ATE135914T1 - Aica riboside zur prophylaktischen behandlung von krankheiten mit einer verminderten durchblutung. - Google Patents

Aica riboside zur prophylaktischen behandlung von krankheiten mit einer verminderten durchblutung.

Info

Publication number: ATE135914T1
Authority: AT; Austria
Prior art keywords: blood circulation; prophylactic treatment; diseases involving; reduced blood; aica riboside
Prior art date: 1986-03-27

Application number

AT86902696T

Other languages

English (en)

Inventor

Harry Edward Gruber

Original Assignee

Gensia Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1986-03-27

Filing date

1986-04-08

Publication date

1996-04-15

1986-04-08 Application filed by Gensia Inc filed Critical Gensia Inc

1996-04-15 Application granted granted Critical

1996-04-15 Publication of ATE135914T1 publication Critical patent/ATE135914T1/de

Links

201000010099 disease Diseases 0.000 title abstract 3
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title abstract 3
RTRQQBHATOEIAF-UHFFFAOYSA-N AICA riboside Natural products NC1=C(C(=O)N)N=CN1C1C(O)C(O)C(CO)O1 RTRQQBHATOEIAF-UHFFFAOYSA-N 0.000 title 1
RTRQQBHATOEIAF-UUOKFMHZSA-N acadesine Chemical compound NC1=C(C(=O)N)N=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](CO)O1 RTRQQBHATOEIAF-UUOKFMHZSA-N 0.000 title 1
230000017531 blood circulation Effects 0.000 title 1
238000011321 prophylaxis Methods 0.000 title 1
OIRDTQYFTABQOQ-KQYNXXCUSA-N adenosine Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O OIRDTQYFTABQOQ-KQYNXXCUSA-N 0.000 abstract 4
239000002126 C01EB10 - Adenosine Substances 0.000 abstract 2
229960005305 adenosine Drugs 0.000 abstract 2
230000001413 cellular effect Effects 0.000 abstract 1
230000029142 excretion Effects 0.000 abstract 1
230000003834 intracellular effect Effects 0.000 abstract 1
230000002792 vascular Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/056—Triazole or tetrazole radicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/052—Imidazole radicals

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Immunology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Molecular Biology (AREA)
Biotechnology (AREA)
Biochemistry (AREA)
Genetics & Genomics (AREA)
Vascular Medicine (AREA)
Urology & Nephrology (AREA)
Epidemiology (AREA)
Transplantation (AREA)
Pulmonology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

AT86902696T 1986-03-27 1986-04-08 Aica riboside zur prophylaktischen behandlung von krankheiten mit einer verminderten durchblutung. ATE135914T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US84562786A	1986-03-27	1986-03-27

Publications (1)

Publication Number	Publication Date
ATE135914T1 true ATE135914T1 (de)	1996-04-15

Family

ID=25295693

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT86902696T ATE135914T1 (de)	1986-03-27	1986-04-08	Aica riboside zur prophylaktischen behandlung von krankheiten mit einer verminderten durchblutung.

Country Status (9)

Country	Link
EP (2)	EP0262125B1 (de)
JP (1)	JP2509202B2 (de)
AT (1)	ATE135914T1 (de)
AU (3)	AU5668886A (de)
BR (1)	BR8607124A (de)
DE (1)	DE3650505T2 (de)
DK (1)	DK175693B1 (de)
FI (1)	FI875245A0 (de)
WO (1)	WO1987005807A1 (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4912092A (en) *	1986-03-27	1990-03-27	The Regents Of The University Of California	Methods for increasing extracellular adenosine and for stabilizing mast cells
EP0427799B1 (de) *	1989-01-24	1994-11-30	Gensia, Inc.	Verfahren und verbindungen zur verabreichung von aica ribosiden und zur erniedrigung des blutglucose gehaltes
US5132291A (en) *	1989-01-24	1992-07-21	Gensia Pharmaceuticals, Inc.	Antivirals and methods for increasing the antiviral activity of azt
IL103294A0 (en) *	1991-09-30	1993-05-13	Gensia Pharma	Pharmaceutical compositions for preventing tissue damage associated with decreased blood flow
US5366960A (en) *	1993-08-26	1994-11-22	Warner-Lambert Company	Method of treating cerebral and cardiovascular disorders employing [R]3-(2-deoxy-β-D-erythro-pentofuranosyl)-3,6,7,8-tetrahydroimidaz 0-[4,5-d][1,3]diazepin-8-ol
EP1174141A3 (de) *	1996-01-23	2003-04-23	ICN Pharmaceuticals, Inc.	Regulierung der TH1/TH2 Cytokinexpression durch Ribavirin and Ribavirinanaloge in activierten T-Lymphocyten
PT879056E (pt) *	1996-01-23	2002-10-31	Ribapharm Inc	Modulacao da expressao das citocinas th1/th2 atraves de ribavirina em linfocitos t activados
RU2169568C2 (ru) *	1998-07-14	2001-06-27	Омская государственная медицинская академия	Средство для коррекции энергетического обмена
WO2000030656A1 (en) *	1998-11-20	2000-06-02	The Salk Institute For Biological Studies	Neuron stimulation by ribavirin, and analogs thereof
US6680292B1 (en)	1998-11-20	2004-01-20	The Salk Institute For Biological Studies	Pharmaceutical composition comprising ribavirin and growth factors and methods of use
SI20802A (sl) *	1999-01-29	2002-08-31	Icn Pharmaceuticals, Inc.	Modulacija imunskega odgovora z ribavirinom
HK1049944A1 (zh) *	1999-12-23	2003-06-06	Icn Pharmaceuticals, Inc.	L-核苷、l-核苷酸及其类似物的组合物和治疗方法
JP2008534601A (ja)	2005-03-28	2008-08-28	ペリコーセラピューティクス，インコーポレイテッド	患者における副作用を予防または減少するための方法、組成物および処方物
WO2007104070A1 (en) *	2006-03-14	2007-09-20	Wholesome Biopharm Pty Ltd	Method and composition for treating allergic diseases
WO2010040110A1 (en)	2008-10-03	2010-04-08	Pericor Therapeutics, Inc.	Methods and compositions for treatment of acute heart failure

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US29835A (en) *		1860-08-28		Surveyor s instrument
US3798209A (en) *	1971-06-01	1974-03-19	Icn Pharmaceuticals	1,2,4-triazole nucleosides
USRE29835E (en) *	1971-06-01	1978-11-14	Icn Pharmaceuticals	1,2,4-Triazole nucleosides
US4211771A (en) *	1971-06-01	1980-07-08	Robins Ronald K	Treatment of human viral diseases with 1-B-D-ribofuranosyl-1,2,4-triazole-3-carboxamide
US3888843A (en) *	1973-06-12	1975-06-10	Toyo Jozo Kk	4-carbamoyl-1-' -d-ribofuranosylimidazolium-5-olate
US3923785A (en) *	1974-04-22	1975-12-02	Parke Davis & Co	(R)-3-(2-deoxy-{62 -D-erythro-pentofuranosyl)-3,6,7,8-tetrahydroimidazo{8 4,5-d{9 {8 1,3{9 diazepin-8-ol
US4163839A (en) *	1977-12-09	1979-08-07	Zaidan Hojin Biselbutsu Kagaku Kenkyu Kai	Isocoformycin and a process for the production thereof
GB2016452B (en) *	1978-02-18	1982-07-21	Kissei Pharmaceutical	Imidazole compounds
JPS5671075A (en) *	1979-11-12	1981-06-13	Sumitomo Chem Co Ltd	Novel imidazole derivative
EP0066909A3 (de) *	1981-05-15	1984-03-07	FISONS plc	Imidazolderivate, deren pharmazeutische Zusammensetzungen und Verfahren zu deren Herstellung
JPS59167515A (ja) *	1983-03-15	1984-09-21	Ajinomoto Co Inc	免疫機能増強剤
US4575498A (en) *	1983-07-21	1986-03-11	Duke University	Method for restoring depleted purine nucleotide pools
JPH05334796A (ja) *	1992-06-02	1993-12-17	Sony Corp	光学式ディスク装置

1986
- 1986-04-08 AT AT86902696T patent/ATE135914T1/de not_active IP Right Cessation
- 1986-04-08 AU AU56688/86A patent/AU5668886A/en not_active Abandoned
- 1986-04-08 WO PCT/US1986/000736 patent/WO1987005807A1/en not_active Ceased
- 1986-04-08 EP EP86902696A patent/EP0262125B1/de not_active Expired - Lifetime
- 1986-04-08 BR BR8607124A patent/BR8607124A/pt unknown
- 1986-04-08 EP EP94107553A patent/EP0623348A1/de not_active Withdrawn
- 1986-04-08 FI FI875245A patent/FI875245A0/fi not_active Application Discontinuation
- 1986-04-08 DE DE3650505T patent/DE3650505T2/de not_active Expired - Lifetime
- 1986-04-08 JP JP61502074A patent/JP2509202B2/ja not_active Expired - Lifetime
1987
- 1987-11-26 DK DK198706214A patent/DK175693B1/da not_active IP Right Cessation
1990
- 1990-07-31 AU AU60060/90A patent/AU6006090A/en not_active Abandoned
1993
- 1993-11-26 AU AU51986/93A patent/AU672243B2/en not_active Ceased

Also Published As

Publication number	Publication date
BR8607124A (pt)	1988-04-05
AU5198693A (en)	1994-02-03
FI875245L (fi)	1987-11-27
FI875245A7 (fi)	1987-11-27
DK175693B1 (da)	2005-01-24
DK621487A (da)	1988-01-26
JPS63503061A (ja)	1988-11-10
EP0262125B1 (de)	1996-03-27
EP0623348A1 (de)	1994-11-09
AU6006090A (en)	1990-11-08
JP2509202B2 (ja)	1996-06-19
AU672243B2 (en)	1996-09-26
WO1987005807A1 (en)	1987-10-08
EP0262125A1 (de)	1988-04-06
DE3650505T2 (de)	1996-09-19
EP0262125A4 (de)	1989-07-26
DK621487D0 (da)	1987-11-26
FI875245A0 (fi)	1987-11-27
DE3650505D1 (de)	1996-05-02
AU5668886A (en)	1987-10-20

Legal Events

Date	Code	Title	Description
1996-09-15	UEP	Publication of translation of european patent specification
2006-07-15	EELA	Cancelled due to lapse of time

Publication	Publication Date	Title
ATE258065T1 (de)	2004-02-15	Behandlung von autoimmun-erkrankungen durch orale verabreichung von autoantigenen
DE3650505D1 (de)	1996-05-02	AICA riboside zur prophylaktischen Behandlung von Krankheiten mit einer verminderten Durchblutung.
DE69133516D1 (de)	2006-05-04	Behandlung von autoimmunkrankheiten durch orale verabreichung von autoantigenen
DE3684305D1 (de)	1992-04-16	Antivirales immunotherapeutisches mittel und dessen herstellung.
DK254887A (da)	1987-12-21	Salve til behandling af hudsygdomme
DE3780091D1 (de)	1992-08-06	Behandlung von pilzinfektionen.
PT86346A (en)	1988-01-01	Method of treatment by means of the 3:-deoxitimidinene-2:(3:deoxi-2:3:-didesidrotimidine) administration to animals of hot blood infected with retrovirus
DE3750934D1 (de)	1995-02-16	Behandlung von nicht-Akne-entzündlichen und -infektiösen Hautkrankheiten.
HU213677B (en)	1997-12-29	Pharmaceutical compositions for preventing and treating tumor diseases, and process for producing them
EP0815204A4 (de)	1999-04-14	Methode zur tumorbehandlung
KR890001580A (ko)	1989-03-27	B형 간염 바이러스에 의해 유발되는 염증 질환을 치료하는 이중가닥 rna를 함유하는 약물
DK586387D0 (da)	1987-11-10	Piperidinderivater til behandling af smertetilstande
EP0308197A3 (de)	1989-11-29	Verfahren zur Stimulierung des Immunsystems
DE3781652D1 (de)	1992-10-15	Zubereitung, geeignet fuer die behandlung von darmstoerungen.
ATE131064T1 (de)	1995-12-15	Behandlung zur ermässigung von ödem und muskelschäden.
ATE44156T1 (de)	1989-07-15	Kovalent gebundener heparin-antithrombin iiikomplex, verfahren zu dessen herstellung und seine verwendung zur behandlung von thrombusembolie.
DE3778587D1 (de)	1992-06-04	Herzschrittmacher zur stimulierung des menschlichen herzens.
IT8721115A0 (it)	1987-06-30	Fitopreparato per la cura di affezioni cutanee.
EP0267297A4 (de)	1988-08-29	Sialosylcholesterol, verfahren zu dessen herstellung und arzneimittel zur behandlung von krankheiten des nervensystems.
DE3775278D1 (de)	1992-01-30	Topische methotrexatzubereitung zur behandlung hyperproliferativer epithelerkrankungen.
DE3877102D1 (de)	1993-02-11	Methode fuer die behandlung von viraler gehirnentzuendung.
DE3280419D1 (de)	1992-11-26	Medizinisches praeparat zur behandlung von hautleiden.
AU1162788A (en)	1988-08-18	Oxime-ethers of 2,6-dioxobicyclo-(3.3.0)octanones for treatment of heart and circulation diseases
DE3776662D1 (de)	1992-03-19	Pharmazeutische zusammensetzungen zur behandlung von hyperproliferativer hautkrankheit.
ATE65394T1 (de)	1991-08-15	Behandlung von knochenschwund.