ATE134369T1 - Fluoreszierende indikatorfarbstoffe für alkalimetall-kationen, ihre herstellung und verwendung - Google Patents
Fluoreszierende indikatorfarbstoffe für alkalimetall-kationen, ihre herstellung und verwendungInfo
- Publication number
- ATE134369T1 ATE134369T1 AT89311760T AT89311760T ATE134369T1 AT E134369 T1 ATE134369 T1 AT E134369T1 AT 89311760 T AT89311760 T AT 89311760T AT 89311760 T AT89311760 T AT 89311760T AT E134369 T1 ATE134369 T1 AT E134369T1
- Authority
- AT
- Austria
- Prior art keywords
- core
- diaza
- over
- metal cations
- chelators
- Prior art date
Links
- 150000001768 cations Chemical class 0.000 title 1
- 239000003269 fluorescent indicator Substances 0.000 title 1
- 239000002184 metal Substances 0.000 title 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 4
- 239000002738 chelating agent Substances 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- -1 alkali metal cations Chemical class 0.000 abstract 2
- 150000003983 crown ethers Chemical class 0.000 abstract 2
- 125000001072 heteroaryl group Chemical group 0.000 abstract 2
- 229910052757 nitrogen Inorganic materials 0.000 abstract 2
- NLMDJJTUQPXZFG-UHFFFAOYSA-N 1,4,10,13-tetraoxa-7,16-diazacyclooctadecane Chemical compound C1COCCOCCNCCOCCOCCN1 NLMDJJTUQPXZFG-UHFFFAOYSA-N 0.000 abstract 1
- STHIZMRUXPMSCW-UHFFFAOYSA-N 1,4,10-trioxa-7,13-diazacyclopentadecane Chemical compound C1COCCNCCOCCOCCN1 STHIZMRUXPMSCW-UHFFFAOYSA-N 0.000 abstract 1
- PWJHXHMUGFXPSN-UHFFFAOYSA-N 1,7-dioxa-4,10-diazacyclododecane Chemical compound C1COCCNCCOCCN1 PWJHXHMUGFXPSN-UHFFFAOYSA-N 0.000 abstract 1
- 229910052783 alkali metal Inorganic materials 0.000 abstract 1
- 150000001907 coumarones Chemical class 0.000 abstract 1
- 230000001086 cytosolic effect Effects 0.000 abstract 1
- 230000003247 decreasing effect Effects 0.000 abstract 1
- 238000010494 dissociation reaction Methods 0.000 abstract 1
- 230000005593 dissociations Effects 0.000 abstract 1
- 230000005284 excitation Effects 0.000 abstract 1
- 238000005558 fluorometry Methods 0.000 abstract 1
- YFHXZQPUBCBNIP-UHFFFAOYSA-N fura-2 Chemical compound CC1=CC=C(N(CC(O)=O)CC(O)=O)C(OCCOC=2C(=CC=3OC(=CC=3C=2)C=2OC(=CN=2)C(O)=O)N(CC(O)=O)CC(O)=O)=C1 YFHXZQPUBCBNIP-UHFFFAOYSA-N 0.000 abstract 1
- 238000003384 imaging method Methods 0.000 abstract 1
- QQVIHTHCMHWDBS-UHFFFAOYSA-N isophthalic acid Chemical group OC(=O)C1=CC=CC(C(O)=O)=C1 QQVIHTHCMHWDBS-UHFFFAOYSA-N 0.000 abstract 1
- UGJCNRLBGKEGEH-UHFFFAOYSA-N sodium-binding benzofuran isophthalate Chemical compound COC1=CC=2C=C(C=3C(=CC(=CC=3)C(O)=O)C(O)=O)OC=2C=C1N(CCOCC1)CCOCCOCCN1C(C(=CC=1C=2)OC)=CC=1OC=2C1=CC=C(C(O)=O)C=C1C(O)=O UGJCNRLBGKEGEH-UHFFFAOYSA-N 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D273/00—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
- G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/84—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving inorganic compounds or pH
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Inorganic Chemistry (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US27150288A | 1988-11-14 | 1988-11-14 | |
| US07/391,879 US5134232A (en) | 1988-11-14 | 1989-08-09 | Fluorescent indicator dyes for alkali metal cations |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE134369T1 true ATE134369T1 (de) | 1996-03-15 |
Family
ID=26954961
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT89311760T ATE134369T1 (de) | 1988-11-14 | 1989-11-14 | Fluoreszierende indikatorfarbstoffe für alkalimetall-kationen, ihre herstellung und verwendung |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP0369733B1 (de) |
| JP (1) | JPH07119218B2 (de) |
| AT (1) | ATE134369T1 (de) |
| CA (1) | CA2002917C (de) |
| DE (1) | DE68925716T2 (de) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5154890A (en) * | 1990-11-07 | 1992-10-13 | Hewlett-Packard Company | Fiber optic potassium ion sensor |
| US5958782A (en) * | 1993-10-21 | 1999-09-28 | Minnesota Mining And Manufacturing Company | Cation-sensing composite structure and compounds for use therein |
| US5747345A (en) * | 1996-08-15 | 1998-05-05 | Johnson & Johnson Clinical Diagnostics, Inc. | Calcium specific diaza-18-crown-6-ether chromoionophores |
| DE69826440T2 (de) * | 1997-03-05 | 2005-09-29 | Ciba Speciality Chemicals Holding Inc. | Kronenether derivatisierte perylene |
| AT405462B (de) * | 1997-05-30 | 1999-08-25 | Avl List Gmbh | Verfahren zur bestimmung eines alkaliions |
| RU2161153C1 (ru) * | 1999-10-08 | 2000-12-27 | Громов Сергей Пантелеймонович | 5'-ацильные производные n-алкилбензомоноазакраун-соединений и способ их получения |
| JP4669704B2 (ja) * | 2005-02-02 | 2011-04-13 | 学校法人東京理科大学 | 紫外線分解化合物 |
| HUP1100731A2 (en) | 2011-12-30 | 2013-06-28 | Stratoxer S Kft | Complex forming compounds |
| US10590155B2 (en) | 2016-07-15 | 2020-03-17 | Arizona Board Of Regents On Behalf Of Arizona State University | Mitochondria-targeting fluorescent potassium+ sensor and method of making the same |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2842862A1 (de) * | 1978-10-02 | 1980-04-10 | Boehringer Mannheim Gmbh | Verfahren zur bestimmung von ionen, polaren und/oder lipophilen substanzen in fluessigkeiten |
| DE3424065A1 (de) * | 1984-06-29 | 1986-01-09 | Bayer Ag, 5090 Leverkusen | Verfahren zur aktivierung von substratoberflaechen fuer die stromlose metallisierung |
| US4659815A (en) * | 1985-02-04 | 1987-04-21 | The President And Trustees Of The Miami University | Chromogenic aza-12-crown-4 ethers and method of using same for the detection of lithium |
-
1989
- 1989-11-14 CA CA002002917A patent/CA2002917C/en not_active Expired - Lifetime
- 1989-11-14 EP EP89311760A patent/EP0369733B1/de not_active Expired - Lifetime
- 1989-11-14 DE DE68925716T patent/DE68925716T2/de not_active Expired - Lifetime
- 1989-11-14 JP JP1295996A patent/JPH07119218B2/ja not_active Expired - Lifetime
- 1989-11-14 AT AT89311760T patent/ATE134369T1/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| JPH02196777A (ja) | 1990-08-03 |
| CA2002917C (en) | 1998-01-06 |
| EP0369733B1 (de) | 1996-02-21 |
| EP0369733A3 (de) | 1991-03-27 |
| JPH07119218B2 (ja) | 1995-12-20 |
| CA2002917A1 (en) | 1990-05-14 |
| DE68925716D1 (de) | 1996-03-28 |
| DE68925716T2 (de) | 1996-06-13 |
| EP0369733A2 (de) | 1990-05-23 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| EELA | Cancelled due to lapse of time |