ATE126533T1 - Plasmid zur herstellung von membranprotein, dieses plasmid enthaltendes bakterium, monoklonaler antikörper hierfür und verfahren zur identifikation von hämophilus influenzae. - Google Patents

Plasmid zur herstellung von membranprotein, dieses plasmid enthaltendes bakterium, monoklonaler antikörper hierfür und verfahren zur identifikation von hämophilus influenzae.

Info

Publication number
ATE126533T1
ATE126533T1 AT87116699T AT87116699T ATE126533T1 AT E126533 T1 ATE126533 T1 AT E126533T1 AT 87116699 T AT87116699 T AT 87116699T AT 87116699 T AT87116699 T AT 87116699T AT E126533 T1 ATE126533 T1 AT E126533T1
Authority
AT
Austria
Prior art keywords
plasmid
membrane protein
haemophilus influenzae
bacterium containing
immunogenic portion
Prior art date
Application number
AT87116699T
Other languages
English (en)
Inventor
Timothy F Murphy
Michael A Apicella
Original Assignee
Univ New York State Res Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ New York State Res Found filed Critical Univ New York State Res Found
Application granted granted Critical
Publication of ATE126533T1 publication Critical patent/ATE126533T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1203—Gram-negative bacteria
    • C07K16/1242—Gram-negative bacteria from Pasteurellaceae (F), e.g. Haemophilus influenza
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/285—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Pasteurellaceae (F), e.g. Haemophilus influenza
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/961—Chemistry: molecular biology and microbiology including a step of forming, releasing, or exposing the antigen or forming the hapten-immunogenic carrier complex or the antigen per se
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/972—Modified antibody, e.g. hybrid, bifunctional

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Pulmonology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
AT87116699T 1986-11-18 1987-11-12 Plasmid zur herstellung von membranprotein, dieses plasmid enthaltendes bakterium, monoklonaler antikörper hierfür und verfahren zur identifikation von hämophilus influenzae. ATE126533T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US93287286A 1986-11-18 1986-11-18
US07/092,948 US5173294A (en) 1986-11-18 1987-10-08 Dna probe for the identification of haemophilus influenzae

Publications (1)

Publication Number Publication Date
ATE126533T1 true ATE126533T1 (de) 1995-09-15

Family

ID=26786217

Family Applications (1)

Application Number Title Priority Date Filing Date
AT87116699T ATE126533T1 (de) 1986-11-18 1987-11-12 Plasmid zur herstellung von membranprotein, dieses plasmid enthaltendes bakterium, monoklonaler antikörper hierfür und verfahren zur identifikation von hämophilus influenzae.

Country Status (8)

Country Link
US (1) US5173294A (de)
EP (1) EP0281673B1 (de)
JP (1) JP2770877B2 (de)
AT (1) ATE126533T1 (de)
DE (1) DE3751467T2 (de)
DK (1) DK173205B1 (de)
ES (1) ES2077557T3 (de)
IE (1) IE71224B1 (de)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2534529B2 (ja) * 1986-07-24 1996-09-18 ブリティシュ・テレコミュニケ−ションズ・パブリック・リミテッド・カンパニ 放射発生器
US4862342A (en) * 1987-12-03 1989-08-29 Sundstrand Corp. DC to AC inverter with neutral having a resonant circuit
US5601831A (en) * 1989-03-09 1997-02-11 Praxis Biologics, Inc. Vaccines for nontypable Haemophilus influenzae
SE466259B (sv) * 1990-05-31 1992-01-20 Arne Forsgren Protein d - ett igd-bindande protein fraan haemophilus influenzae, samt anvaendning av detta foer analys, vacciner och uppreningsaendamaal
US5843463A (en) * 1990-12-21 1998-12-01 Antexbiologics, Inc. Adhesin-oligosaccharide conjugate vaccine for Haemophilus influenzae
WO1992010936A1 (en) * 1990-12-21 1992-07-09 Microcarb, Inc. ADHESIN-OLIGOSACCHARIDE CONJUGATE VACCINE FOR $i(HAEMOPHILUS INFLUENZAE)
GB9202219D0 (en) * 1992-02-03 1992-03-18 Connaught Lab A synthetic heamophilus influenzae conjugate vaccine
GB9224584D0 (en) 1992-11-23 1993-01-13 Connaught Lab Use of outer membrane protein d15 and its peptides as vaccine against haempohilus influenzae diseases
US6153406A (en) * 1993-07-23 2000-11-28 North American Vaccine, Inc. Method for the high level expression, purification and refolding of the outer membrane protein P2 from Haemophilus influenzae type B
US5681570A (en) * 1995-01-12 1997-10-28 Connaught Laboratories Limited Immunogenic conjugate molecules
AU3196099A (en) * 1998-03-27 1999-10-18 President And Fellows Of Harvard College Systematic identification of essential genes by (in vitro) transposon mutagenesis
GB9809683D0 (en) * 1998-05-06 1998-07-01 Smithkline Beecham Biolog Novel compounds
KR100642044B1 (ko) 1999-03-19 2006-11-10 글락소스미스클라인 바이오로지칼즈 에스.에이. 백신
GB0022742D0 (en) 2000-09-15 2000-11-01 Smithkline Beecham Biolog Vaccine
GB0025486D0 (en) * 2000-10-17 2000-11-29 Smithkline Beecham Biolog Novel compounds
GB0103171D0 (en) 2001-02-08 2001-03-28 Smithkline Beecham Biolog Vaccine composition
DE20321889U1 (de) 2002-08-02 2012-03-12 Glaxosmithkline Biologicals S.A. Impfstoffzusammensetzung
TWI457133B (zh) 2005-12-13 2014-10-21 Glaxosmithkline Biolog Sa 新穎組合物
GB0607088D0 (en) 2006-04-07 2006-05-17 Glaxosmithkline Biolog Sa Vaccine
CN103251940A (zh) 2005-12-22 2013-08-21 葛兰素史密丝克莱恩生物有限公司 疫苗
SG10201600336RA (en) 2006-01-17 2016-02-26 Arne Forsgren A novel surface exposed haemophilus influenzae protein (protein e; pe)
MX2009013949A (es) 2007-06-26 2010-05-24 Glaxosmithkline Biolog Sa Vacuna que comprende conjugados de polisacárido capsular de streptococcus pneumoniae.
GB201003924D0 (en) 2010-03-09 2010-04-21 Glaxosmithkline Biolog Sa Immunogenic composition
GB201003922D0 (en) 2010-03-09 2010-04-21 Glaxosmithkline Biolog Sa Conjugation process
JP2013521326A (ja) 2010-03-10 2013-06-10 グラクソスミスクライン バイオロジカルズ ソシエテ アノニム 免疫原性組成物
GB201103836D0 (en) 2011-03-07 2011-04-20 Glaxosmithkline Biolog Sa Conjugation process
WO2012170356A1 (en) 2011-06-04 2012-12-13 Rochester General Hospital Research Institute Compositions and methods related to p6 of haemophilus influenzae
JP6311959B2 (ja) * 2012-10-04 2018-04-18 国立大学法人三重大学 微生物の迅速診断を可能とする特異抗体の高効率作製法
CN105242040B (zh) * 2014-08-18 2017-01-18 董俊 人流感嗜血杆菌量子点免疫层析检测卡及其制备方法和应用
GB201518684D0 (en) 2015-10-21 2015-12-02 Glaxosmithkline Biolog Sa Vaccine
GB201621686D0 (en) 2016-12-20 2017-02-01 Glaxosmithkline Biologicals Sa Novel methods for inducing an immune response
FR3066920A1 (fr) 2017-05-30 2018-12-07 Glaxosmithkline Biologicals S.A. Nouveaux procedes de fabrication d'un adjuvant
JP2021504424A (ja) 2017-12-01 2021-02-15 グラクソスミスクライン バイオロジカルズ ソシエテ アノニム サポニン精製
EP3833382A1 (de) 2018-08-07 2021-06-16 GlaxoSmithKline Biologicals S.A. Verfahren und impfstoffe
WO2020109365A1 (en) 2018-11-29 2020-06-04 Glaxosmithkline Biologicals Sa Methods for manufacturing an adjuvant
BR112021024363A2 (pt) 2019-06-05 2022-03-22 Glaxosmithkline Biologicals Sa Purificação de saponina
GB202205833D0 (en) 2022-04-21 2022-06-08 Glaxosmithkline Biologicals Sa Bacteriophage
EP4558170A1 (de) 2022-07-19 2025-05-28 GlaxoSmithKline Biologicals S.A. Kontinuierliches verfahren zur herstellung von impfstoffen

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4496538A (en) * 1982-07-06 1985-01-29 Connaught Laboratories, Inc. Haemophilus influenzae b polysaccharide-diphtheria toxoid conjugate vaccine
JPH0671067B2 (ja) * 1985-11-20 1994-09-07 株式会社日立製作所 半導体装置

Also Published As

Publication number Publication date
DE3751467T2 (de) 1996-02-15
DK173205B1 (da) 2000-03-13
IE71224B1 (en) 1997-02-12
ES2077557T3 (es) 1995-12-01
EP0281673B1 (de) 1995-08-16
JP2770877B2 (ja) 1998-07-02
JPH01157387A (ja) 1989-06-20
DK602087D0 (da) 1987-11-17
EP0281673A1 (de) 1988-09-14
DE3751467D1 (de) 1995-09-21
US5173294A (en) 1992-12-22
IE873051L (en) 1988-05-18
DK602087A (da) 1988-05-19

Similar Documents

Publication Publication Date Title
ATE126533T1 (de) Plasmid zur herstellung von membranprotein, dieses plasmid enthaltendes bakterium, monoklonaler antikörper hierfür und verfahren zur identifikation von hämophilus influenzae.
ATE479756T1 (de) Streptococcus pneumoniae-antigene und impfstoffe
ATE83801T1 (de) Verfahren und mittel zur herstellung eines proteins mit der gleichen igg-spezifizitaet wie protein g.
KR870010189A (ko) HTLV-Ⅲgag/ env 유전자 단백질의 발현 및 정제
DE69636075D1 (de) Verbindungen und verfahren zur diagnose von tuberkulose
UA42668C2 (uk) Поліпептид, що має антигенні властивості вірусу гепатиту с (hcv) (варіанти), діагностичний реагент для виявлення антитіл до вірусу гепатиту с (варіанти), набір для виявлення антитіл до вірусу гепатиту с (варіанти), спосіб виявлення антитіл до вірусу гепатиту с (варіанти)
ATE91629T1 (de) Adhesin-antigene, antikoerper und dns-fragmente die das antigen kodieren, verfahren und mittel zur diagnose und immunisierung, usw.
ATE159982T1 (de) Antikörper mit modifiziertem kohlenhydratgehalt und verfahren zur herstellung und verwendung
EP0252685A3 (en) Diagnostic methods for detecting lymphomas in humans
ATE141956T1 (de) Verfahren zur vervielfältigung von nukleinsäuresequenzen
DK1114864T4 (da) Pattedyrcelleoverfladeantigener samt tilhørende reagenser
FI895050A0 (fi) Diagnostiska preparat och vaccin foer mykobakterier i folkhaelso-, medicinsk och veterinaermedicinsk praxis.
DE3587422D1 (de) Fuer ein hirudinaehnliches protein kodierende dns-sequenz und verfahren zur herstellung eines solchen proteins.
KR910012244A (ko) 톡소플라스마 곤디 항원, 이의 제조방법 및 이의 용도
DE3752131D1 (de) Impfstoffe und diagnosetest für haemophilus influenzae
BR9713450A (pt) Quimiocinas de mamìfero
AU8503898A (en) Monospecific antibody reactive with fibrinogen and fibrinopeptide
EP0276984A3 (de) Bestimmung von Anti-DNS-Antikörpern
DE3277915D1 (en) Process for the production of hybridisation probes
ATE133205T1 (de) Diagnoseverfahren für infektionskrankheiten sowie verfahren zum nachweis und identifizierung von mikroorganismen
PORTIER et al. Translation in vitro of Tetrahymena pyriformis Polyadenylated mRNA: Identification of Tubulin amongst the Translated Products and Demonstration of Its Heterogeneity
ATE107033T1 (de) Nachweis von tumorassozierten anzeigern in biologischen flüssigkeiten.
Brown et al. Comparative analyses of vesiculovirus proteins utilizing partial cleavage fragments at tryptophan residues
Barahona et al. Site of tubulin synthesis in Tetrahymena pyriformis
Shimizu et al. Techniques for assaying C 1, C 2 and D botulinal antitoxins.

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
EELA Cancelled due to lapse of time