ATE138655T1 - L-glutamsäure-derivate - Google Patents
L-glutamsäure-derivateInfo
- Publication number
- ATE138655T1 ATE138655T1 AT91103482T AT91103482T ATE138655T1 AT E138655 T1 ATE138655 T1 AT E138655T1 AT 91103482 T AT91103482 T AT 91103482T AT 91103482 T AT91103482 T AT 91103482T AT E138655 T1 ATE138655 T1 AT E138655T1
- Authority
- AT
- Austria
- Prior art keywords
- glutamic acid
- acid derivatives
- derivatives
- hydroxypyrimidin
- diamino
- Prior art date
Links
- 150000008539 L-glutamic acids Chemical class 0.000 title 1
- 229960002989 glutamic acid Drugs 0.000 abstract 2
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-Glutamic acid Natural products OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 abstract 1
- 229940034982 antineoplastic agent Drugs 0.000 abstract 1
- 239000002246 antineoplastic agent Substances 0.000 abstract 1
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 abstract 1
- 125000004528 pyrimidin-5-yl group Chemical group N1=CN=CC(=C1)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/48—Two nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/510,669 US5013738A (en) | 1990-04-18 | 1990-04-18 | L-glutamic acid derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE138655T1 true ATE138655T1 (de) | 1996-06-15 |
Family
ID=24031685
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT91103482T ATE138655T1 (de) | 1990-04-18 | 1991-03-07 | L-glutamsäure-derivate |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US5013738A (de) |
| EP (1) | EP0452660B1 (de) |
| JP (1) | JPH05262746A (de) |
| AT (1) | ATE138655T1 (de) |
| CA (1) | CA2037015A1 (de) |
| DE (1) | DE69119819T2 (de) |
| SG (1) | SG49323A1 (de) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5945427A (en) * | 1995-06-07 | 1999-08-31 | Agouron Pharmaceuticals, Inc. | Antiproliferative substituted 5-thiapyrimidinone and 5-selenopyrimidinone compounds |
| US5739141A (en) * | 1992-12-16 | 1998-04-14 | Agouron Pharmaceuticals, Inc. | Antiproliferative substituted 5-thiapyrimidinone and 5-selenopyrimidinone compounds |
| US5594139A (en) * | 1993-01-29 | 1997-01-14 | Agouron Pharmaceuticals, Inc. | Processes for preparing antiproliferative garft-inhibiting compounds |
| US5831100A (en) * | 1995-06-07 | 1998-11-03 | Agouron Pharmaceuticals, Inc. | Syntheses of optically pure compounds useful as GARFT inhibitors and their intermediates |
| WO1999049856A2 (en) * | 1998-03-27 | 1999-10-07 | Genentech, Inc. | Antagonists for treatment of cd11/cd18 adhesion receptor mediated disorders |
| JP2005528397A (ja) * | 2002-04-05 | 2005-09-22 | ザ スクリプス リサーチ インスティテュート | グリシンアミドリボヌクレオチドトランスホルミラーゼの阻害剤 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8625019D0 (en) * | 1986-10-18 | 1986-11-19 | Wellcome Found | Compounds |
| US4871743A (en) * | 1988-01-19 | 1989-10-03 | The Trustees Of Princeton University | L-glutamic acid derivatives |
-
1990
- 1990-04-18 US US07/510,669 patent/US5013738A/en not_active Expired - Fee Related
-
1991
- 1991-02-25 CA CA002037015A patent/CA2037015A1/en not_active Abandoned
- 1991-03-06 JP JP3065397A patent/JPH05262746A/ja active Pending
- 1991-03-07 AT AT91103482T patent/ATE138655T1/de not_active IP Right Cessation
- 1991-03-07 EP EP91103482A patent/EP0452660B1/de not_active Expired - Lifetime
- 1991-03-07 SG SG1996009299A patent/SG49323A1/en unknown
- 1991-03-07 DE DE69119819T patent/DE69119819T2/de not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| DE69119819T2 (de) | 1996-11-28 |
| US5013738A (en) | 1991-05-07 |
| EP0452660A3 (en) | 1992-01-29 |
| JPH05262746A (ja) | 1993-10-12 |
| CA2037015A1 (en) | 1991-10-19 |
| EP0452660A2 (de) | 1991-10-23 |
| EP0452660B1 (de) | 1996-05-29 |
| SG49323A1 (en) | 1998-05-18 |
| DE69119819D1 (de) | 1996-07-04 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |