ATE138266T1 - Verwendung von xanthinen zur herstellung von arzneimitteln zur hemmung der vermehrung menschlicher retroviren - Google Patents

Verwendung von xanthinen zur herstellung von arzneimitteln zur hemmung der vermehrung menschlicher retroviren

Info

Publication number: ATE138266T1
Authority: AT; Austria
Prior art keywords: group; chem; formula; carbon atoms; stands
Prior art date: 1990-11-07

Application number

AT91118347T

Other languages

English (en)

Inventor

Bruce J Dezube

Arthur B Pardee

Ruth M Ruprecht

William J Novick Jr

Original Assignee

Hoechst Roussel Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-11-07

Filing date

1991-10-28

Publication date

1996-06-15

1991-10-28 Application filed by Hoechst Roussel Pharma filed Critical Hoechst Roussel Pharma

1996-06-15 Application granted granted Critical

1996-06-15 Publication of ATE138266T1 publication Critical patent/ATE138266T1/de

Links

229940065721 systemic for obstructive airway disease xanthines Drugs 0.000 title abstract 2
229940126601 medicinal product Drugs 0.000 title 1
125000004432 carbon atom Chemical group C* 0.000 abstract 4
150000001875 compounds Chemical class 0.000 abstract 3
241000725303 Human immunodeficiency virus Species 0.000 abstract 2
125000000217 alkyl group Chemical group 0.000 abstract 2
230000010076 replication Effects 0.000 abstract 2
241001430294 unidentified retrovirus Species 0.000 abstract 2
LRFVTYWOQMYALW-UHFFFAOYSA-N 9H-xanthine Chemical class O=C1NC(=O)NC2=C1NC=N2 LRFVTYWOQMYALW-UHFFFAOYSA-N 0.000 abstract 1
OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
239000004215 Carbon black (E152) Substances 0.000 abstract 1
208000031886 HIV Infections Diseases 0.000 abstract 1
208000037357 HIV infectious disease Diseases 0.000 abstract 1
241000282412 Homo Species 0.000 abstract 1
125000001931 aliphatic group Chemical group 0.000 abstract 1
125000004183 alkoxy alkyl group Chemical group 0.000 abstract 1
125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 abstract 1
208000033519 human immunodeficiency virus infectious disease Diseases 0.000 abstract 1
229930195733 hydrocarbon Natural products 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
125000004356 hydroxy functional group Chemical group O* 0.000 abstract 1
125000002768 hydroxyalkyl group Chemical group 0.000 abstract 1
230000002401 inhibitory effect Effects 0.000 abstract 1
230000005764 inhibitory process Effects 0.000 abstract 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
125000004043 oxo group Chemical group O=* 0.000 abstract 1
125000004430 oxygen atom Chemical group O* 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Epidemiology (AREA)
Virology (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

AT91118347T 1990-11-07 1991-10-28 Verwendung von xanthinen zur herstellung von arzneimitteln zur hemmung der vermehrung menschlicher retroviren ATE138266T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US61023090A	1990-11-07	1990-11-07

Publications (1)

Publication Number	Publication Date
ATE138266T1 true ATE138266T1 (de)	1996-06-15

Family

ID=24444220

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT91118347T ATE138266T1 (de)	1990-11-07	1991-10-28	Verwendung von xanthinen zur herstellung von arzneimitteln zur hemmung der vermehrung menschlicher retroviren

Country Status (16)

Country	Link
EP (1)	EP0484785B1 (de)
JP (1)	JPH054922A (de)
KR (1)	KR920009397A (de)
AT (1)	ATE138266T1 (de)
AU (1)	AU649278B2 (de)
CA (1)	CA2055041A1 (de)
DE (1)	DE69119700T2 (de)
DK (1)	DK0484785T3 (de)
ES (1)	ES2087205T3 (de)
GR (1)	GR3020017T3 (de)
HU (1)	HUT61468A (de)
IE (1)	IE913879A1 (de)
IL (1)	IL99966A0 (de)
PT (1)	PT99434A (de)
TW (1)	TW209169B (de)
ZA (1)	ZA918801B (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
TW288977B (de) *	1992-02-22	1996-10-21	Hoechst Ag
JP2004525109A (ja)	2001-02-15	2004-08-19	キング・ファーマシューティカルズ・インコーポレイティッド	安定化された甲状腺ホルモン医薬組成物、及びその製法
US7101569B2 (en)	2001-08-14	2006-09-05	Franz G Andrew	Methods of administering levothyroxine pharmaceutical compositions
ES2275400B1 (es) *	2005-04-20	2008-04-01	Universidad Autonoma De Madrid	Uso de compuestos agonistas de la actividad tubulina desacetilasa de la proteina hdac6 en la elaboracion de composiciones farmaceuticas, dichas composiciones farmaceuticas y sus aplicaciones en el tratamiento de infecciones virales.
KR20100121527A (ko)	2008-02-29	2010-11-17	콘서트 파마슈티컬즈, 인크.	치환된 잔틴 유도체
US20110053961A1 (en)	2009-02-27	2011-03-03	Concert Pharmaceuticals, Inc.	Substituted xanthine derivatives
CA2771331A1 (en)	2009-09-02	2011-03-10	Concert Pharmaceuticals, Inc.	Substituted xanthine derivatives
EP2611807A2 (de)	2010-09-01	2013-07-10	Concert Pharmaceuticals Inc.	Polymorphe aus (s)-1-(4,4,6,6,6-pentadeutero-5-hydroxyhexyl)-3-7-dimethyl-1h-purin-2,6(3h,7h)dion
US20140296263A1 (en)	2011-07-19	2014-10-02	Concert Pharmaceuticals, Inc.	Substituted xanthine derivatives
CN104364255A (zh)	2012-04-13	2015-02-18	康塞特医药品有限公司	取代的黄嘌呤衍生物
WO2013159006A1 (en)	2012-04-20	2013-10-24	Concert Pharmaceuticals, Inc.	Polymorphs of (s)-1-(4,4,6,6,6-pentadeutero-5-hydroxyhexyl)-3,7-dimethyl-1h-purine-2,6(3h,7h)-dione

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3737433A (en) *	1964-09-05	1973-06-05	Albert Ag Chem Werke	Certain oxoalkyldimethylxanthines
CH608236A5 (de) *	1974-01-22	1978-12-29	Wuelfing J A Fa
US4663317A (en) *	1984-04-18	1987-05-05	Board Of Regents, University Of Texas System	Methods and compositions for treating viral infections
US4636507A (en) *	1984-04-30	1987-01-13	Hoechst-Roussel Pharmaceuticals Inc.	Host defense mechanism enhancement
DE3525801A1 (de) *	1985-07-19	1987-01-22	Hoechst Ag	Tertiaere hydroxyalkylxanthine, verfahren zu ihrer herstellung, die sie enthaltenden arzneimittel und ihre verwendung
GB8610136D0 (en) *	1986-04-25	1986-05-29	Wellcome Found	Compounds
DE3725554A1 (de) *	1987-08-01	1989-02-09	Hoechst Ag	Pharmazeutisches kombinationspraeparat sowie dessen herstellung und verwendung

1991
- 1991-10-28 EP EP91118347A patent/EP0484785B1/de not_active Expired - Lifetime
- 1991-10-28 ES ES91118347T patent/ES2087205T3/es not_active Expired - Lifetime
- 1991-10-28 DK DK91118347.3T patent/DK0484785T3/da active
- 1991-10-28 DE DE69119700T patent/DE69119700T2/de not_active Expired - Fee Related
- 1991-10-28 AT AT91118347T patent/ATE138266T1/de not_active IP Right Cessation
- 1991-11-05 AU AU86998/91A patent/AU649278B2/en not_active Ceased
- 1991-11-05 IL IL99966A patent/IL99966A0/xx unknown
- 1991-11-06 JP JP3289900A patent/JPH054922A/ja active Pending
- 1991-11-06 PT PT99434A patent/PT99434A/pt not_active Application Discontinuation
- 1991-11-06 CA CA002055041A patent/CA2055041A1/en not_active Abandoned
- 1991-11-06 IE IE387991A patent/IE913879A1/en not_active Application Discontinuation
- 1991-11-06 ZA ZA918801A patent/ZA918801B/xx unknown
- 1991-11-07 HU HU913502A patent/HUT61468A/hu unknown
- 1991-11-07 KR KR1019910019714A patent/KR920009397A/ko not_active Ceased
1992
- 1992-01-25 TW TW081100520A patent/TW209169B/zh active
1996
- 1996-05-23 GR GR960401329T patent/GR3020017T3/el unknown

Also Published As

Publication number	Publication date
PT99434A (pt)	1992-09-30
HU913502D0 (en)	1992-01-28
EP0484785B1 (de)	1996-05-22
EP0484785A2 (de)	1992-05-13
AU649278B2 (en)	1994-05-19
IE913879A1 (en)	1992-05-20
GR3020017T3 (en)	1996-08-31
ES2087205T3 (es)	1996-07-16
TW209169B (de)	1993-07-11
CA2055041A1 (en)	1992-05-08
DE69119700T2 (de)	1996-11-07
JPH054922A (ja)	1993-01-14
DK0484785T3 (da)	1996-09-23
EP0484785A3 (en)	1992-12-16
AU8699891A (en)	1992-05-14
IL99966A0 (en)	1992-08-18
HUT61468A (en)	1993-01-28
DE69119700D1 (de)	1996-06-27
KR920009397A (ko)	1992-06-25
ZA918801B (en)	1992-12-30

Legal Events

Date	Code	Title	Description
1996-11-15	UEP	Publication of translation of european patent specification
2004-07-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
AU671933B2 (en)	1996-09-12	The administration of monoamine acridine in cholinergic neuronal deficit states
DE69116503D1 (de)	1996-02-29	Aminoglycosid-Zusammensetzung mit wesentlich verminderter Nephrotoxizität
ES8308314A1 (es)	1983-09-01	Procedimiento para preparar derivados de 2-amino-4-hidroxiquinazolina.
ATE160341T1 (de)	1997-12-15	Benzolsulfonamid-derivate und verfahren zur herstellung
IL103944A (en)	1997-06-10	Piperazine derivatives, their preparation and pharmaceutical compositions containing them
ES468119A1 (es)	1979-09-01	Un procedimiento para la preparacion de triazinas
NO308739B1 (no)	2000-10-23	Imidazolderivater samt medisinsk sammensetning og anti-HIV- sammensetning omfattende samme
ATE76864T1 (de)	1992-06-15	Aromatische polycyclische derivate, verfahren zu ihrer herstellung und ihre verwendung in pharmazeutischen und kosmetischen zubereitungen.
ZA877518B (en)	1989-06-28	Use of 1-benzyl-aminoalkyl-pyrrolidinones as antidepressandihydropyridine derivatives,their preparation and their usts e
DE69119700D1 (de)	1996-06-27	Verwendung von Xanthinen zur Herstellung von Arzneimitteln zur Hemmung der Vermehrung menschlicher Retroviren
HUT68000A (en)	1995-05-29	Herbicidal isoxazole-derivatives, compositions containing them and process for their preparation
ATE113030T1 (de)	1994-11-15	Hydroxyalkancarbonsäure-derivate und deren verwendung.
AU3376193A (en)	1993-08-26	The use of xanthine derivatives for the treatment of muscle damage after interruption of the blood circulation
DK0570245T3 (da)	1997-04-14	Octahydronaphthalenoximderivater til inbibering af kolesterolbiosyntese, deres fremstilling og anvendelse
ES8400406A1 (es)	1983-11-01	Procedimiento para preparar derivados de indano.
AU1093692A (en)	1992-08-27	Disubstituted ureas and thioureas derivatives
ATE149352T1 (de)	1997-03-15	Thiadiazol-derivate zur behandlung von depressiven zuständen