ATE129714T1 - Heterocyclische biphosphonsäurederivate. - Google Patents

Heterocyclische biphosphonsäurederivate.

Info

Publication number: ATE129714T1
Authority: AT; Austria
Prior art keywords: chem; hydrogen atom; acid derivatives; hydroxyl group; biphosphoic
Prior art date: 1988-08-12

Application number

AT89308180T

Other languages

English (en)

Inventor

Yasuo Isomura

Makoto Takeuchi

Tetsushi Abe

Original Assignee

Yamanouchi Pharma Co Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-08-12

Filing date

1989-08-11

Publication date

1995-11-15

1989-08-11 Application filed by Yamanouchi Pharma Co Ltd filed Critical Yamanouchi Pharma Co Ltd

1995-11-15 Application granted granted Critical

1995-11-15 Publication of ATE129714T1 publication Critical patent/ATE129714T1/de

Links

239000002253 acid Substances 0.000 title abstract 2
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 3
125000000217 alkyl group Chemical group 0.000 abstract 2
229940078581 Bone resorption inhibitor Drugs 0.000 abstract 1
239000004480 active ingredient Substances 0.000 abstract 1
125000004429 atom Chemical group 0.000 abstract 1
239000002617 bone density conservation agent Substances 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000005843 halogen group Chemical group 0.000 abstract 1
125000000623 heterocyclic group Chemical group 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Biochemistry (AREA)
General Health & Medical Sciences (AREA)
Molecular Biology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Detergent Compositions (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Adhesives Or Adhesive Processes (AREA)

AT89308180T 1988-08-12 1989-08-11 Heterocyclische biphosphonsäurederivate. ATE129714T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
JP20153588		1988-08-12
JP20153688		1988-08-12

Publications (1)

Publication Number	Publication Date
ATE129714T1 true ATE129714T1 (de)	1995-11-15

Family

ID=26512843

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT89308180T ATE129714T1 (de)	1988-08-12	1989-08-11	Heterocyclische biphosphonsäurederivate.

Country Status (14)

Country	Link
US (2)	US4990503A (de)
EP (1)	EP0354806B1 (de)
KR (1)	KR0156239B1 (de)
CN (1)	CN1027167C (de)
AT (1)	ATE129714T1 (de)
AU (1)	AU624405B2 (de)
CA (1)	CA1332058C (de)
DE (1)	DE68924681T2 (de)
DK (1)	DK170257B1 (de)
ES (1)	ES2082780T3 (de)
GR (1)	GR3018086T3 (de)
HU (2)	HU205766B (de)
IE (1)	IE71185B1 (de)
PH (1)	PH26376A (de)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0521622B1 (de) *	1991-07-03	1997-08-13	PHARMACIA & UPJOHN COMPANY	Pyrazolopyrimiden- und Pyrimidinylbisphosphonsäureester als entzündungshemmende Mittel
TW222637B (de) *	1991-12-12	1994-04-21	Hoechst Ag
US5270365A (en) *	1991-12-17	1993-12-14	Merck & Co., Inc.	Prevention and treatment of periodontal disease with alendronate
JPH05345791A (ja) *	1992-03-18	1993-12-27	Hoechst Japan Ltd	環状アミノメチレンビスホスホン酸誘導体
WO1994000462A1 (fr) *	1992-06-23	1994-01-06	Yamanouchi Pharmaceutical Co., Ltd.	Nouveau cristal de monohydrate de derive de bis(acide phosphonique) heterocyclique
EP0663919A1 (de) *	1992-10-09	1995-07-26	PHARMACIA & UPJOHN COMPANY	Pyrimidin bisphosphonsäureestern als anti-inflammatorisches mittel
ES2129485T3 (es) *	1992-12-02	1999-06-16	Hoechst Ag	Derivados de acidos guanidinoalquil-1,1-bisfosfonicos, procedimiento para su preparacion y su utilizacion.
JPH06298779A (ja) *	1993-04-15	1994-10-25	Hoechst Japan Ltd	ヘテロ環イミノビスメチレンビスホスホン酸誘導体
US5728650A (en) *	1993-10-07	1998-03-17	Zeneca Limited	Herbicidal aza bisphosphonic acids and compositions containing the same
US5854227A (en) *	1994-03-04	1998-12-29	Hartmann; John F.	Therapeutic derivatives of diphosphonates
US5880111A (en) *	1995-06-07	1999-03-09	Farcasiu; Dan	Therapeutic derivations of diphosphonates
WO1998039344A1 (en)	1997-03-07	1998-09-11	Metabasis Therapeutics, Inc.	Novel purine inhibitors of fructose-1,6-bisphosphatase
AU6691798A (en) *	1997-03-07	1998-09-22	Metabasis Therapeutics, Inc.	Novel indole and azaindole inhibitors of fructose-1,6-bisphosphatase
US7008645B2 (en) *	1998-07-14	2006-03-07	Yissum Research Development Company Of The Hebrew University Of Jerusalem	Method of inhibiting restenosis using bisphosphonates
JP3219402B2 (ja)	1998-12-25	2001-10-15	山之内製薬株式会社	多発性骨髄腫の骨病変治療用医薬組成物
US20030036537A1 (en) *	2001-07-16	2003-02-20	Marc Lecouvey	Bisphosphonate derivatives, their preparations and uses
ES2530791T3 (es)	2002-12-20	2015-03-05	Hoffmann La Roche	Formulación de ibandronato de altas dosis
HUP0300227A2 (hu) *	2003-01-28	2004-09-28	Richter Gedeon Vegyészeti Gyár Rt.	Eljárás nagy tisztaságú 2-szubsztituált -1-(hidroxi-etilidén)-1,1-biszfoszfonsavak és sóik előállítására
US20060051407A1 (en) *	2003-06-27	2006-03-09	Yoram Richter	Method of treating ischemia-reperfusion injury
US10517883B2 (en)	2003-06-27	2019-12-31	Zuli Holdings Ltd.	Method of treating acute myocardial infarction
EP1709968A1 (de) *	2004-01-30	2006-10-11	Astellas Pharma Inc.	P2x rezeptor-hemmer
CN101531681B (zh) *	2008-03-10	2013-06-05	北京德众万全医药科技有限公司	一种高纯度的米诺膦酸及其制备方法
WO2010033980A2 (en) *	2008-09-22	2010-03-25	Isis Innovation Ltd.	4-azaindole bisphosphonates
KR20110079813A (ko) *	2008-09-22	2011-07-08	아이시스 이노베이션 리미티드	이미다조〔1,2－α〕피리디닐 비스포스포네이트
CA2778015C (en)	2009-10-26	2016-08-02	Warner Chilcott Company, Llc	Bisphosphonate compounds for treating bone metabolism disorders
CN101973993A (zh) *	2010-11-05	2011-02-16	天津药物研究院	一种制备2-[咪唑并(1,2-a)吡啶-3-基]乙酸的方法
CN102153585B (zh) *	2011-02-24	2013-04-17	北京欧克兰医药技术开发中心	一种米诺膦酸中间体的合成方法及米诺膦酸的合成
CN102268042B (zh) *	2011-06-01	2014-06-25	广东宏远集团药业有限公司	一种米诺膦酸晶型ii及其制备方法
US9993427B2 (en)	2013-03-14	2018-06-12	Biorest Ltd.	Liposome formulation and manufacture
CN107033187A (zh) *	2017-04-28	2017-08-11	江苏笃诚医药科技股份有限公司	一种米诺膦酸的制备方法
KR20220115062A (ko)	2021-02-09	2022-08-17	(주)오스티오뉴로젠	크로몬 구조의 화합물을 포함하는 골다공증의 예방 및 치료용 약학적 조성물

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3203308A1 (de) *	1982-01-27	1983-07-28	Schering Ag, 1000 Berlin Und 4619 Bergkamen	Diphosphonsaeure-derivate und diese enthaltende pharmazeutische praeparate
DE3428524A1 (de) *	1984-08-02	1986-02-13	Boehringer Mannheim Gmbh, 6800 Mannheim	Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel
DE3626058A1 (de) *	1986-08-01	1988-02-11	Boehringer Mannheim Gmbh	Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel
EP0272208B1 (de) *	1986-11-21	1991-06-12	Ciba-Geigy Ag	Aromatisch substituierte Azacyclo-alkylalkandiphosphonsäuren
DE3640938A1 (de) *	1986-11-29	1988-06-01	Boehringer Mannheim Gmbh	Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindung enthaltende arzneimittel
EP0317505A1 (de) *	1987-11-13	1989-05-24	Ciba-Geigy Ag	Neue Azacycloalkylalkandiphosphonsäuren

1989
- 1989-08-07 US US07/390,090 patent/US4990503A/en not_active Expired - Lifetime
- 1989-08-08 AU AU39419/89A patent/AU624405B2/en not_active Ceased
- 1989-08-09 CA CA000607874A patent/CA1332058C/en not_active Expired - Fee Related
- 1989-08-11 AT AT89308180T patent/ATE129714T1/de not_active IP Right Cessation
- 1989-08-11 DK DK394789A patent/DK170257B1/da not_active IP Right Cessation
- 1989-08-11 HU HU894150A patent/HU205766B/hu unknown
- 1989-08-11 DE DE68924681T patent/DE68924681T2/de not_active Expired - Fee Related
- 1989-08-11 IE IE260189A patent/IE71185B1/en not_active IP Right Cessation
- 1989-08-11 ES ES89308180T patent/ES2082780T3/es not_active Expired - Lifetime
- 1989-08-11 PH PH39086A patent/PH26376A/en unknown
- 1989-08-11 EP EP89308180A patent/EP0354806B1/de not_active Expired - Lifetime
- 1989-08-11 KR KR1019890011432A patent/KR0156239B1/ko not_active Expired - Fee Related
- 1989-08-12 CN CN89106373A patent/CN1027167C/zh not_active Expired - Fee Related
1990
- 1990-08-10 US US07/566,145 patent/US5039669A/en not_active Expired - Fee Related
1995
- 1995-06-30 HU HU95P/P00618P patent/HU211949A9/hu unknown
- 1995-11-15 GR GR950403204T patent/GR3018086T3/el unknown

Also Published As

Publication number	Publication date
IE892601L (en)	1990-02-12
US4990503A (en)	1991-02-05
CA1332058C (en)	1994-09-20
ES2082780T3 (es)	1996-04-01
EP0354806B1 (de)	1995-11-02
PH26376A (en)	1992-06-01
DK170257B1 (da)	1995-07-17
EP0354806A2 (de)	1990-02-14
IE71185B1 (en)	1997-01-29
CN1040590A (zh)	1990-03-21
DE68924681T2 (de)	1996-04-04
HUT51637A (en)	1990-05-28
KR900003186A (ko)	1990-03-26
KR0156239B1 (ko)	1998-12-01
EP0354806A3 (de)	1991-05-02
AU3941989A (en)	1990-02-15
CN1027167C (zh)	1994-12-28
US5039669A (en)	1991-08-13
DK394789A (da)	1990-02-13
DK394789D0 (da)	1989-08-11
HU205766B (en)	1992-06-29
AU624405B2 (en)	1992-06-11
GR3018086T3 (en)	1996-02-29
HU211949A9 (en)	1996-01-29
DE68924681D1 (de)	1995-12-07

Legal Events

Date	Code	Title	Description
1996-06-15	UEP	Publication of translation of european patent specification
2009-05-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
AU624405B2 (en)	1992-06-11	Heterocyclic bisphosphonic acid derivatives
FI890689A0 (fi)	1989-02-14	3-alkenyl-1-azabicyklo-/3.2.0/ -hept-2-en-2-karboxylsyrafoereningar.
DK0378255T3 (da)	1994-05-24	2-aminopyrimidinoderivater
ES2055235T3 (es)	1994-08-16	Composicion anti-inflamatoria y/o antialergica que comprende derivados de glutation.
NO893820L (no)	1990-03-28	Fremgangsmaate for fremstilling av pyridoindol-derivater.
DK0420224T3 (da)	1993-04-05	Anthihepatopatisk middel
DK23089D0 (da)	1989-01-19	Thioformamidderivater og deres anvendelse
DE68923231D1 (de)	1995-08-03	Antihypertensive 3-Piperidinylindazol-Derivate.
DE3783821D1 (de)	1993-03-11	Tetracyclische indolderivate.
ATE81466T1 (de)	1992-10-15	Verwendung von 2-oxo-imidazolidin-derivaten zur prophylaxe und zur behandlung von herzinsuffizienz.
EP0420086A3 (en)	1991-11-06	Pyrimidoindole derivatives and processes for preparation thereof