ATE136908T1 - Peptide und antikörper, die die integrin- ligandbindung inhibieren - Google Patents

Peptide und antikörper, die die integrin- ligandbindung inhibieren

Info

Publication number
ATE136908T1
ATE136908T1 AT89911963T AT89911963T ATE136908T1 AT E136908 T1 ATE136908 T1 AT E136908T1 AT 89911963 T AT89911963 T AT 89911963T AT 89911963 T AT89911963 T AT 89911963T AT E136908 T1 ATE136908 T1 AT E136908T1
Authority
AT
Austria
Prior art keywords
antibodies
ligand binding
peptides
integrin ligand
inhibit integrin
Prior art date
Application number
AT89911963T
Other languages
English (en)
Inventor
Edward F Plow
Souza Stanley D D
Mark H Ginsberg
Original Assignee
Scripps Research Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/252,674 external-priority patent/US5149780A/en
Application filed by Scripps Research Inst filed Critical Scripps Research Inst
Application granted granted Critical
Publication of ATE136908T1 publication Critical patent/ATE136908T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70546—Integrin superfamily
    • C07K14/70557—Integrin beta3-subunit-containing molecules, e.g. CD41, CD51, CD61
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2839—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily
    • C07K16/2848—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily against integrin beta3-subunit-containing molecules, e.g. CD41, CD51, CD61
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Cell Biology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
AT89911963T 1988-10-03 1989-10-03 Peptide und antikörper, die die integrin- ligandbindung inhibieren ATE136908T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/252,674 US5149780A (en) 1988-10-03 1988-10-03 Peptides and antibodies that inhibit integrin-ligand binding
US07/415,025 US5204445A (en) 1988-10-03 1989-10-02 Peptides and antibodies that inhibit integrin-ligand binding

Publications (1)

Publication Number Publication Date
ATE136908T1 true ATE136908T1 (de) 1996-05-15

Family

ID=26942544

Family Applications (1)

Application Number Title Priority Date Filing Date
AT89911963T ATE136908T1 (de) 1988-10-03 1989-10-03 Peptide und antikörper, die die integrin- ligandbindung inhibieren

Country Status (10)

Country Link
US (1) US5204445A (de)
EP (1) EP0436660B1 (de)
AT (1) ATE136908T1 (de)
AU (1) AU4427389A (de)
CA (1) CA2000048A1 (de)
DE (1) DE68926303T2 (de)
ES (1) ES2024728A6 (de)
GR (1) GR1001291B (de)
PT (1) PT91888A (de)
WO (1) WO1990003983A1 (de)

Families Citing this family (48)

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AU645016B2 (en) * 1989-06-02 1994-01-06 Johns Hopkins University School Of Medicine, The Monoclonal antibodies against leukocyte adhesion receptor beta-chain, methods of producing these antibodies and use therefore
GB8914020D0 (en) † 1989-06-19 1989-08-09 Antisoma Ltd Synthetic peptides for use in thrombus detection
US6521594B1 (en) 1990-04-06 2003-02-18 La Jolla Cancer Research Foundation Method and composition for treating thrombosis
US5672585A (en) * 1990-04-06 1997-09-30 La Jolla Cancer Research Foundation Method and composition for treating thrombosis
US5780303A (en) * 1990-04-06 1998-07-14 La Jolla Cancer Research Foundation Method and composition for treating thrombosis
US5612311A (en) * 1990-04-06 1997-03-18 La Jolla Cancer Research Foundation Method and composition for treating thrombosis
JPH06500555A (ja) * 1990-08-27 1994-01-20 カイロン　コーポレイション 病気の処置のためのペプチドの薬物
CA2109332A1 (en) * 1991-05-03 1992-11-04 Elaine Tuomanen Antibody recognizing endothelial cell ligand for leukocyte cr3
ATE167525T1 (de) * 1991-07-01 1998-07-15 Blood Center Of Southeastern W Pen-polymorphismus von menschlichem plättchenmembran-glykoprotein-iiia und diagnostische und therapeutische anwendung davon
US5962643A (en) 1991-07-11 1999-10-05 The Regents Of The University Of California Integrin β subunit and uses thereof
FI934751A7 (fi) * 1992-10-30 1994-05-01 Bristol Myers Squibb Co Solunulkoiset matriisireseptoriligandit, jotka muutavat leukosyyttitoimintaa
CA2188287A1 (en) * 1994-04-19 1995-10-26 Stephen Benedict Icam-1/lfa-1 short-chain peptides and method of using same
US5559099A (en) * 1994-09-08 1996-09-24 Genvec, Inc. Penton base protein and methods of using same
US5846782A (en) 1995-11-28 1998-12-08 Genvec, Inc. Targeting adenovirus with use of constrained peptide motifs
US6465253B1 (en) * 1994-09-08 2002-10-15 Genvec, Inc. Vectors and methods for gene transfer to cells
US5770442A (en) * 1995-02-21 1998-06-23 Cornell Research Foundation, Inc. Chimeric adenoviral fiber protein and methods of using same
US6127525A (en) * 1995-02-21 2000-10-03 Cornell Research Foundation, Inc. Chimeric adenoviral coat protein and methods of using same
JPH11500914A (ja) 1995-02-25 1999-01-26 インペリアル キャンサー リサーチ テクノロジィ リミテッド 乾癬モデルとしての形質転換動物
US6783980B2 (en) * 1995-06-15 2004-08-31 Crucell Holland B.V. Packaging systems for human recombinant adenovirus to be used in gene therapy
SI0833934T2 (sl) * 1995-06-15 2013-04-30 Crucell Holland B.V. Pakirni sistemi za humani rekombinantni adenovirus za uporabo v genski terapiji
US5817750A (en) * 1995-08-28 1998-10-06 La Jolla Cancer Research Foundation Structural mimics of RGD-binding sites
HUP9901192A3 (en) 1996-01-10 2000-02-28 Amersham Health As Contrast media
GB9600427D0 (en) * 1996-01-10 1996-03-13 Nycomed Imaging As Contrast media
US6087332A (en) * 1997-12-23 2000-07-11 Galler; Lawrence Isaac Streptokinase derivatives with high affinity for activated platelets and methods of their production and use in thrombolytic therapy
US20040043489A1 (en) * 1998-07-08 2004-03-04 Menzo Havenga Gene delivery vectors provided with a tissue tropism for dendritic cells and methods of use
US20030017138A1 (en) * 1998-07-08 2003-01-23 Menzo Havenga Chimeric adenoviruses
US6929946B1 (en) 1998-11-20 2005-08-16 Crucell Holland B.V. Gene delivery vectors provided with a tissue tropism for smooth muscle cells, and/or endothelial cells
US20050232900A1 (en) * 1999-05-18 2005-10-20 Crucell Holland B.V. Serotype of adenovirus and uses thereof
US6913922B1 (en) * 1999-05-18 2005-07-05 Crucell Holland B.V. Serotype of adenovirus and uses thereof
US6492169B1 (en) 1999-05-18 2002-12-10 Crucell Holland, B.V. Complementing cell lines
AU6090200A (en) * 1999-07-15 2001-02-05 Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The Peptides and their utility in modulation of behavior of cells expressing alpha3beta1 integrins
US7129052B1 (en) 2000-07-12 2006-10-31 The United States Of America As Represented By The Department Of Health And Human Services Peptides and their utility in modulation of behavior of cells expressing α3β1 integrins
EP1157999A1 (de) * 2000-05-24 2001-11-28 Introgene B.V. Verfahren und Mitteln zur Verbesserung der Haut-Transplantation mittels Genabgabe-Vehikel mit Tropismus für primären Fibroblasten, sowie andere Verwendungsmöglichkeiten für diesen
CA2421864A1 (en) * 2000-09-20 2002-03-28 Crucell Holland B.V. Transduction of dendritic cells using adenoviral vectors
DE60138403D1 (de) * 2000-09-26 2009-05-28 Crucell Holland Bv Adenovirale vektoren für die übertragung von genen in zellen der skelettmuskulatur oder myoblasten
EP1372720A4 (de) * 2001-03-02 2006-07-26 Medimmune Inc Verfahren zur prävention oder behandlung von entzündlichen erkrankungen oder autoimmunkrankheiten durch verabreichung von integrin-alphav-beta3-antagonisten
WO2003062400A2 (en) * 2002-01-24 2003-07-31 The Scripps Research Institute Fiber shaft modifications for efficient targeting
CA2478317A1 (en) * 2002-03-04 2003-09-18 Medimmune, Inc. Methods of preventing or treating disorders by administering an integrin .alpha.v.beta.3 antagonist in combination with an hmg-coa reductase inhibitor or a bisphosphonate
AU2003217930A1 (en) * 2002-03-04 2003-09-22 Medimmune, Llc The prevention or treatment of cancer using integrin alphavbeta3 antagonists in combination with other agents
US7371383B2 (en) * 2002-04-12 2008-05-13 Medimmune, Inc. Recombinant anti-interleukin-9 antibodies
KR101021387B1 (ko) * 2002-04-25 2011-03-14 크루셀 홀란드 비.브이. 아데노바이러스 벡터를 생산하기 위한 수단 및 방법
JP2006516635A (ja) * 2003-01-30 2006-07-06 メディミューン，インコーポレーテッド インテグリンαｖβ３アンタゴニストの使用
JP4764818B2 (ja) 2003-04-11 2011-09-07 メディミューン，エルエルシー 組換えｉｌ−９抗体およびその使用
US7351739B2 (en) * 2004-04-30 2008-04-01 Wellgen, Inc. Bioactive compounds and methods of uses thereof
US20060121042A1 (en) 2004-10-27 2006-06-08 Medimmune, Inc. Modulation of antibody specificity by tailoring the affinity to cognate antigens
AU2007272970C1 (en) 2006-07-11 2013-01-10 Roy C. Levitt Rhinosinusitis prevention and therapy with proinflammatory cytokine inhibitors
EP3669878A1 (de) 2006-08-10 2020-06-24 Roy C. Levitt Lokalisierte therapie von entzündungskrankheiten der unteren atemwege mit hemmern für proinflammatorische zytokine
MX342270B (es) * 2010-02-18 2016-09-21 The Regents Of The Univ Of California * ANTICUERPO NEUTRALIZANTE DE LA INTEGRINA AVß8.

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1988006592A1 (en) * 1987-02-26 1988-09-07 Dana-Farber Cancer Institute, Inc. Cloning of lfa-1
US5114842A (en) * 1987-07-08 1992-05-19 The Scripps Research Institute Peptides and antibodies that inhibit platelet adhesion

Also Published As

Publication number Publication date
EP0436660A4 (en) 1992-02-12
EP0436660A1 (de) 1991-07-17
GR890100632A (en) 1990-11-29
US5204445A (en) 1993-04-20
DE68926303T2 (de) 1996-11-21
EP0436660B1 (de) 1996-04-17
DE68926303D1 (de) 1996-05-23
CA2000048A1 (en) 1990-04-03
ES2024728A6 (es) 1992-03-01
AU4427389A (en) 1990-05-01
WO1990003983A1 (en) 1990-04-19
PT91888A (pt) 1990-04-30
GR1001291B (el) 1993-07-30

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