ATE141601T1 - 3-(1-substituierte pyrazoyl)-2-oxindolderivate - Google Patents

3-(1-substituierte pyrazoyl)-2-oxindolderivate

Info

Publication number
ATE141601T1
ATE141601T1 AT91913692T AT91913692T ATE141601T1 AT E141601 T1 ATE141601 T1 AT E141601T1 AT 91913692 T AT91913692 T AT 91913692T AT 91913692 T AT91913692 T AT 91913692T AT E141601 T1 ATE141601 T1 AT E141601T1
Authority
AT
Austria
Prior art keywords
pyrazoyl
substituted
biosynthesis
interleukin
oxindole derivatives
Prior art date
Application number
AT91913692T
Other languages
English (en)
Inventor
Carl Joseph Goddard
Gary Richard Schulte
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Application granted granted Critical
Publication of ATE141601T1 publication Critical patent/ATE141601T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Rheumatology (AREA)
  • Neurosurgery (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
AT91913692T 1990-07-24 1991-06-12 3-(1-substituierte pyrazoyl)-2-oxindolderivate ATE141601T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/557,265 US5064851A (en) 1990-07-24 1990-07-24 3-(1-substituted-pyrazoyl)-2-oxindole derivatives, compositions and use

Publications (1)

Publication Number Publication Date
ATE141601T1 true ATE141601T1 (de) 1996-09-15

Family

ID=24224706

Family Applications (1)

Application Number Title Priority Date Filing Date
AT91913692T ATE141601T1 (de) 1990-07-24 1991-06-12 3-(1-substituierte pyrazoyl)-2-oxindolderivate

Country Status (13)

Country Link
US (1) US5064851A (de)
EP (1) EP0540614B1 (de)
JP (1) JP2504659B2 (de)
AT (1) ATE141601T1 (de)
CA (1) CA2086432C (de)
DE (1) DE69121571T2 (de)
DK (1) DK0540614T3 (de)
ES (1) ES2090345T3 (de)
FI (1) FI107609B (de)
GR (1) GR3021291T3 (de)
IE (1) IE74689B1 (de)
PT (1) PT98404B (de)
WO (1) WO1992001684A1 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5698399A (en) * 1996-04-05 1997-12-16 Duff; Gordon W. Detecting genetic predisposition for osteoporosis
ID21775A (id) * 1996-10-25 1999-07-22 Yoshitomi Pharmaceutical Senyawa-senyawa 1-fenilpirazol dan penggunaan farmasinya
BR9714328A (pt) 1997-01-29 2000-03-21 Pfizer da atividade de interleucina-1
EP1270565B1 (de) * 1997-01-29 2004-06-30 Pfizer Inc. 4-Substituiertes Furan-2-sulfonamid und dessen Verwendung in der Herstellung von Sulfonylharnstoff-Derivate
CA2327185A1 (en) * 1998-04-08 1999-10-14 Abbott Laboratories Pyrazole inhibitors of cytokine production
WO2001054335A1 (en) * 2000-01-20 2001-07-26 Nortel Networks Limited Adaptive frame structures for hybrid cdma/tdma system
CN107233337A (zh) 2009-04-29 2017-10-10 阿马里纳药物爱尔兰有限公司 含有epa和心血管剂的药物组合物以及使用其的方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3259622A (en) * 1962-09-07 1966-07-05 Merck & Co Inc 1-benzyl-3-indolyl-alpha-haloalkyl and alkylidenyl acetic acids
DE3310891A1 (de) * 1983-03-25 1984-09-27 Boehringer Mannheim Gmbh, 6800 Mannheim Neue indolinon-(2)-derivate, verfahren zu ihrer herstellung, diese verbindungen enthaltende arzneimittel und zwischenprodukte
US4556672A (en) * 1984-03-19 1985-12-03 Pfizer Inc. 3-Substituted 2-oxindole-1-carboxamides as analgesic and anti-inflammatory agents
US4569942A (en) * 1984-05-04 1986-02-11 Pfizer Inc. N,3-Disubstituted 2-oxindole-1-carboxamides as analgesic and antiinflammatory agents
US4861794A (en) * 1988-04-13 1989-08-29 Pfizer Inc. 3-substituted-2-oxindole-1-carboxamides as inhibitors of interleukin-1 biosynthesis
US5047554A (en) * 1989-04-18 1991-09-10 Pfizer Inc. 3-substituted-2-oxindole derivatives

Also Published As

Publication number Publication date
DE69121571D1 (de) 1996-09-26
JP2504659B2 (ja) 1996-06-05
WO1992001684A1 (en) 1992-02-06
EP0540614B1 (de) 1996-08-21
PT98404B (pt) 1999-01-29
DK0540614T3 (da) 1996-09-09
IE74689B1 (en) 1997-07-30
FI107609B (fi) 2001-09-14
ES2090345T3 (es) 1996-10-16
FI930263L (fi) 1993-01-22
CA2086432A1 (en) 1992-01-25
CA2086432C (en) 1997-12-16
PT98404A (pt) 1992-05-29
EP0540614A1 (de) 1993-05-12
IE912574A1 (en) 1992-01-29
FI930263A0 (fi) 1993-01-22
GR3021291T3 (en) 1997-01-31
DE69121571T2 (de) 1997-01-09
US5064851A (en) 1991-11-12
JPH05504773A (ja) 1993-07-22

Similar Documents

Publication Publication Date Title
BG91773A (bg) Заместени на трето място производни на 2-оксиндола
MXPA03011681A (es) Uso de inhibidores de epoxido hidrolasa soluble, para tratar enfermedades relacionadas con la enfermedad cardiovascular.
EA200000358A1 (ru) Способ получения диарилпиридинов, полезных в качестве ингибиторов cox-2
EA200300248A1 (ru) Бициклопиразолы, активные в качестве ингибиторов киназы, способ их получения и включающие их фармацевтические композиции
IL154710A0 (en) Isoxazole derivatives and pharmaceutical compositions containing the same
MXPA04000328A (es) Derivados de alfa-hidroxiamida estatina para tratamiento de enfermedad de alzheimer.
WO2002060879A3 (en) Bacterial gyrase inhibitors and uses thereof
NO20083411L (no) Indaneddiksyrederivater og deres anvendelse som farmasoytiske midler, intermediater og fremgangsmater for fremstilling
NO20051100L (no) Pyrazolsammensetninger anvendelige som GSK-3-inhibitorer
PT1305286E (pt) Ciclopentanoindoles composicoes que contem os referidos compostos e metodos de tratamento
GEP20084435B (en) Substituted pyrrolo-pyrazole derivatives as kinase inhibitors
UA48939C2 (uk) Дизаміщені фуранони, способи їх одержання, фармацевтична композиція на їх основі, спосіб лікування запального захворювання, проміжні сполуки
NZ312840A (en) Ketoheterocyclic inhibitors of factor Xa
NL970035I2 (nl) Indool-derivaten.
DK391289A (da) Indolderivater
MXPA02011858A (es) Inhibidores de adhesion de celula mediada por alfabeta2.
DE69121571D1 (de) 3-(1-substituierte pyrazoyl)-2-oxindolderivate
NZ336042A (en) Farnesyl transferase inhibitors
ATE27144T1 (de) 2-((2,6es830321
EA200300066A1 (ru) Производные аминоалкоксибензоил-бензофурана или бензотиофена, способ их получения и содержащие их композиции
ATE223376T1 (de) Bisarylcyclobutenderivate als cyclooxygenasehemmer
EE9800230A (et) Difenüülstilbeenid kui COX-2 inhibiitorite eelravimid
CY1108187T1 (el) Μεθοδος για την παρασκευη παραγωγων της (3-οξο 2,3-διυδρο-1η-ισοϊνδολ-1-υλο)-ακετυλογουανιδινης
NO994049L (no) Metode for aa fremstille farmasöytiske forbindelser
DK1226819T3 (da) Inhibitor for 20-HETE-producerende enzym

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee