ATE126227T1 - Verwendung von (omega-(4-(2-pyrimidinyl)-1- piperazinyl)-alkyl)1h-azolderivate für die herstellung von heilmitteln zur behandlung von störungen kognitiver funktionen. - Google Patents
Verwendung von (omega-(4-(2-pyrimidinyl)-1- piperazinyl)-alkyl)1h-azolderivate für die herstellung von heilmitteln zur behandlung von störungen kognitiver funktionen.Info
- Publication number
- ATE126227T1 ATE126227T1 AT92400163T AT92400163T ATE126227T1 AT E126227 T1 ATE126227 T1 AT E126227T1 AT 92400163 T AT92400163 T AT 92400163T AT 92400163 T AT92400163 T AT 92400163T AT E126227 T1 ATE126227 T1 AT E126227T1
- Authority
- AT
- Austria
- Prior art keywords
- radical
- alkyl
- treatment
- aryl
- substituted
- Prior art date
Links
- 230000003920 cognitive function Effects 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- -1 alkyl radical Chemical class 0.000 abstract 9
- 150000003254 radicals Chemical class 0.000 abstract 4
- 208000024827 Alzheimer disease Diseases 0.000 abstract 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 208000022540 Consciousness disease Diseases 0.000 abstract 1
- 206010036631 Presenile dementia Diseases 0.000 abstract 1
- 206010039966 Senile dementia Diseases 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- MDFFNEOEWAXZRQ-UHFFFAOYSA-N aminyl Chemical class [NH2] MDFFNEOEWAXZRQ-UHFFFAOYSA-N 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 150000005840 aryl radicals Chemical class 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- JEVCWSUVFOYBFI-UHFFFAOYSA-N cyanyl Chemical compound N#[C] JEVCWSUVFOYBFI-UHFFFAOYSA-N 0.000 abstract 1
- 230000006866 deterioration Effects 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 239000012634 fragment Substances 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- BLNWTAHYTCHDJH-UHFFFAOYSA-O hydroxy(oxo)azanium Chemical compound O[NH+]=O BLNWTAHYTCHDJH-UHFFFAOYSA-O 0.000 abstract 1
- TUJKJAMUKRIRHC-UHFFFAOYSA-N hydroxyl Chemical compound [OH] TUJKJAMUKRIRHC-UHFFFAOYSA-N 0.000 abstract 1
- 230000007074 memory dysfunction Effects 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000003107 substituted aryl group Chemical group 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Veterinary Medicine (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9100861A FR2671972B1 (fr) | 1991-01-25 | 1991-01-25 | Utilisation de derives 1-h-azole-(omega-(4-(2-pyrimidinyl)-1-piperazinyl)-alkyl) pour la preparation de medicaments destines au traitement des troubles des fonctions cognitives. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE126227T1 true ATE126227T1 (de) | 1995-08-15 |
Family
ID=9409058
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT92400163T ATE126227T1 (de) | 1991-01-25 | 1992-01-22 | Verwendung von (omega-(4-(2-pyrimidinyl)-1- piperazinyl)-alkyl)1h-azolderivate für die herstellung von heilmitteln zur behandlung von störungen kognitiver funktionen. |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US5182281A (de) |
| EP (1) | EP0497658B1 (de) |
| JP (1) | JPH07121865B2 (de) |
| KR (1) | KR970001655B1 (de) |
| AT (1) | ATE126227T1 (de) |
| AU (1) | AU646137B2 (de) |
| CA (1) | CA2059984A1 (de) |
| DE (1) | DE69203874T2 (de) |
| DK (1) | DK0497658T3 (de) |
| ES (1) | ES2125207B1 (de) |
| FR (1) | FR2671972B1 (de) |
| GR (1) | GR3017648T3 (de) |
| HU (1) | HU214319B (de) |
| NO (1) | NO179695C (de) |
| RU (1) | RU2078568C1 (de) |
| ZA (1) | ZA92504B (de) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5681956A (en) * | 1990-12-28 | 1997-10-28 | Neurogen Corporation | 4-aryl substituted piperazinylmethyl phenylimidazole derivatives; a new class of dopamine receptor subtype specific ligands |
| US5633377A (en) * | 1990-12-28 | 1997-05-27 | Neurogen Corporation | 4-piperidino- and piperazinomethyl-2-cyclohexyl imidazole derivatives; dopamine receptor subtype specific ligands |
| FR2701260B1 (fr) * | 1993-02-05 | 1995-05-05 | Esteve Labor Dr | Dérivés de 2-[4-(4-azolylbutyl)-1-pipérazinyl]-5-hydroxypyrimidine, leur préparation et leur application en tant que médicaments. |
| FR2705098B1 (fr) * | 1993-05-10 | 1995-08-04 | Esteve Labor Dr | Procédé de préparation de 2-{4-[4-(chloro-1-pyrazolyl)butyl]1-pipérazinyl}pyrimidine (Lesopitron) . |
| GB9408084D0 (en) * | 1994-04-23 | 1994-06-15 | Boots Co Plc | Medical treatment |
| US6355659B1 (en) | 1994-07-29 | 2002-03-12 | Laboratorios Del Dr. Esteve, S.A. | 4-(4-Chlorophenyl)-1236-tetrahydro-1(1H-124-triazol-1-yl)butty)pyrideine and salts thereof; pharmaceutical compositions and method of treating psychoses utilizing same |
| FR2723091B1 (fr) * | 1994-07-29 | 1996-11-08 | Esteve Labor Dr | Tetrahydropyridine-(6,4-hydroxypiperidine) alkylazoles |
| ES2117934B1 (es) * | 1994-07-29 | 1999-04-01 | Esteve Labor Dr | Tetrahidropiridinas (0 4-hidroxipiperidinas) alquilazoles. |
| ES2099031B1 (es) * | 1995-05-31 | 1997-12-01 | Esteve Labor Dr | Nuevos polimorfos de diclorhidrato de lesopitron y sus formas hidratadas, procedimientos de preparacion y composiciones que los contienen. |
| US6166205A (en) * | 1998-09-02 | 2000-12-26 | Neurogen Corporation | 2-Aryl-4-(1-[4-heteroaryl]piperazin-1-yl)methylimidazoles: dopamine . D.sub4 receptor subtype ligands |
| US8152837B2 (en) | 2004-10-20 | 2012-04-10 | The Board Of Trustees Of The Leland Stanford Junior University | Systems and methods for posterior dynamic stabilization of the spine |
| US8945183B2 (en) * | 2004-10-20 | 2015-02-03 | Vertiflex, Inc. | Interspinous process spacer instrument system with deployment indicator |
| US8613747B2 (en) * | 2004-10-20 | 2013-12-24 | Vertiflex, Inc. | Spacer insertion instrument |
| US8128662B2 (en) | 2004-10-20 | 2012-03-06 | Vertiflex, Inc. | Minimally invasive tooling for delivery of interspinous spacer |
| US9119680B2 (en) | 2004-10-20 | 2015-09-01 | Vertiflex, Inc. | Interspinous spacer |
| US8123782B2 (en) * | 2004-10-20 | 2012-02-28 | Vertiflex, Inc. | Interspinous spacer |
| US8167944B2 (en) | 2004-10-20 | 2012-05-01 | The Board Of Trustees Of The Leland Stanford Junior University | Systems and methods for posterior dynamic stabilization of the spine |
| US7763074B2 (en) * | 2004-10-20 | 2010-07-27 | The Board Of Trustees Of The Leland Stanford Junior University | Systems and methods for posterior dynamic stabilization of the spine |
| US8317864B2 (en) | 2004-10-20 | 2012-11-27 | The Board Of Trustees Of The Leland Stanford Junior University | Systems and methods for posterior dynamic stabilization of the spine |
| US8409282B2 (en) | 2004-10-20 | 2013-04-02 | Vertiflex, Inc. | Systems and methods for posterior dynamic stabilization of the spine |
| US8123807B2 (en) | 2004-10-20 | 2012-02-28 | Vertiflex, Inc. | Systems and methods for posterior dynamic stabilization of the spine |
| US8012207B2 (en) * | 2004-10-20 | 2011-09-06 | Vertiflex, Inc. | Systems and methods for posterior dynamic stabilization of the spine |
| WO2009009049A2 (en) | 2004-10-20 | 2009-01-15 | Vertiflex, Inc. | Interspinous spacer |
| US9161783B2 (en) | 2004-10-20 | 2015-10-20 | Vertiflex, Inc. | Interspinous spacer |
| US8277488B2 (en) * | 2004-10-20 | 2012-10-02 | Vertiflex, Inc. | Interspinous spacer |
| US9023084B2 (en) * | 2004-10-20 | 2015-05-05 | The Board Of Trustees Of The Leland Stanford Junior University | Systems and methods for stabilizing the motion or adjusting the position of the spine |
| US8425559B2 (en) | 2004-10-20 | 2013-04-23 | Vertiflex, Inc. | Systems and methods for posterior dynamic stabilization of the spine |
| US8864828B2 (en) * | 2004-10-20 | 2014-10-21 | Vertiflex, Inc. | Interspinous spacer |
| EP2219538B1 (de) | 2004-12-06 | 2022-07-06 | Vertiflex, Inc. | Instrument zum einsetzen von abstandsstücken |
| US8845726B2 (en) | 2006-10-18 | 2014-09-30 | Vertiflex, Inc. | Dilator |
| EP2155121B1 (de) | 2007-04-16 | 2015-06-17 | Vertiflex, Inc. | Interspinöses abstandsglied |
| US8740948B2 (en) | 2009-12-15 | 2014-06-03 | Vertiflex, Inc. | Spinal spacer for cervical and other vertebra, and associated systems and methods |
| US9675303B2 (en) | 2013-03-15 | 2017-06-13 | Vertiflex, Inc. | Visualization systems, instruments and methods of using the same in spinal decompression procedures |
| WO2015171814A1 (en) | 2014-05-07 | 2015-11-12 | Vertiflex, Inc. | Spinal nerve decompression systems, dilation systems, and methods of using the same |
| US12102542B2 (en) | 2022-02-15 | 2024-10-01 | Boston Scientific Neuromodulation Corporation | Interspinous spacer and methods and systems utilizing the interspinous spacer |
| US12433646B2 (en) | 2023-02-21 | 2025-10-07 | Boston Scientific Neuromodulation Corporation | Interspinous spacer with actuator locking arrangements and methods and systems |
| US12390340B2 (en) | 2023-03-15 | 2025-08-19 | Boston Scientific Neuromodulation Corporation | Interspinous spacer with a range of deployment positions and methods and systems |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2642759B1 (fr) * | 1989-02-09 | 1991-05-17 | Laboratorios Esteve Sa | Derives de pyrimidyl-piperazinyl-alkyl azoles avec activite anxiolytique et/ou tranquillisante |
| FR2654621B1 (fr) * | 1989-11-22 | 1994-09-23 | Esteve Labor Dr | Inhibition du syndrome d'abstinence. |
-
1991
- 1991-01-25 FR FR9100861A patent/FR2671972B1/fr not_active Expired - Lifetime
-
1992
- 1992-01-17 ES ES9200092A patent/ES2125207B1/es not_active Expired - Fee Related
- 1992-01-22 DK DK92400163.9T patent/DK0497658T3/da active
- 1992-01-22 DE DE69203874T patent/DE69203874T2/de not_active Expired - Fee Related
- 1992-01-22 AT AT92400163T patent/ATE126227T1/de not_active IP Right Cessation
- 1992-01-22 EP EP92400163A patent/EP0497658B1/de not_active Expired - Lifetime
- 1992-01-23 AU AU10445/92A patent/AU646137B2/en not_active Ceased
- 1992-01-24 KR KR1019920001052A patent/KR970001655B1/ko not_active Expired - Fee Related
- 1992-01-24 RU SU925010696A patent/RU2078568C1/ru active
- 1992-01-24 CA CA002059984A patent/CA2059984A1/fr not_active Abandoned
- 1992-01-24 US US07/824,995 patent/US5182281A/en not_active Expired - Fee Related
- 1992-01-24 ZA ZA92504A patent/ZA92504B/xx unknown
- 1992-01-24 NO NO920342A patent/NO179695C/no not_active IP Right Cessation
- 1992-01-24 JP JP4011131A patent/JPH07121865B2/ja not_active Expired - Lifetime
- 1992-01-24 HU HU9200232A patent/HU214319B/hu not_active IP Right Cessation
-
1995
- 1995-10-04 GR GR950402761T patent/GR3017648T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU1044592A (en) | 1992-07-30 |
| RU2078568C1 (ru) | 1997-05-10 |
| HU9200232D0 (en) | 1992-04-28 |
| FR2671972B1 (fr) | 1995-03-03 |
| EP0497658B1 (de) | 1995-08-09 |
| NO179695B (no) | 1996-08-26 |
| NO920342L (no) | 1992-07-27 |
| US5182281A (en) | 1993-01-26 |
| ES2125207B1 (es) | 1999-01-01 |
| KR970001655B1 (ko) | 1997-02-13 |
| NO920342D0 (no) | 1992-01-24 |
| EP0497658A1 (de) | 1992-08-05 |
| NO179695C (no) | 1996-12-04 |
| JPH04312529A (ja) | 1992-11-04 |
| GR3017648T3 (en) | 1996-01-31 |
| DE69203874D1 (de) | 1995-09-14 |
| DK0497658T3 (da) | 1995-10-02 |
| JPH07121865B2 (ja) | 1995-12-25 |
| HU214319B (hu) | 1998-03-02 |
| AU646137B2 (en) | 1994-02-10 |
| FR2671972A1 (fr) | 1992-07-31 |
| HUT60433A (en) | 1992-09-28 |
| CA2059984A1 (fr) | 1992-07-26 |
| KR920014472A (ko) | 1992-08-25 |
| DE69203874T2 (de) | 1995-12-07 |
| ZA92504B (en) | 1992-10-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |