ATE127801T1 - Pyrazolopyridinverbindungen und verfahren zu ihrer herstellung. - Google Patents

Pyrazolopyridinverbindungen und verfahren zu ihrer herstellung.

Info

Publication number: ATE127801T1
Authority: AT; Austria
Prior art keywords: group; formula; lower alkyl; production; chem
Prior art date: 1987-06-15

Application number

AT88109331T

Other languages

English (en)

Inventor

Youichi Shiokawa

Atsushi Akahane

Hirohito Katayama

Takafumi Mitsunaga

Original Assignee

Fujisawa Pharmaceutical Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-06-15

Filing date

1988-06-11

Publication date

1995-09-15

1987-06-15 Priority claimed from GB878713908A external-priority patent/GB8713908D0/en

1987-08-20 Priority claimed from GB878719724A external-priority patent/GB8719724D0/en

1987-12-31 Priority claimed from GB878730330A external-priority patent/GB8730330D0/en

1988-06-11 Application filed by Fujisawa Pharmaceutical Co filed Critical Fujisawa Pharmaceutical Co

1995-09-15 Application granted granted Critical

1995-09-15 Publication of ATE127801T1 publication Critical patent/ATE127801T1/de

Links

150000005229 pyrazolopyridines Chemical class 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 3
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 3
229910052739 hydrogen Inorganic materials 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
125000001424 substituent group Chemical group 0.000 abstract 2
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
125000002252 acyl group Chemical group 0.000 abstract 1
125000001931 aliphatic group Chemical group 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
125000004093 cyano group Chemical group *C#N 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
125000000623 heterocyclic group Chemical group 0.000 abstract 1
150000002431 hydrogen Chemical class 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
-1 pyrazolopyridine compound Chemical class 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Cardiology (AREA)
Diabetes (AREA)
Hematology (AREA)
Heart & Thoracic Surgery (AREA)
Reproductive Health (AREA)
Endocrinology (AREA)
Hospice & Palliative Care (AREA)
Urology & Nephrology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pyridine Compounds (AREA)
Developing Agents For Electrophotography (AREA)
Position Input By Displaying (AREA)

AT88109331T 1987-06-15 1988-06-11 Pyrazolopyridinverbindungen und verfahren zu ihrer herstellung. ATE127801T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
GB878713908A GB8713908D0 (en)	1987-06-15	1987-06-15	Pyrazolopyridine compound
GB878719724A GB8719724D0 (en)	1987-08-20	1987-08-20	Pyrazolopyridine compound
GB878730330A GB8730330D0 (en)	1987-12-31	1987-12-31	Pyrazolopyridine compound & processes for preparation thereof

Publications (1)

Publication Number	Publication Date
ATE127801T1 true ATE127801T1 (de)	1995-09-15

Family

ID=27263458

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT88109331T ATE127801T1 (de)	1987-06-15	1988-06-11	Pyrazolopyridinverbindungen und verfahren zu ihrer herstellung.

Country Status (16)

Country	Link
US (6)	US4925849A (de)
EP (1)	EP0299209B1 (de)
JP (1)	JP2674099B2 (de)
KR (1)	KR890000483A (de)
CN (1)	CN1031376A (de)
AT (1)	ATE127801T1 (de)
AU (1)	AU615913B2 (de)
DE (1)	DE3854454T2 (de)
DK (1)	DK323688A (de)
ES (1)	ES2076935T3 (de)
FI (1)	FI882813A7 (de)
GR (1)	GR3017850T3 (de)
HU (1)	HU200180B (de)
IL (1)	IL86674A0 (de)
NO (1)	NO168585C (de)
PT (1)	PT87700B (de)

Families Citing this family (67)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4925849A (en) *	1987-06-15	1990-05-15	Fujisawa Pharmaceutical Company, Ltd.	Pharmaceutically useful pyrazolopyridines
US5338743A (en) *	1988-06-06	1994-08-16	Fujisawa Pharmaceutical Co., Ltd.	New use of the adenosine antagonist
GB8901423D0 (en) *	1989-01-23	1989-03-15	Fujisawa Pharmaceutical Co	Pyrazolopyridine compound and processes for preparation thereof
DE3942357A1 (de) *	1989-12-21	1991-06-27	Boehringer Mannheim Gmbh	3-aminopyrazolo-heterocyclen, deren verwendung zur bestimmung von wasserstoffperoxid, wasserstoffperoxid-bildenden systemen, peroxidase, peroxidatisch wirksamen substanzen oder von elektronenreichen aromatischen verbindungen, entsprechende bestimmungsverfahren und hierfuer geeignete mittel
GB9015764D0 (en) *	1990-07-18	1990-09-05	Fujisawa Pharmaceutical Co	Pyrazolopyridine compound and processes for preparation thereof
DE69232323T2 (de) *	1991-01-29	2002-08-08	Fujisawa Pharmaceutical Co., Ltd.	Verwendung von Adenosinantagonisten zur Vorbeugung und Behandlung von Pankreatitis und Ulcera
GB9107513D0 (en) *	1991-04-10	1991-05-29	Fujisawa Pharmaceutical Co	Pyrazolopyridine compound and processes for preparation thereof
DE69228707T2 (de) *	1992-01-29	1999-10-21	E.I. Du Pont De Nemours And Co., Wilmington	Substituierte phenylheterozyklische herbizide
US5670455A (en) *	1992-01-29	1997-09-23	E. I. Du Pont De Nemours And Company	Substituted phenylheterocyclic herbicides
US6358885B1 (en)	1992-01-29	2002-03-19	Mississippi State University	Substituted phenylheterocyclic herbicides
DE69315836T2 (de) *	1992-06-10	1998-04-09	Fujisawa Pharmaceutical Co	Pyrazolpyridine für die behandlung der anämie
WO1993025553A1 (en) *	1992-06-17	1993-12-23	The Upjohn Company	Pyridino-, pyrrolidino- and azepino-substituted oximes useful as anti-atherosclerosis and anti-hypercholesterolemic agents
US5541213A (en) *	1993-06-24	1996-07-30	Eisai Co., Ltd.	Propenoic acid derivatives diazole propenoic acid compounds which have useful pharmaceutical utility
CN1046724C (zh) *	1993-12-29	1999-11-24	藤泽药品工业株式会社	吡唑并吡啶化合物、含有它们的药物组合物、及其制法与用途
US5646156A (en) *	1994-04-25	1997-07-08	Merck & Co., Inc.	Inhibition of eosinophil activation through A3 adenosine receptor antagonism
ES2176448T3 (es) *	1995-04-27	2002-12-01	Fujisawa Pharmaceutical Co	Nuevo uso de compuestos de pirazolopiridina.
WO1997040047A1 (en) *	1996-04-25	1997-10-30	Fujisawa Pharmaceutical Co., Ltd.	Preventives and remedies for ischemic intestinal lesion and ileus
AUPO111096A0 (en) *	1996-07-18	1996-08-08	Fujisawa Pharmaceutical Co., Ltd.	New compound
WO1998041237A1 (en) *	1997-03-18	1998-09-24	Fujisawa Pharmaceutical Co., Ltd.	Preventives and remedies for hyperphosphatemia
NZ500590A (en)	1997-04-22	2001-11-30	Cocensys Inc	Carbocyclic and heterocyclic substituted semicarbazones and thiosemicarbazones and the use thereof
EP1568690A1 (de) *	1997-04-22	2005-08-31	Euro-Celtique S.A.	Durch carbozyklische und heterozyklische substituierte Semicarbazone und Thiosemicarbazone und ihre Anwendung als Natriumkanalblocker
DK1032575T3 (da)	1997-09-05	2003-10-20	Glaxo Group Ltd	2,3-diaryl-pyrazol(1,5-b)pyridazinderivater, deres fremstilling og anvendelse som cyclooxygenase 2 (COX-2) inhibitor
AUPP672198A0 (en) *	1998-10-23	1998-11-19	Fujisawa Pharmaceutical Co., Ltd.	Pyrazolopyridine compound and pharmaceutical use thereof
US7223772B1 (en)	1998-11-03	2007-05-29	Smithkline Beecham Corporation	Pyrazolopyridine derivatives as selective cox-2 inhibitors
ATE261444T1 (de)	1999-02-27	2004-03-15	Glaxo Group Ltd	Pyrazolopyridine
US20040152659A1 (en) *	1999-05-12	2004-08-05	Fujisawa Pharmaceutical Co. Ltd.	Method for the treatment of parkinson's disease comprising administering an A1A2a receptor dual antagonist
FR2801308B1 (fr)	1999-11-19	2003-05-09	Oreal	COMPOSITIONS DE TEINTURE DE FIBRES KERATINIQUES CONTENANT DE DES 3-AMINO PYRAZOLO-[1,(-a]-PYRIDINES, PROCEDE DE TEINTURE, NOUVELLES 3-AMINO PYRAZOLO-[1,5-a]-PYRIDINES
GB9930358D0 (en)	1999-12-22	2000-02-09	Glaxo Group Ltd	Process for the preparation of chemical compounds
PE20020506A1 (es) *	2000-08-22	2002-07-09	Glaxo Group Ltd	Derivados de pirazol fusionados como inhibidores de la proteina cinasa
AUPQ969800A0 (en) *	2000-08-28	2000-09-21	Fujisawa Pharmaceutical Co., Ltd.	Pyrazolopyridine compound and pharmaceutical use thereof
ATE301653T1 (de) *	2000-12-15	2005-08-15	Glaxo Group Ltd	Pyrazolopyridine
JP2004515550A (ja) *	2000-12-15	2004-05-27	グラクソグループリミテッド	治療用化合物
TWI312347B (en)	2001-02-08	2009-07-21	Eisai R&D Man Co Ltd	Bicyclic nitrogen-containing condensed ring compounds
WO2002072581A2 (en) *	2001-03-08	2002-09-19	Smithkline Beecham Corporation	Pyrazolopyriadine derivatives
WO2002078701A1 (en) *	2001-03-30	2002-10-10	Smithkline Beecham Corporation	Use of pyrazolopyridines as therapeutic compounds
WO2002078700A1 (en) *	2001-03-30	2002-10-10	Smithkline Beecham Corporation	Pyralopyridines, process for their preparation and use as therapteutic compounds
ES2266487T3 (es) *	2001-04-10	2007-03-01	Smithkline Beecham Corporation	Compuestos de pirazolopirina antivirales.
ATE296826T1 (de) *	2001-04-27	2005-06-15	Smithkline Beecham Corp	Pyrazolo(1,5)pyridinderivate
HUP0401292A3 (en) *	2001-04-27	2011-01-28	Eisai R & D Man Co	Pyrazolo[1,5-a]pyridines, pharmaceutical compositions containing the same and process for preparation thereof
US6756498B2 (en)	2001-04-27	2004-06-29	Smithkline Beecham Corporation	Process for the preparation of chemical compounds
AUPR548601A0 (en) *	2001-06-06	2001-06-28	Fujisawa Pharmaceutical Co., Ltd.	Pyrazolopyrazinecompound and pharmaceutical use thereof
ATE337316T1 (de) *	2001-06-21	2006-09-15	Smithkline Beecham Corp	Imidazo 1,2-aöpyridin-derivate zur prophylaxe und behandlung von herpes-infektionen
US20040214834A1 (en) *	2001-09-07	2004-10-28	Kristjan Gudmunsson	Pyrazolo-pyridines for the treatment of herpes infections
EP1432712B1 (de) *	2001-10-05	2006-05-17	SmithKline Beecham Corporation	Imidazopyridinderivate zur verwendung bei der behandlung von herpes-vireninfektion
JP2005516916A (ja) *	2001-12-11	2005-06-09	スミスクラインビーチャムコーポレーション	抗ヘルペス薬としてのピラゾロ−ピリジン誘導体
US20040021778A1 (en) *	2002-08-05	2004-02-05	Oldani Jerome L.	Security system with remote access and control
JP2006504728A (ja) *	2002-10-03	2006-02-09	スミスクラインビーチャムコーポレーション	ピラソロピリジン誘導体系治療用化合物
US7176216B2 (en) *	2002-10-22	2007-02-13	Eisai Co., Ltd.	7-phenylpyrazolopyridine compounds
TWI283679B (en) *	2002-10-22	2007-07-11	Eisai Co Ltd	7-phenylpyrazolopyridine compounds
TW200517114A (en)	2003-10-15	2005-06-01	Combinatorx Inc	Methods and reagents for the treatment of immunoinflammatory disorders
DE602004031356D1 (de)	2003-11-21	2011-03-24	Zalicus Inc	Verfahren und reagenzien zur behandlung von entzündlichen erkrankungen
JP2009514969A (ja)	2005-11-09	2009-04-09	コンビナトアールエックスインコーポレーティッド	医学的状態を治療するための方法、組成物、およびキット
RU2008152776A (ru) *	2006-06-06	2010-07-20	Эвиджен Инк. (Us)	СОЕДИНЕНИЯ ЗАМЕЩЕННОГО ПИРАЗОЛО[1,5-a]ПИРИДИНА И СПОСОБЫ ИХ ПРИМЕНЕНИЯ
EP1939180A1 (de) *	2006-12-20	2008-07-02	sanofi-aventis	Heteroarylacrylamide und ihre Verwendung als Arzneimittel für die Stimulation der Expression der endothelialen NO-Synthase
US7536799B2 (en) *	2007-06-07	2009-05-26	Keson Industries	Chalk line apparatus with strategically located chalk fill opening
EP2266990B1 (de) *	2008-04-15	2012-09-26	Eisai R&D Management Co., Ltd.	3-PHENYLPYRAZOL[5,1-b]THIAZOL-VERBINDUNG
US20100092479A1 (en) *	2008-08-18	2010-04-15	Combinatorx (Singapore) Pte. Ltd.	Compositions and methods for treatment of viral diseases
EP2177218A1 (de)	2008-10-15	2010-04-21	Medizinische Universität Wien	Regenerative Therapie
AR078521A1 (es) *	2009-10-08	2011-11-16	Eisai R&D Man Co Ltd	Compuesto pirazolotiazol
EP2487177A1 (de) *	2009-10-08	2012-08-15	Eisai R&D Management Co., Ltd.	Pyrazoloxazolverbindung
EP2855489B1 (de)	2012-04-26	2017-01-04	Bristol-Myers Squibb Company	Imidazothiadiazol- und imidazopyridazinderivate als proteaseaktivierte rezeptor 4 (par4)-inhibitoren zur behandlung von thrombozytenaggregation
SI2841437T1 (sl)	2012-04-26	2017-09-29	Bristol-Myers Squibb Company	Derivati imidazotiadiazola in imidazopirazina kot proteazno aktivirani receptor 4 (PAR4) inhibitorji za zdravljenje agregacije trombocitov
SG11201406759YA (en)	2012-04-26	2014-11-27	Bristol Myers Squibb Co	Imidazothiadiazole derivatives as protease activated receptor 4 (par4) inhibitors for treating platelet aggregation
US9617279B1 (en)	2014-06-24	2017-04-11	Bristol-Myers Squibb Company	Imidazooxadiazole compounds
US9598419B1 (en)	2014-06-24	2017-03-21	Universite De Montreal	Imidazotriazine and imidazodiazine compounds
AU2020288559C1 (en) *	2019-06-04	2025-07-24	Hager Biosciences, Llc	Pyrazole and imidazole derivatives, compositions and methods as orexin antagonists
US11970499B1 (en)	2023-12-22	2024-04-30	King Faisal University	Pyrazolo[1,5-c]pyrimidine compounds as CK2 inhibitors

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS5229318B2 (de) *	1972-03-30	1977-08-01
US4017597A (en) *	1974-10-30	1977-04-12	Monsanto Company	Unitized solid phase immunoassay kit and method
US4097483A (en) *	1974-11-01	1978-06-27	Kyorin Pharmaceutical Co., Ltd.	Pyrazolo 1,5-a!pyridines
JPS5154583A (en) *	1974-11-01	1976-05-13	Kyorin Seiyaku Kk	Shinkipirazoro * 1 55a * pirijinjudotaino seizoho
NZ204589A (en) *	1982-06-16	1985-12-13	May & Baker Ltd	3-(n,n-dimethylcarbamoyl)-pyrazolo(1,5-a)pyridine and pharmaceutical compositions
JPS60248689A (ja) *	1984-05-24	1985-12-09	Mitsubishi Paper Mills Ltd	３−（３′−ピラゾロ〔１，５−ａ〕ピリジル）アクロレイン誘導体
US4925849A (en) *	1987-06-15	1990-05-15	Fujisawa Pharmaceutical Company, Ltd.	Pharmaceutically useful pyrazolopyridines

1988
- 1988-06-06 US US07/202,526 patent/US4925849A/en not_active Expired - Fee Related
- 1988-06-09 IL IL86674A patent/IL86674A0/xx unknown
- 1988-06-09 PT PT87700A patent/PT87700B/pt not_active IP Right Cessation
- 1988-06-10 AU AU17602/88A patent/AU615913B2/en not_active Ceased
- 1988-06-11 DE DE3854454T patent/DE3854454T2/de not_active Expired - Fee Related
- 1988-06-11 AT AT88109331T patent/ATE127801T1/de not_active IP Right Cessation
- 1988-06-11 ES ES88109331T patent/ES2076935T3/es not_active Expired - Lifetime
- 1988-06-11 EP EP88109331A patent/EP0299209B1/de not_active Expired - Lifetime
- 1988-06-13 FI FI882813A patent/FI882813A7/fi not_active Application Discontinuation
- 1988-06-14 JP JP63146080A patent/JP2674099B2/ja not_active Expired - Lifetime
- 1988-06-14 DK DK323688A patent/DK323688A/da not_active Application Discontinuation
- 1988-06-14 KR KR1019880007185A patent/KR890000483A/ko not_active Ceased
- 1988-06-14 HU HU883046A patent/HU200180B/hu not_active IP Right Cessation
- 1988-06-14 CN CN88104322A patent/CN1031376A/zh active Pending
- 1988-06-14 NO NO882608A patent/NO168585C/no unknown
1989
- 1989-09-15 US US07/407,747 patent/US4994453A/en not_active Expired - Fee Related
1990
- 1990-03-12 US US07/492,486 patent/US5087629A/en not_active Expired - Fee Related
- 1990-03-19 US US07/495,799 patent/US5102878A/en not_active Expired - Fee Related
- 1990-06-19 US US07/540,325 patent/US5102869A/en not_active Expired - Fee Related
1992
- 1992-10-30 US US07/968,664 patent/US5296490A/en not_active Expired - Fee Related
1995
- 1995-10-25 GR GR950402954T patent/GR3017850T3/el unknown

Also Published As

Publication number	Publication date
US5296490A (en)	1994-03-22
DK323688A (da)	1988-12-16
US5102869A (en)	1992-04-07
FI882813A0 (fi)	1988-06-13
EP0299209A3 (en)	1990-05-09
DE3854454T2 (de)	1996-02-15
HUT47110A (en)	1989-01-30
CN1031376A (zh)	1989-03-01
NO168585C (no)	1992-03-11
NO882608L (no)	1988-12-16
GR3017850T3 (en)	1996-01-31
JP2674099B2 (ja)	1997-11-05
DE3854454D1 (de)	1995-10-19
AU615913B2 (en)	1991-10-17
DK323688D0 (da)	1988-06-14
EP0299209B1 (de)	1995-09-13
HU200180B (en)	1990-04-28
NO882608D0 (no)	1988-06-14
ES2076935T3 (es)	1995-11-16
KR890000483A (ko)	1989-03-14
PT87700B (pt)	1992-10-30
US5087629A (en)	1992-02-11
EP0299209A2 (de)	1989-01-18
AU1760288A (en)	1988-12-15
IL86674A0 (en)	1988-11-30
US4994453A (en)	1991-02-19
JPS6445385A (en)	1989-02-17
FI882813A7 (fi)	1988-12-16
US5102878A (en)	1992-04-07
US4925849A (en)	1990-05-15
PT87700A (pt)	1988-07-01
NO168585B (no)	1991-12-02

Legal Events

Date	Code	Title	Description
1996-04-15	UEP	Publication of translation of european patent specification
2000-03-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
ATE127801T1 (de)	1995-09-15	Pyrazolopyridinverbindungen und verfahren zu ihrer herstellung.
ATE150462T1 (de)	1997-04-15	Pyrazolopyridinverbindungen und verfahren zu ihrer herstellung
ATE172731T1 (de)	1998-11-15	Pyrazolopyridinverbindung und verfahren zu ihrer herstellung
ATE133667T1 (de)	1996-02-15	Thiazolderivate, verfahren zur ihrer herstellung und pharmazeutische zusammensetzungen, die sie enthalten
MX9804107A (es)	1998-09-30	Derivados de quinolina.
DE3677798D1 (de)	1991-04-11	Aminosaeurederivate und deren verfahren zur herstellung.
ATE48001T1 (de)	1989-12-15	Cephemverbindungen, verfahren zu ihrer herstellung und ihre pharmazeutischen praeparate.
ATE141606T1 (de)	1996-09-15	Cephemverbindungen und verfahren zu ihrer herstellung
DE3686979D1 (de)	1992-11-26	Cephemverbindungen und verfahren zu ihrer herstellung.
PT87277A (pt)	1988-05-01	Process for the preparation of new bicyclic compounds and pharmaceutical compositions comprising same
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