ATE138098T1 - Analoga von menschlichem wachstumshormon und ihre verwendung - Google Patents

Analoga von menschlichem wachstumshormon und ihre verwendung

Info

Publication number: ATE138098T1
Authority: AT; Austria
Prior art keywords: amino acid; mutants; growth hormone; human growth; hgh
Prior art date: 1991-09-27

Application number

AT92202956T

Other languages

English (en)

Inventor

Guido Grandi

Giuliano Galli

Y Ros Immaculada Margarit

Susanna Campagnoli

Original Assignee

Eniricerche Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-09-27

Filing date

1992-09-25

Publication date

1996-06-15

1992-09-25 Application filed by Eniricerche Spa filed Critical Eniricerche Spa

1996-06-15 Application granted granted Critical

1996-06-15 Publication of ATE138098T1 publication Critical patent/ATE138098T1/de

Links

102000002265 Human Growth Hormone Human genes 0.000 title abstract 5
108010000521 Human Growth Hormone Proteins 0.000 title abstract 5
239000000854 Human Growth Hormone Substances 0.000 title abstract 5
ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 abstract 3
COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 abstract 3
AYFVYJQAPQTCCC-GBXIJSLDSA-N L-threonine Chemical compound C[C@@H](O)[C@H](N)C(O)=O AYFVYJQAPQTCCC-GBXIJSLDSA-N 0.000 abstract 3
HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 abstract 2
125000000539 amino acid group Chemical group 0.000 abstract 2
239000004475 Arginine Substances 0.000 abstract 1
208000010392 Bone Fractures Diseases 0.000 abstract 1
QNAYBMKLOCPYGJ-UHFFFAOYSA-N D-alpha-Ala Natural products CC([NH3+])C([O-])=O QNAYBMKLOCPYGJ-UHFFFAOYSA-N 0.000 abstract 1
206010062767 Hypophysitis Diseases 0.000 abstract 1
QNAYBMKLOCPYGJ-UWTATZPHSA-N L-Alanine Natural products C[C@@H](N)C(O)=O QNAYBMKLOCPYGJ-UWTATZPHSA-N 0.000 abstract 1
ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 abstract 1
QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 abstract 1
235000019454 L-leucine Nutrition 0.000 abstract 1
239000004395 L-leucine Substances 0.000 abstract 1
229930182821 L-proline Natural products 0.000 abstract 1
239000004473 Threonine Substances 0.000 abstract 1
229960003767 alanine Drugs 0.000 abstract 1
150000001413 amino acids Chemical group 0.000 abstract 1
ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 abstract 1
230000004071 biological effect Effects 0.000 abstract 1
230000004064 dysfunction Effects 0.000 abstract 1
230000007515 enzymatic degradation Effects 0.000 abstract 1
229960002885 histidine Drugs 0.000 abstract 1
229960003136 leucine Drugs 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
230000001575 pathological effect Effects 0.000 abstract 1
229960005190 phenylalanine Drugs 0.000 abstract 1
229960002429 proline Drugs 0.000 abstract 1
230000001225 therapeutic effect Effects 0.000 abstract 1
229960002898 threonine Drugs 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/61—Growth hormone [GH], i.e. somatotropin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Endocrinology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Molecular Biology (AREA)
Dermatology (AREA)
Toxicology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biochemistry (AREA)
Zoology (AREA)
Genetics & Genomics (AREA)
Gastroenterology & Hepatology (AREA)
Biophysics (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Peptides Or Proteins (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)

AT92202956T 1991-09-27 1992-09-25 Analoga von menschlichem wachstumshormon und ihre verwendung ATE138098T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
ITMI912582A IT1251895B (it)	1991-09-27	1991-09-27	Mutanti dell'ormone della crescita umano e loro impiego

Publications (1)

Publication Number	Publication Date
ATE138098T1 true ATE138098T1 (de)	1996-06-15

Family

ID=11360779

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT92202956T ATE138098T1 (de)	1991-09-27	1992-09-25	Analoga von menschlichem wachstumshormon und ihre verwendung

Country Status (7)

Country	Link
EP (1)	EP0534568B1 (de)
JP (1)	JPH05310794A (de)
AT (1)	ATE138098T1 (de)
DE (1)	DE69210733T2 (de)
DK (1)	DK0534568T3 (de)
ES (1)	ES2087434T3 (de)
IT (1)	IT1251895B (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SE0000837D0 (sv)	2000-03-13	2000-03-13	Pharmacia & Upjohn Ab	New use
JP2003079379A (ja) *	2001-09-13	2003-03-18	Itoham Foods Inc	成長ホルモンの高発現用ｄｎａおよびその使用
GB2389115B (en) *	2001-12-14	2005-03-16	Asterion Ltd	Polypeptide having a plurality of modified growth hormone receptor binding domains of growth hormone
KR20110039348A (ko)	2008-08-06	2011-04-15	노보 노르디스크 헬스 케어 악티엔게젤샤프트	연장된 생체내 효능을 가지는 콘쥬게이트된 단백질
KR20110122100A (ko)	2009-01-22	2011-11-09	노보 노르디스크 헬스 케어 악티엔게젤샤프트	안정한 성장 호르몬 화합물
JP6086528B2 (ja)	2009-08-06	2017-03-01	ノヴォ・ノルディスク・ヘルス・ケア・アーゲー	長期のインビボ有効性を有する成長ホルモン
JP5980689B2 (ja) *	2010-01-22	2016-08-31	ノヴォ・ノルディスク・ヘルス・ケア・アーゲー	安定な成長ホルモン化合物
CN106139158B (zh)	2010-01-22	2024-06-21	诺沃—诺迪斯克保健股份有限公司	体内功效延长的生长激素
WO2012010516A1 (en)	2010-07-22	2012-01-26	Novo Nordisk Health Care Ag	Growth hormone conjugates
EP2981282B1 (de)	2013-04-05	2020-11-04	Novo Nordisk Health Care AG	Wachstumshormonverbindungsformulierung

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IT1223577B (it) *	1987-12-22	1990-09-19	Eniricerche Spa	Procedimento migliorato per la preparazione dell'ormone della crescita umano naturale in forma pura

1991
- 1991-09-27 IT ITMI912582A patent/IT1251895B/it active IP Right Grant
1992
- 1992-09-25 ES ES92202956T patent/ES2087434T3/es not_active Expired - Lifetime
- 1992-09-25 DE DE69210733T patent/DE69210733T2/de not_active Expired - Fee Related
- 1992-09-25 DK DK92202956.6T patent/DK0534568T3/da active
- 1992-09-25 EP EP92202956A patent/EP0534568B1/de not_active Expired - Lifetime
- 1992-09-25 AT AT92202956T patent/ATE138098T1/de not_active IP Right Cessation
- 1992-09-28 JP JP4281045A patent/JPH05310794A/ja not_active Withdrawn

Also Published As

Publication number	Publication date
DK0534568T3 (da)	1996-07-15
EP0534568B1 (de)	1996-05-15
ITMI912582A0 (it)	1991-09-27
ITMI912582A1 (it)	1993-03-27
DE69210733T2 (de)	1996-10-02
EP0534568A3 (de)	1994-03-16
IT1251895B (it)	1995-05-26
JPH05310794A (ja)	1993-11-22
DE69210733D1 (de)	1996-06-20
ES2087434T3 (es)	1996-07-16
EP0534568A2 (de)	1993-03-31

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Legal Events

Date	Code	Title	Description
1996-11-15	UEP	Publication of translation of european patent specification
1999-06-15	REN	Ceased due to non-payment of the annual fee