ATE137759T1 - S'-adenosyl-methionin-decarboxylase-inhibitoren - Google Patents

S'-adenosyl-methionin-decarboxylase-inhibitoren

Info

Publication number: ATE137759T1
Authority: AT; Austria
Prior art keywords: chem; decarboxylase inhibitors; adenosyl; methionine decarboxylase; adenosinyl
Prior art date: 1988-07-21

Application number

AT89401845T

Other languages

English (en)

Inventor

Patrick Casara

Charles Danzin

Original Assignee

Merrell Pharma Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-07-21

Filing date

1989-06-28

Publication date

1996-05-15

1989-06-28 Application filed by Merrell Pharma Inc filed Critical Merrell Pharma Inc

1996-05-15 Application granted granted Critical

1996-05-15 Publication of ATE137759T1 publication Critical patent/ATE137759T1/de

Links

239000003954 decarboxylase inhibitor Substances 0.000 title abstract 2
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 2
102000005758 Adenosylmethionine decarboxylase Human genes 0.000 abstract 1
108010070753 Adenosylmethionine decarboxylase Proteins 0.000 abstract 1
230000010261 cell growth Effects 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
125000000896 monocarboxylic acid group Chemical group 0.000 abstract 1
230000035755 proliferation Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Genetics & Genomics (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Tropical Medicine & Parasitology (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
Molecular Biology (AREA)
Virology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Pyridine Compounds (AREA)
Enzymes And Modification Thereof (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

AT89401845T 1988-07-21 1989-06-28 S'-adenosyl-methionin-decarboxylase-inhibitoren ATE137759T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP88401896A EP0351475A1 (de)	1988-07-21	1988-07-21	S-Adenosylmethionin-decarboxylase-Inhibitoren

Publications (1)

Publication Number	Publication Date
ATE137759T1 true ATE137759T1 (de)	1996-05-15

Family

ID=8200409

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT89401845T ATE137759T1 (de)	1988-07-21	1989-06-28	S'-adenosyl-methionin-decarboxylase-inhibitoren

Country Status (8)

Country	Link
US (1)	US5416076A (de)
EP (1)	EP0351475A1 (de)
AT (1)	ATE137759T1 (de)
DE (1)	DE68926418T2 (de)
ES (1)	ES2088903T3 (de)
GR (1)	GR3019893T3 (de)
HU (1)	HU204536B (de)
ZA (1)	ZA895387B (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5308837A (en) *	1990-08-22	1994-05-03	Merrell Dow Pharmaceuticals Inc.	5'-amine substituted adenosine analogs as immunosuppressants
ZA916464B (en) *	1990-08-22	1992-05-27	Merrell Dow Pharma	5'-amine substituted adenosine analogs as immunosuppressants
US5750496A (en) *	1996-08-12	1998-05-12	Utah State University	Method of controlling cryptosporidium infectons using protease inhibitors
US5733889A (en) *	1996-10-29	1998-03-31	The Metrohealth System	Treatment for cardiac arrhythmias
US6534651B2 (en) *	2000-04-06	2003-03-18	Inotek Pharmaceuticals Corp.	7-Substituted isoindolinone inhibitors of inflammation and reperfusion injury and methods of use thereof
US20030224970A1 (en) *	2002-05-17	2003-12-04	Sanjoy Mahanty	Methods for the identification of inhibitors of S-adenosylmethionine decarboxylase as antibiotics
EP1834669A1 (de) *	2006-03-15	2007-09-19	Heinrich-Pette-Institut	Verwendung von Hydrazonverbindungen zur Behandlung viraler Infektionen
WO2008157438A1 (en) *	2007-06-15	2008-12-24	Genzyme Corporation	Inhibitors of s-adenosyl-l-methionine decarboxylase
NZ582850A (en) *	2007-08-02	2011-10-28	Southern Res Inst	5'-substituted adenosynes, preparation thereof and use as inhibitors of s-adenosylmethionine decarboxylase

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4134918A (en) *	1977-09-06	1979-01-16	Merrell Toraude Et Compagnie	Alpha-halomethyl derivatives of amines
US4794174A (en) *	1987-02-10	1988-12-27	Southern Research Institute	5'deoxy-5'-substituted adenosines

1988
- 1988-07-21 EP EP88401896A patent/EP0351475A1/de not_active Withdrawn
1989
- 1989-06-28 DE DE68926418T patent/DE68926418T2/de not_active Expired - Lifetime
- 1989-06-28 AT AT89401845T patent/ATE137759T1/de not_active IP Right Cessation
- 1989-06-28 ES ES89401845T patent/ES2088903T3/es not_active Expired - Lifetime
- 1989-07-14 ZA ZA895387A patent/ZA895387B/xx unknown
- 1989-07-20 HU HU893694A patent/HU204536B/hu not_active IP Right Cessation
1992
- 1992-06-09 US US07/896,733 patent/US5416076A/en not_active Expired - Lifetime
1996
- 1996-05-13 GR GR960401274T patent/GR3019893T3/el unknown

Also Published As

Publication number	Publication date
GR3019893T3 (en)	1996-08-31
ZA895387B (en)	1990-04-25
DE68926418T2 (de)	1996-09-19
HUT50354A (en)	1990-01-29
US5416076A (en)	1995-05-16
DE68926418D1 (de)	1996-06-13
EP0351475A1 (de)	1990-01-24
HU204536B (en)	1992-01-28
ES2088903T3 (es)	1996-10-01

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Legal Events

Date	Code	Title	Description
1996-10-15	UEP	Publication of translation of european patent specification
2004-03-15	REN	Ceased due to non-payment of the annual fee