ATE125270T1 - Tert-butyloxycarbonyl-l-tyrosyl- peptidoglycanmonomer und deren 125 i-markiertes derivat, deren herstellung und verwendung. - Google Patents

Tert-butyloxycarbonyl-l-tyrosyl- peptidoglycanmonomer und deren 125 i-markiertes derivat, deren herstellung und verwendung.

Info

Publication number: ATE125270T1
Authority: AT; Austria
Prior art keywords: preparation; tyrosyl; butyloxycarbonyl; tert; derivative
Prior art date: 1990-12-21

Application number

AT91121871T

Other languages

English (en)

Inventor

Djurdjica Dr Ljevakovic

Branka Dr Vranesic

Jelka Dr Tomasevic

Ivo Dr Hrsak

Branko Dr Ladesic

Original Assignee

Pliva Pharm & Chem Works

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-12-21

Filing date

1991-12-19

Publication date

1995-08-15

1991-12-19 Application filed by Pliva Pharm & Chem Works filed Critical Pliva Pharm & Chem Works

1995-08-15 Application granted granted Critical

1995-08-15 Publication of ATE125270T1 publication Critical patent/ATE125270T1/de

Links

239000000178 monomer Substances 0.000 title abstract 2
MSFSPUZXLOGKHJ-UHFFFAOYSA-N Muraminsaeure Natural products OC(=O)C(C)OC1C(N)C(O)OC(CO)C1O MSFSPUZXLOGKHJ-UHFFFAOYSA-N 0.000 title 1
108010013639 Peptidoglycan Proteins 0.000 title 1
230000000259 anti-tumor effect Effects 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
230000003308 immunostimulating effect Effects 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
- C07K9/001—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence having less than 12 amino acids and not being part of a ring structure
- C07K9/005—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence having less than 12 amino acids and not being part of a ring structure containing within the molecule the substructure with m, n > 0 and m+n > 0, A, B, D, E being heteroatoms; X being a bond or a chain, e.g. muramylpeptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2121/00—Preparations for use in therapy

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Medicinal Chemistry (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Immunology (AREA)
Biochemistry (AREA)
General Chemical & Material Sciences (AREA)
Epidemiology (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Optics & Photonics (AREA)
Physics & Mathematics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Crystallography & Structural Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

AT91121871T 1990-12-21 1991-12-19 Tert-butyloxycarbonyl-l-tyrosyl- peptidoglycanmonomer und deren 125 i-markiertes derivat, deren herstellung und verwendung. ATE125270T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
YU242490		1990-12-21

Publications (1)

Publication Number	Publication Date
ATE125270T1 true ATE125270T1 (de)	1995-08-15

Family

ID=25557920

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT91121871T ATE125270T1 (de)	1990-12-21	1991-12-19	Tert-butyloxycarbonyl-l-tyrosyl- peptidoglycanmonomer und deren 125 i-markiertes derivat, deren herstellung und verwendung.

Country Status (14)

Country	Link
US (1)	US5290576A (de)
EP (1)	EP0492478B1 (de)
JP (1)	JPH05194596A (de)
CN (1)	CN1062735A (de)
AT (1)	ATE125270T1 (de)
BG (1)	BG95668A (de)
CA (1)	CA2058247A1 (de)
CZ (1)	CZ394791A3 (de)
DE (1)	DE69111401T2 (de)
ES (1)	ES2077785T3 (de)
GR (1)	GR3017349T3 (de)
HU (1)	HU208160B (de)
PL (2)	PL167043B1 (de)
RO (1)	RO108348B1 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ATE194143T1 (de) *	1996-08-28	2000-07-15	Immunomedics Inc	Stabile radioiodium-konjugate und verfahren zu deren herstellung
US6558669B1 (en)	1996-08-28	2003-05-06	Immunomedics, Inc.	Stable radioiodine conjugates and methods for their synthesis
US6663866B1 (en)	1996-08-28	2003-12-16	Immunomedics, Inc.	Stable radioiodine conjugates and methods for their synthesis
US7521531B2 (en)	1996-08-28	2009-04-21	Immunomedics, Inc.	Methods for the purification of stable radioiodine conjugates
CZ301451B6 (cs) *	2005-10-18	2010-03-03	Ústav organické chemie a biochemie, Akademie ved CR	Deriváty kyseliny glukosaminylmuramové
CN105132372B (zh) *	2015-08-28	2019-04-30	淄博金砖生物科技有限公司	一种诱导dc-cik细胞的化合物在肿瘤细胞免疫治疗中的应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4310514A (en) *	1980-05-05	1982-01-12	Merck & Co., Inc.	Immunologically active dipeptidyl 5-0,6-0-acyl-2-amino-2-deoxy-D-glucofuranose derivatives and methods of preparation
YU62689A (en) *	1989-03-27	1991-02-28	Pliva Pharm & Chem Works	N-acyl derivatives of peptidoglican monomer, their pharmaceutically acceptable salts, process for preparing thereof and their use as immunity modulators and immunoadjuvant

1991
- 1991-12-19 AT AT91121871T patent/ATE125270T1/de not_active IP Right Cessation
- 1991-12-19 ES ES91121871T patent/ES2077785T3/es not_active Expired - Lifetime
- 1991-12-19 EP EP91121871A patent/EP0492478B1/de not_active Expired - Lifetime
- 1991-12-19 DE DE69111401T patent/DE69111401T2/de not_active Expired - Fee Related
- 1991-12-20 HU HU914066A patent/HU208160B/hu not_active IP Right Cessation
- 1991-12-20 JP JP3338725A patent/JPH05194596A/ja active Pending
- 1991-12-20 CZ CS913947A patent/CZ394791A3/cs unknown
- 1991-12-20 BG BG095668A patent/BG95668A/bg unknown
- 1991-12-20 US US07/810,010 patent/US5290576A/en not_active Expired - Fee Related
- 1991-12-20 PL PL91292898A patent/PL167043B1/pl unknown
- 1991-12-20 PL PL91305128A patent/PL167068B1/pl unknown
- 1991-12-20 CA CA002058247A patent/CA2058247A1/en not_active Abandoned
- 1991-12-21 CN CN91111723A patent/CN1062735A/zh active Pending
1992
- 1992-03-19 RO RO92-200368A patent/RO108348B1/ro unknown
1995
- 1995-09-13 GR GR950402464T patent/GR3017349T3/el unknown

Also Published As

Publication number	Publication date
US5290576A (en)	1994-03-01
GR3017349T3 (en)	1995-12-31
EP0492478A3 (en)	1993-05-12
HUT60509A (en)	1992-09-28
DE69111401T2 (de)	1996-02-22
PL292898A1 (en)	1992-09-07
HU208160B (en)	1993-08-30
CA2058247A1 (en)	1992-06-22
HU914066D0 (en)	1992-03-30
JPH05194596A (ja)	1993-08-03
BG95668A (bg)	1993-12-24
CZ394791A3 (en)	1993-02-17
PL167043B1 (en)	1995-07-31
DE69111401D1 (de)	1995-08-24
RO108348B1 (ro)	1994-04-28
ES2077785T3 (es)	1995-12-01
EP0492478A2 (de)	1992-07-01
EP0492478B1 (de)	1995-07-19
PL167068B1 (pl)	1995-07-31
CN1062735A (zh)	1992-07-15

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Legal Events

Date	Code	Title	Description
1996-02-15	UEP	Publication of translation of european patent specification
1997-03-15	REN	Ceased due to non-payment of the annual fee