ATE135T1 - 2-SUBSTITUTED-3-HETEROCYCLOINDOLS, METHOD OF PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM. - Google Patents

2-SUBSTITUTED-3-HETEROCYCLOINDOLS, METHOD OF PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.

Info

Publication number
ATE135T1
ATE135T1 AT79103669T AT79103669T ATE135T1 AT E135 T1 ATE135 T1 AT E135T1 AT 79103669 T AT79103669 T AT 79103669T AT 79103669 T AT79103669 T AT 79103669T AT E135 T1 ATE135 T1 AT E135T1
Authority
AT
Austria
Prior art keywords
substituted
heterocycloindols
preparation
pharmaceutical compositions
compositions containing
Prior art date
Application number
AT79103669T
Other languages
German (de)
Inventor
Martin Steinman
Pirouz Tahbaz
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Application granted granted Critical
Publication of ATE135T1 publication Critical patent/ATE135T1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C243/00—Compounds containing chains of nitrogen atoms singly-bound to each other, e.g. hydrazines, triazanes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/55—Acids; Esters

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)

Abstract

This invention relates to compositions of matter classified in the art of chemistry as substituted 2-[(methylsulfinyl)acetyl]-3-heterocyclicindoles, various derivatives thereof, and to the processes for making and using such compositions as immunosuppressants.
AT79103669T 1978-10-02 1979-09-27 2-SUBSTITUTED-3-HETEROCYCLOINDOLS, METHOD OF PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM. ATE135T1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US05/947,979 US4225711A (en) 1978-10-02 1978-10-02 Substituted 2-[(methylsulfinyl)acetyl]-3-heterocyclicindoles and their use as immunosuppressants
EP79103669A EP0010617B1 (en) 1978-10-02 1979-09-27 Novel 2-substituted-3-heterocyclylindoles, their preparation and pharmaceutical compositions containing them

Publications (1)

Publication Number Publication Date
ATE135T1 true ATE135T1 (en) 1981-08-15

Family

ID=25487067

Family Applications (1)

Application Number Title Priority Date Filing Date
AT79103669T ATE135T1 (en) 1978-10-02 1979-09-27 2-SUBSTITUTED-3-HETEROCYCLOINDOLS, METHOD OF PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.

Country Status (13)

Country Link
US (1) US4225711A (en)
EP (1) EP0010617B1 (en)
JP (1) JPS5566578A (en)
AT (1) ATE135T1 (en)
AU (1) AU526088B2 (en)
CA (1) CA1128944A (en)
DE (1) DE2960583D1 (en)
DK (1) DK411279A (en)
FI (1) FI793035A7 (en)
GR (1) GR73698B (en)
IL (1) IL58367A (en)
NZ (1) NZ191710A (en)
ZA (1) ZA795070B (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3706427A1 (en) * 1987-02-27 1988-09-08 Boehringer Mannheim Gmbh NEW SUBSTITUTED 3H-INDOLES, INTERMEDIATE PRODUCTS, METHOD FOR THEIR PRODUCTION AND MEDICINAL PRODUCTS
EP0350990B1 (en) * 1988-07-11 1995-09-20 Akzo Nobel N.V. Pyridazinone derivatives
IL155486A (en) * 2000-10-17 2009-09-22 Ihara Chemical Ind Co Process for producing substituted aniline compound
ITMI20040874A1 (en) * 2004-04-30 2004-07-30 Ist Naz Stud Cura Dei Tumori INDOLIC AND AZAINDOLIC DERIVATIVES WITH ANTI-TUMORAL ACTION

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL23847A (en) * 1964-08-07 1969-02-27 Merck & Co Inc Benzimidazoles useful as antifungals
US3370063A (en) * 1964-10-05 1968-02-20 Mcneilab Inc Substituted dimethoxy indoles and method of making the same
DE1695647A1 (en) * 1967-09-01 1971-05-13 Rhein Pharma Arzneimittel Gmbh 3-Pyridyl (4) indoles and process for their preparation
US3927023A (en) * 1974-05-24 1975-12-16 Warner Lambert Co Imidazolyl benzofurans
GB1523276A (en) * 1974-09-20 1978-08-31 Lafon Labor Sulphur-containing amino compounds
US4059583A (en) * 1975-11-13 1977-11-22 Mcneil Laboratories, Incorporated Substituted indoles

Also Published As

Publication number Publication date
AU526088B2 (en) 1982-12-16
US4225711A (en) 1980-09-30
EP0010617A1 (en) 1980-05-14
ZA795070B (en) 1981-05-27
FI793035A7 (en) 1981-01-01
DE2960583D1 (en) 1981-11-05
JPS5566578A (en) 1980-05-20
CA1128944A (en) 1982-08-03
EP0010617B1 (en) 1981-08-05
JPS6345386B2 (en) 1988-09-09
NZ191710A (en) 1984-04-27
IL58367A0 (en) 1980-01-31
GR73698B (en) 1984-04-03
DK411279A (en) 1980-04-03
IL58367A (en) 1984-05-31
AU5134579A (en) 1980-04-17

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee