ATE138929T1 - Verfahren zur anomizierung von nukleosiden - Google Patents

Verfahren zur anomizierung von nukleosiden

Info

Publication number: ATE138929T1
Authority: AT; Austria
Prior art keywords: nucleosides; anomizing; anomer; anomeric mixture; nucleoside
Prior art date: 1992-09-01

Application number

AT93306886T

Other languages

English (en)

Inventor

Thomas Charles Britton

Tourneau Michael Edward Le

Original Assignee

Lilly Co Eli

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-09-01

Filing date

1993-08-31

Publication date

1996-06-15

1993-08-31 Application filed by Lilly Co Eli filed Critical Lilly Co Eli

1996-06-15 Application granted granted Critical

1996-06-15 Publication of ATE138929T1 publication Critical patent/ATE138929T1/de

Links

239000002777 nucleoside Substances 0.000 title abstract 4
239000000203 mixture Substances 0.000 abstract 2
150000003833 nucleoside derivatives Chemical class 0.000 abstract 2
XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical compound [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 abstract 1
125000003835 nucleoside group Chemical group 0.000 abstract 1
239000003960 organic solvent Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/048—Pyridine radicals

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Saccharide Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

AT93306886T 1992-09-01 1993-08-31 Verfahren zur anomizierung von nukleosiden ATE138929T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US93879192A	1992-09-01	1992-09-01

Publications (1)

Publication Number	Publication Date
ATE138929T1 true ATE138929T1 (de)	1996-06-15

Family

ID=25471966

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT93306886T ATE138929T1 (de)	1992-09-01	1993-08-31	Verfahren zur anomizierung von nukleosiden

Country Status (15)

Country	Link
US (1)	US5420266A (de)
EP (1)	EP0587364B1 (de)
JP (1)	JP3462893B2 (de)
KR (1)	KR100252451B1 (de)
AT (1)	ATE138929T1 (de)
BR (1)	BR9303658A (de)
CA (1)	CA2105112C (de)
DE (1)	DE69302977T2 (de)
DK (1)	DK0587364T3 (de)
ES (1)	ES2090880T3 (de)
GR (1)	GR3020426T3 (de)
HU (1)	HU214980B (de)
IL (1)	IL106840A (de)
MX (1)	MX9305301A (de)
TW (1)	TW356472B (de)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
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US5627160A (en) *	1993-05-25	1997-05-06	Yale University	L-2',3'-dideoxy nucleoside analogs as anti-hepatitis B (HBV) and anti-HIV agents
TW374087B (en) *	1993-05-25	1999-11-11	Univ Yale	L-2',3'-dideoxy nucleotide analogs as anti-hepatitis B(HBV) and anti-HIV agents
US5637688A (en) *	1994-12-13	1997-06-10	Eli Lilly And Company	Process for preparing 1-(2'-deoxy-2'-difluoro-d-ribofuranosyl)-4-aminopyrimidin-2-one hydrochloride
US5869461A (en) *	1995-03-16	1999-02-09	Yale University	Reducing toxicity of L-nucleosides with D-nucleosides
US5633367A (en) *	1995-03-24	1997-05-27	Eli Lilly And Company	Process for the preparation of a 2-substituted 3,3-difluorofuran
CA2171518A1 (en) *	1995-03-24	1996-09-25	Douglas Patton Kjell	Process for the preparation of 2,2'-anhydro- and 2' -keto-1-(3', 5'-di-o-protected-.beta.-d-arabinofuranosyl) nucleosides
US6013790A (en) *	1996-09-25	2000-01-11	Board Of Regents University Of Nebraska-Lincoln	Heavily fluorinated sugar analogs
US6248878B1 (en) *	1996-12-24	2001-06-19	Ribozyme Pharmaceuticals, Inc.	Nucleoside analogs
MY164523A (en)	2000-05-23	2017-12-29	Univ Degli Studi Cagliari	Methods and compositions for treating hepatitis c virus
PL359169A1 (en)	2000-05-26	2004-08-23	Idenix (Cayman) Limited	Methods and compositions for treating flaviviruses and pestiviruses
KR100467016B1 (ko) *	2002-05-30	2005-01-24	삼성전자주식회사	반도체기판의 세정방법
CN101172993A (zh)	2002-06-28	2008-05-07	埃迪尼克斯(开曼)有限公司	用于治疗黄病毒感染的2′－c－甲基－3′－o－l－缬氨酸酯核糖呋喃基胞苷
US7608600B2 (en)	2002-06-28	2009-10-27	Idenix Pharmaceuticals, Inc.	Modified 2′ and 3′-nucleoside prodrugs for treating Flaviviridae infections
KR20050035194A (ko)	2002-06-28	2005-04-15	이데닉스 (케이만) 리미티드	플라비비리다에 감염 치료용 2'-ｃ-메틸-3'-ｏ-ｌ-발린에스테르 리보푸라노실 사이티딘
AU2003298658A1 (en)	2002-11-15	2004-06-15	Idenix (Cayman) Limited	2'-branched nucleosides and flaviviridae mutation
US7598373B2 (en)	2002-12-12	2009-10-06	Idenix Pharmaceuticals, Inc.	Process for the production of 2-C-methyl-D-ribonolactone
RU2358979C2 (ru) *	2003-05-30	2009-06-20	Фармассет, Инк.	Модифицированные фторированные аналоги нуклеозида
CN101023094B (zh) *	2004-07-21	2011-05-18	法莫赛特股份有限公司	烷基取代的2-脱氧-2-氟代-d-呋喃核糖基嘧啶和嘌呤及其衍生物的制备
ES2725457T3 (es)	2004-09-14	2019-09-24	Gilead Pharmasset Llc	Preparación de ribofuranosil pirimidinas y purinas 2'fluoro-2'-alquil-sustituidas u otras opcionalmente sustituidas y sus derivados
DE602005019626D1 (de) *	2005-03-04	2010-04-08	Fresenius Kabi Oncology Ltd	Zwischenprodukt und verfahren zur herstellung von an beta-anomeren angereicherten 2'-desoxy,2',2'-difluor-d-ribufuranosylnukleosiden
US7781576B2 (en)	2005-12-23	2010-08-24	Idenix Pharmaceuticals, Inc.	Process for preparing a synthetic intermediate for preparation of branched nucleosides
US7964580B2 (en) *	2007-03-30	2011-06-21	Pharmasset, Inc.	Nucleoside phosphoramidate prodrugs
US8173621B2 (en) *	2008-06-11	2012-05-08	Gilead Pharmasset Llc	Nucleoside cyclicphosphates
CL2009002206A1 (es)	2008-12-23	2011-08-26	Gilead Pharmasset Llc	Compuestos derivados de pirrolo -(2-3-d]-pirimidin-7(6h)-tetrahidrofuran-2-il fosfonamidato, composicion farmaceutica; y su uso en el tratamiento de enfermedades virales.
AR074897A1 (es) *	2008-12-23	2011-02-23	Pharmasset Inc	Fosforamidatos de nucleosidos
MX2011006890A (es) *	2008-12-23	2011-07-20	Pharmasset Inc	Analogos de nucleosidos.
US8618076B2 (en)	2009-05-20	2013-12-31	Gilead Pharmasset Llc	Nucleoside phosphoramidates
TWI576352B (zh)	2009-05-20	2017-04-01	基利法瑪席特有限責任公司	核苷磷醯胺
AP2012006535A0 (en)	2010-03-31	2012-10-31	Gilead Pharmasset Llc	Stereoselective synthesis of phosphorous containing actives
PL3290428T3 (pl)	2010-03-31	2022-02-07	Gilead Pharmasset Llc	Tabletka zawierająca krystaliczny (S)-2-(((S)-(((2R,3R,4R,5R)-5-(2,4-diokso-3,4-dihydropirymidyn-1(2H)-ylo)-4-fluoro-3-hydroksy-4-metylotetrahydrofuran-2-ylo)metoksy)(fenoksy)fosforylo)amino)propanian izopropylu
ES2716158T3 (es)	2010-11-30	2019-06-10	Gilead Pharmasset Llc	2'-spiro-nucleótidos para el tratamiento de hepatitis C
US8889159B2 (en)	2011-11-29	2014-11-18	Gilead Pharmasset Llc	Compositions and methods for treating hepatitis C virus
CN102603838B (zh) *	2012-02-14	2015-02-18	江苏八巨药业有限公司	一种制备吉西他滨盐酸盐的方法
EA201690473A1 (ru)	2013-08-27	2017-03-31	ГАЙЛИД ФАРМАССЕТ ЭлЭлСи	Комбинированный состав двух противовирусных соединений
AU2019296174B2 (en)	2018-06-29	2021-10-07	Changchun Changcheng Pharmaceutical Technology Co., LTD	Phosphorus-containing prodrugs of gemcitabine
CN121949418B (zh) *	2026-04-01	2026-07-28	山东安弘制药有限公司	一种盐酸吉西他滨的制备方法

1993
- 1993-08-30 CA CA002105112A patent/CA2105112C/en not_active Expired - Lifetime
- 1993-08-30 KR KR1019930017031A patent/KR100252451B1/ko not_active Expired - Fee Related
- 1993-08-30 IL IL10684093A patent/IL106840A/en not_active IP Right Cessation
- 1993-08-30 TW TW082107028A patent/TW356472B/zh active
- 1993-08-30 HU HU9302452A patent/HU214980B/hu not_active IP Right Cessation
- 1993-08-31 DE DE69302977T patent/DE69302977T2/de not_active Expired - Lifetime
- 1993-08-31 MX MX9305301A patent/MX9305301A/es unknown
- 1993-08-31 DK DK93306886.8T patent/DK0587364T3/da active
- 1993-08-31 JP JP21565393A patent/JP3462893B2/ja not_active Expired - Fee Related
- 1993-08-31 AT AT93306886T patent/ATE138929T1/de not_active IP Right Cessation
- 1993-08-31 BR BR9303658A patent/BR9303658A/pt not_active Application Discontinuation
- 1993-08-31 EP EP93306886A patent/EP0587364B1/de not_active Expired - Lifetime
- 1993-08-31 ES ES93306886T patent/ES2090880T3/es not_active Expired - Lifetime
1994
- 1994-01-03 US US08/176,981 patent/US5420266A/en not_active Expired - Lifetime
1996
- 1996-07-02 GR GR960401799T patent/GR3020426T3/el unknown

Also Published As

Publication number	Publication date
DE69302977T2 (de)	1996-10-31
JP3462893B2 (ja)	2003-11-05
US5420266A (en)	1995-05-30
ES2090880T3 (es)	1996-10-16
KR100252451B1 (ko)	2000-04-15
DK0587364T3 (da)	1996-07-01
GR3020426T3 (en)	1996-10-31
TW356472B (en)	1999-04-21
CA2105112C (en)	2005-08-02
IL106840A0 (en)	1993-12-08
IL106840A (en)	1998-09-24
JPH06157571A (ja)	1994-06-03
KR940007053A (ko)	1994-04-26
MX9305301A (es)	1994-06-30
HU9302452D0 (en)	1993-11-29
CA2105112A1 (en)	1994-03-02
BR9303658A (pt)	1994-03-22
HU214980B (hu)	1998-08-28
HUT65137A (en)	1994-04-28
DE69302977D1 (de)	1996-07-11
EP0587364B1 (de)	1996-06-05
EP0587364A1 (de)	1994-03-16

Legal Events

Date	Code	Title	Description
1996-11-15	UEP	Publication of translation of european patent specification
2003-05-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
DE69302977D1 (de)	1996-07-11	Verfahren zur Anomizierung von Nukleosiden
ATE155476T1 (de)	1997-08-15	Verfahren zur herstellung von mit alpha-anomeren angereichterten 2-deoxy-2,2-difluor-d- ribofuranosyl sulfonaten
DE69314239D1 (de)	1997-11-06	Verfahren zur Stereoselektivglycosylierung
FI905535A7 (fi)	1990-11-08	Menetelmä havupuiden monistamiseksi somaattisella embryogeneesillä
DE3884826D1 (de)	1993-11-18	Vorrichtung zum Verhindern der Verschmutzung von Motorfahrzeug-Heckleuchteneinheiten.
ATE140923T1 (de)	1996-08-15	Verfahren zur herstellung von n4-acyl-5'-desoxy-5-fluorocytidinderivate
ATE149505T1 (de)	1997-03-15	Verfahren zur trennung von 2-deoxy-2,2-difluor-d- ribofuranosyl-alkyl-sulfonat-anomeren
DK572788A (da)	1989-04-15	Polysvovlsyreestere af bis-aldonamider og derivater deraf samt fremgangsmaade til fremstilling af samme
DE69020481D1 (de)	1995-08-03	Verfahren und Vorrichtung zum Biegen von Glas.
ATE189195T1 (de)	2000-02-15	Verfahren und vorrichtung zum biegen von glasscheiben
DE69311000D1 (de)	1997-07-03	Verfahren zur Herstellung von mit Alpha-Anomeren angereicherten 1-Halogen-2-Deoxy-2,2-Difluor-D-Ribofuranosyl-Derivaten
EP0405913A3 (en)	1991-10-09	Hydrophobic nucleic acid probe
DE3787273D1 (de)	1993-10-07	Vorrichtung und Verfahren zum Durchführen von optischen Fasern durch röhrenförmige Artikeln.
DE69003633D1 (de)	1993-11-04	Verfahren zum biegen von glastafeln.
DE58907015D1 (de)	1994-03-24	Verfahren zum zusammenbauen von zwei glastafeln zu einer isolierglasscheibe.
EP0328959A3 (de)	1990-03-07	Verfahren zur Reinigung von langkettigen Alkylglucosiden
DE69010030D1 (de)	1994-07-28	Verfahren zur Produktion von Fruktose-1,6-diphosphat.
PT92726A (pt)	1990-06-29	Processo de eliminacao de etanol de bebidas produzidas por fermentacao
DE3886209D1 (de)	1994-01-20	Mit flossen versehenes stabilisierungsheckteil für ein pfeilgeschoss.
DE3781913D1 (de)	1992-11-05	Verfahren zur herstellung von makrolid-verbindungen.
ATE137562T1 (de)	1996-05-15	Verfahren zur ausgestaltung von brunnenbereichen
DE58905748D1 (de)	1993-11-04	Verfahren und vorrichtung zum herstellen von hohlglaesern aus einem hohlglasteil und mindestens einem massivglasteil.
ATE312116T1 (de)	2005-12-15	Verfahren zur herstellung von nukleosid-derivaten
DE59006740D1 (de)	1994-09-15	Vorrichtung zum Innenlackieren von Hohlkörpern.
ATE119168T1 (de)	1995-03-15	Verfahren zum abspalten von delta-4-ungesättigter uronsäure aus glycosaminoglykanen.