Lifetime
- 1991-07-09 TW TW080105309A patent/TW255897B/zh active
1994
- 1994-08-23 AU AU71407/94A patent/AU677403B2/en not_active Ceased
1995
- 1995-09-18 GR GR950402562T patent/GR3017437T3/el unknown
1996
- 1996-06-27 HK HK111996A patent/HK111996A/en not_active IP Right Cessation

Also Published As

Publication number	Publication date
PL290719A1 (en)	1992-07-27
TW255897B (de)	1995-09-01
FI912964A0 (fi)	1991-06-18
CS185191A3 (en)	1992-01-15
HU210548B (en)	1995-05-29
ES2076502T3 (es)	1995-11-01
EP0462935B1 (de)	1995-07-19
IL98524A0 (en)	1992-07-15
MY107022A (en)	1995-08-30
PT97994A (pt)	1992-03-31
IE68417B1 (en)	1996-06-12
KR920000772A (ko)	1992-01-29
AU7843991A (en)	1992-01-02
DE69111311T2 (de)	1996-03-14
EP0462935A1 (de)	1991-12-27
AU649681B2 (en)	1994-06-02
PL164981B1 (pl)	1994-10-31
PT97994B (pt)	1998-11-30
HK111996A (en)	1996-07-05
HU911882D0 (en)	1991-12-30
IE912081A1 (en)	1992-01-01
DE69111311D1 (de)	1995-08-24
JPH04270276A (ja)	1992-09-25
FI912964A7 (fi)	1991-12-20
AU7140794A (en)	1994-11-03
FI912964L (fi)	1991-12-20
NZ238573A (en)	1993-11-25
GR3017437T3 (en)	1995-12-31
DK0462935T3 (da)	1995-11-06
HUT58340A (en)	1992-02-28
JP2709330B2 (ja)	1998-02-04
CA2044786A1 (en)	1991-12-20
AU677403B2 (en)	1997-04-24
IL98524A (en)	1995-12-31

Legal Events

Date	Code	Title	Description
1996-03-15	UEP	Publication of translation of european patent specification
2000-03-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
AU652981B2 (en)	1994-09-15	Condensed benzoxa ring compound, production thereof, and pharmaceutical composition containing the same
DE3773660D1 (de)	1991-11-14	Morpholinoethylester von mycophenolsaeure und ihre derivate, ihre herstellung und verwendung in pharmazeutische zusammensetzungen.
ATE124695T1 (de)	1995-07-15	Kondensierte heterocyclische verbindungen, ihre herstellung und verwendung.
DE69414554D1 (de)	1998-12-17	Heterocyclische verbindungen und ihre herstellung und verwendung
PT928788E (pt)	2003-04-30	Compostos farmaceuticamente activos
ZA902633B (en)	1991-01-30	New sulphonamides derived from benzo-cyclic or benzo heterocyclic acids,their preparation and their application in therapy
BR8902929A (pt)	1990-03-20	Artigo vendavel
ATE13178T1 (de)	1985-05-15	2-oxoazetidin-derivate, ihre herstellung und verwendung.
DE3586649D1 (de)	1992-10-22	Verwendung von spergualinderivaten zur herstellung von arzneimitteln mit immunodepressiver wirkung.
AU649681B2 (en)	1994-06-02	Enantiomers of 2-tetrahydrofuran derivatives and their preparation
ES2100177T3 (es)	1997-06-16	Compuestos de cefalosporina y su produccion.
IT1197841B (it)	1988-12-06	Derivati pirido-benzotiazinici ad attivita' antibatterica ed a lunga durata di azione
ATE58129T1 (de)	1990-11-15	Dem antibiotikum tan-749 aehnliche verbindungen und ihre herstellung.
ATE40118T1 (de)	1989-02-15	Benzazepinderivate, ihre herstellung und ihre verwendung als arzneimittel.
ATE157868T1 (de)	1997-09-15	Therapeutische verwendung von pycnogenolen zur herstellung eines medikamentes mit antiinflammatorischer wirkung
DE69828037D1 (de)	2005-01-13	Pyrroloindol-derivate und zwischenprodukte zu ihrer herstellung
ATE101151T1 (de)	1994-02-15	(aryl oder heteroaromatische methyl)-2,2'-bi-1h- imidazole.