ATE134644T1 - Weitere antivirale pyrimidin-nukleosiden - Google Patents

Weitere antivirale pyrimidin-nukleosiden

Info

Publication number: ATE134644T1
Authority: AT; Austria
Prior art keywords: hydroxy; fluoro; hydrogen; pyrimidine nucleosides; monoalkylamino
Prior art date: 1989-10-04

Application number

AT90310857T

Other languages

English (en)

Inventor

Richard Walker

Paul Coe

Saad George Rahim

Original Assignee

Univ Birmingham

Wellcome Found

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-10-04

Filing date

1990-10-04

Publication date

1996-03-15

1989-10-04 Priority claimed from GB898922397A external-priority patent/GB8922397D0/en

1989-10-04 Priority claimed from GB898922393A external-priority patent/GB8922393D0/en

1989-10-04 Priority claimed from GB898922322A external-priority patent/GB8922322D0/en

1990-10-04 Application filed by Univ Birmingham, Wellcome Found filed Critical Univ Birmingham

1996-03-15 Application granted granted Critical

1996-03-15 Publication of ATE134644T1 publication Critical patent/ATE134644T1/de

Links

230000000840 anti-viral effect Effects 0.000 title 1
239000002718 pyrimidine nucleoside Substances 0.000 title 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 5
125000001153 fluoro group Chemical group F* 0.000 abstract 3
229910052739 hydrogen Inorganic materials 0.000 abstract 3
239000001257 hydrogen Substances 0.000 abstract 3
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical compound C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 abstract 2
125000004663 dialkyl amino group Chemical group 0.000 abstract 2
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 2
208000036142 Viral infection Diseases 0.000 abstract 1
125000003342 alkenyl group Chemical group 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
125000000304 alkynyl group Chemical group 0.000 abstract 1
239000011203 carbon fibre reinforced carbon Substances 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000004093 cyano group Chemical group *C#N 0.000 abstract 1
125000000262 haloalkenyl group Chemical group 0.000 abstract 1
125000001188 haloalkyl group Chemical group 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
125000005843 halogen group Chemical group 0.000 abstract 1
150000002431 hydrogen Chemical class 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
-1 monoalkylamino Chemical group 0.000 abstract 1
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
239000005450 thionucleoside Substances 0.000 abstract 1
230000009385 viral infection Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Oncology (AREA)
General Chemical & Material Sciences (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Virology (AREA)
Communicable Diseases (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
Biotechnology (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

AT90310857T 1989-10-04 1990-10-04 Weitere antivirale pyrimidin-nukleosiden ATE134644T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
GB898922397A GB8922397D0 (en)	1989-10-04	1989-10-04	Antiviral pentofuranosides
GB898922393A GB8922393D0 (en)	1989-10-04	1989-10-04	Antiviral pyrimidines
GB898922322A GB8922322D0 (en)	1989-10-04	1989-10-04	Antiviral nucleosides

Publications (1)

Publication Number	Publication Date
ATE134644T1 true ATE134644T1 (de)	1996-03-15

Family

ID=27264717

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT90310857T ATE134644T1 (de)	1989-10-04	1990-10-04	Weitere antivirale pyrimidin-nukleosiden

Country Status (13)

Country	Link
EP (1)	EP0421777B1 (de)
JP (1)	JPH05505791A (de)
KR (1)	KR927003615A (de)
AT (1)	ATE134644T1 (de)
AU (1)	AU656122B2 (de)
CA (1)	CA2067094A1 (de)
DE (1)	DE69025529T2 (de)
ES (1)	ES2086376T3 (de)
HU (1)	HUT61777A (de)
IE (1)	IE74701B1 (de)
NZ (1)	NZ235537A (de)
PT (1)	PT95510B (de)
WO (1)	WO1991004982A1 (de)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IE902574A1 (en) *	1989-07-17	1991-02-27	Univ Birmingham	Antiviral pyrimidine nucleosides
US5128458A (en) *	1990-04-20	1992-07-07	Southern Research Institute	2',3'-dideoxy-4'-thioribonucleosides as antiviral agents
GB9009861D0 (en)	1990-05-02	1990-06-27	Glaxo Group Ltd	Chemical compounds
US5521163A (en) *	1990-07-13	1996-05-28	University Of Birmingham	Antiviral pyrimidine nucleosides and methods for using same
FR2668153B1 (fr) *	1990-10-22	1995-03-31	Pasteur Merieux Serums Vacc	Nouveaux composes ribonucleosides, leur procede de preparation et les medicaments les contenant.
IL100502A (en) *	1991-01-03	1995-12-08	Iaf Biochem Int	PHARMACEUTICAL PREPARATIONS CONTAINING CIS-4-AMINO-1-) 2-HYDROXIMETHIL-1,3-OXETYOLEN-5-IL (-
GB9109186D0 (en) *	1991-04-29	1991-06-19	Wellcome Found	Preparation of thionucleosides
GB9110874D0 (en) *	1991-05-20	1991-07-10	Iaf Biochem Int	Medicaments
JPH07508531A (ja) *	1992-07-02	1995-09-21	ザ・ウエルカム・ファウンデーション・リミテッド	治療用ヌクレオシド
GB9218810D0 (en) *	1992-09-04	1992-10-21	Univ Birmingham	Antiviral pyrimidine nucleosides
WO1997038001A1 (en) *	1996-04-09	1997-10-16	Yamasa Corporation	1-(2-DEOXY-2-FLUORO-4-THIO-β-D-ARABINOFURANOSYL)CYTOSINES
CA2224165A1 (en) *	1996-04-09	1997-10-16	Yamasa Corporation	9-(2-deoxy-2-fluoro-4-thio-.beta.-d-arabinofuranosyl)purine derivatives
WO1999043690A1 (en) *	1998-02-25	1999-09-02	Rational Drug Design Laboratories	L-4'-arabinofuranonucleoside compound and medicine composition comprising the same
WO1999062921A1 (en) *	1998-06-01	1999-12-09	S & T Science And Technology Inc.	Antiviral phosphorus derivatives of 4'-thio-5-ethyl-2'-deoxyuridine
KR20000008131A (ko) *	1998-07-10	2000-02-07	정낙신	치오뉴클레오시드 유도체 및 그들의 제조방법
CA2338415C (en) *	1998-07-23	2006-10-10	Southern Research Institute	Preparation of thioarabinofuranosyl compounds and use thereof
TWI247609B (en) *	2001-01-23	2006-01-21	Nihon Mediphysics Co Ltd	Agent for diagnosis of tissue proliferation activity or the treatment of proliferative disease
CA2538252C (en)	2003-09-18	2014-02-25	Isis Pharmaceuticals, Inc.	4'-thionucleosides and oligomeric compounds
JP5326173B2 (ja) *	2007-09-10	2013-10-30	栄一児玉	エプスタイン・バールウイルス関連疾患に対する薬剤およびそのスクリーニング法
US8859589B2 (en)	2008-03-12	2014-10-14	Southern Research Institute	Use of 4′-thio-2′-deoxynucleosides as anti orthopoxvirus agents
WO2011109012A1 (en)	2010-03-02	2011-09-09	Southern Research Institute	Use of 2'-deoxy-4'-thiocytidine and its analogues as dna hypomethylating anticancer agents
WO2011109383A1 (en) *	2010-03-02	2011-09-09	Southern Research Institute	Use of 2'-deoxy -4'-thiocytidine and its analogues as dna hypomethylating anticancer agents
WO2013133399A1 (ja) *	2012-03-09	2013-09-12	大鵬薬品工業株式会社	Ｄｎａ障害剤
SG10201603288XA (en)	2012-03-28	2016-05-30	Fujifilm Corp	Salt Of 1-(2-Deoxy-2-Fluoro-4-Thio-beta-D-Arabinofuranosyl)Cytosine
KR20170001722A (ko)	2012-08-13	2017-01-04	후지필름 가부시키가이샤	1-(2-데옥시-2-플루오로-4-티오-β-D-아라비노푸라노실)시토신의 합성 중간체, 티오뉴클레오시드의 합성 중간체, 및 그들의 제조법
EP3109245B1 (de)	2014-02-18	2018-01-03	FUJIFILM Corporation	Verfahren zur herstellung eines thiolanskelettartigen glycokonjugats und thiolanskelettartiges glycokonjugat
JP6204223B2 (ja)	2014-02-19	2017-09-27	富士フイルム株式会社	チオピラノース化合物等の製造方法
TWI678373B (zh)	2014-10-31	2019-12-01	日商富士軟片股份有限公司	硫代核苷衍生物或其鹽及醫藥組合物
IL265044B2 (en)	2016-08-31	2025-02-01	Fujifilm Corp	An antitumor preparation containing the substances nab-paclitaxel and 1-(2-deoxy-2-fluoro-4-thio-D-beta-arabinofurnosyl)cytosine, a kit containing these substances and their uses
WO2019146130A1 (ja)	2018-01-29	2019-08-01	富士フイルム株式会社	胆道がん用抗腫瘍剤および胆道がんの処置方法
WO2022008025A1 (en) *	2020-07-05	2022-01-13	Since & Technology Development Fund Authority	2-hydroxyiminopyrimidine nucleosides and derivitives and antiviral uses thereto
MX2023011870A (es) *	2021-04-09	2023-12-07	Univ Emory	Análogos de nucleósidos y de nucleótidos como agentes antivirales para coronavirus y otros virus.
US11938143B2 (en)	2021-10-19	2024-03-26	Akirabio, Inc.	Compositions comprising 2′-deoxycytidine analogs and use thereof for the treatment of sickle cell disease, thalassemia, and cancers

1990
- 1990-10-01 IE IE350290A patent/IE74701B1/en not_active IP Right Cessation
- 1990-10-02 NZ NZ235537A patent/NZ235537A/xx unknown
- 1990-10-04 CA CA002067094A patent/CA2067094A1/en not_active Abandoned
- 1990-10-04 DE DE69025529T patent/DE69025529T2/de not_active Expired - Fee Related
- 1990-10-04 AU AU64413/90A patent/AU656122B2/en not_active Ceased
- 1990-10-04 HU HU9201139A patent/HUT61777A/hu unknown
- 1990-10-04 PT PT95510A patent/PT95510B/pt not_active IP Right Cessation
- 1990-10-04 KR KR1019920700746A patent/KR927003615A/ko not_active Ceased
- 1990-10-04 ES ES90310857T patent/ES2086376T3/es not_active Expired - Lifetime
- 1990-10-04 JP JP90513649A patent/JPH05505791A/ja active Pending
- 1990-10-04 WO PCT/GB1990/001518 patent/WO1991004982A1/en not_active Ceased
- 1990-10-04 AT AT90310857T patent/ATE134644T1/de not_active IP Right Cessation
- 1990-10-04 EP EP90310857A patent/EP0421777B1/de not_active Expired - Lifetime

Also Published As

Publication number	Publication date
IE903502A1 (en)	1991-04-10
AU6441390A (en)	1991-04-28
EP0421777B1 (de)	1996-02-28
DE69025529T2 (de)	1996-10-17
PT95510A (pt)	1991-08-14
PT95510B (pt)	1997-08-29
EP0421777A1 (de)	1991-04-10
ES2086376T3 (es)	1996-07-01
CA2067094A1 (en)	1991-04-05
NZ235537A (en)	1992-12-23
DE69025529D1 (de)	1996-04-04
JPH05505791A (ja)	1993-08-26
AU656122B2 (en)	1995-01-27
IE74701B1 (en)	1997-07-30
HUT61777A (en)	1993-03-01
KR927003615A (ko)	1992-12-18
WO1991004982A1 (en)	1991-04-18

Legal Events

Date	Code	Title	Description
1996-08-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
ATE134644T1 (de)	1996-03-15	Weitere antivirale pyrimidin-nukleosiden
DK0674634T3 (da)	2003-08-04	Fremgangsmåde til fremstilling af substituerede 1,3-oxathiolaner med antivirale egenskaber
HUT59694A (en)	1992-06-29	Process for producing pyrimidine nucleosides of antiviral activity
NL300241I1 (nl)	2006-12-01	Hydroxymethyl(methyleencyclopentyl)uurines en -pyrimidines.
ATE135363T1 (de)	1996-03-15	Nucleoside zur verwendung für die therapie
DK535789A (da)	1990-04-30	Pyrimidindionderivater, fremgangsmaade til fremstilling heraf og antiarytmika omfattende samme
ZA913033B (en)	1992-01-29	N-(3-fluoro-2-phosphonylmethoxypropyl)derivatives of purine and pyrimidine heterocyclic basis,their preparation and use
ATE107633T1 (de)	1994-07-15	Pyrimidinon-derivate.
NO911322D0 (no)	1991-04-04	Nukleosid-derivater.
ES2088903T3 (es)	1996-10-01	Nuevos inhibidores de la s-adenosilmetionina descarboxilasa.
DK0541322T3 (da)	1996-10-14	1-Alkyl-2-acyl-1,2-disulfonylhydraziner med antineoplastisk aktivitet
ATE88176T1 (de)	1993-04-15	2-hydroxy-3-aryloxy-propylaminderivate mit kardiovaskulaerer wirkung.
DK0432898T3 (da)	1994-05-16	Glutarsyrederivater og fremstillingen deraf
FI812773L (fi)	1982-03-13	Foerfarande foer framstaellning av n-/4-/(2,4-diamino-6-pteridinyl)-metyl/metylamino/benzoyl/glutaminsyra
ES2039270T3 (es)	1993-09-16	Derivados de gamma-l-glutamil-4-nitroanilida y procedimiento para determinar actividad de gamma-gtp utilizandolos.
EP0264951A3 (en)	1988-09-14	Procaterol-derivatives
TH9308A (th)	1991-08-01	พิริมิดีนคลีโอไซด์ที่ใช้ต้านไวรัส