ATE126438T1 - Stabile injizierbare pharmazeutische formulation mit folinsäure und leukovorinsalze und verfahren. - Google Patents

Stabile injizierbare pharmazeutische formulation mit folinsäure und leukovorinsalze und verfahren.

Info

Publication number: ATE126438T1
Authority: AT; Austria
Prior art keywords: salts; folic acid; leucovine; methods; pharmaceutical formulation
Prior art date: 1989-08-21

Application number

AT90112426T

Other languages

English (en)

Inventor

Bruce Edwin Haeger

Original Assignee

American Cyanamid Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-08-21

Filing date

1990-06-29

Publication date

1995-09-15

1990-06-29 Application filed by American Cyanamid Co filed Critical American Cyanamid Co

1995-09-15 Application granted granted Critical

1995-09-15 Publication of ATE126438T1 publication Critical patent/ATE126438T1/de

Links

OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 title abstract 4
OVBPIULPVIDEAO-UHFFFAOYSA-N N-Pteroyl-L-glutaminsaeure Natural products C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-UHFFFAOYSA-N 0.000 title abstract 2
235000019152 folic acid Nutrition 0.000 title abstract 2
239000011724 folic acid Substances 0.000 title abstract 2
229960000304 folic acid Drugs 0.000 title abstract 2
238000000034 method Methods 0.000 title 1
239000008194 pharmaceutical composition Substances 0.000 title 1
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 abstract 2
239000000203 mixture Substances 0.000 abstract 2
VVIAGPKUTFNRDU-UHFFFAOYSA-N 6S-folinic acid Natural products C1NC=2NC(N)=NC(=O)C=2N(C=O)C1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 VVIAGPKUTFNRDU-UHFFFAOYSA-N 0.000 abstract 1
239000003795 chemical substances by application Substances 0.000 abstract 1
235000008191 folinic acid Nutrition 0.000 abstract 1
239000011672 folinic acid Substances 0.000 abstract 1
VVIAGPKUTFNRDU-ABLWVSNPSA-N folinic acid Chemical compound C1NC=2NC(N)=NC(=O)C=2N(C=O)C1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 VVIAGPKUTFNRDU-ABLWVSNPSA-N 0.000 abstract 1
229960001691 leucovorin Drugs 0.000 abstract 1
PJUIMOJAAPLTRJ-UHFFFAOYSA-N monothioglycerol Chemical compound OCC(O)CS PJUIMOJAAPLTRJ-UHFFFAOYSA-N 0.000 abstract 1
WVDDGKGOMKODPV-ZQBYOMGUSA-N phenyl(114C)methanol Chemical compound O[14CH2]C1=CC=CC=C1 WVDDGKGOMKODPV-ZQBYOMGUSA-N 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
239000011780 sodium chloride Substances 0.000 abstract 1
LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 abstract 1
229960000281 trometamol Drugs 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
- A61K31/515—Barbituric acids; Derivatives thereof, e.g. sodium pentobarbital
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Epidemiology (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Diabetes (AREA)
Nutrition Science (AREA)
Hematology (AREA)
Obesity (AREA)
Bioinformatics & Cheminformatics (AREA)
Dermatology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Oil, Petroleum & Natural Gas (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)

AT90112426T 1989-08-21 1990-06-29 Stabile injizierbare pharmazeutische formulation mit folinsäure und leukovorinsalze und verfahren. ATE126438T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US39657389A	1989-08-21	1989-08-21

Publications (1)

Publication Number	Publication Date
ATE126438T1 true ATE126438T1 (de)	1995-09-15

Family

ID=23567787

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT90112426T ATE126438T1 (de)	1989-08-21	1990-06-29	Stabile injizierbare pharmazeutische formulation mit folinsäure und leukovorinsalze und verfahren.

Country Status (11)

Country	Link
EP (1)	EP0416232B1 (de)
JP (1)	JP3043381B2 (de)
KR (1)	KR0159768B1 (de)
AT (1)	ATE126438T1 (de)
AU (1)	AU628211B2 (de)
CA (1)	CA2023563C (de)
DE (1)	DE69021673T2 (de)
DK (1)	DK0416232T3 (de)
ES (1)	ES2076263T3 (de)
GR (1)	GR3017143T3 (de)
PT (1)	PT95026B (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CH684644A5 (de)	1992-07-13	1994-11-15	Eprova Ag	5,10-Methylentetrahydrofolsäure-Cyclodextrin-Einschlussverbindungen.
CH687062A5 (de) *	1994-02-14	1996-09-13	Cerbios Pharma Sa	Konzentrierte Injektionsloesung von Alkalimetallsalzen von reduzierten Folaten.
AUPQ899400A0 (en) *	2000-07-26	2000-08-17	Csl Limited	A method of stabilisation and compositions for use therein
RU2316317C2 (ru) *	2001-12-28	2008-02-10	Эм-Джи-Ай Джи-Пи, Инк.	Составленные на основе воды фармацевтические композиции водорастворимых пролекарств пропофола
JP4956942B2 (ja) *	2004-09-15	2012-06-20	ニプロ株式会社	安定化された注射用水溶液製剤
KR20060051135A (ko) *	2004-09-15	2006-05-19	니프로 가부시키가이샤	안정화된 주사용 수용액 제재
JP4545632B2 (ja) *	2005-04-25	2010-09-15	株式会社伊藤園	葉酸含有組成物及び葉酸の安定化方法
JP4919024B2 (ja) *	2006-11-16	2012-04-18	横河電機株式会社	圧力センサ
JP4906546B2 (ja) *	2007-03-15	2012-03-28	株式会社ヤクルト本社	レボホリナート含有水溶液製剤
US9528879B2 (en)	2013-01-21	2016-12-27	Panasonic Intellectual Property Management Co., Ltd.	Infrared detection element, infrared detector, and infrared type gas sensor
JP6057254B2 (ja) *	2013-01-23	2017-01-11	パナソニックＩｐマネジメント株式会社	赤外線受光ユニット、赤外線式ガスセンサ
EP2799061A1 (de)	2013-04-30	2014-11-05	Aprofol AG	Stabile pharmazeutische Hochdosiszusammensetzungen enthaltend Folate
EP2799060A1 (de)	2013-04-30	2014-11-05	Aprofol AG	Stabile hochdosierte pharmazeutische Zusammensetzung enthaltend Levoleucovorin
CA2974953A1 (en)	2015-01-27	2016-08-04	La Vita Compounding Pharmacy	Stable 5-methyltetrahydrofolate formulations to moderate methylenetetrahydrofolate reductase associated polymorphisms
AU2020214314B2 (en) *	2019-01-31	2025-09-18	Scpharmaceuticals Inc.	Concentrated liquid pharmaceutical formulations of furosemide and methods of administering the same
CN112198302B (zh) *	2020-10-25	2022-12-16	中铁二局第一工程有限公司	一种细集料含泥量快速检测方法及测量工具
CN117224478B (zh) *	2023-10-21	2026-02-06	陕西丽彩药业有限公司	一种盐酸乌拉地尔注射液及其制备方法
CN118059042A (zh) *	2024-04-17	2024-05-24	成都瑞尔医药科技有限公司	一种亚叶酸钙注射液及其制备方法
US12564592B1 (en)	2024-12-23	2026-03-03	Riconpharma LLC	Injectable leucovorin formulations and methods of preparing same

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2695860A (en) *	1952-04-29	1954-11-30	American Cyanamid Co	Stabilized pteroyl solutions
US4071620A (en) *	1977-01-10	1978-01-31	American Home Products Corporation	Stabilization of oxygen sensitive dose forms
WO1988004927A1 (en) *	1986-12-31	1988-07-14	Davirand, Inc.	Compositions and formulations containing folic acid, method of treating tissue with folic acid and method for preparing compositions and formulations of folic acid

1990
- 1990-06-29 DE DE69021673T patent/DE69021673T2/de not_active Expired - Lifetime
- 1990-06-29 ES ES90112426T patent/ES2076263T3/es not_active Expired - Lifetime
- 1990-06-29 EP EP90112426A patent/EP0416232B1/de not_active Expired - Lifetime
- 1990-06-29 DK DK90112426.3T patent/DK0416232T3/da active
- 1990-06-29 AT AT90112426T patent/ATE126438T1/de not_active IP Right Cessation
- 1990-07-31 KR KR1019900011721A patent/KR0159768B1/ko not_active Expired - Fee Related
- 1990-08-17 PT PT95026A patent/PT95026B/pt not_active IP Right Cessation
- 1990-08-17 CA CA002023563A patent/CA2023563C/en not_active Expired - Lifetime
- 1990-08-20 JP JP2218854A patent/JP3043381B2/ja not_active Expired - Lifetime
- 1990-08-20 AU AU61165/90A patent/AU628211B2/en not_active Expired
1995
- 1995-08-17 GR GR950400785T patent/GR3017143T3/el unknown

Also Published As

Publication number	Publication date
JPH0390026A (ja)	1991-04-16
CA2023563C (en)	2000-02-22
DE69021673T2 (de)	1996-05-02
GR3017143T3 (en)	1995-11-30
DE69021673D1 (de)	1995-09-21
AU6116590A (en)	1991-02-21
KR0159768B1 (ko)	1998-12-01
EP0416232A3 (en)	1992-01-02
PT95026A (pt)	1991-04-18
KR910004194A (ko)	1991-03-28
DK0416232T3 (da)	1995-09-18
ES2076263T3 (es)	1995-11-01
JP3043381B2 (ja)	2000-05-22
AU628211B2 (en)	1992-09-10
PT95026B (pt)	1997-12-31
CA2023563A1 (en)	1991-02-22
EP0416232B1 (de)	1995-08-16
EP0416232A2 (de)	1991-03-13

Legal Events

Date	Code	Title	Description
1996-04-15	UEP	Publication of translation of european patent specification
2010-09-15	EELA	Cancelled due to lapse of time

Publication	Publication Date	Title
DE69021673D1 (de)	1995-09-21	Stabile injizierbare pharmazeutische Formulation mit Folinsäure und Leukovorinsalze und Verfahren.
DE68916731D1 (de)	1994-08-18	Morphin enthaltende Zusammensetzung.
DE69516540D1 (de)	2000-05-31	AMINO-IMIDAZO [4,5-c] CHINOLINE
DE69625046D1 (de)	2003-01-09	Pharmazeutische zusammensetzung stabilisiert mit einem basischen medium
ATE47715T1 (de)	1989-11-15	Stabile salze von sam mit polyanionen.
ATE83924T1 (de)	1993-01-15	Ibuprofen-cyclodextrin-einschlusskomplexe enthaltende pharmazeutische zubereitungen.
DE59410151D1 (de)	2002-08-14	Feste Flupirtin enthaltende orale Darreichungsformen mit kontrollierter Wirkstoffabgabe
DK0598770T3 (da)	1997-12-15	Pyrazinderivater samt fremstilling og anvendelse deraf
LV10178A (lv)	1994-10-20	Fiziologiski saderigu glabajot stabilu cilveka olbaltumvielu preparatu iegusanas panemiens
NO902488D0 (no)	1990-06-05	Karboplatinapreparat.
ATE122675T1 (de)	1995-06-15	Stabile salze von 5,10- methylentetrahydrofolsäure.
PT90308A (pt)	1989-11-10	Processo para a preparacao de composicoes farmaceuticas contendo azelastina com libertacao controlada da substancia activa
DK0397147T3 (da)	1995-03-20	Stabile opløsninger af rebeccamycinanalog og fremstilling deraf
ATE104554T1 (de)	1994-05-15	Topische praeparate.
YU184090A (sh)	1992-09-07	Stabilizovani interferoni leukocita
ATE47518T1 (de)	1989-11-15	Injizierbare pharmazeutische zusammenstellungen die bestaendige 5-adenosyl-l-methionin-salze enthalten.
DE69121058D1 (de)	1996-08-29	Salze von Glykosaminoglykanen mit Aminosäureester, ihre Herstellung sowie sie enthaltende pharmazeutische Zusammensetzungen
MX9400215A (es)	1994-07-29	Compuestos farmaceuticos.
UA43797A (uk)	2001-12-17	Ін'єкційна форма препарату, що проявляє протиішемічну активність