ATE133421T1 - Verfahren zur herstellung von rekombinantem humaninterferon-beta in reiner form - Google Patents

Verfahren zur herstellung von rekombinantem humaninterferon-beta in reiner form

Info

Publication number
ATE133421T1
ATE133421T1 AT91103719T AT91103719T ATE133421T1 AT E133421 T1 ATE133421 T1 AT E133421T1 AT 91103719 T AT91103719 T AT 91103719T AT 91103719 T AT91103719 T AT 91103719T AT E133421 T1 ATE133421 T1 AT E133421T1
Authority
AT
Austria
Prior art keywords
recombinant human
interferon
human beta
eluted
beta
Prior art date
Application number
AT91103719T
Other languages
English (en)
Inventor
Otello Protasi
Paolo Rappuoli
Original Assignee
Sclavo Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sclavo Spa filed Critical Sclavo Spa
Application granted granted Critical
Publication of ATE133421T1 publication Critical patent/ATE133421T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/555—Interferons [IFN]
    • C07K14/565—IFN-beta
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Plant Pathology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Microbiology (AREA)
  • Toxicology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT91103719T 1990-03-16 1991-03-12 Verfahren zur herstellung von rekombinantem humaninterferon-beta in reiner form ATE133421T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT19699A IT1240612B (it) 1990-03-16 1990-03-16 Procedimento di purificazione del b-interferone umano ricombinante

Publications (1)

Publication Number Publication Date
ATE133421T1 true ATE133421T1 (de) 1996-02-15

Family

ID=11160484

Family Applications (1)

Application Number Title Priority Date Filing Date
AT91103719T ATE133421T1 (de) 1990-03-16 1991-03-12 Verfahren zur herstellung von rekombinantem humaninterferon-beta in reiner form

Country Status (6)

Country Link
EP (1) EP0446850B1 (de)
JP (1) JPH0568583A (de)
KR (1) KR910016928A (de)
AT (1) ATE133421T1 (de)
DE (1) DE69116582D1 (de)
IT (1) IT1240612B (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0551535A1 (de) * 1992-01-13 1993-07-21 SCLAVO S.p.A. Verfahren zur Reinigung von rekombinant-menschlichem Interferon-Beta, dadurch gereinigtes Interferon-Beta und pharmazeutische Zusammensetzungen, die diese enthalten
KR100524872B1 (ko) 2003-12-04 2005-11-01 씨제이 주식회사 인터페론 베타의 정제방법
DE102009032179A1 (de) 2009-07-07 2011-01-13 Biogenerix Ag Verfahren zur Reinigung von Interferon beta

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL67896A (en) * 1983-02-13 1987-03-31 Yeda Res & Dev Two biologically active human gama interferon subtypes,purification thereof and pharmaceutical compositions containing them
US4908432A (en) * 1987-01-09 1990-03-13 New York University Novel polypeptide having gamma-interferon activity
IT1222427B (it) * 1987-07-31 1990-09-05 Sclavo Spa Procedimento per la purificazione di interferone

Also Published As

Publication number Publication date
EP0446850B1 (de) 1996-01-24
EP0446850A2 (de) 1991-09-18
EP0446850A3 (de) 1991-11-06
IT9019699A1 (it) 1991-09-16
IT9019699A0 (it) 1990-03-16
JPH0568583A (ja) 1993-03-23
DE69116582D1 (de) 1996-03-07
IT1240612B (it) 1993-12-17
KR910016928A (ko) 1991-11-05

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Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties