ATE138929T1 - Verfahren zur anomizierung von nukleosiden - Google Patents

Verfahren zur anomizierung von nukleosiden

Info

Publication number: ATE138929T1
Authority: AT; Austria
Prior art keywords: nucleosides; anomizing; anomer; anomeric mixture; nucleoside
Prior art date: 1992-09-01

Application number

AT93306886T

Other languages

English (en)

Inventor

Thomas Charles Britton

Tourneau Michael Edward Le

Original Assignee

Lilly Co Eli

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-09-01

Filing date

1993-08-31

Publication date

1996-06-15

1993-08-31 Application filed by Lilly Co Eli filed Critical Lilly Co Eli

1996-06-15 Application granted granted Critical

1996-06-15 Publication of ATE138929T1 publication Critical patent/ATE138929T1/de

Links

239000002777 nucleoside Substances 0.000 title abstract 4
239000000203 mixture Substances 0.000 abstract 2
150000003833 nucleoside derivatives Chemical class 0.000 abstract 2
XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical compound [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 abstract 1
125000003835 nucleoside group Chemical group 0.000 abstract 1
239000003960 organic solvent Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/048—Pyridine radicals

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Saccharide Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

AT93306886T 1992-09-01 1993-08-31 Verfahren zur anomizierung von nukleosiden ATE138929T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US93879192A	1992-09-01	1992-09-01

Publications (1)

Publication Number	Publication Date
ATE138929T1 true ATE138929T1 (de)	1996-06-15

Family

ID=25471966

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT93306886T ATE138929T1 (de)	1992-09-01	1993-08-31	Verfahren zur anomizierung von nukleosiden

Country Status (15)

Country	Link
US (1)	US5420266A (de)
EP (1)	EP0587364B1 (de)
JP (1)	JP3462893B2 (de)
KR (1)	KR100252451B1 (de)
AT (1)	ATE138929T1 (de)
BR (1)	BR9303658A (de)
CA (1)	CA2105112C (de)
DE (1)	DE69302977T2 (de)
DK (1)	DK0587364T3 (de)
ES (1)	ES2090880T3 (de)
GR (1)	GR3020426T3 (de)
HU (1)	HU214980B (de)
IL (1)	IL106840A (de)
MX (1)	MX9305301A (de)
TW (1)	TW356472B (de)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
TW374087B (en) *	1993-05-25	1999-11-11	Univ Yale	L-2',3'-dideoxy nucleotide analogs as anti-hepatitis B(HBV) and anti-HIV agents
US5627160A (en) *	1993-05-25	1997-05-06	Yale University	L-2',3'-dideoxy nucleoside analogs as anti-hepatitis B (HBV) and anti-HIV agents
US5637688A (en) *	1994-12-13	1997-06-10	Eli Lilly And Company	Process for preparing 1-(2'-deoxy-2'-difluoro-d-ribofuranosyl)-4-aminopyrimidin-2-one hydrochloride
US5869461A (en) *	1995-03-16	1999-02-09	Yale University	Reducing toxicity of L-nucleosides with D-nucleosides
CA2171518A1 (en) *	1995-03-24	1996-09-25	Douglas Patton Kjell	Process for the preparation of 2,2'-anhydro- and 2' -keto-1-(3', 5'-di-o-protected-.beta.-d-arabinofuranosyl) nucleosides
US5633367A (en) *	1995-03-24	1997-05-27	Eli Lilly And Company	Process for the preparation of a 2-substituted 3,3-difluorofuran
US6013790A (en) *	1996-09-25	2000-01-11	Board Of Regents University Of Nebraska-Lincoln	Heavily fluorinated sugar analogs
US6248878B1 (en) *	1996-12-24	2001-06-19	Ribozyme Pharmaceuticals, Inc.	Nucleoside analogs
MY164523A (en)	2000-05-23	2017-12-29	Univ Degli Studi Cagliari	Methods and compositions for treating hepatitis c virus
EP1736478B1 (de)	2000-05-26	2015-07-22	IDENIX Pharmaceuticals, Inc.	Verfahren und Zusammensetzungen zur Behandlung von Flaviviren und Pestiviren
KR100467016B1 (ko) *	2002-05-30	2005-01-24	삼성전자주식회사	반도체기판의 세정방법
NZ537662A (en)	2002-06-28	2007-10-26	Idenix Cayman Ltd	2'-C-methyl-3'-O-L-valine ester ribofuranosyl cytidine for treatment of flaviviridae infections
US7608600B2 (en)	2002-06-28	2009-10-27	Idenix Pharmaceuticals, Inc.	Modified 2′ and 3′-nucleoside prodrugs for treating Flaviviridae infections
CN1678326A (zh)	2002-06-28	2005-10-05	埃迪尼克斯(开曼)有限公司	用于治疗黄病毒感染的2'－c－甲基－3'－o－l－缬氨酸酯核糖呋喃基胞苷
LT1576138T (lt)	2002-11-15	2017-06-26	Idenix Pharmaceuticals Llc	2`-šakoti nukleozidai derinyje su interferonu ir flaviviridae mutacija
AU2003300901A1 (en)	2002-12-12	2004-06-30	Idenix (Cayman) Limited	Process for the production of 2'-branched nucleosides
HUE029877T2 (en) *	2003-05-30	2017-04-28	Gilead Pharmasset Llc	Modified fluorinated nucleoside analogues
CN101023094B (zh) *	2004-07-21	2011-05-18	法莫赛特股份有限公司	烷基取代的2-脱氧-2-氟代-d-呋喃核糖基嘧啶和嘌呤及其衍生物的制备
US8492539B2 (en) *	2004-09-14	2013-07-23	Gilead Pharmasset Llc	Preparation of 2′-fluoro-2′-alkyl-substituted or other optionally substituted ribofuranosyl pyrimidines and purines and their derivatives
KR20070112774A (ko) *	2005-03-04	2007-11-27	다브르 파마 리미티드	베타―아노머가 많은２１데옥시，２１，２１－디플루오로－ｄ－리보푸라노실뉴클레오시드의 제조를 위한 중간체 및 제조 방법
ES2422290T3 (es)	2005-12-23	2013-09-10	Idenix Pharmaceuticals Inc	Procedimiento para preparar un producto intermedio sintético para la preparación de nucleósidos ramificados
US7964580B2 (en)	2007-03-30	2011-06-21	Pharmasset, Inc.	Nucleoside phosphoramidate prodrugs
US8173621B2 (en)	2008-06-11	2012-05-08	Gilead Pharmasset Llc	Nucleoside cyclicphosphates
AU2009329872B2 (en)	2008-12-23	2016-07-07	Gilead Pharmasset Llc	Synthesis of purine nucleosides
PA8855601A1 (es)	2008-12-23	2010-07-27		Forformidatos de nucleósidos
NZ593649A (en) *	2008-12-23	2013-11-29	Gilead Pharmasset Llc	Nucleoside analogs
TWI583692B (zh) *	2009-05-20	2017-05-21	基利法瑪席特有限責任公司	核苷磷醯胺
US8618076B2 (en)	2009-05-20	2013-12-31	Gilead Pharmasset Llc	Nucleoside phosphoramidates
US8563530B2 (en)	2010-03-31	2013-10-22	Gilead Pharmassel LLC	Purine nucleoside phosphoramidate
SG184324A1 (en)	2010-03-31	2012-11-29	Gilead Pharmasset Llc	Nucleoside phosphoramidates
CA2818853A1 (en)	2010-11-30	2012-06-07	Gilead Pharmasset Llc	2'-spirocyclo-nucleosides for use in therapy of hcv or dengue virus
US8889159B2 (en)	2011-11-29	2014-11-18	Gilead Pharmasset Llc	Compositions and methods for treating hepatitis C virus
CN102603838B (zh) *	2012-02-14	2015-02-18	江苏八巨药业有限公司	一种制备吉西他滨盐酸盐的方法
PT3038601T (pt)	2013-08-27	2020-06-30	Gilead Pharmasset Llc	Formulação combinada de dois compostos antivirais
EP3820879B1 (de)	2018-06-29	2024-11-06	Changchun Changcheng Pharmaceutical Technology Co., LTD	Phosphorhaltige prodrugs von gemcitabin

1993
- 1993-08-30 TW TW082107028A patent/TW356472B/zh active
- 1993-08-30 IL IL10684093A patent/IL106840A/en not_active IP Right Cessation
- 1993-08-30 HU HU9302452A patent/HU214980B/hu not_active IP Right Cessation
- 1993-08-30 KR KR1019930017031A patent/KR100252451B1/ko not_active Expired - Fee Related
- 1993-08-30 CA CA002105112A patent/CA2105112C/en not_active Expired - Lifetime
- 1993-08-31 ES ES93306886T patent/ES2090880T3/es not_active Expired - Lifetime
- 1993-08-31 DK DK93306886.8T patent/DK0587364T3/da active
- 1993-08-31 MX MX9305301A patent/MX9305301A/es unknown
- 1993-08-31 JP JP21565393A patent/JP3462893B2/ja not_active Expired - Fee Related
- 1993-08-31 AT AT93306886T patent/ATE138929T1/de not_active IP Right Cessation
- 1993-08-31 BR BR9303658A patent/BR9303658A/pt not_active Application Discontinuation
- 1993-08-31 DE DE69302977T patent/DE69302977T2/de not_active Expired - Lifetime
- 1993-08-31 EP EP93306886A patent/EP0587364B1/de not_active Expired - Lifetime
1994
- 1994-01-03 US US08/176,981 patent/US5420266A/en not_active Expired - Lifetime
1996
- 1996-07-02 GR GR960401799T patent/GR3020426T3/el unknown

Also Published As

Publication number	Publication date
JPH06157571A (ja)	1994-06-03
BR9303658A (pt)	1994-03-22
EP0587364A1 (de)	1994-03-16
MX9305301A (es)	1994-06-30
CA2105112C (en)	2005-08-02
CA2105112A1 (en)	1994-03-02
JP3462893B2 (ja)	2003-11-05
HU9302452D0 (en)	1993-11-29
IL106840A (en)	1998-09-24
KR940007053A (ko)	1994-04-26
ES2090880T3 (es)	1996-10-16
EP0587364B1 (de)	1996-06-05
DE69302977D1 (de)	1996-07-11
US5420266A (en)	1995-05-30
KR100252451B1 (ko)	2000-04-15
TW356472B (en)	1999-04-21
HU214980B (hu)	1998-08-28
HUT65137A (en)	1994-04-28
DE69302977T2 (de)	1996-10-31
DK0587364T3 (da)	1996-07-01
GR3020426T3 (en)	1996-10-31
IL106840A0 (en)	1993-12-08

Legal Events

Date	Code	Title	Description
1996-11-15	UEP	Publication of translation of european patent specification
2003-05-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
ATE138929T1 (de)	1996-06-15	Verfahren zur anomizierung von nukleosiden
ATE155476T1 (de)	1997-08-15	Verfahren zur herstellung von mit alpha-anomeren angereichterten 2-deoxy-2,2-difluor-d- ribofuranosyl sulfonaten
DE69314239D1 (de)	1997-11-06	Verfahren zur Stereoselektivglycosylierung
FI905535A7 (fi)	1990-11-08	Menetelmä havupuiden monistamiseksi somaattisella embryogeneesillä
DE3884826D1 (de)	1993-11-18	Vorrichtung zum Verhindern der Verschmutzung von Motorfahrzeug-Heckleuchteneinheiten.
ATE140923T1 (de)	1996-08-15	Verfahren zur herstellung von n4-acyl-5'-desoxy-5-fluorocytidinderivate
ATE149505T1 (de)	1997-03-15	Verfahren zur trennung von 2-deoxy-2,2-difluor-d- ribofuranosyl-alkyl-sulfonat-anomeren
DK572788A (da)	1989-04-15	Polysvovlsyreestere af bis-aldonamider og derivater deraf samt fremgangsmaade til fremstilling af samme
DE69020481D1 (de)	1995-08-03	Verfahren und Vorrichtung zum Biegen von Glas.
ES2103433T3 (es)	1997-09-16	Procedimiento para preparar derivados de 1-halo-2-desoxi-2,2-difluoro-d-ribofuranosilo enriquecidos en anomero alfa.
DE3787273D1 (de)	1993-10-07	Vorrichtung und Verfahren zum Durchführen von optischen Fasern durch röhrenförmige Artikeln.
DE69003633D1 (de)	1993-11-04	Verfahren zum biegen von glastafeln.
BR8902815A (pt)	1990-02-01	Processo de recuperacao de niquel de uma solucao aquosa amoniacal
DE69010030D1 (de)	1994-07-28	Verfahren zur Produktion von Fruktose-1,6-diphosphat.
EP0328959A3 (de)	1990-03-07	Verfahren zur Reinigung von langkettigen Alkylglucosiden
DE3581984D1 (de)	1991-04-11	Vorrichtung zum reinigen von glastafeln.
PT92726A (pt)	1990-06-29	Processo de eliminacao de etanol de bebidas produzidas por fermentacao
EP0640614A3 (de)	1995-05-03	Stereoselektives Verfahren zur Herstellung von Beta-Anomer angereicherten 2-deoxy-2,2-difluoro-D-ribofuranosyl-3,5-hydroxy-geschützten 1-alkyl und aryl-sulfonat-Zwischenprodukten.
DE59202129D1 (de)	1995-06-14	Verfahren zum Vergüten von Hohlglaskörpern.
DE3885135D1 (de)	1993-12-02	Verfahren zum Entfernen von Sägehilfsmittelresten von Scheiben.
DE3886209D1 (de)	1994-01-20	Mit flossen versehenes stabilisierungsheckteil für ein pfeilgeschoss.
DE69217030D1 (de)	1997-03-06	Verfahren zur Herstellung eines Fructosesirups (HFCS) aus Glucose unter Verwendung von Edelgasen
DE3781913D1 (de)	1992-11-05	Verfahren zur herstellung von makrolid-verbindungen.
ATE312116T1 (de)	2005-12-15	Verfahren zur herstellung von nukleosid-derivaten
DE59006740D1 (de)	1994-09-15	Vorrichtung zum Innenlackieren von Hohlkörpern.