ATE130435T1 - Verfahren zum messen von freiliganden in biologischen flüssigkeiten. - Google Patents

Verfahren zum messen von freiliganden in biologischen flüssigkeiten.

Info

Publication number: ATE130435T1
Authority: AT; Austria
Prior art keywords: ligand; bound; protein; free; concentration
Prior art date: 1985-10-04

Application number

AT86300336T

Other languages

English (en)

Inventor

El Shami A Said

Original Assignee

Diagnostic Products Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1985-10-04

Filing date

1986-01-17

Publication date

1995-12-15

1986-01-17 Application filed by Diagnostic Products Corp filed Critical Diagnostic Products Corp

1995-12-15 Application granted granted Critical

1995-12-15 Publication of ATE130435T1 publication Critical patent/ATE130435T1/de

Links

239000003446 ligand Substances 0.000 title abstract 17
238000000034 method Methods 0.000 title abstract 3
239000007788 liquid Substances 0.000 title 1
102000014914 Carrier Proteins Human genes 0.000 abstract 5
108091008324 binding proteins Proteins 0.000 abstract 5
239000000700 radioactive tracer Substances 0.000 abstract 5
239000013060 biological fluid Substances 0.000 abstract 3
102000004169 proteins and genes Human genes 0.000 abstract 3
108090000623 proteins and genes Proteins 0.000 abstract 3
MUMGGOZAMZWBJJ-DYKIIFRCSA-N Testostosterone Chemical compound O=C1CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 MUMGGOZAMZWBJJ-DYKIIFRCSA-N 0.000 abstract 2
239000011230 binding agent Substances 0.000 abstract 2
GHAFORRTMVIXHS-UHFFFAOYSA-L bromosulfophthalein sodium Chemical compound [Na+].[Na+].C1=C(S([O-])(=O)=O)C(O)=CC=C1C1(C=2C=C(C(O)=CC=2)S([O-])(=O)=O)C(C(Br)=C(Br)C(Br)=C2Br)=C2C(=O)O1 GHAFORRTMVIXHS-UHFFFAOYSA-L 0.000 abstract 2
229960001734 sulfobromophthalein Drugs 0.000 abstract 2
UFBJCMHMOXMLKC-UHFFFAOYSA-N 2,4-dinitrophenol Chemical compound OC1=CC=C([N+]([O-])=O)C=C1[N+]([O-])=O UFBJCMHMOXMLKC-UHFFFAOYSA-N 0.000 abstract 1
FWEOQOXTVHGIFQ-UHFFFAOYSA-N 8-anilinonaphthalene-1-sulfonic acid Chemical compound C=12C(S(=O)(=O)O)=CC=CC2=CC=CC=1NC1=CC=CC=C1 FWEOQOXTVHGIFQ-UHFFFAOYSA-N 0.000 abstract 1
YGSDEFSMJLZEOE-UHFFFAOYSA-M salicylate Chemical compound OC1=CC=CC=C1C([O-])=O YGSDEFSMJLZEOE-UHFFFAOYSA-M 0.000 abstract 1
229960001860 salicylate Drugs 0.000 abstract 1
239000000126 substance Substances 0.000 abstract 1
229960003604 testosterone Drugs 0.000 abstract 1

Classifications

- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
- G01N33/743—Steroid hormones
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
- G01N33/78—Thyroid gland hormones, e.g. T3, T4, TBH, TBG or their receptors

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Molecular Biology (AREA)
Immunology (AREA)
Chemical & Material Sciences (AREA)
Biomedical Technology (AREA)
Urology & Nephrology (AREA)
Hematology (AREA)
Biotechnology (AREA)
Analytical Chemistry (AREA)
Cell Biology (AREA)
Endocrinology (AREA)
Food Science & Technology (AREA)
Medicinal Chemistry (AREA)
Physics & Mathematics (AREA)
Microbiology (AREA)
Biochemistry (AREA)
General Health & Medical Sciences (AREA)
General Physics & Mathematics (AREA)
Pathology (AREA)
Investigating Or Analysing Biological Materials (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

AT86300336T 1985-10-04 1986-01-17 Verfahren zum messen von freiliganden in biologischen flüssigkeiten. ATE130435T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US78485785A	1985-10-04	1985-10-04

Publications (1)

Publication Number	Publication Date
ATE130435T1 true ATE130435T1 (de)	1995-12-15

Family

ID=25133738

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
AT86300336T ATE130435T1 (de)	1985-10-04	1986-01-17	Verfahren zum messen von freiliganden in biologischen flüssigkeiten.
AT95103930T ATE169410T1 (de)	1985-10-04	1986-01-17	Verfahren zum messen von freitestosteronen in biologischen flüssigkeiten

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
AT95103930T ATE169410T1 (de)	1985-10-04	1986-01-17	Verfahren zum messen von freitestosteronen in biologischen flüssigkeiten

Country Status (13)

Country	Link
EP (2)	EP0218309B1 (de)
JP (2)	JPH081436B2 (de)
AT (2)	ATE130435T1 (de)
AU (1)	AU602864B2 (de)
CA (1)	CA1299984C (de)
DE (2)	DE3650437T2 (de)
DK (1)	DK169365B1 (de)
ES (1)	ES8707342A1 (de)
FI (1)	FI92878C (de)
IE (1)	IE60715B1 (de)
IL (1)	IL79283A (de)
NO (1)	NO168002C (de)
NZ (1)	NZ216326A (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3624464A1 (de) *	1986-07-19	1988-01-28	Boehringer Mannheim Gmbh	Verfahren zum nachweis eines analyten sowie hierfuer geeignetes mittel
US5198340A (en) *	1991-01-17	1993-03-30	Genentech, Inc.	Assay for free igf-i, igf-ii, and gh levels in body fluids
US6159698A (en) *	1996-07-18	2000-12-12	Dade Behring Marburg Gmbh	Reagents for assays for mycophenolic acid
CA2231775A1 (en)	1996-07-18	1998-01-29	Behringwerke Aktiengesellschaft	Reagents for assays for ligands
JP2005283380A (ja) *	2004-03-30	2005-10-13	Teikoku Hormone Mfg Co Ltd	バイオアベイラブルステロイドホルモンの測定方法
JP5163883B2 (ja) *	2008-05-30	2013-03-13	東ソー株式会社	Ｂ型肝炎ウイルスコア抗原又はそれに対する抗体の測定方法
US20160313310A1 (en)	2013-12-13	2016-10-27	Siemens Healthcare Diagnostics Inc.	Pretreatment agent in non-agglutination assays
JP7472320B2 (ja) *	2020-12-18	2024-04-22	中外製薬株式会社	動的解析による相対ｆｕ比の測定方法
CN113624982B (zh) *	2021-08-04	2024-11-26	深圳市辰纳生物科技有限公司	一种睾酮的磁颗粒酶促化学发光免疫检测试剂
JP2025181317A (ja) *	2024-05-31	2025-12-11	シスメックス株式会社	トランスサイレチン四量体の検出方法、安定性の評価方法、試薬及び試薬キット

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3928553A (en) *	1972-03-23	1975-12-23	Univ New York	Radioimmunoassay method for triiodothyronine and thyroxine
US4381291A (en) *	1979-02-23	1983-04-26	Ab Fortia	Measurement of free ligands
US4410633A (en) *	1980-09-25	1983-10-18	Corning Glass Works	Method for the measurement of free thyroxine or 3,5,3'-triiodothyronine in a liquid sample
US4430435A (en) *	1980-12-24	1984-02-07	Burroughs Wellcome Co.	Assay system
US4468469A (en) *	1981-11-04	1984-08-28	Miles Laboratories, Inc.	Substituted phenylacetic acids and salts as TBP blocking agents in iodothyronine immunoassays
JPS5886461A (ja) *	1981-11-04	1983-05-24	マイルス・ラボラトリ−ズ・インコ−ポレ−テツド	免疫試験用試薬、試験キツト及びそれらを用いる免疫試験法
EP0089806B1 (de) *	1982-03-22	1989-06-28	AMERSHAM INTERNATIONAL plc	Bestimmung des freien Anteils von Substanzen in biologischen Flüssigkeiten
GB8317124D0 (en) *	1983-06-23	1983-07-27	Ekins R P	Free ligand assay
US4622293A (en) *	1983-07-05	1986-11-11	Miles Laboratories, Inc.	Iodothyronine immunoassays employing HMS as TBP blocking agent
GB8404843D0 (en) *	1984-02-24	1984-03-28	Amersham Int Plc	Free analyte assay
DE3415818C1 (de) *	1984-04-27	1985-04-18	Henning Berlin Gmbh Chemie- Und Pharmawerk, 1000 Berlin	Verfahren zur Bestimmung freier Substanzen in biologischen Fluessigkeiten
EP0165669A1 (de) *	1984-05-04	1985-12-27	Corning Glass Works	Methode zur Messung freien Ligands

1986
- 1986-01-17 DE DE3650437T patent/DE3650437T2/de not_active Expired - Fee Related
- 1986-01-17 AT AT86300336T patent/ATE130435T1/de not_active IP Right Cessation
- 1986-01-17 DE DE3650691T patent/DE3650691T2/de not_active Expired - Fee Related
- 1986-01-17 EP EP86300336A patent/EP0218309B1/de not_active Expired - Lifetime
- 1986-01-17 EP EP95103930A patent/EP0661540B1/de not_active Expired - Lifetime
- 1986-01-17 AT AT95103930T patent/ATE169410T1/de not_active IP Right Cessation
- 1986-05-12 DK DK219686A patent/DK169365B1/da not_active IP Right Cessation
- 1986-05-16 AU AU57521/86A patent/AU602864B2/en not_active Ceased
- 1986-05-28 NZ NZ216326A patent/NZ216326A/xx unknown
- 1986-05-28 ES ES555425A patent/ES8707342A1/es not_active Expired
- 1986-06-04 CA CA000510762A patent/CA1299984C/en not_active Expired - Lifetime
- 1986-06-05 IE IE149586A patent/IE60715B1/en not_active IP Right Cessation
- 1986-06-06 NO NO862278A patent/NO168002C/no not_active IP Right Cessation
- 1986-06-30 IL IL79283A patent/IL79283A/xx not_active IP Right Cessation
- 1986-07-04 JP JP61157772A patent/JPH081436B2/ja not_active Expired - Lifetime
- 1986-08-05 FI FI863186A patent/FI92878C/fi not_active IP Right Cessation
1995
- 1995-01-25 JP JP7010194A patent/JP2575338B2/ja not_active Expired - Fee Related

Also Published As

Publication number	Publication date
FI92878C (fi)	1995-01-10
AU5752186A (en)	1987-04-09
DK169365B1 (da)	1994-10-10
JPS6283666A (ja)	1987-04-17
FI863186L (fi)	1987-04-05
IE861495L (en)	1987-04-04
DE3650691T2 (de)	1998-12-10
AU602864B2 (en)	1990-11-01
NO168002B (no)	1991-09-23
CA1299984C (en)	1992-05-05
DE3650437T2 (de)	1996-04-18
IE60715B1 (en)	1994-08-10
EP0661540B1 (de)	1998-08-05
IL79283A0 (en)	1986-09-30
DE3650437D1 (de)	1995-12-21
JPH07311200A (ja)	1995-11-28
ES555425A0 (es)	1987-07-16
JP2575338B2 (ja)	1997-01-22
JPH081436B2 (ja)	1996-01-10
EP0218309A2 (de)	1987-04-15
EP0218309B1 (de)	1995-11-15
ATE169410T1 (de)	1998-08-15
ES8707342A1 (es)	1987-07-16
EP0661540A1 (de)	1995-07-05
DK219686A (da)	1987-04-05
IL79283A (en)	1991-06-30
DE3650691D1 (de)	1998-09-10
NO862278D0 (no)	1986-06-06
DK219686D0 (da)	1986-05-12
EP0218309A3 (en)	1988-08-31
NO862278L (no)	1987-04-06
FI863186A0 (fi)	1986-08-05
NZ216326A (en)	1989-02-24
FI92878B (fi)	1994-09-30
NO168002C (no)	1992-01-02

Legal Events

Date	Code	Title	Description
1996-05-15	UEP	Publication of translation of european patent specification
2001-10-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
NO903124D0 (no)	1990-07-13	Testmetode og reagenssett for denne.
NO900534D0 (no)	1990-02-05	Bestemmelse av omgivelseskonsentrasjonen i flere analytter
DE59309900D1 (de)	2000-01-20	Verfahren zur Analyse partikelverstärkter Agglutinationsreaktionen auf Zentrifugalanalysatoren durch Bestimmung der Trübungsaufhellung
FI891012A0 (fi)	1989-03-02	Menetelmä ja väline immuunikokeissa esiintyvien häiriötekijöiden kompensoimiseksi
ATE77149T1 (de)	1992-06-15	Verfahren und testkit zur bestimmung freier wirkstoffe in biologischen fluessigkeiten.
FI89379B (fi)	1993-06-15	Bestaemning av glykosylerat hemoglobin i blodet
DE3650437D1 (de)	1995-12-21	Verfahren zum Messen von Freiliganden in biologischen Flüssigkeiten.
ATE138205T1 (de)	1996-06-15	Verfahren zum nachweis von phosphoryliertes tyrosin enthaltenden proteinen
DE68900106D1 (de)	1991-07-18	Verfahren zur bestimmung der freien ligandenfraktion einer biologischen fluessigkeit.
NO943759L (no)	1994-10-06	Fremgangsmåte for bestemmelse av mengden av en ligand i et biologisk fluid, samt et analysesett for utförelse av en slik fremgangsmåte
FI885312A0 (fi)	1988-11-16	Menetelmä spesifisesti sitovan proteiinin ja vastaavan sidottavan aineen välisen reaktion yhden tai useamman komponentin määrittämiseksi koenäytteestä käyttäen ainakin yhtä leimattua komponenttia, menetelmä leimatun komponentin valmistamiseksi sekä koepakkaus.......
ATE145480T1 (de)	1996-12-15	Verfahren zur bestimmung eines analyten
KR870005248A (ko)	1987-06-05	결합가능한 분석물을 정량하는 방법 및 시약
DE69014087D1 (de)	1994-12-15	Verfahren zur quantitativen und qualitativen Bestimmung von Antikörpern gegen bakterielle Antigene mittels photometrischer Messung der Agglutination.
ATE115630T1 (de)	1994-12-15	Trennung von antikörpern gegen metallchelate.
Borek	1983	An introduction to radioimmnoassay and related techniques: Vol. 6, Part II of the series ‘Laboratory Techniques in Biochemistry and Molecular Biology’, by T. Chard. Elsevier Biomedical Press, Amsterdam, 1982 (xiv+ 284 pp., illus.)(paperback) $79.00/Dfl. 170.00