ATE129637T1 - Verwendung von dibenzo(b,f>(1,4>oxazepin (und thiazepin)-11(10h)-one und -thione zur herstellung eines arzneimittels zur prävention und behandlung von aids. - Google Patents

Verwendung von dibenzo(b,f>(1,4>oxazepin (und thiazepin)-11(10h)-one und -thione zur herstellung eines arzneimittels zur prävention und behandlung von aids.

Info

Publication number
ATE129637T1
ATE129637T1 AT90116339T AT90116339T ATE129637T1 AT E129637 T1 ATE129637 T1 AT E129637T1 AT 90116339 T AT90116339 T AT 90116339T AT 90116339 T AT90116339 T AT 90116339T AT E129637 T1 ATE129637 T1 AT E129637T1
Authority
AT
Austria
Prior art keywords
aids
prevention
treatment
thiazepine
oxazepine
Prior art date
Application number
AT90116339T
Other languages
English (en)
Inventor
Karl D Dr Hargrave
Guenther Dr Schmidt
Wolfhard Dr Engel
Kurt Dr Schromm
Original Assignee
Boehringer Ingelheim Pharma
Thomae Gmbh Dr K
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Pharma, Thomae Gmbh Dr K filed Critical Boehringer Ingelheim Pharma
Application granted granted Critical
Publication of ATE129637T1 publication Critical patent/ATE129637T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D281/02—Seven-membered rings
    • C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
    • C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D281/12—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with two six-membered rings
    • C07D281/16—[b, f]-condensed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D267/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D267/02—Seven-membered rings
    • C07D267/08—Seven-membered rings having the hetero atoms in positions 1 and 4
    • C07D267/12—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D267/16—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with two six-membered rings
    • C07D267/20—[b, f]-condensed

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
AT90116339T 1989-08-29 1990-08-27 Verwendung von dibenzo(b,f>(1,4>oxazepin (und thiazepin)-11(10h)-one und -thione zur herstellung eines arzneimittels zur prävention und behandlung von aids. ATE129637T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US40025489A 1989-08-29 1989-08-29

Publications (1)

Publication Number Publication Date
ATE129637T1 true ATE129637T1 (de) 1995-11-15

Family

ID=23582850

Family Applications (1)

Application Number Title Priority Date Filing Date
AT90116339T ATE129637T1 (de) 1989-08-29 1990-08-27 Verwendung von dibenzo(b,f>(1,4>oxazepin (und thiazepin)-11(10h)-one und -thione zur herstellung eines arzneimittels zur prävention und behandlung von aids.

Country Status (13)

Country Link
US (1) US5571806A (de)
EP (1) EP0419861B1 (de)
JP (1) JP2862980B2 (de)
KR (1) KR0165108B1 (de)
AT (1) ATE129637T1 (de)
AU (1) AU639255B2 (de)
CA (1) CA2024040C (de)
DE (1) DE69023311T2 (de)
DK (1) DK0419861T3 (de)
GR (1) GR3018757T3 (de)
HU (1) HU211077B (de)
NZ (1) NZ235082A (de)
ZA (1) ZA906834B (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9109557D0 (en) * 1991-05-02 1991-06-26 Wellcome Found Chemical compounds
GB9109497D0 (en) * 1991-05-02 1991-06-26 Wellcome Found Chemical compounds
DE4122240A1 (de) * 1991-07-05 1993-01-07 Boehringer Mannheim Gmbh Dibenz(b,e)azepinderivate und diese enthaltende arzneimittel
DE4138853A1 (de) * 1991-11-27 1993-06-03 Bayer Ag 5,6-dihydro-dibenz(b,e)azepin-6,11-dion-11- oxime
DE4138908A1 (de) * 1991-11-27 1993-06-03 Bayer Ag 6-thiono-dibenz(b,e)azepine
JP2001514253A (ja) * 1997-09-04 2001-09-11 スミスクライン・ビーチャム・コーポレイション インテグリンレセプターアンタゴニスト
WO2000000678A1 (en) * 1998-06-26 2000-01-06 University Of Washington Crystallization media
US7015212B1 (en) 1999-05-12 2006-03-21 The United States Of America As Represented By The Department Of Health And Human Services Thiazepine inhibitors of HIV-1 integrase
FI3324948T3 (fi) * 2015-07-17 2023-05-05 Be Pharbel Mfg Monikerroksisia farmaseuttisesti aktiivista yhdistettä vapauttavia mikropartikkeleita nestemäisessä annosmuodossa
US11649218B2 (en) 2018-03-09 2023-05-16 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services C-Abl tyrosine kinase inhibitory compound embodiments and methods of making and using the same
KR102276547B1 (ko) * 2020-09-04 2021-07-13 주식회사유한양행 오메프라졸, 에스오메프라졸 또는 이의 약제학적으로 허용가능한 염을 포함하는 정제 형태의 약학 조성물 및 이의 제조방법

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1060786A (en) * 1963-10-09 1967-03-08 Wander Ag Dr A Process for the preparation of lactams
NL127795C (de) * 1966-01-28
US3546214A (en) * 1967-07-11 1970-12-08 Boehringer Sohn Ingelheim Amino-substituted dibenz(b,f)(1,4)oxazepin-11(10h)-ones
US3541085A (en) * 1969-05-09 1970-11-17 American Cyanamid Co Method of preparing thiotricyclic compounds
JPS572278A (en) * 1980-06-04 1982-01-07 Chugai Pharmaceut Co Ltd Dibenzoxazepin derivative
JPS57106673A (en) * 1980-12-24 1982-07-02 Chugai Pharmaceut Co Ltd Dibenzo(b,f)(1,4)oxazepin derivative
US4663317A (en) * 1984-04-18 1987-05-05 Board Of Regents, University Of Texas System Methods and compositions for treating viral infections
US4728735A (en) * 1984-10-15 1988-03-01 Merck & Co., Inc. 10,11-dihydro-dibenzo-[b,f][1,4]-thiazepin derivatives
DE3705117A1 (de) * 1987-02-18 1988-09-01 Goedecke Ag Verwendung von benzothiazepin-derivaten, insbesondere diltiazem bei der protektion von lymphozyten

Also Published As

Publication number Publication date
AU6191690A (en) 1991-03-07
KR910004579A (ko) 1991-03-29
ZA906834B (en) 1992-05-27
EP0419861A3 (en) 1992-06-10
DE69023311D1 (de) 1995-12-07
DE69023311T2 (de) 1996-04-25
AU639255B2 (en) 1993-07-22
GR3018757T3 (en) 1996-04-30
JP2862980B2 (ja) 1999-03-03
KR0165108B1 (ko) 1999-02-18
CA2024040A1 (en) 1991-03-01
EP0419861A2 (de) 1991-04-03
HU905511D0 (en) 1991-02-28
US5571806A (en) 1996-11-05
EP0419861B1 (de) 1995-11-02
HU211077B (en) 1995-10-30
CA2024040C (en) 2002-02-19
JPH03163021A (ja) 1991-07-15
NZ235082A (en) 1997-04-24
HUT57589A (en) 1991-12-30
DK0419861T3 (da) 1996-03-04

Similar Documents

Publication Publication Date Title
ATE129637T1 (de) Verwendung von dibenzo(b,f>(1,4>oxazepin (und thiazepin)-11(10h)-one und -thione zur herstellung eines arzneimittels zur prävention und behandlung von aids.
SE9202911D0 (sv) Fixture provided with micro-threads
LU91446I2 (fr) "Efavirenz/emtricitabine/fumarate de ténolovir disoproxil"
DE69900207D1 (de) Verwendung von 11-(3-dimethylaminopropyliden)-6,11-dihydrodibenz[b,e]oxepin-2-essigsäure und deren pharmazeutisch annehmbaren salzen zur herstellung eines medikaments zur behandlung nicht-allergisch-bedingten augenentzündungen und zur prevention der okularen neovaskularisation
ATE126231T1 (de) Pyrido(2,3-f)(1,4)thiazepine und pyrido(3,2- b)(1,5)benzothiazepine.
LT99016A (en) Use of 2-phenyl-1,2-benzisoselenazol-3(2h)-one for producing a pharmaceutical preparation intended for treatment of the alzheimer's disease
ES2023774A6 (es) Procedimiento para la preparacion del intermedio de diltiazem.
FR2720930B1 (fr) Insert d'implant cotyloïdien, réalisé en une matière synthétique biocompatible et radiotransparente.
EP0420264A3 (en) Transdermal delivery of (+)(2s,3s)-3-acetoxy-8-chloro-5-(2-dimethyl-aminoethyl)-2,3-dihydro-2-(4-methoxyphenyl)-1,5-benzothiazepin-4-(5h)-one
GR3015469T3 (en) 5,11-dihydro-6H-pyrido[2,3,-b][1,4]benzodiazepin-6-ones and -thiones and their use in the prevention or treatment of AIDS.
DE69024136D1 (de) Pyrido[2,3-b][1,5]-Benzoxazepin (und -Thiazepin)-5(6H)-one und -thione und ihre Verwendung zur Vorbeugung und Behandlung von HIV-Infektion
DE3781456D1 (de) Pharmazeutische zusammensetzung, die eine 8-chlor-benzothiazepin-verbindung enthaelt und ihre verwendung.
IL102137A0 (en) Benzodioxan derivatives
IL49996A (en) Solution of a solubilized and stabilized 2-chloro-11-(4-methyl-1-piperazinyl)dibenz(b,f)(1,4)oxazepine for oral or parenteral adminstration
EP0415304A3 (en) Dipyrido(3,2-b:2',3'-e)(1,4)oxazepin (and thiazepin)-6(5h)-ones and -thiones and their use in the prevention or treatment of aids
HUT61988A (en) New process for producing 1,5-benzothiazepine derivatives
BE1003313A3 (fr) Procede de purification de produits intermediaires pour la preparation du diltiazem.
ES2153738A1 (es) Pieza para implantes dentales.

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee