ATE125869T1 - Wachstumshormonfusionsproteine. - Google Patents

Wachstumshormonfusionsproteine.

Info

Publication number: ATE125869T1
Authority: AT; Austria
Prior art keywords: pct; growth hormone; growth; igf; polypeptide
Prior art date: 1989-06-09

Application number

AT90908176T

Other languages

English (en)

Inventor

Julian Richard Este Wells

Robert Michael King

Geoffrey Leonard Francis

Original Assignee

Gropep Pty Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-06-09

Filing date

1990-05-22

Publication date

1995-08-15

1990-05-22 Application filed by Gropep Pty Ltd filed Critical Gropep Pty Ltd

1995-08-15 Application granted granted Critical

1995-08-15 Publication of ATE125869T1 publication Critical patent/ATE125869T1/de

Links

102000037865 fusion proteins Human genes 0.000 title abstract 3
108020001507 fusion proteins Proteins 0.000 title abstract 3
102000018997 Growth Hormone Human genes 0.000 title abstract 2
108010051696 Growth Hormone Proteins 0.000 title abstract 2
239000000122 growth hormone Substances 0.000 title abstract 2
229920001184 polypeptide Polymers 0.000 abstract 3
102000004196 processed proteins & peptides Human genes 0.000 abstract 3
108090000765 processed proteins & peptides Proteins 0.000 abstract 3
NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 abstract 2
241000287828 Gallus gallus Species 0.000 abstract 1
206010056438 Growth hormone deficiency Diseases 0.000 abstract 1
102000017286 Histone H2A Human genes 0.000 abstract 1
108050005231 Histone H2A Proteins 0.000 abstract 1
102000004877 Insulin Human genes 0.000 abstract 1
108090001061 Insulin Proteins 0.000 abstract 1
102000048143 Insulin-Like Growth Factor II Human genes 0.000 abstract 1
108090001117 Insulin-Like Growth Factor II Proteins 0.000 abstract 1
241001465754 Metazoa Species 0.000 abstract 1
102000040945 Transcription factor Human genes 0.000 abstract 1
108091023040 Transcription factor Proteins 0.000 abstract 1
230000010261 cell growth Effects 0.000 abstract 1
238000006243 chemical reaction Methods 0.000 abstract 1
238000003776 cleavage reaction Methods 0.000 abstract 1
230000012010 growth Effects 0.000 abstract 1
239000003102 growth factor Substances 0.000 abstract 1
230000003054 hormonal effect Effects 0.000 abstract 1
208000015181 infectious disease Diseases 0.000 abstract 1
208000014674 injury Diseases 0.000 abstract 1
229940125396 insulin Drugs 0.000 abstract 1
239000013612 plasmid Substances 0.000 abstract 1
102000004169 proteins and genes Human genes 0.000 abstract 1
108090000623 proteins and genes Proteins 0.000 abstract 1
230000007017 scission Effects 0.000 abstract 1
230000008733 trauma Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/61—Growth hormone [GH], i.e. somatotropin
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/465—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from birds
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/65—Insulin-like growth factors, i.e. somatomedins, e.g. IGF-1, IGF-2
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Genetics & Genomics (AREA)
Medicinal Chemistry (AREA)
Zoology (AREA)
Biochemistry (AREA)
Biophysics (AREA)
General Health & Medical Sciences (AREA)
Toxicology (AREA)
Gastroenterology & Hepatology (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Endocrinology (AREA)
Diabetes (AREA)
Peptides Or Proteins (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)

AT90908176T 1989-06-09 1990-05-22 Wachstumshormonfusionsproteine. ATE125869T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
AUPJ467289		1989-06-09

Publications (1)

Publication Number	Publication Date
ATE125869T1 true ATE125869T1 (de)	1995-08-15

Family

ID=3773983

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT90908176T ATE125869T1 (de)	1989-06-09	1990-05-22	Wachstumshormonfusionsproteine.

Country Status (6)

Country	Link
US (1)	US5330971A (de)
EP (1)	EP0429586B1 (de)
AT (1)	ATE125869T1 (de)
CA (1)	CA2033176C (de)
DE (1)	DE69021335T2 (de)
WO (1)	WO1990015142A1 (de)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5977307A (en) *	1989-09-07	1999-11-02	Alkermes, Inc.	Transferrin receptor specific ligand-neuropharmaceutical agent fusion proteins
CA2074166C (en) *	1990-02-13	2003-11-25	Francis J. Ballard	Method for treating intestinal diseases
US5679771A (en) *	1990-02-13	1997-10-21	Gropep Pty. Ltd.	Method for treating intestinal diseases
US5210017A (en) *	1990-11-19	1993-05-11	Genentech, Inc.	Ligand-mediated immunofunctional hormone binding protein assay method
FR2686899B1 (fr) *	1992-01-31	1995-09-01	Rhone Poulenc Rorer Sa	Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant.
ES2257734T3 (es) *	1992-05-18	2006-08-01	Genentech, Inc.	Activacion de los receptores de oligomerizacion por medio de los ligandos de receptores fusionados.
US5684136A (en) *	1992-05-18	1997-11-04	Genentech, Inc.	Chimeric hepatocyte growth factor (HGF) ligand variants
NZ260309A (en) *	1992-06-08	1997-07-27	Pharmacia Ab Substituted For K	Use of 1gf-2 for prevention or treatment of nutritional or gastrointestinal disorders and promoting neonatal growth
CA2114419A1 (en) *	1992-06-08	1993-12-23	Peter D. Gluckman	Use of growth factor igf-i and/or igf-ii
US5444045A (en) *	1992-09-17	1995-08-22	Gropep, Pty. Ltd.	Method of administering IGF-1, IGF-2, and analogs thereof to birds
WO1995013290A1 (en) *	1993-11-12	1995-05-18	North Shore University Hospital Research Corporation	Method of treating muscular dystrophy
GB9526733D0 (en) *	1995-12-30	1996-02-28	Delta Biotechnology Ltd	Fusion proteins
AU757658B2 (en) *	1998-03-09	2003-02-27	Zealand Pharma A/S	Pharmacologically active peptide conjugates having a reduced tendency towards enzymatic hydrolysis
AUPP298498A0 (en) *	1998-04-17	1998-05-07	Gropep Pty Ltd	Matrix binding factor
AU1805200A (en) *	1998-12-10	2000-06-26	Samyang Genex Corporation	Method of separating basic peptide or basic protein
AUPQ387599A0 (en)	1999-11-05	1999-12-02	Metabolic Pharmaceuticals Limited	Product and method for control of obesity
CN1296974A (zh) *	1999-11-23	2001-05-30	上海博容基因开发有限公司	一种新的多肽——人组蛋白h2a.21和编码这种多肽的多核苷酸
EP1274720A4 (de) *	2000-04-12	2004-08-18	Human Genome Sciences Inc	Albumin enthaltende fusionsproteine
US6946134B1 (en)	2000-04-12	2005-09-20	Human Genome Sciences, Inc.	Albumin fusion proteins
AU2002239560B2 (en) *	2000-11-28	2006-03-02	Premacure Ab	Determination of risk and treatment of complications of prematurity
US20050054051A1 (en) *	2001-04-12	2005-03-10	Human Genome Sciences, Inc.	Albumin fusion proteins
US20060084794A1 (en) *	2001-04-12	2006-04-20	Human Genome Sciences, Inc.	Albumin fusion proteins
US20050244931A1 (en) *	2001-04-12	2005-11-03	Human Genome Sciences, Inc.	Albumin fusion proteins
US7507413B2 (en)	2001-04-12	2009-03-24	Human Genome Sciences, Inc.	Albumin fusion proteins
WO2003030821A2 (en) *	2001-10-05	2003-04-17	Human Genome Sciences, Inc.	Albumin fusion proteins
PT1463751E (pt)	2001-12-21	2013-08-26	Human Genome Sciences Inc	Proteínas de fusão de albumina
CA2513213C (en)	2003-01-22	2013-07-30	Human Genome Sciences, Inc.	Albumin fusion proteins
US7355018B2 (en)	2003-09-30	2008-04-08	Regeneron Pharmaceuticals, Inc.	Modified IGF1 polypeptides with increased stability and potency
AU2006203882B2 (en)	2005-01-07	2011-05-12	Regeneron Pharmaceuticals, Inc.	IGF-1 fusion polypeptides and therapeutic uses thereof
US20080103457A1 (en) *	2005-01-11	2008-05-01	Heart Failure Technologies, Inc. University Enterprise Laboratories (Uel)	Method and System for Treating Heart Failure
WO2007068053A1 (en) *	2005-12-15	2007-06-21	Gropep Limited	Recombinant protein production
WO2008035230A2 (en) *	2006-09-18	2008-03-27	Novozymes Gropep Limited	Liquid compositions comprising substantially purified igf at or below ph 5.0
EP3129463B1 (de)	2014-04-10	2021-05-26	Bayer Healthcare LLC	Zellformulierung in pulverform und verfahren zur herstellung von flüssigen zellkulturmedium
DK3344758T3 (da)	2015-09-01	2021-11-01	Ncardia B V	Fremgangsmåde in vitro til differentiering af en human pluripotent stamcellepopulation i en kardiomyocytcellepopulation

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DK108685A (da) *	1984-03-19	1985-09-20	Fujisawa Pharmaceutical Co	Vaekstfaktor i
US5028531A (en) *	1984-03-19	1991-07-02	Fujisawa Pharmaceutical Company, Ltd.	IGF-I fusion proteins; protection of IGF-I from degradation by host cell; and processes for the production thereof
ATE81779T1 (de) *	1985-08-22	1992-11-15	Gropep Pty Ltd	Peptidanalogedes insulinaehnlichen wachstumsfaktors-1 bei saeugetieren.
AU613876B2 (en) *	1986-10-01	1991-08-15	Merck & Co., Inc.	Synthetic genes encoding proteins from plasmid containing eucaryotic secretory signal peptides and process for secreting encoded proteins
FR2619719B1 (fr) *	1987-09-01	1991-05-10	Sanofi Sa	Procede d'obtention d'interleukine-2 a partir de cellules eucaryotes, vecteurs necessaires a sa mise en oeuvre et lignees cellulaires hautement productrices
JPH01144981A (ja) *	1987-12-02	1989-06-07	Wakunaga Pharmaceut Co Ltd	蛋白質の製造
JP2507106B2 (ja) *	1987-12-24	1996-06-12	グロペッププロプライエタリーリミテッド	インスリン様成長因子１（ｉｇｆ―１）または因子２（ｉｇｆ―２）の類縁ペプチド

1990
- 1990-05-22 AT AT90908176T patent/ATE125869T1/de not_active IP Right Cessation
- 1990-05-22 WO PCT/AU1990/000210 patent/WO1990015142A1/en not_active Ceased
- 1990-05-22 DE DE69021335T patent/DE69021335T2/de not_active Expired - Lifetime
- 1990-05-22 US US07/646,616 patent/US5330971A/en not_active Expired - Lifetime
- 1990-05-22 EP EP90908176A patent/EP0429586B1/de not_active Expired - Lifetime
- 1990-05-22 CA CA002033176A patent/CA2033176C/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
EP0429586A4 (en)	1992-07-08
DE69021335T2 (de)	1996-04-11
EP0429586B1 (de)	1995-08-02
WO1990015142A1 (en)	1990-12-13
CA2033176C (en)	1999-12-14
EP0429586A1 (de)	1991-06-05
DE69021335D1 (de)	1995-09-07
US5330971A (en)	1994-07-19
CA2033176A1 (en)	1990-12-10

Legal Events

Date	Code	Title	Description
1996-02-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
DE69021335D1 (de)	1995-09-07	Wachstumshormonfusionsproteine.
ATE309358T1 (de)	2005-11-15	Superaktive, wachstumshormone freisetzende hormonanaloge vom schwein
ES8602947A1 (es)	1985-12-01	Un metodo para producir un polipeptido.
DK488386A (da)	1986-12-15	Human-metallothionein-ii promotor i pattedyrekspressionssystemer
ES8500325A1 (es)	1984-11-01	Procedimiento para la preparacion de proteinas funcionales de uroquinasa humana.
ATE84707T1 (de)	1993-02-15	Implantate mit verzoegerter abgabe fuer die anwendung von rekombinanten wachstumshormonen.
DK80886A (da)	1986-11-21	Biologisk aktive proteiner samt fremgangsmaade til deres fremstillingog anvendelse
EP0216742A3 (de)	1989-11-15	Wachstumsfaktoren
DE68922602D1 (de)	1995-06-14	Polypeptide mit hormonwachstumsbefreiender wirkung.
AU7681687A (en)	1988-02-18	Expression of platelet-derived growth factor and analogues
AU601959B2 (en)	1990-09-27	GM-CSF protein, its derivatives, the preparation of proteins of this type, and their use
ATE246247T1 (de)	2003-08-15	Varianten des humanen rekombinanten interferon- gamma (rhu-ifn-gamma) mit erhöhter thermischer stabilität
AU2308992A (en)	1993-02-11	Cysteine depleted il-6 muteins
SE9403055D0 (sv)	1994-09-13	A new human peptide antibiotic (FALL-39) and its use
MXPA01011158A (es)	2004-06-03	Factor de crecimiento homologo zvegf4.
NO963806L (no)	1996-09-11	Rekombinante viruser som koder for en glutamat-dekarboksylase (GAD)aktivitet
CA2004764A1 (en)	1990-06-10	Ancrod proteins, their preparation and use
KR900006516A (ko)	1990-05-08	소의 트로포블라스트 단백질-1의 유전자를 코딩하는 상보적 dna 및 그의 제조방법
DK411389D0 (da)	1989-08-22	Fremgangsmaade og middel til forbedring af koedkvalitet
IT1262997B (it)	1996-07-23	Composto proteico e sequenze nucleotidiche codificanti per esso.
SG165136A1 (en)	2010-10-28	Recombinant molecules and uses therefor
NO941982L (no)	1994-05-27	Fremstilling av proteiner ved anvendelse av 7B2 protein