ATE135346T1 - Dideoxy-l-arabinitol derivate als antivirus- verbindungen - Google Patents

Dideoxy-l-arabinitol derivate als antivirus- verbindungen

Info

Publication number
ATE135346T1
ATE135346T1 AT89870169T AT89870169T ATE135346T1 AT E135346 T1 ATE135346 T1 AT E135346T1 AT 89870169 T AT89870169 T AT 89870169T AT 89870169 T AT89870169 T AT 89870169T AT E135346 T1 ATE135346 T1 AT E135346T1
Authority
AT
Austria
Prior art keywords
compounds
antivirus
dideoxy
arabinitol
derivatives
Prior art date
Application number
AT89870169T
Other languages
English (en)
Inventor
Francis Jan Koszyk
Richard Allen Partis
Richard August Mueller
Original Assignee
Searle & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/266,718 external-priority patent/US4876268A/en
Priority claimed from US07/410,638 external-priority patent/US4937357A/en
Priority claimed from US07/410,640 external-priority patent/US4973602A/en
Application filed by Searle & Co filed Critical Searle & Co
Application granted granted Critical
Publication of ATE135346T1 publication Critical patent/ATE135346T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/12—Oxygen or sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/03—Ethers having all ether-oxygen atoms bound to acyclic carbon atoms
    • C07C43/14—Unsaturated ethers
    • C07C43/164—Unsaturated ethers containing six-membered aromatic rings
    • C07C43/166—Unsaturated ethers containing six-membered aromatic rings having unsaturation outside the aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/40—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation with ozone; by ozonolysis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C47/00—Compounds having —CHO groups
    • C07C47/20—Unsaturated compounds having —CHO groups bound to acyclic carbon atoms
    • C07C47/277—Unsaturated compounds having —CHO groups bound to acyclic carbon atoms containing ether groups, groups, groups, or groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
AT89870169T 1988-11-03 1989-10-31 Dideoxy-l-arabinitol derivate als antivirus- verbindungen ATE135346T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US07/266,718 US4876268A (en) 1988-11-03 1988-11-03 Antiviral compounds and use thereof
US07/410,638 US4937357A (en) 1988-11-03 1989-09-26 Intermediates for antiviral compounds
US07/410,640 US4973602A (en) 1988-11-03 1989-09-26 Antiviral compounds and a method of use thereas

Publications (1)

Publication Number Publication Date
ATE135346T1 true ATE135346T1 (de) 1996-03-15

Family

ID=27401904

Family Applications (1)

Application Number Title Priority Date Filing Date
AT89870169T ATE135346T1 (de) 1988-11-03 1989-10-31 Dideoxy-l-arabinitol derivate als antivirus- verbindungen

Country Status (7)

Country Link
EP (1) EP0367747B1 (de)
JP (1) JP2840334B2 (de)
AT (1) ATE135346T1 (de)
CA (1) CA2002105C (de)
DE (1) DE68925940T2 (de)
ES (1) ES2086323T3 (de)
GR (1) GR3019885T3 (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1040827A3 (de) * 1995-09-08 2000-10-11 Novo Nordisk A/S Verwendung von 3,4-dihydroxy-2-hydroxymethylpyrrolidin zur behandlung von diabetes
WO1999029321A1 (en) 1997-12-11 1999-06-17 The Chancellor, Masters And Scholars Of The University Of Oxford Inhibition of membrane-associated viral replication
ES2302697T3 (es) * 1999-08-10 2008-08-01 The Chancellor, Masters And Scholars Of The University Of Oxford Compuestos n-alquilicos de cadena larga y derivados oxa de los mismos y uso como composiciones antivirales.
US8975280B2 (en) * 2006-05-24 2015-03-10 The Chancellor, Masters And Scholars Of The University Of Oxford Deoxynojirimycin and D-arabinitol analogs and methods of using

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4999360A (en) * 1987-12-21 1991-03-12 Monsanto Company Method of inhibiting virus

Also Published As

Publication number Publication date
EP0367747A2 (de) 1990-05-09
GR3019885T3 (en) 1996-08-31
DE68925940D1 (de) 1996-04-18
CA2002105A1 (en) 1990-05-03
JP2840334B2 (ja) 1998-12-24
EP0367747A3 (de) 1991-05-08
DE68925940T2 (de) 1996-10-24
ES2086323T3 (es) 1996-07-01
EP0367747B1 (de) 1996-03-13
CA2002105C (en) 1999-01-19
JPH02172972A (ja) 1990-07-04

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee