ATE133654T1 - Neue tricyclischen steroid-analogen - Google Patents
Neue tricyclischen steroid-analogenInfo
- Publication number
- ATE133654T1 ATE133654T1 AT92121556T AT92121556T ATE133654T1 AT E133654 T1 ATE133654 T1 AT E133654T1 AT 92121556 T AT92121556 T AT 92121556T AT 92121556 T AT92121556 T AT 92121556T AT E133654 T1 ATE133654 T1 AT E133654T1
- Authority
- AT
- Austria
- Prior art keywords
- fluoroalkyl
- carbonyl
- alkyl
- different
- same
- Prior art date
Links
- 150000003431 steroids Chemical class 0.000 title abstract 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 abstract 2
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 2
- 125000003709 fluoroalkyl group Chemical group 0.000 abstract 2
- KXYGKDBONOVZOM-UHFFFAOYSA-N 1h-cyclopenta[a]naphthalene Chemical compound C1=CC=CC2=C3CC=CC3=CC=C21 KXYGKDBONOVZOM-UHFFFAOYSA-N 0.000 abstract 1
- 102000005915 GABA Receptors Human genes 0.000 abstract 1
- 108010005551 GABA Receptors Proteins 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000002708 enhancing effect Effects 0.000 abstract 1
- 125000004185 ester group Chemical group 0.000 abstract 1
- 229960003692 gamma aminobutyric acid Drugs 0.000 abstract 1
- BTCSSZJGUNDROE-UHFFFAOYSA-N gamma-aminobutyric acid Chemical compound NCCCC(O)=O BTCSSZJGUNDROE-UHFFFAOYSA-N 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 239000002555 ionophore Substances 0.000 abstract 1
- 230000000236 ionophoric effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/67—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids
- C07C69/716—Esters of keto-carboxylic acids or aldehydo-carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
- A61P23/02—Local anaesthetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/02—Ortho- or ortho- and peri-condensed systems
- C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
- C07C2603/06—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members
- C07C2603/10—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings
- C07C2603/12—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings only one five-membered ring
- C07C2603/16—Benz[e]indenes; Hydrogenated benz[e]indenes
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Anesthesiology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Reproductive Health (AREA)
- Urology & Nephrology (AREA)
- Steroid Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/811,208 US5206415A (en) | 1991-12-20 | 1991-12-20 | Tricyclic steroid analogs |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE133654T1 true ATE133654T1 (de) | 1996-02-15 |
Family
ID=25205887
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT92121556T ATE133654T1 (de) | 1991-12-20 | 1992-12-18 | Neue tricyclischen steroid-analogen |
Country Status (7)
| Country | Link |
|---|---|
| US (3) | US5206415A (de) |
| EP (1) | EP0548824B1 (de) |
| JP (1) | JP3238962B2 (de) |
| AT (1) | ATE133654T1 (de) |
| CA (1) | CA2085819A1 (de) |
| DE (1) | DE69208068T2 (de) |
| DK (1) | DK0548824T3 (de) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5434274A (en) * | 1991-12-20 | 1995-07-18 | Washington University | Benz(epsilon)indene compounds |
| US5696199A (en) * | 1995-12-07 | 1997-12-09 | Minnesota Mining And Manufacturing Company | Pressure-sensitive adhesive polyacrylate polymer and method of making |
| US6787530B1 (en) | 1996-08-23 | 2004-09-07 | Monash University | Use of pregnane-diones as analgesic agents |
| CA2330611A1 (en) | 1998-05-22 | 1999-12-02 | The Board Of Trustees Of The Leland Stanford Junior University | Bifunctional molecules and therapies based thereon |
| AU4701299A (en) | 1998-06-23 | 2000-01-10 | Stuart R. Adler | Therapeutic applications of estrogenic carboxylic acids |
| CA2420967A1 (en) * | 2000-08-07 | 2002-02-14 | Neurogen Corporation | Heterocyclic compounds as ligands of the gabaa receptor |
| US20020072509A1 (en) * | 2000-10-11 | 2002-06-13 | Stein Donald Gerald | Methods for the treatment of a traumatic central nervous system injury |
| AR031473A1 (es) * | 2000-11-20 | 2003-09-24 | Lundbeck & Co As H | Intensificadores de gaba en el tratamiento de enfermedades relacionadas con una reducida actividad neuroesteroide |
| US20030037354A1 (en) * | 2001-08-02 | 2003-02-20 | Ornitz David M. | Animal model with disrupted Fgf14 gene |
| US7473687B2 (en) * | 2005-03-24 | 2009-01-06 | Emory University | Methods for the treatment of a traumatic central nervous system injury |
| PT1868614E (pt) * | 2005-03-24 | 2012-11-23 | Univ Emory | Regime de dosagem para o tratamento de uma lesão cerebral traumática com progesterona |
| SI1889198T1 (sl) | 2005-04-28 | 2015-02-27 | Proteus Digital Health, Inc. | Farma-informacijski sistem |
| WO2007035716A2 (en) | 2005-09-16 | 2007-03-29 | Raptor Pharmaceutical Inc. | Compositions comprising receptor-associated protein (rap) variants specific for cr-containing proteins and uses thereof |
| DK2398500T3 (da) | 2009-02-20 | 2019-05-13 | 2 Bbb Medicines B V | Glutathion-baseret lægemiddelafgivelsessystem |
| SG175896A1 (en) | 2009-05-06 | 2011-12-29 | Lab Skin Care Inc | Dermal delivery compositions comprising active agent-calcium phosphate particle complexes and methods of using the same |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2830075A (en) * | 1954-05-10 | 1958-04-08 | Farinacci Nicholas Thomas | 2-alpha-carbonylated 8, 13-dimethyl polyhydrophenanthrene compounds and preparation thereof |
| US2830325A (en) * | 1956-05-10 | 1958-04-15 | Davol Rubber Co | Mold for forming open-ended bulbs |
| US3293284A (en) * | 1964-08-07 | 1966-12-20 | Searle & Co | 1, 2-seco-alpha-nor-5 alpha-androstane-1, 2, 17 beta-triols, 17-alkylated-1, 2-seco-alpha-nor-5 alpha-androstane-1, 2, 17 beta-triols and esters thereof |
| US3281431A (en) * | 1964-09-28 | 1966-10-25 | Searle & Co | 17-oxygenated-2-thia-5alpha-androstanes and derivatives thereof |
| FR1526962A (fr) * | 1967-01-06 | 1968-05-31 | Roussel Uclaf | Nouveau procédé de préparation d'un composé gonatriénique et produits en résultant |
| IL32496A (en) * | 1968-07-24 | 1973-06-29 | Roussel Uclaf | 1-oxa-a-nor-androstanes |
| US3821288A (en) * | 1971-07-01 | 1974-06-28 | Syntex Inc | 16,17-seco-a-nor steroids |
| GB2068363A (en) * | 1980-01-30 | 1981-08-12 | Sarabhai Ambalal Ets | Substituted Benzhydrindanes |
| US4874891A (en) * | 1986-05-01 | 1989-10-17 | Washington University | Open "D" ring hormone analogs |
| EP0382790A4 (en) * | 1987-08-25 | 1991-03-27 | Kelvin W. Gee | Compositions and methods for alleviating stress, anxiety and seizure activity |
-
1991
- 1991-12-20 US US07/811,208 patent/US5206415A/en not_active Expired - Lifetime
-
1992
- 1992-12-18 EP EP92121556A patent/EP0548824B1/de not_active Expired - Lifetime
- 1992-12-18 CA CA002085819A patent/CA2085819A1/en not_active Abandoned
- 1992-12-18 AT AT92121556T patent/ATE133654T1/de not_active IP Right Cessation
- 1992-12-18 JP JP33897092A patent/JP3238962B2/ja not_active Expired - Fee Related
- 1992-12-18 DE DE69208068T patent/DE69208068T2/de not_active Expired - Fee Related
- 1992-12-18 DK DK92121556.2T patent/DK0548824T3/da active
-
1993
- 1993-01-14 US US08/004,768 patent/US5292906A/en not_active Expired - Lifetime
- 1993-10-15 US US08/136,150 patent/US5344826A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| EP0548824B1 (de) | 1996-01-31 |
| JP3238962B2 (ja) | 2001-12-17 |
| JPH05306257A (ja) | 1993-11-19 |
| US5292906A (en) | 1994-03-08 |
| DE69208068T2 (de) | 1996-05-30 |
| US5344826A (en) | 1994-09-06 |
| EP0548824A1 (de) | 1993-06-30 |
| DE69208068D1 (de) | 1996-03-14 |
| CA2085819A1 (en) | 1993-06-21 |
| DK0548824T3 (da) | 1996-02-19 |
| US5206415A (en) | 1993-04-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |