ATE133954T1 - Substituierte cephalosporinsulfone als anti- entzündliche und anti-degenerative mittel - Google Patents

Substituierte cephalosporinsulfone als anti- entzündliche und anti-degenerative mittel

Info

Publication number: ATE133954T1
Authority: AT; Austria
Prior art keywords: inflammatory; cephalosporine; sulphones; substituted; degenerative agents
Prior art date: 1986-11-12

Application number

AT87309688T

Other languages

English (en)

Inventor

James B Doherty

Paul E Finke

Raymond A Firestone

William K Hagmann

Kevan R Thompson

Shrenik K Shah

Original Assignee

Merck & Co Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1986-11-12

Filing date

1987-11-02

Publication date

1996-02-15

1987-11-02 Application filed by Merck & Co Inc filed Critical Merck & Co Inc

1996-02-15 Application granted granted Critical

1996-02-15 Publication of ATE133954T1 publication Critical patent/ATE133954T1/de

Links

230000001796 anti-degenerative effect Effects 0.000 title abstract 2
230000003110 anti-inflammatory effect Effects 0.000 title abstract 2
HOKIDJSKDBPKTQ-UHFFFAOYSA-N 3-(acetyloxymethyl)-7-[(5-amino-5-carboxypentanoyl)amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid Chemical class S1CC(COC(=O)C)=C(C(O)=O)N2C(=O)C(NC(=O)CCCC(N)C(O)=O)C12 HOKIDJSKDBPKTQ-UHFFFAOYSA-N 0.000 title 1
229930186147 Cephalosporin Natural products 0.000 abstract 1
229940124587 cephalosporin Drugs 0.000 abstract 1
-1 cephalosporin sulfones Chemical class 0.000 abstract 1
239000003795 chemical substances by application Substances 0.000 abstract 1
239000003602 elastase inhibitor Substances 0.000 abstract 1
230000003389 potentiating effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Cephalosporin Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Pyrane Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

AT87309688T 1986-11-12 1987-11-02 Substituierte cephalosporinsulfone als anti- entzündliche und anti-degenerative mittel ATE133954T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US93019386A	1986-11-12	1986-11-12

Publications (1)

Publication Number	Publication Date
ATE133954T1 true ATE133954T1 (de)	1996-02-15

Family

ID=25459038

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT87309688T ATE133954T1 (de)	1986-11-12	1987-11-02	Substituierte cephalosporinsulfone als anti- entzündliche und anti-degenerative mittel

Country Status (16)

Country	Link
EP (1)	EP0267723B1 (de)
JP (1)	JPS63198688A (de)
KR (1)	KR880006249A (de)
CN (1)	CN87107753A (de)
AT (1)	ATE133954T1 (de)
AU (1)	AU611104B2 (de)
CA (1)	CA1339275C (de)
DE (1)	DE3751700D1 (de)
DK (1)	DK590787A (de)
FI (1)	FI874839A7 (de)
HU (1)	HUT52511A (de)
IL (1)	IL84359A0 (de)
NO (1)	NO874699L (de)
NZ (1)	NZ222399A (de)
PT (1)	PT86074B (de)
ZA (1)	ZA878467B (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB8808701D0 (en) *	1988-04-13	1988-05-18	Erba Carlo Spa	Beta-lactam derivatives
GB8811388D0 (en) *	1988-05-13	1988-06-15	Erba Carlo Spa	1,1-dioxo-cephem-4-carbothiolic acid derivatives
US4992541A (en) *	1989-08-01	1991-02-12	Merck & Co., Inc.	Process for the preparation of 1,1-dioxo-7-substituted cephems
US5264429A (en) *	1989-10-06	1993-11-23	Synphar Laboratories, Inc.	2-spirocyclopropyl cephalosporin sulfone derivatives
EP0494914B1 (de) *	1989-10-06	1998-12-23	Synphar Laboratories Inc.	2-spirocyclopropylcephalosporinderivate und verfahren zu ihrer herstellung
US5258377A (en) *	1991-04-08	1993-11-02	Taiho Pharmaceutical Co., Ltd.	2-spirocyclopropyl 4-acylcephems
US5348953A (en) *	1991-06-25	1994-09-20	Merck & Co., Inc.	Substituted azetidinones as anti-inflammatory and antidegenerative agents
WO1993016043A1 (en) *	1992-02-18	1993-08-19	Otsuka Kagaku Kabushiki Kaisha	β-LACTAM COMPOUND AND CEPHEM COMPOUND, AND PRODUCTION THEREOF
GB2266525A (en) *	1992-03-17	1993-11-03	Merck & Co Inc	Substituted cephalosporin sulfone compositions useful in the treatment of leukemia
GB2266526A (en) *	1992-03-17	1993-11-03	Merck & Co Inc	Substituted cephalosporin sulfones useful in the treatment of leukemia
WO1993024493A1 (en) *	1992-05-27	1993-12-09	Teijin Limited	Cephalosporin derivative
JPH08502752A (ja) *	1992-10-27	1996-03-26	メルクエンドカンパニーインコーポレーテッド	抗炎症剤及び抗変性剤としての新規の置換アゼチジノン
US5591737A (en) *	1992-12-17	1997-01-07	Merck & Co., Inc.	Substituted azetidinones as anti-inflammatory and antidegenerative agents
US5439904A (en) *	1993-12-07	1995-08-08	Synphar Laboratories, Inc.	2-spiro(2'-spirocycloalkyl)cyclopropyl cephalosporin sulfones as antiinflammatory and antigenerative agents
US5747485A (en) *	1995-04-13	1998-05-05	Merck & Co., Inc.	Substituted azetidiones as anti-inflammatory and antidegenerative agents
JPH11514345A (ja) *	1995-08-31	1999-12-07	スミスクライン・ビーチャム・コーポレイション	インターロイキン変換酵素およびアポプトーシス
JPH11511463A (ja) *	1995-08-31	1999-10-05	スミスクライン・ビーチャム・コーポレイション	インターロイキン変換酵素およびアポプトーシス
GB9525697D0 (en) *	1995-12-15	1996-02-14	Pharmacia Spa	Cephem derivatives
CN113372368B (zh) *	2020-03-09	2022-04-12	苏州爱科百发生物医药技术有限公司	一种弹性蛋白酶抑制剂前药及其用途

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4623645A (en) *	1983-04-18	1986-11-18	Merck & Co., Inc.	Substituted cephalosporin sulfoxides as anti-inflammatory and antidegenerative agents
EP0124081A3 (de) *	1983-05-02	1986-11-26	Merck & Co. Inc.	Substituierte Cephalosporinsulfone mit Antientzündungs- und Antidegenerativwirkung, sie enthaltende Zusammensetzungen und Verfahren zur Herstellung
US4699904A (en) *	1985-07-01	1987-10-13	Merck & Co., Inc.	Tetrazolyl derivatives of β-lactams useful as elastase inhibitors

1987
- 1987-11-02 AT AT87309688T patent/ATE133954T1/de not_active IP Right Cessation
- 1987-11-02 EP EP87309688A patent/EP0267723B1/de not_active Expired - Lifetime
- 1987-11-02 NZ NZ222399A patent/NZ222399A/xx unknown
- 1987-11-02 DE DE3751700T patent/DE3751700D1/de not_active Expired - Lifetime
- 1987-11-03 AU AU80624/87A patent/AU611104B2/en not_active Expired - Fee Related
- 1987-11-03 IL IL84359A patent/IL84359A0/xx unknown
- 1987-11-03 FI FI874839A patent/FI874839A7/fi not_active IP Right Cessation
- 1987-11-04 PT PT86074A patent/PT86074B/pt not_active IP Right Cessation
- 1987-11-10 CA CA000551525A patent/CA1339275C/en not_active Expired - Fee Related
- 1987-11-11 CN CN198787107753A patent/CN87107753A/zh active Pending
- 1987-11-11 ZA ZA878467A patent/ZA878467B/xx unknown
- 1987-11-11 NO NO874699A patent/NO874699L/no unknown
- 1987-11-11 HU HU875022A patent/HUT52511A/hu unknown
- 1987-11-11 KR KR870012677A patent/KR880006249A/ko not_active Withdrawn
- 1987-11-11 DK DK590787A patent/DK590787A/da not_active Application Discontinuation
- 1987-11-12 JP JP62284386A patent/JPS63198688A/ja active Pending

Also Published As

Publication number	Publication date
CA1339275C (en)	1997-08-12
PT86074B (pt)	1990-11-07
NZ222399A (en)	1991-07-26
FI874839A0 (fi)	1987-11-03
PT86074A (en)	1987-12-01
EP0267723A3 (en)	1989-12-06
EP0267723B1 (de)	1996-02-07
EP0267723A2 (de)	1988-05-18
KR880006249A (ko)	1988-07-22
JPS63198688A (ja)	1988-08-17
CN87107753A (zh)	1988-06-29
FI874839A7 (fi)	1988-05-13
DK590787A (da)	1988-05-13
AU8062487A (en)	1988-05-19
AU611104B2 (en)	1991-06-06
DK590787D0 (da)	1987-11-11
IL84359A0 (en)	1988-04-29
NO874699D0 (no)	1987-11-11
NO874699L (no)	1988-05-13
HUT52511A (en)	1990-07-28
DE3751700D1 (de)	1996-03-21
ZA878467B (en)	1988-09-28

Legal Events

Date	Code	Title	Description
1996-08-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
DE3751700D1 (de)	1996-03-21	Substituierte Cephalosporinsulfone als anti-entzündliche und anti-degenerative Mittel
FI852974L (fi)	1986-02-04	Nya n-hydroxylgruppen skyddande grupper och framstaellningsfoerfarande foer 3-acylamino-1-hydroxi-2-azetidinoner.
ES553821A0 (es)	1988-02-16	Un procedimiento para la preparacion de nuevas azetidinonas sustituidas.
GR3017656T3 (en)	1996-01-31	New substituted azetidinones as anti-inflammatory and antidegenerative agents.
DE3787784D1 (de)	1993-11-18	Sulfon-Peroxycarbonsäuren.
DK506587D0 (da)	1987-09-25	Imidderivater
DE68928262D1 (de)	1997-09-25	Derivate von Alkanolaminen als kardiovaskuläre Mittel
PT86785A (pt)	1988-03-01	Novel naphthalene derivatives having use as antiallergy and antiinflammatory agents
AT388377B (de)	1989-06-12	7-((m-subst.)-phenylglycin)-1-carba-1dethiacephalosporine
ITMI931012A1 (it)	1994-11-18	Composti spiro-piranici dotati di caratteristiche fotocromatiche
FI932691A0 (fi)	1993-06-11	Nya benzyl- och benzhydrylalkoholer
ATE118209T1 (de)	1995-02-15	Pyridin-3-percarboxylsäure monopersulfat.
DE3685712D1 (de)	1992-07-23	Dermatica.
DK439286A (da)	1986-09-12	Propanolderivater