ATE138925T1 - Erythromycinderivate, herstellung und verwendung davon - Google Patents

Erythromycinderivate, herstellung und verwendung davon

Info

Publication number: ATE138925T1
Authority: AT; Austria
Prior art keywords: hemiacetal; salt; erythromycin derivative; positions; hydroxyl group
Prior art date: 1992-03-19

Application number

AT93104504T

Other languages

English (en)

Inventor

Setsuo Harada

Yasunori Funabashi

Nobuhiro Inatomi

Shigeharu Tanayama

Seiichi Tanida

Original Assignee

Takeda Chemical Industries Ltd

Kitasato Inst

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-03-19

Filing date

1993-03-19

Publication date

1996-06-15

1993-03-19 Application filed by Takeda Chemical Industries Ltd, Kitasato Inst filed Critical Takeda Chemical Industries Ltd

1996-06-15 Application granted granted Critical

1996-06-15 Publication of ATE138925T1 publication Critical patent/ATE138925T1/de

Links

238000004519 manufacturing process Methods 0.000 title abstract 2
ULGZDMOVFRHVEP-RWJQBGPGSA-N Erythromycin Chemical class O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 ULGZDMOVFRHVEP-RWJQBGPGSA-N 0.000 title 1
150000003839 salts Chemical class 0.000 abstract 4
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 3
230000007661 gastrointestinal function Effects 0.000 abstract 2
230000001737 promoting effect Effects 0.000 abstract 2
102000004316 Oxidoreductases Human genes 0.000 abstract 1
108090000854 Oxidoreductases Proteins 0.000 abstract 1
230000001988 toxicity Effects 0.000 abstract 1
231100000419 toxicity Toxicity 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/44—Preparation of O-glycosides, e.g. glucosides
- C12P19/60—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
- C12P19/62—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin the hetero ring having eight or more ring members and only oxygen as ring hetero atoms, e.g. erythromycin, spiramycin, nystatin
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
Genetics & Genomics (AREA)
General Health & Medical Sciences (AREA)
Wood Science & Technology (AREA)
Zoology (AREA)
Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
General Engineering & Computer Science (AREA)
Microbiology (AREA)
General Chemical & Material Sciences (AREA)
Molecular Biology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)

AT93104504T 1992-03-19 1993-03-19 Erythromycinderivate, herstellung und verwendung davon ATE138925T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
JP6424392		1992-03-19
JP15246792		1992-06-11

Publications (1)

Publication Number	Publication Date
ATE138925T1 true ATE138925T1 (de)	1996-06-15

Family

ID=26405362

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT93104504T ATE138925T1 (de)	1992-03-19	1993-03-19	Erythromycinderivate, herstellung und verwendung davon

Country Status (5)

Country	Link
US (2)	US5470961A (de)
EP (1)	EP0561413B1 (de)
AT (1)	ATE138925T1 (de)
CA (1)	CA2092045C (de)
DE (1)	DE69302938T2 (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2092045C (en) *	1992-03-19	2004-08-10	Setsuo Harada	Erythromycin derivatives, preparation and use thereof
US6077943A (en) *	1996-03-01	2000-06-20	Takeda Chemical Industries, Ltd.	Method of producing erythromycin derivative
DE19805822B4 (de) *	1998-02-13	2009-02-05	Solvay Pharmaceuticals Gmbh	11-Acetyl-12,13-dioxabicyclo[8.2.1]tridecenon-Derivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
CA2399198A1 (en)	2000-02-18	2001-08-23	Christopher Carreras	Motilide compounds
JP2004530108A (ja)	2001-02-15	2004-09-30	コーサンバイオサイエンシーズ，インコーポレイテッド	治療効力を評価するための方法
US7521420B2 (en)	2003-06-18	2009-04-21	Tranzyme Pharma, Inc.	Macrocyclic antagonists of the motilin receptor
US20050113319A1 (en) *	2003-08-26	2005-05-26	Christopher Carreras	11-Deoxy-6,9-ether erythromycin compounds
US7407941B2 (en) *	2003-08-26	2008-08-05	Pfizer, Inc.	N-desmethyl-N-substituted-11-deoxyerythromycin compounds
US7211568B2 (en) *	2003-12-18	2007-05-01	Kosan Biosciences Incorporated	9-Desoxoerythromycin compounds as prokinetic agents
US7582611B2 (en) *	2005-05-24	2009-09-01	Pfizer Inc.	Motilide compounds
JP2009518396A (ja) *	2005-12-08	2009-05-07	ファイザー・インク	エリスロマイシン化合物の３’−ジメチルアミノ基を脱メチルする方法
EP2054429B1 (de)	2006-09-11	2013-11-06	Tranzyme Pharma, Inc.	Makrozyklische motilinrezeptor antagonisten zur behandlung von gastro-intestinaler störungen
KR101120483B1 (ko) *	2006-12-05	2012-02-29	브리스톨-마이어즈 스퀴브 컴페니	모틸라이드 다형체
US20080287371A1 (en) *	2007-05-17	2008-11-20	Tranzyme Pharma Inc.	Macrocyclic antagonists of the motilin receptor for modulation of the migrating motor complex
WO2022146980A1 (en) *	2020-12-28	2022-07-07	Georgia Tech Research Corporation	Compositions and methods for inhibiting fibrosis, inflammation and cancer

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE2926959A1 (de) *	1979-07-04	1981-01-22	Hoechst Ag	Vorrichtung zur fluessig-fluessig- extraktion
US5008249A (en) *	1985-08-31	1991-04-16	Kitasato Kenkyusho	Therapeutic method of stimulating digestive tract contractile motion in mammals
EP0215355B1 (de) *	1985-08-31	1994-04-06	Kitasato Kenkyusho	Erythromycinderivat und Verfahren zu dessen Herstellung
US4672056A (en) *	1985-11-12	1987-06-09	Abbott Laboratories	Erythromycin A derivatives and method of use
JPH0633312B2 (ja) *	1986-05-02	1994-05-02	大正製薬株式会社	１４−ハイドロキシエリスロマイシン誘導体およびその製造方法
US5106961A (en) *	1987-05-26	1992-04-21	Eli Lilly And Company	Erythromycin ring-contracted derivatives
US4920102A (en) *	1988-04-18	1990-04-24	Eli Lilly And Company	Method for treating gastrointestinal disorders
CA2092045C (en) *	1992-03-19	2004-08-10	Setsuo Harada	Erythromycin derivatives, preparation and use thereof

1993
- 1993-03-19 CA CA002092045A patent/CA2092045C/en not_active Expired - Fee Related
- 1993-03-19 AT AT93104504T patent/ATE138925T1/de not_active IP Right Cessation
- 1993-03-19 DE DE69302938T patent/DE69302938T2/de not_active Expired - Fee Related
- 1993-03-19 EP EP93104504A patent/EP0561413B1/de not_active Expired - Lifetime
- 1993-03-19 US US08/033,777 patent/US5470961A/en not_active Expired - Fee Related
1995
- 1995-06-07 US US08/475,557 patent/US5854407A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
EP0561413B1 (de)	1996-06-05
DE69302938D1 (de)	1996-07-11
DE69302938T2 (de)	1996-10-17
EP0561413A1 (de)	1993-09-22
CA2092045A1 (en)	1993-09-20
CA2092045C (en)	2004-08-10
US5854407A (en)	1998-12-29
US5470961A (en)	1995-11-28

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Legal Events

Date	Code	Title	Description
1996-12-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties