ATE132868T1 - Azabicyclo- und azacyclooxime und -amine mit cholinergischer wirkung und ihre pharmazeutisch annehmbaren salze - Google Patents

Azabicyclo- und azacyclooxime und -amine mit cholinergischer wirkung und ihre pharmazeutisch annehmbaren salze

Info

Publication number
ATE132868T1
ATE132868T1 AT91103308T AT91103308T ATE132868T1 AT E132868 T1 ATE132868 T1 AT E132868T1 AT 91103308 T AT91103308 T AT 91103308T AT 91103308 T AT91103308 T AT 91103308T AT E132868 T1 ATE132868 T1 AT E132868T1
Authority
AT
Austria
Prior art keywords
azabicyclo
amines
oximes
azacyclooximes
pharmaceutically acceptable
Prior art date
Application number
AT91103308T
Other languages
English (en)
Inventor
David Jeffrey Lauffer
Walter Hamilton Moos
Michael Raymond Pavia
Haile Tecle
Anthony Jerome Thomas
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Application granted granted Critical
Publication of ATE132868T1 publication Critical patent/ATE132868T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Medicinal Chemistry (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
AT91103308T 1990-03-06 1991-03-05 Azabicyclo- und azacyclooxime und -amine mit cholinergischer wirkung und ihre pharmazeutisch annehmbaren salze ATE132868T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US48891690A 1990-03-06 1990-03-06
US59164790A 1990-10-02 1990-10-02
US64147891A 1991-01-22 1991-01-22

Publications (1)

Publication Number Publication Date
ATE132868T1 true ATE132868T1 (de) 1996-01-15

Family

ID=27413829

Family Applications (1)

Application Number Title Priority Date Filing Date
AT91103308T ATE132868T1 (de) 1990-03-06 1991-03-05 Azabicyclo- und azacyclooxime und -amine mit cholinergischer wirkung und ihre pharmazeutisch annehmbaren salze

Country Status (19)

Country Link
EP (1) EP0445731B1 (de)
JP (3) JP3223192B2 (de)
KR (1) KR0182268B1 (de)
CN (1) CN1054601A (de)
AT (1) ATE132868T1 (de)
AU (1) AU630542B2 (de)
CA (1) CA2037541C (de)
DE (1) DE69116185T2 (de)
DK (1) DK0445731T3 (de)
ES (1) ES2082024T3 (de)
FI (1) FI95705C (de)
GR (1) GR3019226T3 (de)
HK (1) HK1005025A1 (de)
HU (1) HUT57210A (de)
IE (1) IE70322B1 (de)
IL (1) IL97266A0 (de)
NO (1) NO177711C (de)
NZ (1) NZ237300A (de)
PT (1) PT96946B (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5306718A (en) * 1990-03-06 1994-04-26 Warner-Lambert Company Oxime and amine substituted azabicyclo and azocyclo muscarinic agonists and methods of treatment
US5264502A (en) * 1990-08-03 1993-11-23 The Dow Chemical Company Diamino-alpha-alkylstilbene curing agents for epoxy resins
US5296570A (en) * 1990-08-03 1994-03-22 The Dow Chemical Company Curable mixtures of mesogenic epoxy resins and mesogenic polyamines and cured compositions
US5276184A (en) * 1990-08-03 1994-01-04 The Dow Chemical Company Sulfonamide compounds containing mesogenic moieties
US5391651A (en) * 1990-08-03 1995-02-21 The Dow Chemical Company Curable mixtures of mesogenic epoxy resins and mesogenic polyamines and cured compositions
US5262509A (en) * 1990-08-03 1993-11-16 The Dow Chemical Company Mesogenic glycidyl amines
US5268434A (en) * 1990-08-03 1993-12-07 The Dow Chemical Company Diamino-alpha-alkylstilbenes as epoxy resin curing agents
US5414125A (en) * 1990-08-03 1995-05-09 The Dow Chemical Company Diamino-alpha-alkylstilbenes
GB2258652A (en) * 1991-08-15 1993-02-17 Merck Sharp & Dohme Pharmaceutically useful azabicyclic oxime ethers
WO1993008191A1 (en) * 1991-10-15 1993-04-29 Warner-Lambert Company Azabicyclo oxime and amine cholinergic agents and methods of treatment
ZA931109B (en) * 1992-03-04 1993-09-22 Akzo Nv Tetrahydropyrimidine derivatives.
US5298575A (en) * 1992-11-30 1994-03-29 The Dow Chemical Company Nitro group terminated mesogenic epoxy resin adducts
US5552407A (en) * 1993-06-11 1996-09-03 New York University Medical Center Anhydroecgonine compounds and their use as anticholinergic agents
US5514812A (en) * 1994-06-10 1996-05-07 Warner-Lambert Company Preparation of stereochemically pure oximes with muscarinic activity
DE59605367D1 (de) * 1995-12-20 2000-07-06 Eckhart Pein Verwendung des alpha,alpha-diphenylessigsäure-4-(n-methyl-piperidyl)esters als spasmoanalgetikum
US6121459A (en) * 1997-01-27 2000-09-19 Warner-Lambert Company Single pot process for producing (Z)-azabicyclo oxime ethers
US5733912A (en) * 1997-02-19 1998-03-31 Abbott Laboratories 7A-heterocycle substituted hexahydro-1H-pyrrolizine compounds useful in controlling chemical synaptic transmission
WO1999032445A1 (en) * 1997-12-23 1999-07-01 Alcon Laboratories, Inc. Oximino-piperidine, -pyrrolidine and -azepine derivatives, their preparation and their use as muscarinic receptor (ant-)agonists
KR20020029115A (ko) * 1999-08-27 2002-04-17 바이세르트, 리펠 살충제로서의 아자비사이클로 및 아자사이클로 옥심 및아민 화합물
KR100465277B1 (ko) * 2002-01-24 2005-01-13 한국과학기술연구원 신규한 옥심계 아자 두 고리 화합물 및 그 제조방법
DE10302912A1 (de) * 2003-01-24 2004-08-12 Bayer Faser Gmbh Chlorbeständige Elastanfasern
RU2315047C1 (ru) * 2006-09-04 2008-01-20 Институт нефтехимии и катализа РАН Способ получения 8-этил-6,7-фуллеро[60]-3-окса-8-азабицикло[3.2.1]октана

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2019536A1 (de) * 1970-04-23 1971-11-11 Basf Ag Oximcarbamate
DE2552176A1 (de) * 1975-11-21 1977-06-02 Hoechst Ag Neue piperidin-derivate, ihre herstellung und verwendung
US4353922A (en) * 1981-03-13 1982-10-12 Syntex (U.S.A.) Inc. Anticholinergic bronchodilators

Also Published As

Publication number Publication date
JP3223192B2 (ja) 2001-10-29
FI911083A7 (fi) 1991-09-07
AU630542B2 (en) 1992-10-29
DK0445731T3 (da) 1996-04-29
FI95705B (fi) 1995-11-30
ES2082024T3 (es) 1996-03-16
DE69116185D1 (de) 1996-02-22
IE70322B1 (en) 1996-11-13
HUT57210A (en) 1991-11-28
NO910860L (no) 1991-09-09
GR3019226T3 (en) 1996-06-30
KR0182268B1 (ko) 1999-05-01
HU910712D0 (en) 1991-09-30
FI95705C (fi) 1996-03-11
IL97266A0 (en) 1992-05-25
KR910016728A (ko) 1991-11-05
NO177711B (no) 1995-07-31
PT96946A (pt) 1991-10-31
FI911083A0 (fi) 1991-03-04
PT96946B (pt) 1998-07-31
AU7260291A (en) 1991-09-12
JP2000239166A (ja) 2000-09-05
CA2037541A1 (en) 1992-08-11
CN1054601A (zh) 1991-09-18
JPH04217660A (ja) 1992-08-07
EP0445731B1 (de) 1996-01-10
HK1005025A1 (en) 1998-12-18
NO177711C (no) 1995-11-08
NO910860D0 (no) 1991-03-05
JP2000212163A (ja) 2000-08-02
CA2037541C (en) 2001-10-02
EP0445731A1 (de) 1991-09-11
DE69116185T2 (de) 1996-05-15
NZ237300A (en) 1993-12-23
IE910731A1 (en) 1991-09-11

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee