ATE131823T1 - Verbindungen, die quinazoline und tetrazolring enthalten, als antitumorverbindungen - Google Patents

Verbindungen, die quinazoline und tetrazolring enthalten, als antitumorverbindungen

Info

Publication number: ATE131823T1
Authority: AT; Austria
Prior art keywords: alkyl; compounds; tetrazole ring; antitumor; quinazoline
Prior art date: 1992-03-11

Application number

AT93301780T

Other languages

English (en)

Inventor

Stephen John Pegg

James Michael Wardleworth

Original Assignee

Zeneca Ltd

British Tech Group

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-03-11

Filing date

1993-03-09

Publication date

1996-01-15

1993-03-09 Application filed by Zeneca Ltd, British Tech Group filed Critical Zeneca Ltd

1996-01-15 Application granted granted Critical

1996-01-15 Publication of ATE131823T1 publication Critical patent/ATE131823T1/de

Links

230000000259 anti-tumor effect Effects 0.000 title abstract 2
JWVCLYRUEFBMGU-UHFFFAOYSA-N quinazoline Chemical compound N1=CN=CC2=CC=CC=C21 JWVCLYRUEFBMGU-UHFFFAOYSA-N 0.000 title abstract 2
150000001875 compounds Chemical class 0.000 title 2
150000003536 tetrazoles Chemical group 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 4
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
150000003839 salts Chemical class 0.000 abstract 2
125000003545 alkoxy group Chemical group 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
150000002148 esters Chemical class 0.000 abstract 1
125000005843 halogen group Chemical group 0.000 abstract 1
238000004519 manufacturing process Methods 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
125000000843 phenylene group Chemical group C1(=C(C=CC=C1)*)* 0.000 abstract 1
150000003246 quinazolines Chemical class 0.000 abstract 1
125000002294 quinazolinyl group Chemical group N1=C(N=CC2=CC=CC=C12)* 0.000 abstract 1
125000001424 substituent group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Adhesives Or Adhesive Processes (AREA)
Dental Preparations (AREA)
Golf Clubs (AREA)

AT93301780T 1992-03-11 1993-03-09 Verbindungen, die quinazoline und tetrazolring enthalten, als antitumorverbindungen ATE131823T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB929205320A GB9205320D0 (en)	1992-03-11	1992-03-11	Anti-tumour compounds

Publications (1)

Publication Number	Publication Date
ATE131823T1 true ATE131823T1 (de)	1996-01-15

Family

ID=10711936

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT93301780T ATE131823T1 (de)	1992-03-11	1993-03-09	Verbindungen, die quinazoline und tetrazolring enthalten, als antitumorverbindungen

Country Status (22)

Country	Link
US (1)	US5955463A (de)
EP (1)	EP0562734B1 (de)
JP (1)	JP3160111B2 (de)
KR (1)	KR100221011B1 (de)
AT (1)	ATE131823T1 (de)
AU (1)	AU659277B2 (de)
CA (1)	CA2090942C (de)
CZ (1)	CZ281811B6 (de)
DE (1)	DE69301048T2 (de)
DK (1)	DK0562734T3 (de)
ES (1)	ES2081178T3 (de)
FI (1)	FI108793B (de)
GB (2)	GB9205320D0 (de)
GR (1)	GR3018501T3 (de)
HK (1)	HK21297A (de)
HU (1)	HU211127A9 (de)
IL (1)	IL104984A (de)
NO (1)	NO301543B1 (de)
NZ (1)	NZ247122A (de)
RU (1)	RU2111209C1 (de)
TW (1)	TW223635B (de)
ZA (1)	ZA931447B (de)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
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GB9223352D0 (en) *	1992-11-06	1992-12-23	Ici Plc	Tricyclic compounds
GB9408936D0 (en) *	1994-05-05	1994-06-22	Cancer Res Inst	Anti-cancer compounds
US5804396A (en) *	1994-10-12	1998-09-08	Sugen, Inc.	Assay for agents active in proliferative disorders
US5837524A (en) *	1994-12-15	1998-11-17	Sugen, Inc.	PYK2 related polynucleotide products
US5837815A (en) *	1994-12-15	1998-11-17	Sugen, Inc.	PYK2 related polypeptide products
JPH11507052A (ja) *	1995-06-07	1999-06-22	スージェン・インコーポレーテッド	キナゾリンおよび医薬組成物
US6716575B2 (en)	1995-12-18	2004-04-06	Sugen, Inc.	Diagnosis and treatment of AUR1 and/or AUR2 related disorders
US7119174B2 (en)	1995-12-18	2006-10-10	Sugen, Inc.	Diagnosis and treatment of AUR1 and/or AUR2 related disorders
US6818440B2 (en)	1997-04-28	2004-11-16	Sugen, Inc.	Diagnosis and treatment of alk-7 related disorders
US6228641B1 (en)	1997-05-20	2001-05-08	Sugen, Inc.	Diagnosis and treatment of PTP04 related disorders
US6342593B1 (en)	1997-06-11	2002-01-29	Sugen, Inc.	Diagnosis and treatment of ALP related disorders
US7115710B2 (en)	1997-06-11	2006-10-03	Sugen, Inc.	Diagnosis and treatment of PTP related disorders
US6388063B1 (en)	1997-06-18	2002-05-14	Sugen, Inc.	Diagnosis and treatment of SAD related disorders
US6495353B1 (en)	1998-01-21	2002-12-17	Sugen, Inc.	Human orthologues of wart
AU3642499A (en)	1998-04-14	1999-11-01	Sugen, Inc.	Ste20-related protein kinases
US6235213B1 (en) *	1998-05-18	2001-05-22	Micron Technology, Inc.	Etching methods, methods of removing portions of material, and methods of forming silicon nitride spacers
US6861442B1 (en)	1998-12-30	2005-03-01	Sugen, Inc.	PYK2 and inflammation
RU2256654C2 (ru) *	1999-01-22	2005-07-20	Кирин Бир Кабусики Кайся	Хинолиновые и хиназолиновые производные
EE05345B1 (et) *	1999-02-10	2010-10-15	Astrazeneca Ab	Kinasoliini derivaadid angiogeneesi inhibiitoritena
GB9904275D0 (en)	1999-02-24	1999-04-21	Cancer Res Campaign Tech	Anti-cancer compounds
EP1222273A2 (de)	1999-10-22	2002-07-17	PHARMACIA & UPJOHN COMPANY	G-protein gekoppelten rezeptoren aus drosophila, nukleinsäuren und zugehörigen verfahren
US6143776A (en) *	2000-02-02	2000-11-07	Sunesis Pharmaceuticals, Inc.	Tosylproline analogs as thymidylate synthase inhibitors
DE60134224D1 (de)	2001-08-10	2008-07-10	Ford Global Tech Inc	Ansaugkrümmer
KR100983962B1 (ko)	2001-08-31	2010-09-27	비티지 인터내셔널 리미티드	항암제로서 사용되는 시클로펜타[ｇ]퀴나졸린 화합물
ES2373644T3 (es)	2001-08-31	2012-02-07	Btg International Limited	Uso de derivados de ciclopenta[g]quinazolina para el tratamiento del c�?ncer.
RU2350618C2 (ru) *	2002-11-04	2009-03-27	Астразенека Аб	ПРОИЗВОДНЫЕ ХИНАЗОЛИНА В КАЧЕСТВЕ ИНГИБИТОРОВ Src ТИРОЗИНКИНАЗЫ
GB0317631D0 (en) *	2003-07-28	2003-08-27	Btg Int Ltd	Synthetic method
TW200526638A (en) *	2003-10-22	2005-08-16	Smithkline Beecham Corp	2-(3,4-dimethylphenyl)-4-{[2-hydroxy-3'-(1H-tetrazol-5-yl)biphenyl-3-yl]-hydrazono}-5-methyl-2,4-dihydropyrazol-3-one choline
WO2005080356A1 (en) *	2004-02-18	2005-09-01	Astrazeneca Ab	Tetrazole compounds and their use as metabotropic glutamate receptor antagonits
EP1962903B1 (de)	2005-12-15	2013-03-13	MedImmune Limited	Kombination eines angiopoetin-2-antagonisten und eines vegf-a, kdr- und/oder fltl-antagonisten zur behandlung von krebs

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0031237B1 (de) *	1979-12-19	1984-10-17	National Research Development Corporation	Chinazolinderivate, Verfahren zu ihrer Herstellung, sie enthaltende Zusammensetzungen und ihre Verwendung als Anti-Krebs-Mittel
JPS5692876A (en) *	1979-12-19	1981-07-27	Nat Res Dev	Anticancerous quinazoline derivative
GB8513754D0 (en) *	1985-05-31	1985-07-03	Jones T R	Anti-cancer quinazoline derivatives
GB8607683D0 (en) *	1986-03-27	1986-04-30	Ici Plc	Anti-tumor agents
US5187167A (en) *	1986-03-27	1993-02-16	Imperial Chemical Industries Plc	Pharmaceutical compositions comprising quinazolin-4-one derivatives
US4725687A (en) *	1986-04-28	1988-02-16	Southern Research Institute	5-methyl-5-deaza analogues of methotrexate and N10 -ethylaminopterin
GB8707053D0 (en) *	1987-03-25	1987-04-29	Ici Plc	Anti-tumour agents
US4857530A (en) *	1987-11-03	1989-08-15	Warner-Lambert Company	Substituted quinazolinones as anticancer agents
US4999424A (en) *	1988-11-10	1991-03-12	The Pennsylvania State University	GAR transformylase inhibitor
US5252573A (en) *	1988-12-15	1993-10-12	Imperial Chemical Industries Plc	Anti-tumor agents
GB8829296D0 (en) *	1988-12-15	1989-01-25	Ici Plc	Anti-tumour compounds
AU640016B2 (en) *	1990-05-30	1993-08-12	Imperial Chemical Industries Plc	Hydroquinazoline derivatives
US5145854A (en) *	1991-11-27	1992-09-08	Nair Madhavan G	1-formyl-5,8,10-trideazafolates

1992
- 1992-03-11 GB GB929205320A patent/GB9205320D0/en active Pending
1993
- 1993-02-25 AU AU33782/93A patent/AU659277B2/en not_active Ceased
- 1993-03-01 ZA ZA931447A patent/ZA931447B/xx unknown
- 1993-03-03 CA CA002090942A patent/CA2090942C/en not_active Expired - Fee Related
- 1993-03-08 CZ CZ93362A patent/CZ281811B6/cs not_active IP Right Cessation
- 1993-03-08 IL IL104984A patent/IL104984A/en not_active IP Right Cessation
- 1993-03-09 US US08/028,158 patent/US5955463A/en not_active Expired - Fee Related
- 1993-03-09 DK DK93301780.8T patent/DK0562734T3/da active
- 1993-03-09 GB GB9304807A patent/GB2264946B/en not_active Expired - Fee Related
- 1993-03-09 DE DE69301048T patent/DE69301048T2/de not_active Expired - Fee Related
- 1993-03-09 AT AT93301780T patent/ATE131823T1/de not_active IP Right Cessation
- 1993-03-09 EP EP93301780A patent/EP0562734B1/de not_active Expired - Lifetime
- 1993-03-09 ES ES93301780T patent/ES2081178T3/es not_active Expired - Lifetime
- 1993-03-10 RU RU93004793A patent/RU2111209C1/ru not_active IP Right Cessation
- 1993-03-10 FI FI931067A patent/FI108793B/fi active
- 1993-03-10 KR KR1019930003536A patent/KR100221011B1/ko not_active Expired - Fee Related
- 1993-03-10 NO NO930881A patent/NO301543B1/no unknown
- 1993-03-11 NZ NZ247122A patent/NZ247122A/xx not_active IP Right Cessation
- 1993-03-11 JP JP05052593A patent/JP3160111B2/ja not_active Expired - Fee Related
- 1993-03-16 TW TW082101928A patent/TW223635B/zh active
1995
- 1995-06-14 HU HU95P/P00202P patent/HU211127A9/hu unknown
- 1995-12-21 GR GR950403484T patent/GR3018501T3/el unknown
1997
- 1997-02-27 HK HK21297A patent/HK21297A/xx not_active IP Right Cessation

Also Published As

Publication number	Publication date
GR3018501T3 (en)	1996-03-31
GB2264946A (en)	1993-09-15
DE69301048D1 (de)	1996-02-01
DE69301048T2 (de)	1996-05-15
FI108793B (fi)	2002-03-28
CA2090942C (en)	2000-02-08
ES2081178T3 (es)	1996-02-16
KR100221011B1 (ko)	1999-09-15
RU2111209C1 (ru)	1998-05-20
ZA931447B (en)	1993-09-13
FI931067A0 (fi)	1993-03-10
AU3378293A (en)	1993-09-16
IL104984A (en)	1998-01-04
GB2264946B (en)	1995-05-17
AU659277B2 (en)	1995-05-11
IL104984A0 (en)	1993-07-08
EP0562734B1 (de)	1995-12-20
NO930881L (no)	1993-09-13
NZ247122A (en)	1995-07-26
NO301543B1 (no)	1997-11-10
JPH06279438A (ja)	1994-10-04
CA2090942A1 (en)	1993-09-12
HU211127A9 (en)	1995-10-30
JP3160111B2 (ja)	2001-04-23
DK0562734T3 (da)	1996-05-06
FI931067L (fi)	1993-09-12
EP0562734A1 (de)	1993-09-29
GB9205320D0 (en)	1992-04-22
NO930881D0 (no)	1993-03-10
TW223635B (de)	1994-05-11
CZ281811B6 (cs)	1997-02-12
HK21297A (en)	1997-02-27
CZ36293A3 (en)	1994-01-19
US5955463A (en)	1999-09-21
KR930019667A (ko)	1993-10-18
GB9304807D0 (en)	1993-04-28

Legal Events

Date	Code	Title	Description
1996-07-15	UEP	Publication of translation of european patent specification
2009-12-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
DE69301048D1 (de)	1996-02-01	Verbindungen, die Quinazoline und Tetrazolring enthalten, als Antitumorverbindungen
MY129970A (en)	2007-05-31	Hypolipidaemic compounds
FI931888A0 (fi)	1993-04-27	Kramploesande cykliska fruktopyranossulfiter -och sulfater
NO307255B1 (no)	2000-03-06	Nye forbindelser og antitumormidler
HUT70194A (en)	1995-09-28	Quinoline- or quinazoline derivatives, process for producing them and pharmaceutical compositions containing them
DE3572978D1 (en)	1989-10-19	Piperazine compound as paf-antagonist
NO931482D0 (no)	1993-04-22	Farmasoeytiske sammensetninger inneholdende quinolin- og quinazolinderivater og nye forbindelser for disse
ATE259376T1 (de)	2004-02-15	Heterozyklische verbindungen, ihre zwischenprodukte und elastase-inhibitoren
IL123776A0 (en)	1998-10-30	Novel derivatives of cyclodepsipeptide PF 1022
HUT72434A (en)	1996-04-29	Novel pyridone carboxylic acid derivatives, pharmaceutical compositions containing them and processes for their production
DE69121259D1 (de)	1996-09-19	Beta-Lactam-Verbindungen und ihre Herstellung
EA200400758A1 (ru)	2005-06-30	Новые соединения бензотиазина и бензотиадиазина, способ их получения и фармацевтические композиции, которые их содержат
EA200400666A3 (ru)	2005-10-27	Новые соединения бензотиазина и бензотиадиазина, способ их получения и фармацевтические композиции, которые их содержат
DE69129790D1 (de)	1998-08-20	5-Amino-5,6,7,8-Tetrahydrochinoline und verwandte Verbindungen, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
HUT71519A (en)	1995-12-28	7-substituted oxa- or azasteroid compounds and pharmaceutical compositions containing the same
MXPA04005839A (es)	2004-09-10	Nuevos compuestos de benzotiazina y benzotiadiazina un proceso para su preparacion y las composiciones farmaceuticas que los contienen.
ATE150970T1 (de)	1997-04-15	Pharmazeutische zusammensetzungen die triazole derivate enthalten zur rektalen verabbrechung