ATE125696T1 - In einem nichtwässrigen perfluorierten trägermedium suspendierte wirkstoffabgabevehikel. - Google Patents

In einem nichtwässrigen perfluorierten trägermedium suspendierte wirkstoffabgabevehikel.

Info

Publication number
ATE125696T1
ATE125696T1 AT91917654T AT91917654T ATE125696T1 AT E125696 T1 ATE125696 T1 AT E125696T1 AT 91917654 T AT91917654 T AT 91917654T AT 91917654 T AT91917654 T AT 91917654T AT E125696 T1 ATE125696 T1 AT E125696T1
Authority
AT
Austria
Prior art keywords
drug delivery
delivery vehicles
aqueous
suspended
carrier medium
Prior art date
Application number
AT91917654T
Other languages
English (en)
Inventor
David Louis Meadows
Original Assignee
Allergan Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Allergan Inc filed Critical Allergan Inc
Application granted granted Critical
Publication of ATE125696T1 publication Critical patent/ATE125696T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0026—Blood substitute; Oxygen transporting formulations; Plasma extender
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/02—Halogenated hydrocarbons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/02—Halogenated hydrocarbons
    • A61K31/025—Halogenated hydrocarbons carbocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Ophthalmology & Optometry (AREA)
  • Hematology (AREA)
  • Dermatology (AREA)
  • Dispersion Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT91917654T 1990-09-27 1991-09-10 In einem nichtwässrigen perfluorierten trägermedium suspendierte wirkstoffabgabevehikel. ATE125696T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/588,697 US5173298A (en) 1990-09-27 1990-09-27 Nonaqueous fluorinated drug delivery vehicle suspensions

Publications (1)

Publication Number Publication Date
ATE125696T1 true ATE125696T1 (de) 1995-08-15

Family

ID=24354930

Family Applications (1)

Application Number Title Priority Date Filing Date
AT91917654T ATE125696T1 (de) 1990-09-27 1991-09-10 In einem nichtwässrigen perfluorierten trägermedium suspendierte wirkstoffabgabevehikel.

Country Status (16)

Country Link
US (1) US5173298A (de)
EP (1) EP0550615B1 (de)
JP (1) JP3253072B2 (de)
KR (1) KR100195760B1 (de)
AT (1) ATE125696T1 (de)
AU (1) AU656919B2 (de)
CA (1) CA2090404C (de)
DE (1) DE69111821T2 (de)
ES (1) ES2075468T3 (de)
IE (1) IE69016B1 (de)
IL (1) IL99290A (de)
NZ (1) NZ239558A (de)
PT (1) PT99108B (de)
TW (1) TW224428B (de)
WO (1) WO1992005770A1 (de)
ZA (1) ZA916770B (de)

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US6048857A (en) * 1989-10-17 2000-04-11 Ellinwood, Jr.; Everett H. Dosing method of administering medicaments via inhalation administration
US5660851A (en) * 1989-12-26 1997-08-26 Yissum Research Development Company Of The Hebrew Univ. Of Jerusalem Ocular inserts
IE67185B1 (en) * 1990-02-02 1996-03-06 Fisons Plc Propellant compositions
WO1991016869A1 (en) * 1990-04-27 1991-11-14 Allergan, Inc. Polymeric drug delivery system
DE4201079C3 (de) * 1992-01-17 1997-09-11 Gramer Eugen Kombinationspräparate zur Augeninnendrucksenkung
AU3924193A (en) * 1992-03-19 1993-10-21 Allergan, Inc. Compositions comprising a drug delivery vehicle suspended in a nonaqueous fluorinated liquid
ATE220327T1 (de) 1992-09-29 2002-07-15 Inhale Therapeutic Syst Pulmonale abgabe von aktiven fragmenten des parathormons
US5336487A (en) * 1993-03-05 1994-08-09 Refojo Miguel F Method of treating eye disorders with silicon/fluorosilicone copolymer oil
JPH10500148A (ja) 1994-03-04 1998-01-06 ユニバーシティ オブ ワシントン ブロック及びグラフトコポリマー並びにそれに関連する方法
ES2218543T3 (es) 1994-03-07 2004-11-16 Nektar Therapeutics Procedimiento y preparacion para la administracion de insulina por via pulmonar.
DE4414755C2 (de) * 1994-04-27 2000-11-16 Lohmann Therapie Syst Lts Kollagenzubereitung zur gesteuerten Abgabe von Wirkstoffen, Verfahren und Verwendung
US5661029A (en) * 1994-05-12 1997-08-26 Biomed Biological culture growth and observation device
US6290991B1 (en) 1994-12-02 2001-09-18 Quandrant Holdings Cambridge Limited Solid dose delivery vehicle and methods of making same
US5503869A (en) * 1994-10-21 1996-04-02 Glaxo Wellcome Inc. Process for forming medicament carrier for dry powder inhalator
US6294563B1 (en) 1994-10-27 2001-09-25 Allergan Sales, Inc. Combinations of prostaglandins and brimonidine or derivatives thereof
CA2218879A1 (en) * 1995-05-12 1996-11-14 Genentech, Inc. Coarse spray delivery of functional biologic materials
US5667809A (en) * 1995-06-07 1997-09-16 Alliance Pharmaceutical Corp. Continuous fluorochemical microdispersions for the delivery of lipophilic pharmaceutical agents
US5874469A (en) * 1996-01-05 1999-02-23 Alcon Laboratories, Inc. Fluoroalkyl hydrocarbons for administering water insoluble or unstable drugs
US5861175A (en) 1996-03-15 1999-01-19 Alliance Pharmaceutical Corp. Use of fluorocarbons for diagnosis and treatment of articular disorders
ES2248847T3 (es) * 1996-05-24 2006-03-16 Angiotech Pharmaceuticals, Inc. Composiciones y metodos para tratar o prevenir enfermedades de las vias de conduccion del cuerpo.
US5955096A (en) * 1996-06-25 1999-09-21 Brown University Research Foundation Methods and compositions for enhancing the bioadhesive properties of polymers using organic excipients
US20030077317A1 (en) * 1996-06-25 2003-04-24 Brown University Research Foundation Methods and compositions for enhancing the bioadhesive properties of polymers using organic excipients
US6090800A (en) * 1997-05-06 2000-07-18 Imarx Pharmaceutical Corp. Lipid soluble steroid prodrugs
US6291425B1 (en) 1999-09-01 2001-09-18 Guilford Pharmaceuticals Inc. Compounds, methods and pharmaceutical compositions for treating cellular damage, such as neural or cardiovascular tissue damage
US6946117B1 (en) 1997-09-29 2005-09-20 Nektar Therapeutics Stabilized preparations for use in nebulizers
US20060165606A1 (en) 1997-09-29 2006-07-27 Nektar Therapeutics Pulmonary delivery particles comprising water insoluble or crystalline active agents
US6565885B1 (en) 1997-09-29 2003-05-20 Inhale Therapeutic Systems, Inc. Methods of spray drying pharmaceutical compositions
US6309623B1 (en) 1997-09-29 2001-10-30 Inhale Therapeutic Systems, Inc. Stabilized preparations for use in metered dose inhalers
US6433040B1 (en) 1997-09-29 2002-08-13 Inhale Therapeutic Systems, Inc. Stabilized bioactive preparations and methods of use
GB9816724D0 (en) * 1998-08-01 1998-09-30 Boots Co Plc Therapeutic agents
WO2000050016A2 (en) * 1999-02-23 2000-08-31 Angiotech Pharmaceuticals, Inc. Compositions and methods for improving integrity of compromised body passageways and cavities
US7442388B2 (en) 2000-05-10 2008-10-28 Weers Jeffry G Phospholipid-based powders for drug delivery
US7871598B1 (en) 2000-05-10 2011-01-18 Novartis Ag Stable metal ion-lipid powdered pharmaceutical compositions for drug delivery and methods of use
US8404217B2 (en) 2000-05-10 2013-03-26 Novartis Ag Formulation for pulmonary administration of antifungal agents, and associated methods of manufacture and use
US20040076682A1 (en) * 2001-02-15 2004-04-22 Toshiyuki Kohzaki Novel ophthalmic compositions
US7368102B2 (en) 2001-12-19 2008-05-06 Nektar Therapeutics Pulmonary delivery of aminoglycosides
EP2284180B1 (de) 2003-03-03 2015-09-09 Dyax Corp. Verwendungen von Spezifisch an HGF-Rezeptor (cMET) bindenden Peptiden
US20050118124A1 (en) * 2003-12-01 2005-06-02 Reinhart Gale M. Compositions for treating keratinous surfaces
JP2008501806A (ja) * 2004-06-08 2008-01-24 オキュラリス ファーマ， インコーポレイテッド 疎水性眼用組成物および使用方法
US8153435B1 (en) 2005-03-30 2012-04-10 Tracer Detection Technology Corp. Methods and articles for identifying objects using encapsulated perfluorocarbon tracers
US20070219127A1 (en) * 2006-03-20 2007-09-20 Walt John G Cyclosporin a compositions
KR20100065190A (ko) 2007-09-14 2010-06-15 닛토덴코 가부시키가이샤 약물 담체
US9057712B1 (en) 2011-10-27 2015-06-16 Copilot Ventures Fund Iii Llc Methods of delivery of encapsulated perfluorocarbon taggants
US11904046B1 (en) * 2022-11-14 2024-02-20 Eton Pharmaceuticals, Inc. Hydrocortisone oral liquid formulations
WO2025265050A1 (en) * 2024-06-21 2025-12-26 Insignis Therapeutics, Inc. Liquid epinephrine prodrug formulations and liquid epinephrine formulations

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3911138B1 (en) * 1973-02-26 1996-10-29 Childrens Hosp Medical Center Artificial blood and method for supporting oxygen transport in animals
US4105798A (en) * 1976-07-19 1978-08-08 Sun Ventures, Inc. Perfluoro polycyclic compounds for use as synthetic blood and perfusion media
US4115544A (en) * 1976-08-18 1978-09-19 Alza Corporation Ocular system made of bioerodible esters having linear ether
DE3049665T1 (de) * 1979-06-25 1982-03-18 Suntech Use of perfluorocarbon as burn treatment
US4452818A (en) * 1982-03-19 1984-06-05 Haidt Sterling J Extraocular method of treating the eye with liquid perfluorocarbons
GR78151B (de) * 1982-04-05 1984-09-26 Alcon Lab Inc
US4649047A (en) * 1985-03-19 1987-03-10 University Of Georgia Research Foundation, Inc. Ophthalmic treatment by topical administration of cyclosporin
US4879304A (en) * 1987-05-01 1989-11-07 Angelini Pharmaceuticals Ltd. Ophthalmic compositions and process for preparing
US4865846A (en) * 1988-06-03 1989-09-12 Kaufman Herbert E Drug delivery system
US4882150A (en) * 1988-06-03 1989-11-21 Kaufman Herbert E Drug delivery system
FR2643572A1 (fr) * 1988-12-22 1990-08-31 Rhone Poulenc Chimie Procede d'encapsulation de particules par pelliculage au moyen d'un copolymere silicone thermoplastique

Also Published As

Publication number Publication date
JP3253072B2 (ja) 2002-02-04
DE69111821D1 (de) 1995-09-07
PT99108B (pt) 1999-02-26
EP0550615B1 (de) 1995-08-02
KR100195760B1 (ko) 1999-06-15
DE69111821T2 (de) 1995-12-14
EP0550615A1 (de) 1993-07-14
US5173298A (en) 1992-12-22
ES2075468T3 (es) 1995-10-01
CA2090404C (en) 2001-11-20
PT99108A (pt) 1993-11-30
AU656919B2 (en) 1995-02-23
IE69016B1 (en) 1996-07-24
JPH06501258A (ja) 1994-02-10
AU8644291A (en) 1992-04-28
IL99290A (en) 1996-09-12
CA2090404A1 (en) 1992-03-28
ZA916770B (en) 1992-04-29
IE913379A1 (en) 1992-04-08
TW224428B (de) 1994-06-01
NZ239558A (en) 1993-10-26
WO1992005770A1 (en) 1992-04-16
IL99290A0 (en) 1992-07-15

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Legal Events

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