ATE141790T1 - Medikament zur hemmung der stickoxid-bildung - Google Patents

Medikament zur hemmung der stickoxid-bildung

Info

Publication number: ATE141790T1
Authority: AT; Austria
Prior art keywords: oxide formation; drug; nitrogen oxide; dimethylguanidine; methylguanidine
Prior art date: 1992-02-28

Application number

AT93870034T

Other languages

English (en)

Inventor

John Andrew Corbett

Michael Lynn Mcdaniel

Ronald Gene Tilton

Joseph Robert Williamson

Original Assignee

Univ Washington

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-02-28

Filing date

1993-02-26

Publication date

1996-09-15

1993-02-26 Application filed by Univ Washington filed Critical Univ Washington

1996-09-15 Application granted granted Critical

1996-09-15 Publication of ATE141790T1 publication Critical patent/ATE141790T1/de

Links

MWUXSHHQAYIFBG-UHFFFAOYSA-N Nitric oxide Chemical compound O=[N] MWUXSHHQAYIFBG-UHFFFAOYSA-N 0.000 title abstract 5
230000015572 biosynthetic process Effects 0.000 title abstract 2
239000003814 drug Substances 0.000 title abstract 2
230000002401 inhibitory effect Effects 0.000 title abstract 2
229940079593 drug Drugs 0.000 title 1
CHJJGSNFBQVOTG-UHFFFAOYSA-N methylguanidine Chemical compound CNC(N)=N CHJJGSNFBQVOTG-UHFFFAOYSA-N 0.000 abstract 4
LINDOXZENKYESA-UHFFFAOYSA-N 1,2-dimethylguanidine Chemical compound CNC(N)=NC LINDOXZENKYESA-UHFFFAOYSA-N 0.000 abstract 2
SWSQBOPZIKWTGO-UHFFFAOYSA-N dimethylaminoamidine Natural products CN(C)C(N)=N SWSQBOPZIKWTGO-UHFFFAOYSA-N 0.000 abstract 2
241000124008 Mammalia Species 0.000 abstract 1
206010012601 diabetes mellitus Diseases 0.000 abstract 1
238000004519 manufacturing process Methods 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
230000002265 prevention Effects 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
230000006492 vascular dysfunction Effects 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical & Material Sciences (AREA)
Epidemiology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
Organic Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Diabetes (AREA)
Hematology (AREA)
Endocrinology (AREA)
Emergency Medicine (AREA)
Obesity (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

AT93870034T 1992-02-28 1993-02-26 Medikament zur hemmung der stickoxid-bildung ATE141790T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US07/843,387 US5246971A (en)	1991-12-16	1992-02-28	Method of inhibiting nitric oxide formation

Publications (1)

Publication Number	Publication Date
ATE141790T1 true ATE141790T1 (de)	1996-09-15

Family

ID=25289823

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT93870034T ATE141790T1 (de)	1992-02-28	1993-02-26	Medikament zur hemmung der stickoxid-bildung

Country Status (7)

Country	Link
US (1)	US5246971A (de)
EP (1)	EP0558468B1 (de)
JP (1)	JP3737523B2 (de)
AT (1)	ATE141790T1 (de)
CA (1)	CA2090574C (de)
DE (1)	DE69304225T2 (de)
DK (1)	DK0558468T3 (de)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5700447A (en) *	1992-05-21	1997-12-23	The Picowder Institute For Medical Research	Methods and materials for the diagnosis and treatment of conditions such as stroke
US5801200A (en) *	1984-03-19	1998-09-01	The Picower Institute For Medical Research	Methods and materials for the diagnosis and treatment of conditions such as stroke
US5733933A (en) *	1984-03-19	1998-03-31	The Picower Institute For Medical Research	Methods and materials for the diagnosis and treatment of conditions such as stroke
US5710181A (en) *	1991-12-16	1998-01-20	Washington University	Inhibition of nitric oxide formation in inflammatory bowel disease
US5837738A (en) *	1991-12-16	1998-11-17	Washington University	Method of inhibiting nitric oxide formation
DE69319140T2 (de) *	1992-12-17	1998-10-01	Cemorc Ltd	4-guanidinobutyramid zur verbesserung des blutkreislaufs
US5424447A (en) *	1993-07-07	1995-06-13	The Medical College Of Wisconsin Research Foundation, Inc.	Heme binding compounds and use thereof
AU688811B2 (en) *	1993-10-21	1998-03-19	G.D. Searle & Co.	Amidino derivatives useful as nitric oxide synthase inhibitors
AU1912595A (en) *	1994-02-03	1995-08-21	Cambridge Neuroscience, Inc.	Therapeutic guanidines
US5807886A (en) *	1994-05-07	1998-09-15	Astra Aktiebolag	Bicyclic amidine dervatives as inhibitors of nitric oxide synthetase
US5621004A (en) *	1994-06-03	1997-04-15	Robert W. Dunn	Method for treating emesis
US5665757A (en) *	1994-07-13	1997-09-09	Robert W. Dunn	Method for treating anxiety
DE4444930A1 (de) *	1994-12-16	1996-06-27	Cassella Ag	2-Amino-1,3-thiazepine und deren Verwendung als Hemmstoffe der Stickstoffmonoxid-Synthase
WO1996021445A1 (en) *	1995-01-13	1996-07-18	The General Hospital Corporation	Methods of inhibiting neurodegenerative diseases
US5929063A (en) *	1995-03-24	1999-07-27	Children's Hospital Medical Center	Mercapto and seleno derivatives as inhibitors of nitric oxide synthase
ES2206571T3 (es) *	1995-04-20	2004-05-16	G.D. SEARLE & CO.	Agentes de amidino ciclico utiles como inhibidores de la oxido nitrico sintasa.
TR199801731T2 (xx) *	1996-03-05	1999-02-22	Children's Hospital Medical Center	Siklooksijenaz önleyicileri olarak merkapto türevleri.
US5945408A (en) *	1996-03-06	1999-08-31	G.D. Searle & Co.	Hydroxyanidino derivatives useful as nitric oxide synthase inhibitors
WO1997045108A1 (en) *	1996-05-30	1997-12-04	Children's Hospital Medical Center	Guanidino derivatives as inhibitors of the cytotoxic effect of peroxynitrite
US5789395A (en) *	1996-08-30	1998-08-04	The Research Foundation Of State University Of New York	Method of using tetracycline compounds for inhibition of endogenous nitric oxide production
US5981556A (en) *	1997-07-22	1999-11-09	G.D. Searle & Co.	1,3-diazolino and 1,3-diazolidino heterocycles as useful nitric oxide synthase inhibitors
CA2333691A1 (en)	1998-06-10	1999-12-16	G.D. Searle & Co.	Heterobicyclic and tricyclic nitric oxide synthase inhibitors
CA2339879C (en)	1998-08-24	2011-11-15	Toshio Miyata	Carbonyl-stress improving agent and peritoneal dialysate
WO2001091773A2 (en)	2000-05-31	2001-12-06	Encelle, Inc.	Method of stimulating hair growth
US6344473B1 (en)	2000-08-07	2002-02-05	G.D. Searle & Co.	Imidazoles useful as nitric oxide synthase inhibitors
WO2003105864A1 (en) *	2002-06-13	2003-12-24	Board Of Regents, The University Of Texas System	Methods and compositions involving aldose reductase inhibitors
CA2685202C (en)	2007-03-23	2017-11-28	The Board Of Regents Of The University Of Texas System	Methods for treating allergic asthma
US20090270490A1 (en) *	2008-04-24	2009-10-29	The Board Of Regents Of The University Of Texas System	Methods involving aldose reductase inhibition

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4983604A (en) *	1987-11-13	1991-01-08	The Rockefeller University	Inhibitors of nonenzymatic cross-linking
US4758583A (en) *	1984-03-19	1988-07-19	The Rockefeller University	Method and agents for inhibiting protein aging
US5218001A (en) *	1984-03-19	1993-06-08	The Rockefeller University	Inhibitors of the advanced glycosylation of proteins and methods of use therefor

1992
- 1992-02-28 US US07/843,387 patent/US5246971A/en not_active Expired - Lifetime
1993
- 1993-02-26 CA CA002090574A patent/CA2090574C/en not_active Expired - Fee Related
- 1993-02-26 EP EP93870034A patent/EP0558468B1/de not_active Expired - Lifetime
- 1993-02-26 DE DE69304225T patent/DE69304225T2/de not_active Expired - Fee Related
- 1993-02-26 AT AT93870034T patent/ATE141790T1/de not_active IP Right Cessation
- 1993-02-26 DK DK93870034.1T patent/DK0558468T3/da active
- 1993-02-26 JP JP03857293A patent/JP3737523B2/ja not_active Expired - Fee Related

Also Published As

Publication number	Publication date
EP0558468B1 (de)	1996-08-28
CA2090574A1 (en)	1993-08-29
DE69304225T2 (de)	1997-01-30
EP0558468A1 (de)	1993-09-01
DE69304225D1 (de)	1996-10-02
DK0558468T3 (da)	1996-09-16
US5246971A (en)	1993-09-21
JP3737523B2 (ja)	2006-01-18
JPH069380A (ja)	1994-01-18
CA2090574C (en)	1999-05-25

Legal Events

Date	Code	Title	Description
2009-11-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
DE69304225D1 (de)	1996-10-02	Medikament zur Hemmung der Stickoxid-Bildung
ZA9410263B (en)	1995-08-29	Accelerated release composition containing bromocriptine
ATE108657T1 (de)	1994-08-15	Galanthemin enthaltende pharmazeutische formulierung zur behandlung des alkoholismus.
CA2106172A1 (en)	1994-03-15	Use of 2-(3,4-Dimethoxycinnamoyl)Aminobenzoic Acid for the Treatment of Restenosis Associated with Coronary Intervention
NZ504618A (en)	2002-09-27	Controlled release therapeutic formulation for administering tolterodine maintaining a constant serum level
TW273550B (de)	1996-04-01
MY111260A (en)	1999-10-30	Pharmaceutical composition for the treatment of nicotine dependence
IL98258A0 (en)	1992-06-21	Composition for treating impotence containing doxazosin,amlodipine,or u.k.52,046
GB9220570D0 (en)	1992-11-11	Therapeutic agent
DK0668077T3 (da)	2001-10-08	Produkter, som indeholder G-CSF og TNF-bindende protein
HUT62192A (en)	1993-04-28	Process for producing pharmaceutical compositions comprising tomoxetine and suitable for treating diseases of lower urinary tract
DK0583026T3 (de)	1997-02-24
EP0799618A3 (de)	1997-11-12	Verwendung von Alpha-1-Adrenorezeptor-Antagonisten zur Herstellung eines Medikaments für die Vorbeugung und die Behandlung von Krebs
GB8816760D0 (en)	1988-08-17	Therapeutic compounds
IL106751A0 (en)	1993-12-08	Pharmaceutical compositions for the treatment of reversible obstructive airways diseases
DK0572557T3 (da)	2010-02-01	Anvendelse af topotecan til fremstilling af et lægemiddel til anvendelse ved behandling af kræft i æggestokkene
DK0457336T3 (da)	1995-08-07	Ny anvendelse af 4-carbamoyl-1-beta-D-ribofuranosylimidazolium-5-olat
EP0356192A3 (de)	1990-12-27	Verhütung und Behandlung von Lebergeschwüren bei Tieren
ES2114681T3 (es)	1998-06-01	Tratamiento transdermico de cancer con camptotecina insoluble en agua en la forma de anillo de lactona cerrado.
NO932596D0 (no)	1993-07-16	Sammensetning og farmsoeytisk forbindelse for behandling av "kalsium-oksalat-sten"-sykdom
IT1267664B1 (it)	1997-02-07	Composizione a base di fosfocreatina e suo uso farmaceutico
SI0825860T1 (en)	2002-02-28	Use of a composition comprising amoxycillin and clavulanic acid for the manufacture of a medicament for the treatment of bacterial infections in paediatric patients
MY110416A (en)	1998-05-30	Composition for the treatment of schizophrenia.