ATE12778T1 - Deka-, undeka-, dodeka- und tridekapeptide mit thymischer taetigkeit, verfahren zu deren herstellung und diese enthaltende zusammensetzungen. - Google Patents

Deka-, undeka-, dodeka- und tridekapeptide mit thymischer taetigkeit, verfahren zu deren herstellung und diese enthaltende zusammensetzungen.

Info

Publication number: ATE12778T1
Authority: AT; Austria
Prior art keywords: sub; pro; leu; preparation; tridecapeptids
Prior art date: 1980-12-22

Application number

AT81305995T

Other languages

English (en)

Inventor

Abraham White

Gordon Henry Jones

John Joseph Nestor

Pamela Miram Burton

Original Assignee

Syntex Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1980-12-22

Filing date

1981-12-21

Publication date

1985-05-15

1981-12-21 Application filed by Syntex Inc filed Critical Syntex Inc

1985-05-15 Application granted granted Critical

1985-05-15 Publication of ATE12778T1 publication Critical patent/ATE12778T1/de

Links

IFPMZBBHBZQTOV-UHFFFAOYSA-N 1,3,5-trinitro-2-(2,4,6-trinitrophenyl)-4-[2,4,6-trinitro-3-(2,4,6-trinitrophenyl)phenyl]benzene Chemical compound [O-][N+](=O)C1=CC([N+](=O)[O-])=CC([N+]([O-])=O)=C1C1=C([N+]([O-])=O)C=C([N+]([O-])=O)C(C=2C(=C(C=3C(=CC(=CC=3[N+]([O-])=O)[N+]([O-])=O)[N+]([O-])=O)C(=CC=2[N+]([O-])=O)[N+]([O-])=O)[N+]([O-])=O)=C1[N+]([O-])=O IFPMZBBHBZQTOV-UHFFFAOYSA-N 0.000 title 1
-1 UNDEKA Chemical compound 0.000 title 1
WHHGLZMJPXIBIX-UHFFFAOYSA-N decabromodiphenyl ether Chemical compound BrC1=C(Br)C(Br)=C(Br)C(Br)=C1OC1=C(Br)C(Br)=C(Br)C(Br)=C1Br WHHGLZMJPXIBIX-UHFFFAOYSA-N 0.000 title 1
239000000203 mixture Substances 0.000 title 1
230000002992 thymic effect Effects 0.000 title 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
108090000765 processed proteins & peptides Proteins 0.000 abstract 2
102000004196 processed proteins & peptides Human genes 0.000 abstract 2
MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 abstract 1
QNAYBMKLOCPYGJ-UWTATZPHSA-N D-alanine Chemical compound C[C@@H](N)C(O)=O QNAYBMKLOCPYGJ-UWTATZPHSA-N 0.000 abstract 1
ROHFNLRQFUQHCH-RXMQYKEDSA-N D-leucine Chemical compound CC(C)C[C@@H](N)C(O)=O ROHFNLRQFUQHCH-RXMQYKEDSA-N 0.000 abstract 1
QIVBCDIJIAJPQS-SECBINFHSA-N D-tryptophane Chemical compound C1=CC=C2C(C[C@@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-SECBINFHSA-N 0.000 abstract 1
DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 abstract 1
125000000174 L-prolyl group Chemical group [H]N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C(*)=O 0.000 abstract 1
AYFVYJQAPQTCCC-GBXIJSLDSA-N L-threonine Chemical compound C[C@@H](O)[C@H](N)C(O)=O AYFVYJQAPQTCCC-GBXIJSLDSA-N 0.000 abstract 1
ZKQOUHVVXABNDG-IUCAKERBSA-N Pro-Leu Chemical compound CC(C)C[C@@H](C(O)=O)NC(=O)[C@@H]1CCCN1 ZKQOUHVVXABNDG-IUCAKERBSA-N 0.000 abstract 1
HATVCTYBNCNMAA-AVGNSLFASA-N Pro-Leu-Met Chemical compound [H]N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(O)=O HATVCTYBNCNMAA-AVGNSLFASA-N 0.000 abstract 1
AYFVYJQAPQTCCC-UHFFFAOYSA-N THREONINE Chemical compound CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 abstract 1
KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Chemical compound CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 abstract 1
125000002252 acyl group Chemical group 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
230000001900 immune effect Effects 0.000 abstract 1
125000001288 lysyl group Chemical group 0.000 abstract 1
108010090894 prolylleucine Proteins 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/655—Somatostatins
- C07K14/6555—Somatostatins at least 1 amino acid in D-form
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/18—Thymus derived hormone or factor; related peptides

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Medicinal Chemistry (AREA)
Biochemistry (AREA)
Biophysics (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Zoology (AREA)
Toxicology (AREA)
Gastroenterology & Hepatology (AREA)
Endocrinology (AREA)
Analytical Chemistry (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Detergent Compositions (AREA)
Curing Cements, Concrete, And Artificial Stone (AREA)

AT81305995T 1980-12-22 1981-12-21 Deka-, undeka-, dodeka- und tridekapeptide mit thymischer taetigkeit, verfahren zu deren herstellung und diese enthaltende zusammensetzungen. ATE12778T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US06/218,886 US4320118A (en)	1980-12-22	1980-12-22	Deca-, undeca-, dodeca- and tridecapeptides with thymic activity
EP81305995A EP0055113B1 (de)	1980-12-22	1981-12-21	Deka-, Undeka-, Dodeka- und Tridekapeptide mit thymischer Tätigkeit, Verfahren zu deren Herstellung und diese enthaltende Zusammensetzungen

Publications (1)

Publication Number	Publication Date
ATE12778T1 true ATE12778T1 (de)	1985-05-15

Family

ID=22816887

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT81305995T ATE12778T1 (de)	1980-12-22	1981-12-21	Deka-, undeka-, dodeka- und tridekapeptide mit thymischer taetigkeit, verfahren zu deren herstellung und diese enthaltende zusammensetzungen.

Country Status (17)

Country	Link
US (1)	US4320118A (de)
EP (1)	EP0055113B1 (de)
JP (1)	JPS57128666A (de)
KR (1)	KR830007522A (de)
AT (1)	ATE12778T1 (de)
AU (1)	AU546769B2 (de)
CA (1)	CA1187869A (de)
DE (1)	DE3170055D1 (de)
DK (1)	DK568281A (de)
FI (1)	FI77046C (de)
HU (1)	HU189550B (de)
IE (1)	IE53004B1 (de)
IL (1)	IL64610A (de)
NO (1)	NO814384L (de)
NZ (1)	NZ199335A (de)
YU (1)	YU42752B (de)
ZA (1)	ZA818829B (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4395404A (en) *	1982-05-14	1983-07-26	George Washington University	Synthetic thymosin β3 and β4 analogues
CS256897B1 (en) *	1984-12-17	1988-04-15	Evzen Kasafirek	Series thymic factor's analogue-type peptides
US4740588A (en) *	1986-08-07	1988-04-26	Washington University	Novel substrate peptides
NZ226557A (en) *	1987-10-15	1990-07-26	Syntex Inc	Pharmaceutical compositions for the intranasal administration of a biologically active polypeptide in powder form and process for their preparation
US5786327A (en)	1993-03-12	1998-07-28	Gensci Regeneration Sciences Inc.	Bone stimulating factor, methods of isolating same, and methods of increasing bone growth comprising administering same
US6352973B1 (en)	1995-06-07	2002-03-05	Osteopharm Inc.	Bone stimulating factor
US6693081B2 (en) *	1995-09-26	2004-02-17	Osteopharm Inc.	Bone stimulating factor
DE19724793A1 (de) *	1997-06-06	1998-12-10	Schering Ag	D-mutierte Peptide mit VEGF-Rezeptor blockierenden Eigenschaften
WO1999025752A1 (en) *	1997-11-18	1999-05-27	Aventis Pharmaceuticals Products Inc.	Functionalized resin for the synthesis of amides and peptides
US6815421B1 (en) *	2001-03-22	2004-11-09	Osteopharm Inc.	Polypeptides for use in ameliorating effects of aging in mammals
GB2385415B (en) *	2002-02-15	2005-09-14	Teraview Ltd	An analysis apparatus and method
CA2508765A1 (en) *	2002-12-05	2004-06-17	Osteopharm Inc.	Bone growth factor

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4046877A (en) *	1975-07-18	1977-09-06	Syntex (U.S.A.) Inc.	Method of increasing immunologic competence

1980
- 1980-12-22 US US06/218,886 patent/US4320118A/en not_active Expired - Fee Related
1981
- 1981-12-17 KR KR1019810004963A patent/KR830007522A/ko not_active Ceased
- 1981-12-21 NO NO814384A patent/NO814384L/no unknown
- 1981-12-21 AU AU78705/81A patent/AU546769B2/en not_active Ceased
- 1981-12-21 FI FI814112A patent/FI77046C/fi not_active IP Right Cessation
- 1981-12-21 IL IL64610A patent/IL64610A/xx unknown
- 1981-12-21 IE IE3004/81A patent/IE53004B1/en unknown
- 1981-12-21 NZ NZ199335A patent/NZ199335A/en unknown
- 1981-12-21 DK DK568281A patent/DK568281A/da not_active Application Discontinuation
- 1981-12-21 ZA ZA818829A patent/ZA818829B/xx unknown
- 1981-12-21 JP JP56205391A patent/JPS57128666A/ja active Pending
- 1981-12-21 CA CA000392786A patent/CA1187869A/en not_active Expired
- 1981-12-21 EP EP81305995A patent/EP0055113B1/de not_active Expired
- 1981-12-21 HU HU813891A patent/HU189550B/hu unknown
- 1981-12-21 DE DE8181305995T patent/DE3170055D1/de not_active Expired
- 1981-12-21 YU YU3035/81A patent/YU42752B/xx unknown
- 1981-12-21 AT AT81305995T patent/ATE12778T1/de not_active IP Right Cessation

Also Published As

Publication number	Publication date
NO814384L (no)	1982-06-23
DK568281A (da)	1982-06-23
YU42752B (en)	1988-12-31
EP0055113B1 (de)	1985-04-17
HU189550B (en)	1986-07-28
DE3170055D1 (en)	1985-05-23
AU7870581A (en)	1982-07-01
US4320118A (en)	1982-03-16
EP0055113A3 (en)	1982-08-11
YU303581A (en)	1984-02-29
CA1187869A (en)	1985-05-28
NZ199335A (en)	1985-05-31
ZA818829B (en)	1983-07-27
FI77046B (fi)	1988-09-30
IL64610A0 (en)	1982-03-31
FI814112L (fi)	1982-06-23
KR830007522A (ko)	1983-10-21
JPS57128666A (en)	1982-08-10
IE813004L (en)	1982-06-22
IE53004B1 (en)	1988-05-11
FI77046C (fi)	1989-01-10
AU546769B2 (en)	1985-09-19
EP0055113A2 (de)	1982-06-30
IL64610A (en)	1985-08-30

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Legal Events

Date	Code	Title	Description
1985-07-15	UEP	Publication of translation of european patent specification
1989-09-15	REN	Ceased due to non-payment of the annual fee