ATE130033T1 - Methode zur erhöhung der produktion von sekundären metaboliten mittels geclusterter biosynthetischer gene. - Google Patents

Methode zur erhöhung der produktion von sekundären metaboliten mittels geclusterter biosynthetischer gene.

Info

Publication number: ATE130033T1
Authority: AT; Austria
Prior art keywords: biosynthetic genes; clustered; increase production; secondary metabolites; antibiotic
Prior art date: 1988-08-11

Application number

AT89202060T

Other languages

English (en)

Inventor

Martinus Antonius Math Groenen

Annemarie Eveline Veenstra

Solingen Pieter Van

Bertus Pieter Koekman

Der Voort Lucia Helena Mar Van

Juan Francisco Martin

Santiago Gutierrez

Bruno Diez

Emilio Alvarez

Jose Luis Barredo

Christina Esmahan

Original Assignee

Gist Brocades Nv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-08-11

Filing date

1989-08-09

Publication date

1995-11-15

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26115259&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE130033(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1989-08-09 Application filed by Gist Brocades Nv filed Critical Gist Brocades Nv

1995-11-15 Application granted granted Critical

1995-11-15 Publication of ATE130033T1 publication Critical patent/ATE130033T1/de

Links

108090000623 proteins and genes Proteins 0.000 title abstract 5
230000001851 biosynthetic effect Effects 0.000 title abstract 4
238000004519 manufacturing process Methods 0.000 title abstract 3
229930000044 secondary metabolite Natural products 0.000 title 1
230000003115 biocidal effect Effects 0.000 abstract 3
229930182555 Penicillin Natural products 0.000 abstract 2
JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 abstract 2
238000002955 isolation Methods 0.000 abstract 2
229940049954 penicillin Drugs 0.000 abstract 2
241000228431 Acremonium chrysogenum Species 0.000 abstract 1
241000228143 Penicillium Species 0.000 abstract 1
230000015572 biosynthetic process Effects 0.000 abstract 1
244000005700 microbiome Species 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/37—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi
- C07K14/375—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi from Basidiomycetes
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1025—Acyltransferases (2.3)
- C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/88—Lyases (4.)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P37/00—Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin

Landscapes

Life Sciences & Earth Sciences (AREA)
Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Genetics & Genomics (AREA)
Engineering & Computer Science (AREA)
Organic Chemistry (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
Bioinformatics & Cheminformatics (AREA)
Biotechnology (AREA)
Biomedical Technology (AREA)
General Engineering & Computer Science (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
General Health & Medical Sciences (AREA)
Microbiology (AREA)
Biophysics (AREA)
Plant Pathology (AREA)
Physics & Mathematics (AREA)
Medicinal Chemistry (AREA)
Mycology (AREA)
Chemical Kinetics & Catalysis (AREA)
Gastroenterology & Hepatology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Crystallography & Structural Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Saccharide Compounds (AREA)
Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
Enzymes And Modification Thereof (AREA)

AT89202060T 1988-08-11 1989-08-09 Methode zur erhöhung der produktion von sekundären metaboliten mittels geclusterter biosynthetischer gene. ATE130033T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP88201714		1988-08-11
EP89201044		1989-04-21

Publications (1)

Publication Number	Publication Date
ATE130033T1 true ATE130033T1 (de)	1995-11-15

Family

ID=26115259

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT89202060T ATE130033T1 (de)	1988-08-11	1989-08-09	Methode zur erhöhung der produktion von sekundären metaboliten mittels geclusterter biosynthetischer gene.

Country Status (15)

Country	Link
US (1)	US5462862A (de)
EP (1)	EP0357119B1 (de)
JP (2)	JP3095391B2 (de)
KR (1)	KR900003364A (de)
AT (1)	ATE130033T1 (de)
AU (1)	AU631806B2 (de)
CA (1)	CA1340916C (de)
DE (1)	DE68924745T2 (de)
DK (1)	DK393089A (de)
ES (1)	ES2081831T3 (de)
FI (1)	FI104264B (de)
GR (1)	GR3018782T3 (de)
HU (1)	HU214244B (de)
IE (1)	IE72167B1 (de)
PT (1)	PT91411B (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6258555B1 (en)	1987-12-09	2001-07-10	Beecham Group P.L.C.	DNA encoding ACV synthetase
EP0444758A1 (de) *	1990-02-28	1991-09-04	Gist-Brocades N.V.	Verfahren zur Modifikation der ACV-Synthetase und Verwendung des modifizierten Enzyms zur Herstellung von beta-Laktam-Antibiotika
US5662898A (en) *	1990-08-20	1997-09-02	Ciba-Geigy Corporation	Genes for the synthesis of antipathogenic substances
US5639949A (en) *	1990-08-20	1997-06-17	Ciba-Geigy Corporation	Genes for the synthesis of antipathogenic substances
US6495348B1 (en) *	1993-10-07	2002-12-17	Regents Of The University Of Minnesota	Mitomycin biosynthetic gene cluster
US6524812B1 (en)	1993-10-07	2003-02-25	Regents Of The University Of Minnesota	Genes encoding resistance to DNA alkylating agents
US6117670A (en) *	1994-06-08	2000-09-12	Novartis Finance Corporation	Pyrrolnitrin biosynthesis genes and uses thereof
US5753458A (en) *	1994-06-10	1998-05-19	Gist-Brocades B.V.	Acylation method for penicillins and cephalosporins
WO1996010084A1 (en) *	1994-09-28	1996-04-04	Novo Nordisk A/S	Process for the production of secondary metabolites
AU4201897A (en) *	1996-07-16	1998-02-09	Gist-Brocades B.V.	Novel process for the preparation of cephalosporins using (acremonium chrysogenum)
US5976836A (en) *	1997-05-07	1999-11-02	Fermalogic, Inc.	Methods and compositions for enhancing erythromycin production
KR20010032246A (ko) *	1997-11-19	2001-04-16	추후제출	키메라형 전구활성화된 전사 인자
EP1026248A3 (de) *	1999-01-29	2002-09-18	RAMOT UNIVERSITY AUTHORITY FOR APPLIED RESEARCH & INDUSTRIAL DEVELOPMENT LTD.	Gencluster
US6284483B1 (en) *	1999-10-06	2001-09-04	Board Of Trustees Operating Michigan State University	Modified synthetases to produce penicillins and cephalosporins under the control of bicarbonate
US6949356B1 (en) *	1999-10-20	2005-09-27	Microbia, Inc.	Methods for improving secondary metabolite production in fungi
US20030194784A1 (en) *	2001-04-17	2003-10-16	Sherman David H.	DNA encoding methymycin and pikromycin
EP2123772A1 (de) *	2008-04-29	2009-11-25	DSM IP Assets B.V.	Beta-Lactamantibiotikum produzierende Stämme
CN109804061A (zh) *	2016-10-07	2019-05-24	出光兴产株式会社	产芽孢细菌的培养方法和有用物质的制造方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4892819A (en) *	1985-11-25	1990-01-09	Eli Lilly And Company	Recombinant DNA expression vectors and DNA compounds that encode isopenicillin N synthetase from penicillium chrysogenum
ATE100147T1 (de) *	1986-09-16	1994-01-15	Gist Brocades Nv	Penicilliumtransformanten und verfahren zu ihrer herstellung.
US4950603A (en) *	1987-11-02	1990-08-21	Eli Lilly And Company	Recombinant DNA expression vectors and DNA compounds that encode isopenicillin N synthetase from Streptomyces lipmanii
GB8728811D0 (en) *	1987-12-09	1988-01-27	Beecham Group Plc	Novel substance
US5108918A (en) *	1988-08-11	1992-04-28	Gist-Brocades	Method for identifying and using biosynthetic genes for enhanced production of secondary metabolites

1989
- 1989-08-07 FI FI893722A patent/FI104264B/fi not_active IP Right Cessation
- 1989-08-09 DE DE68924745T patent/DE68924745T2/de not_active Revoked
- 1989-08-09 EP EP89202060A patent/EP0357119B1/de not_active Revoked
- 1989-08-09 ES ES89202060T patent/ES2081831T3/es not_active Expired - Lifetime
- 1989-08-09 PT PT91411A patent/PT91411B/pt not_active IP Right Cessation
- 1989-08-09 AT AT89202060T patent/ATE130033T1/de not_active IP Right Cessation
- 1989-08-10 IE IE257289A patent/IE72167B1/en not_active IP Right Cessation
- 1989-08-10 DK DK393089A patent/DK393089A/da not_active Application Discontinuation
- 1989-08-10 HU HU894104A patent/HU214244B/hu not_active IP Right Cessation
- 1989-08-10 CA CA000608022A patent/CA1340916C/en not_active Expired - Fee Related
- 1989-08-11 JP JP01209493A patent/JP3095391B2/ja not_active Expired - Fee Related
- 1989-08-11 KR KR1019890011451A patent/KR900003364A/ko not_active Ceased
- 1989-08-11 AU AU39569/89A patent/AU631806B2/en not_active Ceased
1993
- 1993-01-25 US US08/008,688 patent/US5462862A/en not_active Expired - Fee Related
1996
- 1996-01-24 GR GR960400181T patent/GR3018782T3/el unknown
2000
- 2000-05-11 JP JP2000138900A patent/JP2000342289A/ja active Pending

Also Published As

Publication number	Publication date
FI104264B1 (fi)	1999-12-15
HUT51335A (en)	1990-04-28
CA1340916C (en)	2000-02-29
US5462862A (en)	1995-10-31
EP0357119A3 (en)	1990-04-04
JP3095391B2 (ja)	2000-10-03
ES2081831T3 (es)	1996-03-16
JP2000342289A (ja)	2000-12-12
GR3018782T3 (en)	1996-04-30
KR900003364A (ko)	1990-03-26
AU3956989A (en)	1990-02-15
DE68924745D1 (de)	1995-12-14
IE892572L (en)	1990-02-11
DK393089A (da)	1990-02-12
FI104264B (fi)	1999-12-15
FI893722A0 (fi)	1989-08-07
PT91411A (pt)	1990-03-08
HU214244B (hu)	1998-03-02
JPH02150284A (ja)	1990-06-08
FI893722L (fi)	1990-02-12
PT91411B (pt)	1995-05-31
DK393089D0 (da)	1989-08-10
AU631806B2 (en)	1992-12-10
EP0357119B1 (de)	1995-11-08
DE68924745T2 (de)	1996-04-11
EP0357119A2 (de)	1990-03-07
IE72167B1 (en)	1997-03-26

Legal Events

Date	Code	Title	Description
1996-05-15	UEP	Publication of translation of european patent specification
2004-02-15	RZN	Patent revoked

Publication	Publication Date	Title
DE68924745D1 (de)	1995-12-14	Methode zur Erhöhung der Produktion von sekundären Metaboliten mittels geclusterter biosynthetischer Gene.
AU7346087A (en)	1988-01-07	Bioreactor for cultivation of microorganisms
DE3689572D1 (de)	1994-03-10	Verfahren zur Isolierung von Genen zur Biosynthese von Antibiotika.
DE3689196D1 (de)	1993-12-02	Verfahren zur Herstellung von Amiden unter Verwendung von Mikroorganismen.
AU7528881A (en)	1982-04-08	Microemulsion of nutrients for microorganisms
EG18796A (en)	1994-09-29	Process for production of avermectins and cultures therefor.
AU6835487A (en)	1987-07-15	Isolation of genes for biosynthesis of polyketide antibiotics
GB8800797D0 (en)	1988-02-17	Method of preparing immobilized enzyme/immobilized microbe
AU1868888A (en)	1989-01-12	Ab-006 antibiotics and process for their production
AU1551988A (en)	1988-11-24	Growth promoter for bifidobacterium species, process for preparing the same and method of using the same
ES432549A1 (es)	1977-02-16	Un procedimiento para la produccion de desacetoxicefalospo- rina c.
ATE105860T1 (de)	1994-06-15	Gen und genprodukt zur herstellung von beta- lactamverbindungen.
ATE81341T1 (de)	1992-10-15	Verfahren zur herstellung von antibiotica 10381b.
DE3884741D1 (de)	1993-11-11	Mikrobiologisches Verfahren zur Herstellung von UK-61.689 und Mikroorganismen zur Verwendung darin.
AU631651B2 (en)	1992-12-03	Method for culturing cells
PT835316E (pt)	2003-08-29	Fenilacetil-coa-ligase de penicillium chrysogenum
DE3673686D1 (de)	1990-10-04	Immobilisierte maltooligosaccharid-bildende amylase und verfahren zur herstellung von maltooligosaccharid unter verwendung des genannten enzyms.
DK0806479T3 (da)	2003-10-06	Produktion af biotin ved fermentering
DE69129869D1 (de)	1998-09-03	Verfahren zur Beeinflussung der Produktion von beta-lactam Antibiotika und zur Isolierung grosser Mengen von ACV-Synthetase
AU6472790A (en)	1991-09-12	Intermediates for the preparation of derivatives of hemi-caronic aldehyde of trans or cis structure
AU603416C (en)	1996-01-11	Process for production of B avermectins and cultures therefor
AU603416B2 (en)	1990-11-15	Process for production of b avermectins and cultures therefor
ES8405439A1 (es)	1984-06-16	Procedimiento para producir acido clavulanico.
ES8604974A1 (es)	1986-02-16	Un procedimiento para la fabricacion de penicilina g.
ES8602804A1 (es)	1985-12-16	Nuevo procedimiento para la obtencion de acido clavulanico