ATE125792T1 - Aminosäurederivate und ihre verwendung als antiviral wirkstoffe. - Google Patents

Aminosäurederivate und ihre verwendung als antiviral wirkstoffe.

Info

Publication number
ATE125792T1
ATE125792T1 AT92107090T AT92107090T ATE125792T1 AT E125792 T1 ATE125792 T1 AT E125792T1 AT 92107090 T AT92107090 T AT 92107090T AT 92107090 T AT92107090 T AT 92107090T AT E125792 T1 ATE125792 T1 AT E125792T1
Authority
AT
Austria
Prior art keywords
formula
alkyl
alkoxycarbonyl
aralkanoyl
heterocyclylcarbonyl
Prior art date
Application number
AT92107090T
Other languages
English (en)
Inventor
Joseph Armstrong Martin
Gareth John Thomas
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB919110170A external-priority patent/GB9110170D0/en
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Application granted granted Critical
Publication of ATE125792T1 publication Critical patent/ATE125792T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/24—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/24—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the same saturated acyclic carbon skeleton
    • C07C255/29—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the same saturated acyclic carbon skeleton containing cyano groups and acylated amino groups bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/60—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Communicable Diseases (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Confectionery (AREA)
  • Cleaning Or Clearing Of The Surface Of Open Water (AREA)
  • Measurement Of Force In General (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AT92107090T 1991-05-10 1992-04-25 Aminosäurederivate und ihre verwendung als antiviral wirkstoffe. ATE125792T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB919110170A GB9110170D0 (en) 1991-05-10 1991-05-10 Amino acid derivatives
GB929203014A GB9203014D0 (en) 1991-05-10 1992-02-13 Amino acid derivatives

Publications (1)

Publication Number Publication Date
ATE125792T1 true ATE125792T1 (de) 1995-08-15

Family

ID=26298885

Family Applications (1)

Application Number Title Priority Date Filing Date
AT92107090T ATE125792T1 (de) 1991-05-10 1992-04-25 Aminosäurederivate und ihre verwendung als antiviral wirkstoffe.

Country Status (24)

Country Link
US (2) US5430041A (de)
EP (1) EP0512343B1 (de)
JP (1) JPH06102639B2 (de)
AT (1) ATE125792T1 (de)
AU (1) AU660308B2 (de)
CA (1) CA2067690C (de)
CZ (1) CZ281839B6 (de)
DE (1) DE69203780T2 (de)
DK (1) DK0512343T3 (de)
DZ (1) DZ1578A1 (de)
ES (1) ES2075976T3 (de)
FI (2) FI110938B (de)
GR (1) GR3017902T3 (de)
HR (1) HRP931025B1 (de)
HU (1) HU210283B (de)
IE (1) IE69169B1 (de)
IL (3) IL112900A (de)
IS (1) IS1747B (de)
MX (1) MX9202146A (de)
MY (1) MY108770A (de)
NO (1) NO300496B1 (de)
NZ (1) NZ242593A (de)
RO (1) RO109540B1 (de)
SK (1) SK281183B6 (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5413999A (en) * 1991-11-08 1995-05-09 Merck & Co., Inc. HIV protease inhibitors useful for the treatment of AIDS
JPH07504654A (ja) * 1992-03-11 1995-05-25 ナルヘックス　リミテッド オキソ及びヒドロキシ置換炭化水素のアミン誘導体
US5888992A (en) * 1992-03-11 1999-03-30 Narhex Limited Polar substituted hydrocarbons
US6071895A (en) * 1992-03-11 2000-06-06 Narhex Limited Polar-substituted hydrocarbons
DE69333270T2 (de) 1992-03-11 2004-08-05 Narhex Ltd. Aminderivate von oxo- und hydroxy- substituierten kohlenwasserstoffen
US5491166A (en) * 1992-12-22 1996-02-13 Eli Lilly And Company Inhibitors of HIV protease useful for the treatment of AIDS
US5733906A (en) * 1993-10-12 1998-03-31 Eli Lilly And Company Inhibitors of HIV Protease useful for the treatment of Aids
MX9308016A (es) * 1992-12-22 1994-08-31 Lilly Co Eli Compuestos inhibidores de la proteasa del virus de la inmunodeficiencia humana, procedimiento para su preparacion y formulacion farmaceutica que los contiene.
US5591885A (en) * 1994-09-23 1997-01-07 Hoffman-La Roche Inc. Process for the preparation of halogenated α-aminoketone compounds
US5523463A (en) * 1994-09-23 1996-06-04 Hoffmann-La Roche Inc. Method of producing halogenated and alpha-aminoalchohols
GB0123467D0 (en) 2001-09-28 2001-11-21 Hoffmann La Roche Carbocyclic HIV Protease inhibitors

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE447633B (sv) * 1978-09-19 1986-12-01 Albany Int Corp Forfarande for separering och modul for genomforande av forfarandet
JPS63166826A (ja) * 1986-12-27 1988-07-11 Shin Etsu Chem Co Ltd 抗ヒトレトロウイルス剤
CA1340588C (en) * 1988-06-13 1999-06-08 Balraj Krishan Handa Amino acid derivatives
CA2010531A1 (en) * 1989-03-06 1990-09-06 Werner Neidhart Amino acid derivatives
CA2012901A1 (en) * 1989-04-05 1990-10-05 Quirico Branca Amino acid derivatives
GB8927913D0 (en) * 1989-12-11 1990-02-14 Hoffmann La Roche Amino acid derivatives
CN1071930A (zh) * 1991-07-10 1993-05-12 伊莱利利公司 用作治疗艾滋病的人免疫缺陷病毒蛋白酶的抑制剂

Also Published As

Publication number Publication date
EP0512343B1 (de) 1995-08-02
EP0512343A3 (en) 1993-03-24
HU9201514D0 (en) 1992-07-28
DK0512343T3 (da) 1995-10-16
HUT61972A (en) 1993-03-29
IL101770A (en) 1996-06-18
JPH06102639B2 (ja) 1994-12-14
FI990399A7 (fi) 1999-02-24
DZ1578A1 (fr) 2002-02-17
IL112900A0 (en) 1995-06-29
RO109540B1 (ro) 1995-03-30
AU660308B2 (en) 1995-06-22
FI922094A7 (fi) 1992-11-11
SK281183B6 (sk) 2001-01-18
NO300496B1 (no) 1997-06-09
ES2075976T3 (es) 1995-10-16
IL112900A (en) 1997-06-10
NZ242593A (en) 1994-06-27
NO921828L (no) 1992-11-11
IL101770A0 (en) 1992-12-30
IS1747B (is) 2000-07-11
HRP931025B1 (en) 2000-06-30
DE69203780D1 (de) 1995-09-07
FI990399A0 (fi) 1999-02-24
US5583248A (en) 1996-12-10
FI110938B (fi) 2003-04-30
CS138492A3 (en) 1992-11-18
CA2067690C (en) 2005-09-06
US5430041A (en) 1995-07-04
MY108770A (en) 1996-11-30
HRP931025A2 (en) 1996-06-30
CA2067690A1 (en) 1992-11-11
HU210283B (en) 1995-03-28
IS3858A (is) 1992-11-11
NO921828D0 (no) 1992-05-08
CZ281839B6 (cs) 1997-02-12
JPH05155834A (ja) 1993-06-22
FI922094A0 (fi) 1992-05-08
AU1600792A (en) 1992-11-12
EP0512343A2 (de) 1992-11-11
DE69203780T2 (de) 1995-12-07
IE69169B1 (en) 1996-08-07
MX9202146A (es) 1992-11-01
GR3017902T3 (en) 1996-01-31
IE921490A1 (en) 1992-11-18

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee