ATE140697T1 - Verfahren zur herstellung von 4-substituierten azetidinonen - Google Patents

Verfahren zur herstellung von 4-substituierten azetidinonen

Info

Publication number
ATE140697T1
ATE140697T1 AT90310206T AT90310206T ATE140697T1 AT E140697 T1 ATE140697 T1 AT E140697T1 AT 90310206 T AT90310206 T AT 90310206T AT 90310206 T AT90310206 T AT 90310206T AT E140697 T1 ATE140697 T1 AT E140697T1
Authority
AT
Austria
Prior art keywords
producing
substituted azetidinones
substituted
azetidinones
beta
Prior art date
Application number
AT90310206T
Other languages
English (en)
Inventor
David Alfred Hall Jr
John Michael Morin Jr
Robert John Ternansky
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Application granted granted Critical
Publication of ATE140697T1 publication Critical patent/ATE140697T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D205/00Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D205/00Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C07D205/085Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a nitrogen atom directly attached in position 3
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D205/00Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C07D205/09Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a sulfur atom directly attached in position 4
    • C07D205/095Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a sulfur atom directly attached in position 4 and with a nitrogen atom directly attached in position 3
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02Silicon compounds
    • C07F7/08Compounds having one or more C—Si linkages
    • C07F7/10Compounds having one or more C—Si linkages containing nitrogen having a Si-N linkage

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Electrolytic Production Of Non-Metals, Compounds, Apparatuses Therefor (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AT90310206T 1989-09-20 1990-09-18 Verfahren zur herstellung von 4-substituierten azetidinonen ATE140697T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/410,173 US4992545A (en) 1989-09-20 1989-09-20 Process for preparing 4-substituted azetidinones

Publications (1)

Publication Number Publication Date
ATE140697T1 true ATE140697T1 (de) 1996-08-15

Family

ID=23623551

Family Applications (1)

Application Number Title Priority Date Filing Date
AT90310206T ATE140697T1 (de) 1989-09-20 1990-09-18 Verfahren zur herstellung von 4-substituierten azetidinonen

Country Status (13)

Country Link
US (1) US4992545A (de)
EP (1) EP0419215B1 (de)
JP (1) JPH03167170A (de)
KR (1) KR910006228A (de)
AT (1) ATE140697T1 (de)
CA (1) CA2025517A1 (de)
DE (1) DE69027900T2 (de)
DK (1) DK0419215T3 (de)
ES (1) ES2088979T3 (de)
GR (1) GR3021309T3 (de)
HU (1) HUT57188A (de)
IE (1) IE74853B1 (de)
IL (1) IL95714A (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5106475A (en) * 1989-09-20 1992-04-21 Eli Lilly And Company Process for preparing 4-substituted azetidinones
US5089610A (en) * 1991-04-25 1992-02-18 Eli Lilly And Company Ring-closure method for 1-carbacephalosporin six-membered ring
WO1994006764A1 (en) * 1992-09-18 1994-03-31 Merck & Co., Inc. Preparation of beta-methyl carbapenem intermediates

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL7806860A (nl) * 1977-07-05 1979-01-09 Farmaceutici Italia Werkwijze voor het bereiden van met nocardicine verwan- te azetidinonen.
US4368156A (en) * 1981-03-09 1983-01-11 Eli Lilly And Company Preparation of 4-haloazetidin-2-ones from 4-sulfinoazetidin-2-ones
US4421686A (en) * 1981-11-30 1983-12-20 E. R. Squibb & Sons, Inc. 4-Norbornyl-sulfonyl azetidinone intermediates and process for preparing (S)-3-acylamino-4-substituted-2-azetidinones
ZA827199B (en) * 1981-11-30 1983-08-31 Squibb & Sons Inc Novel intermediates and process for preparing(s)-3-acylamino-4-substituted-2-azetidinones
HU190404B (en) * 1982-07-30 1986-09-29 Richter Gedeon Vegyeszeti Gyar Rt,Hu Process for preparing amino-lactone-carboxylic acid
US4652651A (en) * 1983-05-31 1987-03-24 Hoffmann-La Roche Inc. Process for the manufacture of 1-sulpho-2-oxoazetidine carboxylic acid intermediates via catalytic ester cleavage
DE3340006A1 (de) * 1983-11-04 1985-05-23 Hans Rudolf Prof. Dipl.-Chem. Dr. 8000 München Pfaendler Verfahren zur herstellung von azetidin-2-onen
US4771135A (en) * 1984-05-22 1988-09-13 Eli Lilly And Company Process for carbon-carbon bond formation at the C-4 position of 3-acylaminoazetidinones and products and starting materials therefor
CA1249279A (en) * 1984-05-22 1989-01-24 Larry C. Blaszczak Process for carbon-carbon bond formation at the c-4 position of 3-acylaminoazetidinones
US4588484A (en) * 1985-02-28 1986-05-13 Eli Lilly And Company Electrochemical reduction of 3-chlorobenzo[b]thiophenes
US4665171A (en) * 1985-07-17 1987-05-12 Harvard University Process and intermediates for β-lactam antibiotics
US4960879A (en) * 1988-03-23 1990-10-02 Shionogi & Co., Ltd. Process for carbapenem intermediates

Also Published As

Publication number Publication date
IE903392A1 (en) 1991-04-10
GR3021309T3 (en) 1997-01-31
EP0419215A3 (en) 1992-04-08
KR910006228A (ko) 1991-04-27
ES2088979T3 (es) 1996-10-01
EP0419215B1 (de) 1996-07-24
JPH03167170A (ja) 1991-07-19
EP0419215A2 (de) 1991-03-27
DK0419215T3 (da) 1996-08-26
IL95714A0 (en) 1991-06-30
HUT57188A (en) 1991-11-28
CA2025517A1 (en) 1991-03-21
IE74853B1 (en) 1997-08-13
DE69027900D1 (de) 1996-08-29
HU905971D0 (en) 1991-03-28
US4992545A (en) 1991-02-12
IL95714A (en) 1994-07-31
DE69027900T2 (de) 1997-01-02

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