ATE126211T1 - 2-decarboxyl-2-alkoxyalkyl-prostaglandine als augenbinnendrucksenkende mittel. - Google Patents

2-decarboxyl-2-alkoxyalkyl-prostaglandine als augenbinnendrucksenkende mittel.

Info

Publication number
ATE126211T1
ATE126211T1 AT92902998T AT92902998T ATE126211T1 AT E126211 T1 ATE126211 T1 AT E126211T1 AT 92902998 T AT92902998 T AT 92902998T AT 92902998 T AT92902998 T AT 92902998T AT E126211 T1 ATE126211 T1 AT E126211T1
Authority
AT
Austria
Prior art keywords
decarboxyl
alkoxyalkyl
carbon atoms
configuration
prostaglandins
Prior art date
Application number
AT92902998T
Other languages
English (en)
Inventor
Ming Fai Chan
David Frederick Woodward
Original Assignee
Allergan Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Allergan Inc filed Critical Allergan Inc
Application granted granted Critical
Publication of ATE126211T1 publication Critical patent/ATE126211T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
    • C07C405/0016—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing only hydroxy, etherified or esterified hydroxy groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT92902998T 1990-12-06 1991-12-04 2-decarboxyl-2-alkoxyalkyl-prostaglandine als augenbinnendrucksenkende mittel. ATE126211T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/623,234 US5139491A (en) 1990-12-06 1990-12-06 2-decarboxyl-2-alkoxyalkyl prostaglandins as ocular hypotensives

Publications (1)

Publication Number Publication Date
ATE126211T1 true ATE126211T1 (de) 1995-08-15

Family

ID=24497288

Family Applications (1)

Application Number Title Priority Date Filing Date
AT92902998T ATE126211T1 (de) 1990-12-06 1991-12-04 2-decarboxyl-2-alkoxyalkyl-prostaglandine als augenbinnendrucksenkende mittel.

Country Status (12)

Country Link
US (1) US5139491A (de)
EP (1) EP0562016B1 (de)
JP (1) JP3186766B2 (de)
AT (1) ATE126211T1 (de)
AU (1) AU645647B2 (de)
BR (1) BR9107155A (de)
CA (1) CA2096945A1 (de)
DE (1) DE69112080T2 (de)
ES (1) ES2075679T3 (de)
HU (1) HUT67535A (de)
IE (1) IE914231A1 (de)
WO (1) WO1992010473A2 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5238961A (en) * 1990-06-14 1993-08-24 Allergan, Inc. Pgf 1-alcohols and their use as ocular hypotensives
US5288754A (en) * 1992-02-04 1994-02-22 Allergan, Inc. Polar C-1 esters of prostaglandins
US6124353A (en) * 1992-11-12 2000-09-26 Allergan Sales, Inc. Method of treating ocular hypertension with 8-epi prostaglandins
US5476872A (en) * 1993-10-18 1995-12-19 Allergan, Inc. 1,11-diesters of prostaglandin-F2α having a polar ester group at C-1
EP2072047A1 (de) * 2005-03-15 2009-06-24 Ono Pharmaceutical CO., LTD. Therapeutischer Wirkstoff zur Behandlung von opthalmischen Erkrankungen

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3069322A (en) * 1958-05-28 1962-12-18 Bergstrom Sune Pge and pgf
IE38604B1 (en) * 1972-12-05 1978-04-26 Ono Pharmaceutical Co Prostaglandin compositions
NL7605381A (nl) * 1975-05-26 1976-11-30 Schering Ag Werkwijze voor het bereiden van prostaanderi- vaten en werkwijze voor het bereiden van een geneesmiddel met prostaglandinewerking.
GB2048254B (en) * 1979-04-02 1983-05-25 Upjohn Co 19,20 -didehydro-19-hydroxy and 19-oxo-prostaglandin derivatives
GB8528032D0 (en) * 1985-11-13 1985-12-18 Ici Plc Ocular treatment
US4824857A (en) * 1986-05-16 1989-04-25 Yasumasa Goh Use of prostaglandin D2 -active substances
US4822820A (en) * 1986-11-24 1989-04-18 Alcon Laboratories, Inc. Use of tri-methyl PG-F2 a and derivatives in glaucoma therapy
ATE108330T1 (de) * 1987-09-18 1994-07-15 R Tech Ueno Ltd Hypotensive okulare mittel.
US4994274A (en) * 1989-07-27 1991-02-19 Allergan, Inc. Intraocular pressure reducing 11,15-diacyl prostaglandins and method of using
US5011856A (en) * 1990-03-12 1991-04-30 Allergan, Inc. Use of prostaglandin F3 α as an ocular hypotensive agent
US5238961A (en) * 1990-06-14 1993-08-24 Allergan, Inc. Pgf 1-alcohols and their use as ocular hypotensives

Also Published As

Publication number Publication date
IE914231A1 (en) 1992-06-17
DE69112080T2 (de) 1996-01-11
DE69112080D1 (de) 1995-09-14
WO1992010473A3 (en) 1992-08-20
EP0562016B1 (de) 1995-08-09
CA2096945A1 (en) 1992-06-07
JPH06503346A (ja) 1994-04-14
BR9107155A (pt) 1993-11-16
AU9161191A (en) 1992-07-08
ES2075679T3 (es) 1995-10-01
JP3186766B2 (ja) 2001-07-11
US5139491A (en) 1992-08-18
AU645647B2 (en) 1994-01-20
EP0562016A1 (de) 1993-09-29
HU9301348D0 (en) 1993-09-28
HUT67535A (en) 1995-04-28
WO1992010473A2 (en) 1992-06-25

Similar Documents

Publication Publication Date Title
DE3271269D1 (en) Benzimidazole derivatives, process for the preparation thereof and pharmaceutical composition containing the same
KR920018029A (ko) 신규한 카복실산 아미드
AU7137591A (en) New derivatives having naphthalene structure, process for preparing these and pharmaceutical compositions containing them
WO1993014743A3 (en) Polar c-1 esters of prostaglandins
ZA82567B (en) Process for the preparation of 2-penem compounds,novel 2-penem compounds produced thereby,and pharmaceutical compositions containing them
DE69121408D1 (de) Pgf 1-alkohole und deren verwendung als augendrucksenkende mittel
CA2056421A1 (en) Agent against autoimmune diseases
ES8505650A1 (es) Un metodo de producir una emulsion grasa que contiene ester alquilico de prostaglandina e1
AU5791190A (en) New peptide derivatives, process for preparing them and pharmaceutical compositions containing them
DE69112080D1 (de) 2-decarboxyl-2-alkoxyalkyl-prostaglandine als augenbinnendrucksenkende mittel.
DE3170937D1 (en) 2-(1,4-benzodioxan-2-ylalkyl) imidazoles, their preparation and pharmaceutical compositions containing them
MX9204457A (es) Compuestos de 6-oxo-azepinoidol, asi como procedimientos y productos intermedios para su preparacion, y medicamentos que contienen estos compuestos.
ATE74924T1 (de) N-(vinblastinoyl-23)-derivate von 1aminomethylposphons|ure, verfahren zu ihrer herstellung und sie enthaltende arzneimittel.
ES8303316A1 (es) Un procedimiento para la fabricacion de un disulfuro intra ointermolecular
ATE94532T1 (de) Neue leukotrien-b4-derivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel.
ATE40359T1 (de) Racemische und optisch aktive 7-oxo-prostacyclin- derivate, verfahren zu deren herstellung und diese verbindungen enthaltende pharmazeutische praeparate.
GB952547A (en) Improvements in or relating to novel substituted phenylalkylamines
KR920004334A (ko) 광학적 활성 알라닌아닐리드 화합물의 산부가염 및 그것을 함유하는 약학적조성물
KR910011846A (ko) 디옥사닐피리딘
GB1412663A (en) 2- 4-biphenylyl- tetrahydrofurans and pharmaceutical compositions containing them
ATE63305T1 (de) Neue carbacycline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel.
PT73789B (de) Neue cephalosporine verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
GB2022583A (en) New ionic polyiodo benzene derivatives useful as X-ray contrast media
FR2361874A1 (fr) Nouvelles compositions analgesiques du levo- ou dextro-propoxyphene et de benzodiazepines et leur procede de preparation

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties