ATE138937T1 - Gamma, delta t-zellenrezeptor und verfahren zum nachweis - Google Patents

Gamma, delta t-zellenrezeptor und verfahren zum nachweis

Info

Publication number
ATE138937T1
ATE138937T1 AT87904762T AT87904762T ATE138937T1 AT E138937 T1 ATE138937 T1 AT E138937T1 AT 87904762 T AT87904762 T AT 87904762T AT 87904762 T AT87904762 T AT 87904762T AT E138937 T1 ATE138937 T1 AT E138937T1
Authority
AT
Austria
Prior art keywords
gamma
cell receptor
delta
detection
polypeptide
Prior art date
Application number
AT87904762T
Other languages
English (en)
Inventor
Michael B Brenner
Jack L Strominger
Jonathan Seidman
Stephen H Ip
Michael S Krangel
Original Assignee
T Cell Sciences Inc
Dana Farber Cancer Inst Inc
Harvard College
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by T Cell Sciences Inc, Dana Farber Cancer Inst Inc, Harvard College filed Critical T Cell Sciences Inc
Application granted granted Critical
Publication of ATE138937T1 publication Critical patent/ATE138937T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56966—Animal cells
    • G01N33/56972—White blood cells
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/868—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof involving autoimmunity, allergy, immediate hypersensitivity, delayed hypersensitivity, immunosuppression, or immunotolerance

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Cell Biology (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Urology & Nephrology (AREA)
  • Virology (AREA)
  • General Physics & Mathematics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Toxicology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
AT87904762T 1986-07-03 1987-06-30 Gamma, delta t-zellenrezeptor und verfahren zum nachweis ATE138937T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US88210086A 1986-07-03 1986-07-03
US07/016,252 US5340921A (en) 1986-07-03 1987-02-19 Γ, δT cell receptor and methods and detection

Publications (1)

Publication Number Publication Date
ATE138937T1 true ATE138937T1 (de) 1996-06-15

Family

ID=26688362

Family Applications (1)

Application Number Title Priority Date Filing Date
AT87904762T ATE138937T1 (de) 1986-07-03 1987-06-30 Gamma, delta t-zellenrezeptor und verfahren zum nachweis

Country Status (9)

Country Link
US (3) US5340921A (de)
EP (2) EP0312542B1 (de)
JP (3) JP2735555B2 (de)
AT (1) ATE138937T1 (de)
AU (1) AU614719B2 (de)
CA (1) CA1341042C (de)
DE (1) DE3751827T2 (de)
IL (1) IL83078A (de)
WO (1) WO1988000209A1 (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5260223A (en) * 1986-07-03 1993-11-09 President & Fellows Of Harvard College Methods for detection of human gamma, γ T cell receptor
US5340921A (en) * 1986-07-03 1994-08-23 T Cell Sciences, Inc. Γ, δT cell receptor and methods and detection
JPH02491A (ja) * 1987-04-25 1990-01-05 Kyowa Hakko Kogyo Co Ltd 抗−Ｔ細胞レセプターγ鎖モノクローナル抗体
US5169938A (en) * 1987-04-25 1992-12-08 Kyowa Hakko Kogyo Co., Ltd. Anti-T cell receptor γ-chain monoclonal antibody
FR2621127B1 (fr) * 1987-09-30 1992-01-31 Roussy Inst Gustave Anticorps monoclonal reconnaissant un epitope de la chaine gamma des recepteurs de surface des cellules t humaines, lignee de cellules d'hybridomes produisant cet anticorps, et utilisation de cet anticorps monoclonal
WO1989008114A1 (en) * 1988-02-25 1989-09-08 The General Hospital Corporation Rapid immunoselection cloning method
US5506126A (en) * 1988-02-25 1996-04-09 The General Hospital Corporation Rapid immunoselection cloning method
FI891226A7 (fi) * 1988-04-28 1989-10-29 The Board Of Trustees Of The Leland Anti-T-solun reseptorideterminantit autoimmuunisairauden hoitoon
US5766947A (en) * 1988-12-14 1998-06-16 Astra Ab Monoclonal antibodies reactive with an epitope of a Vβ3.1 variable region of a T cell receptor
US5223426A (en) * 1988-12-15 1993-06-29 T Cell Sciences, Inc. Monoclonal antibodies reactive with defined regions of the t-cell antigen receptor
US5776459A (en) * 1989-07-19 1998-07-07 Connetics Corporation TCR V beta 5 peptides
US5614192A (en) * 1989-07-19 1997-03-25 Connective Therapeutics, Inc. T cell receptor peptides as therapeutics for immune-related disease
KR920703844A (ko) * 1989-11-15 1992-12-18 원본 미기재 사람에 있어 t-세포 표면 항원의 측정방법
FR2656532A1 (fr) * 1989-12-29 1991-07-05 Inst Nat Sante Rech Med Proteine antigenique presente sur des cellules sat, anticorps correspondants et leurs applications.
EP0725277A3 (de) * 1990-05-01 1996-12-04 Univ Leland Stanford Junior Variable Transskripte von T-Zellen als Marker für Krankheiten
US6416971B1 (en) * 1990-05-15 2002-07-09 E.R. Squibb & Sons, Inc. Soluble single chain T cell receptors
FR2698880B1 (fr) * 1992-11-25 1995-02-24 Inst Nat Sante Rech Med Procédé de production de récepteurs T solubles, produits ainsi obtenus et leur utilisation dans des compositions diagnostiques ou thérapeutiques.
US5552300A (en) * 1994-01-13 1996-09-03 T Cell Sciences, Inc. T cell antigen receptor V region proteins and methods of preparation thereof
US6759243B2 (en) 1998-01-20 2004-07-06 Board Of Trustees Of The University Of Illinois High affinity TCR proteins and methods
JP2002519007A (ja) * 1998-06-30 2002-07-02 ザ ブリガム アンド ウィメンズ ホスピタル，インコーポレイテッド ヒトγ−δＴ細胞機能の特異的モジュレータとしてのアルキルアミンおよびそれらの前駆体
US6737398B1 (en) * 1999-09-30 2004-05-18 National Jewish Medical And Research Center Modulation of γδ T cells to regulate airway hyperresponsiveness
US20020165149A1 (en) * 2000-12-08 2002-11-07 Kranz David M. Mutated class II major histocompatibility proteins
US20080248025A1 (en) * 2007-03-27 2008-10-09 National Jewish Medical And Research Center Gamma Delta T Cells and Methods of Treatment of Interleukin-17 Related Conditions

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4614720A (en) * 1980-01-08 1986-09-30 Ortho Pharmaceutical Corporation Hybrid cell line for producing monoclonal antibody to a human T cell antigen, antibody, and methods
US4444744A (en) * 1980-03-03 1984-04-24 Goldenberg Milton David Tumor localization and therapy with labeled antibodies to cell surface antigens
US4550086A (en) * 1983-02-16 1985-10-29 Dana-Farber Cancer Institute, Inc. Monoclonal antibodies that recognize human T cells
US4713332A (en) * 1984-01-13 1987-12-15 The Ontario Cancer Institute T cell specific CDNA clone
US4874845A (en) * 1984-06-13 1989-10-17 Massachusetts Institute Of Technology T lymphocyte receptor subunit
EP0200350A3 (de) * 1985-04-15 1987-05-13 The Ontario Cancer Institute Nukleinsäure mit Code für ein T-Zellen-Antigenrezeptor-Polypeptid
KR960001741B1 (ko) * 1985-12-03 1996-02-05 티 셀 사이언시즈, 인코포레이티드 세포-없는 t 세포항원 수용체 단백질의 감지방법
US4845026A (en) * 1985-12-03 1989-07-04 T Cell Sciences, Inc. Assay systems for detecting cell-free T cell antigen receptor related molecules and the clinical utilities of the assays
US5024940A (en) * 1987-02-19 1991-06-18 T Cell Sciences, Inc. Nucleic acids encoding the delta chain of the T cell antigen receptor
US5340921A (en) * 1986-07-03 1994-08-23 T Cell Sciences, Inc. Γ, δT cell receptor and methods and detection
US4956281A (en) * 1987-06-03 1990-09-11 Biogen, Inc. DNA sequences, recombinant DNA molecules and processes for producing lymphocyte function associated antigen-3

Also Published As

Publication number Publication date
EP0312542B1 (de) 1996-06-05
DE3751827D1 (de) 1996-07-11
EP0312542A4 (de) 1990-04-10
US6313263B1 (en) 2001-11-06
JPH02500322A (ja) 1990-02-08
JP2735555B2 (ja) 1998-04-02
WO1988000209A1 (en) 1988-01-14
JP2975914B2 (ja) 1999-11-10
IL83078A0 (en) 1987-12-31
AU614719B2 (en) 1991-09-12
DE3751827T2 (de) 1996-11-28
US5340921A (en) 1994-08-23
EP0709396A1 (de) 1996-05-01
JPH11164689A (ja) 1999-06-22
HK1005882A1 (en) 1999-01-29
EP0312542A1 (de) 1989-04-26
US5601822A (en) 1997-02-11
AU7709587A (en) 1988-01-29
IL83078A (en) 1994-11-28
JPH1084960A (ja) 1998-04-07
JP3128544B2 (ja) 2001-01-29
CA1341042C (en) 2000-07-04

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee